ライフサイエンスコーパス: ubiquitin-conjugating enzyme

1 ventional genes such as Argonaute2 and an E2-ubiquitin conjugating enzyme.

2 (RBX1) subunit and preventing binding to the ubiquitin-conjugating enzyme.

3 53 localization and activity by Ubc13, an E2 ubiquitin-conjugating enzyme.

4 plexes by providing a recognition site for a ubiquitin-conjugating enzyme.

5 iquitin chains with Ubc13-Mms2 acting as the ubiquitin-conjugating enzyme.

6 ith a SUMO-conjugating enzyme but not with a ubiquitin-conjugating enzyme.

7 bstrates for polyubiquitination by the Cdc34 ubiquitin-conjugating enzyme.

8 which is the mammalian homolog of a yeast E2 ubiquitin-conjugating enzyme.

9 n subunit to a cullin that in turn binds the ubiquitin-conjugating enzyme.

10 two-subunit catalytic core that recruits the ubiquitin-conjugating enzyme.

11 f Mdm2 facilitates the recruitment of the E2 ubiquitin-conjugating enzyme.

12 s insights into the structural plasticity of ubiquitin-conjugating enzymes.

13 Nedd4-2 cooperation with UBE2D and UBE2L3 E2 ubiquitin-conjugating enzymes.

14 and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes.

15 ct subsets of E2 (ubiquitin carrier protein) ubiquitin-conjugating enzymes.

16 Human Ubc9 is homologous to ubiquitin-conjugating enzymes.

17 appears to be required for interaction with ubiquitin-conjugating enzymes.

18 identified a P. falciparum homolog of the E2 ubiquitin-conjugating enzyme 13 (UBC13) as an endogenous

19 at-shock protein 90 (13%); osteopontin (4%); ubiquitin-conjugating enzyme (15%); translation-initiati

20 Here, we report that the plant ubiquitin-conjugating enzyme 32 (UBC32), an ER-bound E2

21 we identify an E2 enzyme, Triticum aestivum Ubiquitin conjugating enzyme 4 (TaU4) that functions in

22 Use of a temperature-sensitive mutant of ubiquitin-conjugating enzyme 4 (Ubc4') as a model substr

23 stability) were Prdm4 (PR domain 4) > Ube4a (Ubiquitin-Conjugating Enzyme 4a) > Enox2 (Ecto-NOX Disul

24 except for modest declines in parkin, human ubiquitin-conjugating enzyme 5 (UbcH5), and beta-TRCP (t

25 munofluorescence staining; HDAC4, Rad51, and ubiquitin-conjugating enzyme 9 (Ubc9) in HCC cell nuclei

26 Ubiquitin-conjugating enzyme 9 (Ubc9) is required for su

27 Ubiquitin-conjugating enzyme 9 (UBC9) is the only known

28 ying Apobec2-interacting proteins, including ubiquitin-conjugating enzyme 9 (Ubc9); topoisomerase I-b

29 arcomeric M-line region.MURF-1 also binds to ubiquitin-conjugating enzyme-9 and isopeptidase T-3, enz

30 Using UbcH5c as ubiquitin-conjugating enzyme, a ubiquitin ligase activit

31 erved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in

32 OspG has been reported to bind host E2 ubiquitin-conjugating enzymes activated with ubiquitin (

33 fore pVHL can serve as an adaptor for both a ubiquitin conjugating enzyme and a kinase.

34 Mechanistically, we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, is

35 L is stabilized when a peroxisome-associated ubiquitin-conjugating enzyme and its membrane anchor are

36 hich is defective in a peroxisome-associated ubiquitin-conjugating enzyme and its membrane tether.

37 licational repair mediated by the Mms2-Ubc13 ubiquitin-conjugating enzyme and Rad5.

