ライフサイエンスコーパス: ubiquitin-dependent proteolysis

1 ia inducible factor (HIF)-alpha subunits for ubiquitin dependent proteolysis.

2 rogression and postmitotic processes through ubiquitin-dependent proteolysis.

3 Many proteins are regulated by ubiquitin-dependent proteolysis.

4 d negatively regulates Ira2 by promoting its ubiquitin-dependent proteolysis.

5 h F-box-binding protein beta-TrCP, undergoes ubiquitin-dependent proteolysis.

6 criptional activity and targets ER alpha for ubiquitin-dependent proteolysis.

7 dulate multiple biological processes through ubiquitin-dependent proteolysis.

8 due to accelerated protein breakdown through ubiquitin-dependent proteolysis.

9 transcription factors, is regulated through ubiquitin-dependent proteolysis.

10 by the ubiquitin E3 ligase SCF(SKP2) through ubiquitin-dependent proteolysis.

11 vel regulatory mechanism of hematopoiesis by ubiquitin-dependent proteolysis.

12 Cdk-dependent G1 phosphorylation leading to ubiquitin-dependent proteolysis.

13 way that regulates the entry into mitosis by ubiquitin-dependent proteolysis.

14 processing of damaged and toxic proteins by ubiquitin-dependent proteolysis.

15 lar levels of many proteins are regulated by ubiquitin-dependent proteolysis.

16 processes by marking regulatory proteins for ubiquitin-dependent proteolysis.

17 n potential yet simultaneously target Mi for ubiquitin-dependent proteolysis.

18 ess increases phytosphingosine and activates ubiquitin-dependent proteolysis.

19 uman papillomaviruses (HPVs) targets p53 for ubiquitin-dependent proteolysis.

20 complexes that target specific proteins for ubiquitin-dependent proteolysis.

21 short-lived proteins that are controlled by ubiquitin-dependent proteolysis.

22 on was not affected in mutants defective for ubiquitin-dependent proteolysis.

23 tin chains, which correlates with defects in ubiquitin-dependent proteolysis.

24 owth, and they have at most minor effects on ubiquitin-dependent proteolysis.

25 the fat facets gene and is thus regulated by ubiquitin-dependent proteolysis.

26 xperiments identifying Gt as a substrate for ubiquitin-dependent proteolysis.

27 ulators, such as cyclins, for destruction by ubiquitin-dependent proteolysis.

28 se, the SCF(SKP2) complex, that mediates p27 ubiquitin-dependent proteolysis [5-7].

29 n, in concert with control of transcription, ubiquitin-dependent proteolysis and cytoskeletal polarit

30 ons or structurally related determinants for ubiquitin-dependent proteolysis and perhaps other proces

31 tes, stabilization of typical substrates for ubiquitin-dependent proteolysis, and enhanced susceptibi

32 etwork of proteins that function together in ubiquitin-dependent proteolysis, and the UBL method offe

33 The flexibility and specificity of ubiquitin-dependent proteolysis are mediated, in part, b

34 ver, Lys(6)-biotinylated ubiquitin inhibited ubiquitin-dependent proteolysis, as conjugates formed wi

35 pass the arrest that results from inhibiting ubiquitin-dependent proteolysis because cdc16-1 cdc55::L

36 a short half-life in yeast, being subject to ubiquitin-dependent proteolysis, but we find that it is

37 the data suggest that Int6 depletion blocks ubiquitin-dependent proteolysis by decreasing both ubiqu

38 everal lines of evidence that c-Myc promotes ubiquitin-dependent proteolysis by directly activating e

39 g enzyme, Doa4, that plays a central role in ubiquitin-dependent proteolysis by the proteasome.

