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1 he KLF5 protein degrades rapidly through the ubiquitin proteasome pathway.
2 ly unappreciated sites of recognition by the ubiquitin proteasome pathway.
3 nd could not be stabilized by inhibiting the ubiquitin proteasome pathway.
4 ted by Wee1 tyrosine kinase, a target of the ubiquitin proteasome pathway.
5 ion through recruitment of components of the ubiquitin proteasome pathway.
6 ant group of enzymes that act within the 26S ubiquitin proteasome pathway.
7 suggesting that degradation occurred via the ubiquitin proteasome pathway.
8 age responses are partially regulated by the ubiquitin proteasome pathway.
9 e phosphorylated TFEB for degradation by the ubiquitin-proteasome pathway.
10 hose degradation is highly regulated via the ubiquitin-proteasome pathway.
11 roteasome system analogous to the eukaryotic ubiquitin-proteasome pathway.
12 s, and that this decrease is mediated by the ubiquitin-proteasome pathway.
13 ption factor 6alpha (ATF6alpha), through the ubiquitin-proteasome pathway.
14 sis protein 1 (COP1) for degradation via the ubiquitin-proteasome pathway.
15 ed in this increasingly important arm of the ubiquitin-proteasome pathway.
16 in and stimulate its degradation through the ubiquitin-proteasome pathway.
17 ratin IF network via phosphorylation and the ubiquitin-proteasome pathway.
18 nation, and promotes its degradation via the ubiquitin-proteasome pathway.
19 ein is known to destabilize myogenin via the ubiquitin-proteasome pathway.
20 nhibitor protected synapses, implicating the ubiquitin-proteasome pathway.
21 tein level during the cell cycle through the ubiquitin-proteasome pathway.
22 This occurs via the ubiquitin-proteasome pathway.
23 (s), at least one of which is related to the ubiquitin-proteasome pathway.
24 causing DELLA repressor degradation via the ubiquitin-proteasome pathway.
25 n the degradation of client proteins via the ubiquitin-proteasome pathway.
26 CL12-induced FAK phosphorylation through the ubiquitin-proteasome pathway.
27 bsence of HSP90 activity is dependent on the ubiquitin-proteasome pathway.
28 N is tightly regulated by the Sel10-mediated ubiquitin-proteasome pathway.
29 ases that mediate protein degradation by the ubiquitin-proteasome pathway.
30 tein level, degradation was mediated via the ubiquitin-proteasome pathway.
31 al of proteins and organelles depends on the ubiquitin-proteasome pathway.
32 the rapid destruction of Las1 depends on the ubiquitin-proteasome pathway.
33 targeting them for rapid degradation via the ubiquitin-proteasome pathway.
34 that mediates the turnover of HIF-1 via the ubiquitin-proteasome pathway.
35 n by preventing the degradation of Bcl-2 via ubiquitin-proteasome pathway.
36 part of the proteolysis was mediated by the ubiquitin-proteasome pathway.
37 to the efficacy of CF drugs that target the ubiquitin-proteasome pathway.
38 teins more susceptible to degradation by the ubiquitin-proteasome pathway.
39 diating HIF-1alpha protein stability via the ubiquitin-proteasome pathway.
40 mplex, leading to HIF-1alpha degradation via ubiquitin-proteasome pathway.
41 ease in FMRP that is rapidly degraded by the ubiquitin-proteasome pathway.
42 trix accompanied by rapid degradation by the ubiquitin-proteasome pathway.
43 s, alpha2 is rapidly degraded in vivo by the ubiquitin-proteasome pathway.
44 phy occurs through increased activity of the ubiquitin-proteasome pathway.
45 l that stimulates RASSF1A degradation by the ubiquitin-proteasome pathway.
46 ausing degradation of DELLA proteins via the ubiquitin-proteasome pathway.
47 ion is mediated, at least in part, through a ubiquitin-proteasome pathway.
48 protein levels of Runx2 are regulated by the ubiquitin-proteasome pathway.
49 eptors are ubiquitinated and degraded by the ubiquitin-proteasome pathway.
50 ucleus to the cytoplasm and degraded via the ubiquitin-proteasome pathway.
51 eavage of cellular and viral proteins by the ubiquitin-proteasome pathway.
52 or retrotranslocation and degradation by the ubiquitin-proteasome pathway.
53 the KLF5 protein is tightly regulated by the ubiquitin-proteasome pathway.
54 ssociation with Hsp90 and degradation by the ubiquitin-proteasome pathway.