38 nt yeast genetic studies have implicated the ubiquitin-conjugating enzyme and ubiquitin ligase functi

39 sentia homologue (Siah) family proteins bind ubiquitin-conjugating enzymes and target proteins for pr

40 ion of reticulocyte proteins, which contains ubiquitin-conjugating enzymes and the proteasome, to det

41 In the ubiquitin-proteasome system, ubiquitin-conjugating enzymes and ubiquitin ligases appe

42 ymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligase

43 e UbcH5 subfamily (ubiquitin carrier protein/ubiquitin-conjugating enzymes), and in the case of caspa

44 ubiquitin ligase, UbcH7 as its associated E2 ubiquitin conjugating enzyme, and a new 22-kilodalton gl

45 ed degradation (ERAD) components Ubc7, an E2 ubiquitin conjugating enzyme, and Hrd1, an E3 ubiquitin

46 onds to HR6B, the yeast homologue of Rad6, a ubiquitin-conjugating enzyme, and a key player in postre

47 ing an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and an E3 ubiquitin ligase

48 These host proteins, such as eEF1A, Cdc34 E2 ubiquitin-conjugating enzyme, and ESCRT proteins (Bro1p

49 CP0 (residues 20-241) bind the UbcH3 (cdc34) ubiquitin-conjugating enzyme, and its carboxy terminus e

50 ugh the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supporte

51 ncentration in the vicinity of the Rbx-bound ubiquitin-conjugating enzyme, and thus the rate at which

52 es the E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and, frequently, a substra

53 tive inactivation, whereas activities of the ubiquitin-conjugating enzymes are more resistant to oxid

54 iquitin ligases, together with their cognate ubiquitin-conjugating enzymes, are responsible for the u

55 that SCF(Cdc4) acts together with the Cdc34 ubiquitin-conjugating enzyme at the level of the G prote

56 g indicated that XERICO interacts with an E2 ubiquitin-conjugating enzyme (AtUBC8) and ASK1-interacti

57 Tsg101 UEV resembles canonical E2 ubiquitin conjugating enzymes, but has an additional N-t

58 ic ablation of Ubc13, a Lys63 (K63)-specific ubiquitin-conjugating enzyme, caused aberrant T cell act

59 in ligase complex that functions with the E2 ubiquitin conjugating enzyme CDC34.

60 The ubiquitin-conjugating enzyme CDC34 (UBC3) is linked to c

61 The ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase

62 t chain assembly by ubiquitin ligase SCF and ubiquitin-conjugating enzyme Cdc34 is facilitated by the

63 We have found that the E2 ubiquitin-conjugating enzyme Cdc34 is required for degra

64 Furthermore, we demonstrate that the ubiquitin-conjugating enzyme Cdc34 mediates cell cycle-d

65 ally blocked in mutants defective for the E2 ubiquitin-conjugating enzyme Cdc34 or the cullin homolog

66 llin-RING ubiquitin ligase SCF(Cdc4) and the ubiquitin-conjugating enzyme Cdc34.

67 demonstrate that San1 can function with two ubiquitin-conjugating enzymes, Cdc34 and Ubc1.

68 ubiquitin ligase SCF(Met30) acting with the ubiquitin-conjugating enzyme Cdc34p.

69 protein ligase that, in conjunction with the ubiquitin-conjugating enzymes Cdc34p and Ubc1p, targets

70 lin-35 and ubc-18, a gene that encodes an E2 ubiquitin-conjugating enzyme closely related to human UB

71 TRIKA1 is a dimeric ubiquitin-conjugating enzyme complex composed of Ubc13 a

72 TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13

73 ement of the Rad5 protein and the Mms2-Ubc13 ubiquitin-conjugating enzyme complex in this repair proc

74 The Rad6-Rad18 ubiquitin-conjugating enzyme complex of Saccharomyces ce

75 bc13, a member along with Uev1A of a dimeric ubiquitin-conjugating enzyme complex.

76 Free ubiquitin and the ubiquitin-conjugating enzyme CrUbc13 are detected in fla

77 Finally, a giant ubiquitin-conjugating enzyme, dBruce, is required to pro

78 f the Not4-interacting protein Ubc4, a known ubiquitin-conjugating enzyme, decreases H3K4me3.

79 scuss how these findings relate to how other ubiquitin-conjugating enzymes direct the lysine specific

80 mber of a small group of inactive variant E2 ubiquitin-conjugating enzyme domain-containing proteins

81 uentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

82 actosidase, peroxiredoxin 1, beta-actin, and ubiquitin-conjugating enzyme E2 among them.

83 The function of RBX1 is to bind the ubiquitin-conjugating enzyme E2 and bring it into close

84 ses (CRLs) assist in ubiquitin transfer from ubiquitin-conjugating enzyme E2 to the substrate.

