ライフサイエンスコーパス: ubiquitin-mediated proteolysis

1 as a protein that is degraded in anaphase by ubiquitin-mediated proteolysis.

2 this family of kinases also is regulated by ubiquitin-mediated proteolysis.

3 ng that Dbf4p is targeted for destruction by ubiquitin-mediated proteolysis.

4 ation, supporting a role for the VHL gene in ubiquitin-mediated proteolysis.

5 1 is regulated throughout the cell cycle via ubiquitin-mediated proteolysis.

6 adation of active cyclin B-CDC2 complexes by ubiquitin-mediated proteolysis.

7 totic cyclins on exit from M phase occurs by ubiquitin-mediated proteolysis.

8 gulatory role in p35 degradation mediated by ubiquitin-mediated proteolysis.

9 unction is required for cell cycle-regulated ubiquitin-mediated proteolysis.

10 SON1/UFD5 and SEN3, which are implicated in ubiquitin-mediated proteolysis.

11 ction for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis.

12 ion was partially prevented by inhibitors of ubiquitin-mediated proteolysis.

13 in destruction via the N-end rule pathway of ubiquitin-mediated proteolysis.

14 es centriole duplication and is regulated by ubiquitin-mediated proteolysis.

15 6AP) and target the tumor suppressor p53 for ubiquitin-mediated proteolysis.

16 After mitosis, APC/C(Cdh1) targets Cik1 for ubiquitin-mediated proteolysis.

17 oteins revealed several proteins involved in ubiquitin-mediated proteolysis.

18 rt because active Src protein is degraded by ubiquitin-mediated proteolysis.

19 et the key effector protein beta-catenin for ubiquitin-mediated proteolysis.

20 tin ligase that regulates PGC-1alpha through ubiquitin-mediated proteolysis.

21 for the extreme N terminus of the protein in ubiquitin-mediated proteolysis.

22 nd master regulator of sex determination, by ubiquitin-mediated proteolysis.

23 . elegans sex determination is controlled by ubiquitin-mediated proteolysis.

24 targeting the Cdc25A protein phosphatase for ubiquitin-mediated proteolysis.

25 self regulated throughout the cell cycle via ubiquitin-mediated proteolysis.

26 et the replication licensing factor Cdt1 for ubiquitin-mediated proteolysis.

27 involves their release from the membrane by ubiquitin-mediated proteolysis.

28 are also components of a complex involved in ubiquitin-mediated proteolysis.

29 sis in Xenopus extracts, and is targeted for ubiquitin-mediated proteolysis.

30 a HPV, which inactivate p53 by targeting its ubiquitin-mediated proteolysis.

31 that inhibition of Nrf2 may also depend upon ubiquitin-mediated proteolysis.

32 AA) family of transcriptional regulators for ubiquitin-mediated proteolysis.

33 e checkpoint, processive DNA replication, or ubiquitin-mediated proteolysis.

34 hydrogen peroxide, where it is destroyed by ubiquitin-mediated proteolysis.

35 whose expression levels can be regulated by ubiquitin-mediated proteolysis.

36 the F-box protein that targets p27(Kip1) for ubiquitin-mediated proteolysis.

37 protein levels are tightly regulated through ubiquitin-mediated proteolysis.

38 erexpression can specifically interfere with ubiquitin-mediated proteolysis.

39 tokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis.

40 r responses to hypoxia, and targets them for ubiquitin-mediated proteolysis.

41 present in the cell is tightly controlled by ubiquitin-mediated proteolysis.

42 some (APC/C) from targeting key proteins for ubiquitin-mediated proteolysis.

43 l growth, are unstable proteins destroyed by ubiquitin-mediated proteolysis.

44 ng the abundance of several proteins through ubiquitin-mediated proteolysis.

45 Degradation of Emi2 via ubiquitin-mediated proteolysis after fertilization requi

46 otein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy.

47 findings indicate a functional link between ubiquitin-mediated proteolysis and cellular resistance t

48 e show here that Dia2 is itself targeted for ubiquitin-mediated proteolysis and that activation of th

49 between c-Myc transcriptional regulation and ubiquitin-mediated proteolysis and together support the

50 We show that Myc is destroyed by ubiquitin-mediated proteolysis, and define two elements

51 Here we show that REST is regulated by ubiquitin-mediated proteolysis, and use an RNA interfere

52 Taken together, our results establish ubiquitin-mediated proteolysis as a previously unidentif

53 in D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation

54 s are proposed to target SUMO conjugates for ubiquitin-mediated proteolysis, but the only in vivo sub

55 eplication initiation factor is targeted for ubiquitin-mediated proteolysis by the E3 ubiquitin ligas

56 Ubiquitin-mediated proteolysis by the proteasome is a cr

57 Not only does ubiquitin-mediated proteolysis constitute a critical com

58 Ubiquitin-mediated proteolysis controls diverse physiolo

59 Ubiquitin-mediated proteolysis controls the abundance of

60 Screening a variety of mutants involved in ubiquitin-mediated proteolysis demonstrated an important

61 is the result of periodic transcription and ubiquitin-mediated proteolysis directed by SCF(hCdc4).

62 we show that Cdt1 is completely degraded by ubiquitin-mediated proteolysis during the course of the

63 eover, the stability of p65 is controlled by ubiquitin-mediated proteolysis, facilitated by a cytokin

64 Ubiquitin-mediated proteolysis has a central role in con

65 Ubiquitin-mediated proteolysis has an important role in

66 The degradation of proteins through ubiquitin-mediated proteolysis has been previously shown

67 of an ancient pathway from which eukaryotic ubiquitin-mediated proteolysis has evolved.