55 of inhibitor of nuclear factor kappaB by the ubiquitin-proteasome pathway.
56 adation of selected proteins in vivo via the ubiquitin-proteasome pathway.
57 le protein that is actively degraded via the ubiquitin-proteasome pathway.
58 isms by which apoptosis are regulated by the ubiquitin-proteasome pathway.
59 lls are targeted for degradation through the ubiquitin-proteasome pathway.
60 the transcription factor MyoD occurs via the ubiquitin-proteasome pathway.
61 of a bile acid transporter expression by the ubiquitin-proteasome pathway.
62 tely 6 h) whose degradation depends upon the ubiquitin-proteasome pathway.
63 t p73 stability is directly regulated by the ubiquitin-proteasome pathway.
64 a, HIF-1alpha is constantly degraded via the ubiquitin-proteasome pathway.
65 central problem concerning the design of the ubiquitin-proteasome pathway.
66 s of several regulatory proteins through the ubiquitin-proteasome pathway.
67 ant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.
68 eurofibromin is dynamically regulated by the ubiquitin-proteasome pathway.
69 BEC3G by targeting it for destruction by the ubiquitin-proteasome pathway.
70 R-induced degradation of Hdm2 occurs via the ubiquitin-proteasome pathway.
71 of a short-lived GFP that is degraded by the ubiquitin-proteasome pathway.
72 MEPA1 with the NEDD4 protein involved in the ubiquitin-proteasome pathway.
73 ds and induces proteolysis of Rb through the ubiquitin-proteasome pathway.
74 ded proteins destined for degradation by the ubiquitin-proteasome pathway.
75 family members; and proteins involved in the ubiquitin-proteasome pathway.
76 uggesting a regulatory role connected to the ubiquitin-proteasome pathway.
77 Here we show that PSD-95 is regulated by the ubiquitin-proteasome pathway.
78 se protein, ataxin-3 (AT3), functions in the ubiquitin-proteasome pathway.
79 the 26S proteasome and is a regulator of the ubiquitin-proteasome pathway.
80 hat the HMGS-1 level is also governed by the ubiquitin-proteasome pathway.
81 ch targeted ER-alpha degradation through the ubiquitin-proteasome pathway.
82 li, IkappaBalpha is rapidly degraded via the ubiquitin-proteasome pathway.
83 APOBEC3F (A3F) for degradation via the host ubiquitin-proteasome pathway.
84 xecutes the degradation of substrates of the ubiquitin-proteasome pathway.
85 in promotes the degradation of STAT3 via the ubiquitin-proteasome pathway.
86 graded in response to DNA damage through the ubiquitin-proteasome pathway.
87 m being subjected to degradation through the ubiquitin-proteasome pathway.
88 s an essential intracellular protease of the ubiquitin-proteasome pathway.
89 I1), which results in JAZ degradation by the ubiquitin-proteasome pathway.
90 teasome operates at the executive end of the ubiquitin-proteasome pathway.
91 by targeting it for degradation through the ubiquitin-proteasome pathway.
92 response system and are degraded through the ubiquitin-proteasome pathway.
93 to Hsp90, which directed the protein to the ubiquitin-proteasome pathway.
94 inute 2, protected synapses, implicating the ubiquitin-proteasome pathway.
95 ype ubiquitin ligase for degradation via the ubiquitin-proteasome pathway.
96 that, upon activation, are degraded via the ubiquitin-proteasome pathway.
97 olyglutamine protein (polyQ) via the nuclear ubiquitin-proteasome pathway.
98 al role in IP(3) receptor processing via the ubiquitin-proteasome pathway.
99 cted miR-30 targets, as well as genes in the ubiquitin-proteasome pathway.
100 s, which are master growth repressors, via a ubiquitin-proteasome pathway.
101 e that results from enhanced activity of the ubiquitin-proteasome pathway.
102 tubule dynamics, Golgi organization, and the ubiquitin-proteasome pathway.
103 broadly affects protein degradation via the ubiquitin/proteasome pathway.
104 vidence that Ikaros degradation involves the ubiquitin/proteasome pathway.
105 monly initiates their downregulation via the ubiquitin/proteasome pathway.
106 we show that KRP1 is a likely target of the ubiquitin/proteasome pathway.
107 d GATA-1 is targeted for degradation via the ubiquitin/proteasome pathway.
108 se protein substrates for degradation by the ubiquitin/proteasome pathway.
109 efficacy of anticancer drugs that target the ubiquitin/proteasome pathway.