85 changes in CBL stability and its binding to ubiquitin-conjugating enzyme E2, by performing blind CBL

86 -encoded proteins were identified, including ubiquitin-conjugating enzyme E2, casein kinase II (CKII)

87 romotes the ubiquitylation of itself and the ubiquitin conjugating enzyme (E2) cdc34 and interacts wi

88 trate that c-IAP1, in collaboration with the ubiquitin conjugating enzyme (E2) enzyme UbcH5a, mediate

89 Here we report that Miz1 interferes with the ubiquitin conjugating enzyme (E2) Ubc13 for binding to t

90 Using the ubiquitin conjugating enzyme (E2) UBE2T and ubiquitin li

91 ediated by ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase

92 tion of RIP1 in vitro in the presence of the ubiquitin conjugating enzymes (E2) UbcH13 or UbcH5a.

93 chain and requiring either a single pair of ubiquitin-conjugating enzyme (E2) and ubiquitin ligase (

94 l-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. r

95 RING domain is unable to bind and activate a ubiquitin-conjugating enzyme (E2) efficiently.

96 Here, we show that UBE2T is the ubiquitin-conjugating enzyme (E2) essential for this pat

97 inus of Ub and the active site cysteine of a ubiquitin-conjugating enzyme (E2) is formed.

98 To identify the ubiquitin-conjugating enzyme (E2) required for dislocati

99 tosol led to the identification of Ubc5 as a ubiquitin-conjugating enzyme (E2) required for IRF3 acti

100 Ubc7p is a ubiquitin-conjugating enzyme (E2) that functions with en

101 UBC13 (also known as UBE2N) is a ubiquitin-conjugating enzyme (E2) that heterodimerizes w

102 itination and proteasomal degradation of the ubiquitin-conjugating enzyme (E2) UbcH10.

103 istically, Ndfip1 facilitated recruitment of ubiquitin-conjugating enzyme (E2) UbcH7 to Itch.

104 ioester bond that links "donor" ubiquitin to ubiquitin-conjugating enzyme (E2) undergoes nucleophilic

105 port that COP10 encodes a protein similar to ubiquitin-conjugating enzyme (E2) variant proteins (UEV)

106 nzymes:a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), a ubiquitin protein l

107 a small RING domain protein Roc1/Rbx1 and a ubiquitin-conjugating enzyme (E2), and a substrate recru

108 called a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-prote

109 It tethers the ERAD ubiquitin-conjugating enzyme (E2), Ubc7p, to the ER and

110 tion leads to a decrease in affinity for the ubiquitin-conjugating enzyme (E2), UbcH5b.

111 intermediate and catalyzes its transfer to a ubiquitin-conjugating enzyme (E2).

112 oning between the attached substrate and the ubiquitin-conjugating enzyme (E2).

113 hemselves due to interactions with a charged ubiquitin-conjugating enzyme (E2).

114 inhibitor that blocks interactions with its ubiquitin-conjugating enzyme (E2).

115 Together with ubiquitin ligases (E3), ubiquitin-conjugating enzymes (E2) are charged with the

116 ity to facilitate transfer of ubiquitin from ubiquitin-conjugating enzymes (E2) to substrates.

117 E1), the three-dimensional structures of the ubiquitin-conjugating enzymes (E2), and the chemistry of

118 including ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligase

119 1), which activate and transfer ubiquitin to ubiquitin-conjugating enzymes (E2).

120 of the anaphase-promoting complex, including ubiquitin-conjugating enzyme E2C, resulting in degradati

121 tudy, including contactin 1, myozenin 2, and ubiquitin-conjugating enzymes E2C and E2S.

122 CH5a-ubiquitin thioester adduct (UBCH5a is a ubiquitin-conjugating enzyme E2D 1 UBC4/5 homolog yeast)

123 o-NOX Disulfide-Thiol Exchanger 2) > Ube2d2 (Ubiquitin-conjugating enzyme E2D 2) > Actb (Actin beta).