68 Ubiquitin-mediated proteolysis has previously been shown

69 otein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mut

70 function by stimulating its degradation via ubiquitin-mediated proteolysis in a reaction requiring E

71 This result for the first time implicates ubiquitin-mediated proteolysis in C-type cyclin regulati

72 cycle control and implicate critical role of ubiquitin-mediated proteolysis in ciliary disassembly.

73 he nucleus, are predominantly turned over by ubiquitin-mediated proteolysis in late mitosis/early G1.

74 nes will help uncover pathways controlled by ubiquitin-mediated proteolysis in mammals.

75 eased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only).

76 ntified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of long

77 Ubiquitin-mediated proteolysis is a key regulatory proce

78 ia protein turnover in other processes where ubiquitin-mediated proteolysis is an essential component

79 Ubiquitin-mediated proteolysis is critical for the alter

80 ion between metaphase and anaphase and their ubiquitin-mediated proteolysis is required for cells to

81 ox protein, which binds to the substrate for ubiquitin-mediated proteolysis, is involved in maintenan

82 ses calcineurin by targeting calcineurin for ubiquitin-mediated proteolysis, leading to inhibition of

83 uppressor p53 is maintained at low levels by ubiquitin-mediated proteolysis mainly through Mdm2.

84 cessive juvenile parkinsonism highlight that ubiquitin-mediated proteolysis may play an important rol

85 essor of photomorphogenesis by promoting the ubiquitin-mediated proteolysis of a subset of positive r

86 only a subset of aggregates, suggesting that ubiquitin-mediated proteolysis of aggregates may be late

87 Mitochondrial dysfunction, impaired ubiquitin-mediated proteolysis of alpha-synuclein, and E

88 Efficient ubiquitin-mediated proteolysis of c-Mos requires proline

89 This facilitates beta-TrCP binding and ubiquitin-mediated proteolysis of Cdc25A throughout inte

90 hroughout evolution in eukaryotes, including ubiquitin-mediated proteolysis of cell cycle regulators

91 s during cell cycle progression depends upon ubiquitin-mediated proteolysis of cell cycle regulators.

92 SKP1 is required for ubiquitin-mediated proteolysis of Cin2p, Clb5p, and the

93 We found that ubiquitin-mediated proteolysis of cyclin B was not compr

94 The ubiquitin-mediated proteolysis of cyclin E plays a centr

95 IAP-like RING domain, can contribute to the ubiquitin-mediated proteolysis of DED caspases.

96 of the proteasome, leading to the idea that ubiquitin-mediated proteolysis of Gcn4 is required for i

97 emonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIgamma and hATF5

98 ed by Pin1-mediated prolyl isomerization and ubiquitin-mediated proteolysis of its p65/RelA subunit.

99 related multisubunit enzymes central to the ubiquitin-mediated proteolysis of many important biologi

100 ase-associated protein 2 (Skp2) that directs ubiquitin-mediated proteolysis of p27(Kip1).

101 Ubiquitin-mediated proteolysis of p27Kip1 is an importan

102 of full-length hPLIC-2 to interfere with the ubiquitin-mediated proteolysis of p53.

103 Transcriptional arrest can trigger ubiquitin-mediated proteolysis of RNA polymerase II (RNA

104 Accumulation of SUMO chains in vivo leads to ubiquitin-mediated proteolysis of RNF4.

105 multigene family and has been linked to the ubiquitin-mediated proteolysis of several different prot

106 Here we demonstrate that Cks1 directs the ubiquitin-mediated proteolysis of the CDK-bound substrat

107 The ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27

108 This occurs principally by ubiquitin-mediated proteolysis of the cyclin subunit con

109 factor Gal4 undergoes two distinct modes of ubiquitin-mediated proteolysis: one that occurs independ

110 we observed that the region in Myc signaling ubiquitin-mediated proteolysis overlaps closely with the

111 t inhibition of intermediate proteins in the ubiquitin-mediated proteolysis pathway (ubiquitin-conjug

112 ome (APC/C) is an E3 ubiquitin ligase in the ubiquitin-mediated proteolysis pathway (UMP).

113 Ubiquitin-mediated proteolysis plays a central role in c

114 Ubiquitin-mediated proteolysis plays a key role in many

115 Ubiquitin-mediated proteolysis regulates all aspects of

116 cate that Cul4A ubiquitin ligases target for ubiquitin-mediated proteolysis regulators of cell-cycle

117 ulate the microtubule-based cytoskeleton and ubiquitin-mediated proteolysis, respectively.

118 stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway

119 iptional activation domains (TADs) to signal ubiquitin-mediated proteolysis suggests an involvement o

120 tion between the transcription machinery and ubiquitin-mediated proteolysis that is developmentally r

121 sensed by the Cys-Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxygen-dependent

122 ependent phosphorylation and is targeted for ubiquitin-mediated proteolysis, thus providing a mechani

123 , including autophagy, which cooperated with ubiquitin-mediated proteolysis to degrade free alpha-glo

124 Cells utilize ubiquitin-mediated proteolysis to regulate the activity

125 Destabilization of Skp2 by ubiquitin-mediated proteolysis was also demonstrated tha

126 required for targeting specific proteins for ubiquitin-mediated proteolysis, we propose that ASK1 con

127 ociated protein-2 (SKP2) plays a key role in ubiquitin-mediated proteolysis, which results in the pro