40 Ubiquitin-dependent proteolysis can initiate at ribosome

41 ns with expanded polyglutamine tracts impair ubiquitin-dependent proteolysis due to their propensity

42 s also demonstrate that KLF4 is targeted for ubiquitin-dependent proteolysis during cell cycle progre

43 vator that targets many mitotic proteins for ubiquitin-dependent proteolysis during late mitosis and

44 These mutants cannot sustain ubiquitin-dependent proteolysis even though neither moti

45 In recent years, ubiquitin-dependent proteolysis has been demonstrated to

46 g hypoxia-inducible factor-alpha subunits to ubiquitin-dependent proteolysis has been well documented

47 suggesting that E7 is also regulated by the ubiquitin-dependent proteolysis in cervical cancer cells

48 Because of the central role of ubiquitin-dependent proteolysis in regulating fundamenta

49 Our observations account for the reduced ubiquitin-dependent proteolysis in sug1 mutants and sugg

50 Previous studies have implicated ubiquitin-dependent proteolysis in the turnover of wild-

51 97 is also involved in pathways that lead to ubiquitin-dependent proteolysis, including ER-associated

52 le without showing obvious signs of impaired ubiquitin-dependent proteolysis, indicating that other d

53 Ubiquitin-dependent proteolysis is an important mechanis

54 Our results indicate that ubiquitin-dependent proteolysis is an important mediator

55 Ubiquitin-dependent proteolysis is catalyzed by the 26S

56 roteins and previous studies have shown that ubiquitin-dependent proteolysis is implicated in the tur

57 Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to

58 to the nucleus in G(1) phase, but undergoes ubiquitin-dependent proteolysis later in cell cycle.

59 Ubiquitin-dependent proteolysis makes a major contributi

60 ce appears to be a result of deregulation of ubiquitin-dependent proteolysis mediated by the anaphase

61 Strikingly, ubiquitin-dependent proteolysis of alpha2 is required fo

62 been postulated to be controlled through the ubiquitin-dependent proteolysis of an unknown inhibitor.

63 oting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory

64 ciated links between fatty acid synthase and ubiquitin-dependent proteolysis of cell-cycle regulatory

65 Promoting Complex, which is required for the ubiquitin-dependent proteolysis of certain proteins duri

66 Ubiquitin-dependent proteolysis of cyclin D1 is associat

67 we characterized the enzymes involved in the ubiquitin-dependent proteolysis of E7.

68 multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regula

69 -promoting complex (APC), which triggers the ubiquitin-dependent proteolysis of key regulatory protei

70 The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory prote

71 t that the oncogenic E6 proteins enhance the ubiquitin-dependent proteolysis of MGMT.

72 The ubiquitin-dependent proteolysis of mitotic cyclin B, whi

73 ng complex/cyclosome pathway responsible for ubiquitin-dependent proteolysis of mitotic cyclins, indi

74 Ubiquitin-dependent proteolysis of p27(kip1) is growth a

75 nset of anaphase, presumably by blocking the ubiquitin-dependent proteolysis of proteins responsible

76 , also known as the cyclosome) regulates the ubiquitin-dependent proteolysis of specific cell-cycle p

77 Ubiquitin-dependent proteolysis of the mitotic cyclins A

78 By triggering the appropriately timed, ubiquitin-dependent proteolysis of the mitotic regulator

79 -based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates im

80 tes cellular growth by modulating either the ubiquitin-dependent proteolysis or the ubiquitination st

81 viously uncharacterized, Fbx29-mediated, and ubiquitin-dependent proteolysis pathway.

82 Ubiquitin-dependent proteolysis plays a critical role in

83 l as gamma-irradiated cells, indicating that ubiquitin-dependent proteolysis plays a role in the norm

84 Ubiquitin-dependent proteolysis plays an important role

85 Ubiquitin-dependent proteolysis plays an important role

86 Ubiquitin-dependent proteolysis regulates gene expressio

87 odified proteins and that failure to execute ubiquitin-dependent proteolysis renders various cell typ

88 ntial susceptibility of the catalytic LCs to ubiquitin-dependent proteolysis therefore might explain

89 n the established role of the RUB pathway in ubiquitin-dependent proteolysis, these data suggest that

90 ns are found in several proteins involved in ubiquitin-dependent proteolysis, though no function has

91 level of E7 in cancer cells is regulated by ubiquitin-dependent proteolysis through the 26S proteaso

92 As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase whe

93 mediates heat stress signaling and activates ubiquitin-dependent proteolysis via the endocytosis vacu

94 checkpoint regulation of mitosis, depends on ubiquitin-dependent proteolysis, we propose that the UBA