124 ndependent manner and cooperates with the E2 ubiquitin-conjugating enzyme E2D2 to promote ubiquitinat

125 or coexpression of the dominant-negative E2 ubiquitin-conjugating enzyme, E2D2, attenuates this modi

126 tide polymorphism in the gene coding for the ubiquitin-conjugating enzyme E2L6 (Ube2l6, also known as

127 bosomal protein L27a) and the ApE2N (Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased a

128 ated the expression of the proapoptotic gene ubiquitin-conjugating enzyme E2N, and downregulated the

129 Here, we report that the stability of Ubiquitin-conjugating enzyme E2S (UBE2S) is regulated by

130 The class III ubiquitin conjugating enzymes (E2s) are distinguished fr

131 Ubiquitin-conjugating enzymes (E2s or Ubcs) are essentia

132 Although the functional interaction between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligase

133 gases (E3s) and function by interacting with ubiquitin-conjugating enzymes (E2s) charged with ubiquit

134 Ubiquitin-conjugating enzymes (E2s) collaborate with the

135 Protein ubiquitination is catalyzed by ubiquitin-conjugating enzymes (E2s) in collaboration wit

136 re, we demonstrate that COP10 interacts with ubiquitin-conjugating enzymes (E2s) in vivo, and can enh

137 bstrate for the E3 ligase Mdm2, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiq

138 by two distinct pathways, one involving the ubiquitin-conjugating enzymes (E2s) Ubc6 and Ubc7 and th

139 In yeast two ubiquitin-conjugating enzymes (E2s), UBC6p and UBC7p are

140 itin ligase (E3) that along with its cognate ubiquitin-conjugating enzymes (E2s), Ubc7 and the C-term

141 ation, suggesting a significant role for the ubiquitin-conjugating enzyme function of Cdc34p in TBSV

142 e P falciparum housekeeping gene (PF08_0085; ubiquitin-conjugating enzyme gene) in bone marrow (n = 1

143 on to cyanobacteria: six protease genes, one ubiquitin-conjugating enzyme gene, and two rRNA genes, a

144 e expression pattern of one protease and the ubiquitin-conjugating enzyme genes was positively correl

145 shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ub

146 In this way, we have uncovered a novel human ubiquitin-conjugating enzyme, have isolated a human cDNA

147 demonstrate that RFPL4 interacts with the E2 ubiquitin-conjugating enzyme HR6A, proteasome subunit be

148 UBR2 interacts with the ubiquitin conjugating enzyme HR6B and its substrate H2A

149 and could autoubquitylate with different E2 ubiquitin conjugating enzymes in vitro.

150 (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC c

151 n select biological pathways, exemplified by ubiquitin-conjugating enzymes in ubiquitination, carrier

152 -SMAD2/3 by binding to and inhibiting the E2 ubiquitin-conjugating enzymes independent of its catalyt

153 The second contains CDC34, encoding a ubiquitin conjugating enzyme, indicating a link between

154 on in the murine Ube2o gene, which encodes a ubiquitin-conjugating enzyme induced during erythropoies

155 analysis to determine that PEX4, an apparent ubiquitin-conjugating enzyme, interacts with a previousl

156 We show that Bendless (BEN), an E2 ubiquitin-conjugating enzyme, interacts with NOPO in a y

157 nkage-specific substrates, including Ubc6, a ubiquitin-conjugating enzyme involved in endoplasmic ret

158 ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzymes is fundamentally important

159 We have recently shown that Rad6B, an ubiquitin-conjugating enzyme, is a transcriptional targe

160 We show that RAD6, an ubiquitin-conjugating enzyme, is significantly overexpre

161 We show that UbcH7, an E2 ubiquitin-conjugating enzyme, is specifically involved i

162 A putative ubiquitin conjugating enzyme known as UBE2Q2 was previou

163 To determine whether hMms2, a ubiquitin-conjugating enzyme-like protein, plays a criti

164 ) receptor ubiquitination is mediated by the ubiquitin-conjugating enzyme, (mam)Ubc7, a component of

165 -specific pattern was observed in the pex4-1 ubiquitin-conjugating enzyme mutant.

166 proteins in vitro in the presence of two E2 ubiquitin-conjugating enzymes, namely, UBE2D1 (UbcH5a) a

167 Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA r

168 Among these genes is cdc34, the ubiquitin-conjugating enzyme of the Skp1/cullin/F-box (S

169 ng complex (APC) E3 ligase functions with E2 ubiquitin-conjugating enzymes of the E2-C and Ubc4/5 fam

170 3 ligase: ICP0 interacts with at least three ubiquitin-conjugating enzymes of which one, UbcH5a, is r

171 ducing function of the peroxisome-associated ubiquitin-conjugating enzyme PEX4 restored PEX10 levels

172 In yeast, the Rad6-Rad18 ubiquitin conjugating enzyme plays a critical role in pr

173 The Cdc34 ubiquitin-conjugating enzyme plays a central role in pro

174 expected to form the docking site of the E2 ubiquitin-conjugating enzyme, providing a structure-base

175 gase Bre1 (human RNF20/40) pairs with the E2 ubiquitin conjugating enzyme Rad6 to monoubiquitinate H2

176 Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methyl

177 The E2 ubiquitin-conjugating enzyme RAD6 is essential for TLS.

178 t non-essential gene, we discovered that the ubiquitin-conjugating enzyme Rad6 is required for methyl

179 The ubiquitin-conjugating enzyme Rad6, which directly intera

180 f phosphorylated Sml1 is dependent on the E2 ubiquitin-conjugating enzyme, Rad6, the E3 ubiquitin lig

181 This degradation pathway shares its ubiquitin-conjugating enzyme, Rad6, with the post-replic

182 in histone H2B ubiquitination along with the ubiquitin-conjugating enzyme Rad6p and the ubiquitin lig

183 ubiquitination requires the presence of the ubiquitin-conjugating enzyme Rad6p and the ubiquitin lig

184 te specificity and, in collaboration with E2 ubiquitin-conjugating enzymes, regulate the nature of po

185 Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonic

186 Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonica

187 een, revealing that mutation in ubcD1, an E2 ubiquitin-conjugating enzyme, resulted in retention of C

188 iochemical and genetic characterization of a ubiquitin-conjugating enzyme Rhp6 (a homolog of budding

189 By recruiting E2 ubiquitin-conjugating enzyme(s), Mdm2 acts as a molecula

190 Knockdown of MAGE-L2-TRIM27 or the Ube2O E2 ubiquitin-conjugating enzyme significantly impaired retr

191 UBE2L3 is an E2 ubiquitin-conjugating enzyme, specially adapted to funct

192 with Pi SLFs, S-RNases, Pi CUL1-G, and an E2 ubiquitin-conjugating enzyme, suggesting that Pi CUL1-G,

193 Rad6 is a yeast E2 ubiquitin conjugating enzyme that monoubiquitinates hist

194 nes, homologs of the yeast RAD6 gene, encode ubiquitin conjugating enzymes that are required for post

195 Fni3 encodes a homolog of the Ubc13-type ubiquitin-conjugating enzyme that catalyzes exclusively

196 s event is tightly regulated by UBE2C, an E2 ubiquitin-conjugating enzyme that donates ubiquitin to t

197 a pivotal negative regulator of Ubc13, an E2 ubiquitin-conjugating enzyme that facilitates TRAF6 K63-

198 UBC6e is a tail-anchored E2 ubiquitin-conjugating enzyme that is part of a dislocati

199 UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7.

200 e findings suggest that Rad6 is an important ubiquitin-conjugating enzyme that may play a significant

201 RAD6 is an E2 ubiquitin-conjugating enzyme that plays a pivotal role i

202 l that PHA-1, a novel protein, and UBC-18, a ubiquitin-conjugating enzyme that we have previously sho

203 s, homologues of the yeast Rad6 gene, encode ubiquitin-conjugating enzymes that are required for post

204 e catalytic cysteine residue of Rsp5p and on ubiquitin-conjugating enzymes that bind Rsp5p.

205 We profiled E2 ubiquitin-conjugating enzymes that pair with Roquins and

206 tion is the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate or a growing

207 which promote ubiquitin transfer from an E2 ubiquitin-conjugating enzyme to a substrate.

208 function is the selection of a particular E2 ubiquitin-conjugating enzyme to accomplish ubiquitinatio

209 mediate the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to specific substrate prote

210 d mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate.

211 tin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin

212 arkin functions with UbcH13/Uev1a, a dimeric ubiquitin-conjugating enzyme, to assemble ubiquitin lysi

213 IN-35 retinoblastoma protein homolog and the ubiquitin-conjugating enzyme UBC-18 function redundantly

214 d region (UTR) of a gene encoding a putative ubiquitin-conjugating enzyme (UBC) in Arabidopsis thalia

215 The ubiquitin-conjugating enzyme (UBC) involved in this impo

216 Here, we show that reduction in the E2 ubiquitin-conjugating enzyme (UBC) of the E2-C family th

217 Ubc3/Cdc34 is a ubiquitin-conjugating enzyme (Ubc) with well established

218 g the differentiation process, the levels of ubiquitin-conjugating enzyme (Ubc)-1 increased approxima

219 ogs, AtCHIP interacts with a unique class of ubiquitin-conjugating enzymes (UBC or E2) that belongs t

220 lutaryl-CoA reductase (HMGR) or deficient in ubiquitin-conjugating enzymes (Ubc; UBC), revealed that

221 Furthermore, we find that the E2 ubiquitin conjugating enzyme, UBC-18, is essential and s

222 a by XIAP is dependent on the activity of E2 ubiquitin conjugating enzyme Ubc13.

223 AP1 by antagonizing interactions with the E2 ubiquitin conjugating enzymes Ubc13 and UbcH5c.

224 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes met

225 We identified both the ubiquitin-conjugating enzyme Ubc13 and the ubiquitin lig

226 m-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rodent cerebellar

227 The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-sp

228 The E2 ubiquitin-conjugating enzyme UBC13 plays pivotal roles i

229 E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically gener

230 ontaining adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor o

231 nuclein (PARK1), and in conjunction with the ubiquitin-conjugating enzyme Ubc13, stimulates K63-linke

232 es NF-kappaB in a manner that depends on the ubiquitin-conjugating enzyme Ubc13, TNF receptor-associa

233 vitro system to examine the activity of the ubiquitin-conjugating enzyme UBC13-UEV1A with TRAF6 in w

234 exhibited partial dependence on RNF8 and the ubiquitin-conjugating enzyme UBC13.

235 ion of Tax is critically dependent on the E2 ubiquitin-conjugating enzyme Ubc13.

236 DNA damage repair by targeting ZEB1 and the ubiquitin-conjugating enzyme Ubc13.

237 ctivation of TAK1 and IKK requires the human ubiquitin-conjugating enzymes Ubc13 and UEV1a.

238 Paracaspase and a ubiquitin-conjugating enzyme (UBC13) were both required

239 Among all the E2 ubiquitin-conjugating enzymes, Ubc13, which heterodimeri

240 However, FBPase import required the ubiquitin-conjugating enzyme Ubc1p.

241 As in other organisms, the E2 ubiquitin-conjugating enzyme Ubc2 and the E3 ubiquitin l

242 es Rhp6, the S. pombe homologue of the human ubiquitin-conjugating enzyme Ubc2.

243 The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the d

244 MicroRNA399-mediated regulation of the ubiquitin-conjugating enzyme UBC24/phosphate2 (PHO2) is

245 biquitin-proteasome pathway involving the E2 ubiquitin conjugating enzymes Ubc4/5 and the HECT (Homol

246 demonstrate that Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin liga

247 The ubiquitin-conjugating enzyme Ubc4 was found in the same

248 itin E3 ligase activity that requires the E2 ubiquitin-conjugating enzyme Ubc4.

249 in the proteasome, and in genes encoding the ubiquitin-conjugating enzymes Ubc4 and Ubc5, stabilized

250 te (ATP) and was stimulated by addition of a ubiquitin-conjugating enzyme, Ubc4.

251 r the gene coding for one of the major yeast ubiquitin-conjugating enzymes, Ubc4, or the gene coding

252 ubiquitylation of target proteins by the E2 ubiquitin-conjugating enzyme Ubc5.

253 gases that activate ubiquitylation by the E2 ubiquitin-conjugating enzyme Ubc5.

254 e (RNAi) studies show that Aup1 recruits the ubiquitin-conjugating enzyme Ubc7 to lipid droplets and

255 Cue1p has been shown to recruit the soluble ubiquitin-conjugating enzyme, Ubc7p, to the cytoplasmic

256 raction of the STRA13 protein with the human ubiquitin-conjugating enzyme (UBC9) protein, the specifi

257 ally important, we provide evidence that the ubiquitin-conjugating enzyme, Ubc9, is expressed at high

258 n of defects is also seen in a mutant in the ubiquitin-conjugating enzyme ubcD1 and a mutant in the 1

259 C) E3 ubiquitin ligase functions with the E2 ubiquitin-conjugating enzyme UbcH10 in the orderly progr

260 The human ubiquitin-conjugating enzyme, UbcH10, is an essential me

261 iquitylation is best supported by a specific ubiquitin-conjugating enzyme, UbcH3/CDC34, and requires

262 nteracts with MLK3 and, together with the E2 ubiquitin-conjugating enzyme UbcH5 (UbcH5a, -b, -c, or -

263 affect the protein levels of cIAP1 or its E2 ubiquitin-conjugating enzymes UbcH5 and Ubc13.

264 on Tgamma was selectively catalyzed by human ubiquitin-conjugating enzymes UbcH5 and UbcH7 and was co

265 In addition, different IAPs require the same ubiquitin-conjugating enzymes UbcH5a and UbcH6 for their

266 omain is found to interact with the cellular ubiquitin-conjugating enzymes UbcH5A to -C and UbcH13, w

267 ubiquitin ligases that cooperate with the E2 ubiquitin-conjugating enzymes UbcH5a, -b, and -c to medi

268 iquitin ligase that acts in conjunction with ubiquitin-conjugating enzymes UbcH5a, UbcH5c, and UbcH6.

269 of interactions between CHIP and its cognate ubiquitin-conjugating enzyme, UbcH5a, which may in turn

270 ubiquitin ligase activity, BARD1 and the E2 ubiquitin-conjugating enzyme, UbcH5a.

271 that are important for interacting with the ubiquitin-conjugating enzyme UbcH5b.

272 that both PJA1 and PJA2 are able to bind the ubiquitin-conjugating enzyme UbcH5B.

273 Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjugating enzyme, UbcH5B (UBE2D2), with stri

274 bunits, Ring1B and Bmi1, together with an E2 ubiquitin-conjugating enzyme, UbcH5c.

275 TSSC5 that can function in concert with the ubiquitin-conjugating enzyme UbcH6.

276 Measurements of the E2 ubiquitin-conjugating enzyme UbcH7 binding to Parkin and

277 We investigated the role of the ubiquitin-conjugating enzyme UBCH7 in nuclear receptor t

278 Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjun

279 ract specifically with the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 and facilitate the ub

280 Siah-1 binds the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 and facilitates mono-

281 ing binds and recruits the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 to syntaxin 1 and fac

282 We have discovered that the ubiquitin-conjugating enzyme UbcM2 is a novel regulator

283 ation is mediated by the concerted action of ubiquitin-conjugating enzymes (Ubcs or E2s) and ubiquiti

284 tein), elusive enzyme-substrate interaction (ubiquitin-conjugating enzyme UBE2D3 with substrate PCNA)

285 l TDP-43 is ubiquitinated, we focused on the ubiquitin-conjugating enzyme UBE2E3 and the ubiquitin is

286 as undertaken to determine whether the human ubiquitin-conjugating enzyme, UBE2E3, is essential for R

287 quality control is to recruit the soluble E2 ubiquitin-conjugating enzyme UBE2G2.

288 RAD) by the ubiquitin E3 ligase HRD1, and E2 ubiquitin conjugating enzyme UBE2J1, and represent one o

289 mal activity and also increases the level of ubiquitin-conjugating enzyme UBE2N (Ubc13) in synaptosom

290 The E2 ubiquitin-conjugating enzyme UBE2N was a preferential bi

291 Here, we found that the conserved ubiquitin-conjugating enzyme UBE2O directly recognized j

292 The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite spec

293 al hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and describe its biop

294 COP10 is a ubiquitin-conjugating enzyme variant (UEV), which is tho

295 ew member of the DLK-1 pathway, UEV-3, an E2 ubiquitin-conjugating enzyme variant.

296 s-63-linked ubiquitination, whereas Suv is a ubiquitin-conjugating enzyme variant.

297 ore, gene and protein expression of UbcH2, a ubiquitin conjugating enzyme, was also increased early i

298 d screening, the mitotic cyclin B1 and an E2 ubiquitin-conjugating enzyme were isolated as HEI10-inte

299 Further analysis of Cdc34p E2 ubiquitin-conjugating enzyme, which is one of the host p

300 UBE2L3 is an E2 ubiquitin-conjugating enzyme with specificity for RING-i