110 ween RNA polymerase II transcription and the ubiquitin/proteasome pathway.
111 duce the protein level of c-IAPs through the ubiquitin/proteasome pathway.
112 adation of nascent class I molecules via the ubiquitin/proteasome pathway.
113 ute to the demise of protein turnover by the ubiquitin/proteasome pathway.
114 Pak1 phosphorylation and beta-TrCP-dependent ubiquitin-proteasome pathways.
115 n activation to deplete p38gamma proteins by ubiquitin-proteasome pathways.
116 member p38gamma protein via c-Jun-dependent ubiquitin-proteasome pathways.
117 increase the expression and activity of the ubiquitin-proteasome pathway, a major proteolytic mechan
118 mediated by protein degradation through the ubiquitin-proteasome pathway, a mechanism related to tha
120 hown to function both as an E3 ligase in the ubiquitin proteasome pathway and as a transcriptional co
121 rgets for new agents in lymphoma include the ubiquitin proteasome pathway and the biochemical reactio
123 y targeting APOBEC3G for degradation via the ubiquitin-proteasome pathway and implicate the proteasom
124 wn-regulation of MARK4 protein level through ubiquitin-proteasome pathway and inhibition of MARK4 kin
125 and EVI1 moieties and degrades EVI1 via the ubiquitin-proteasome pathway and MDS1 in a proteasome-in
126 lti-protein complex that interfaces with the ubiquitin-proteasome pathway and plays critical developm
127 on of P-glycoprotein can be regulated by the ubiquitin-proteasome pathway and suggest that modulating
128 6AP is a component of ER degradation via the ubiquitin-proteasome pathway and that Ca(2+)/calmodulin
129 on of cis-acting degradation signals and the ubiquitin-proteasome pathway and that modulation of Fad3
130 RTA can induce K-RBP degradation through the ubiquitin-proteasome pathway and that two regions in RTA
131 ed virus budding has been linked to both the ubiquitin-proteasome pathway and the vacuolar protein-so
132 turnover of eEF-2 kinase is regulated by the ubiquitin-proteasome pathway and, therefore, modulating
133 y to melanosomes and its degradation via the ubiquitin-proteasome pathway and/or the endosomal/lysoso
134 e examined the functional involvement of the ubiquitin/proteasome pathway and rate-limiting aspects o
136 he level of MSH2 protein is modulated by the ubiquitin-proteasome pathway, and histone deacetylase 6
137 m (ER)-associated degradation (ERAD) via the ubiquitin-proteasome pathway, and inhibition of proteaso
140 isfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogene
142 roliferation and encystation, suggesting the ubiquitin-proteasome pathway as a viable therapeutic tar
144 d Cx43 degradation is likely mediated by the ubiquitin-proteasome pathway, as (i) treatment with prot
145 FL SIRT3 degradation is mediated by the ubiquitin-proteasome pathway, at least partially through
146 n is at least partially mediated through the ubiquitin-proteasome pathway because proteasome inhibito
147 any human cancers and may be degraded by the ubiquitin-proteasome pathway, but components of the path
148 e during S-phase and is degraded through the ubiquitin-proteasome pathway, but its turnover is enhanc
150 nduces degradation of DELLA proteins via the ubiquitin/proteasome pathway, but light promotes accumul
151 of LSD1 occurs posttranscriptionally via the ubiquitin-proteasome pathway by an E3 ubiquitin ligase,
152 ibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin
153 The regulated degradation of AT1R via a ubiquitin/proteasome pathway by activation of D5R provid
154 ring tumorigenesis, negatively regulates the ubiquitin/proteasome pathway by interfering with protein
155 results show that homeostatic control of the ubiquitin-proteasome pathway can be achieved through sig
157 suggesting that decreased expression of the ubiquitin-proteasome pathway components may contribute t
161 ion licensing factor Cdt1 is degraded by the ubiquitin-proteasome pathway during S phase of the cell
162 n transcription and proteins involved in the ubiquitin-proteasome pathway encompasses both proteolyti
165 de BOK via the ER-associated degradation and ubiquitin-proteasome pathways; following proteasome inhi
167 nt approaches that exploit components of the ubiquitin-proteasome pathway for amelioration of these d
168 6S proteasome is at the executive end of the ubiquitin-proteasome pathway for the controlled degradat
169 nificance of the endogenous Siah-1-dependent ubiquitin/proteasome pathway for beta-catenin degradatio
171 te synaptic strength and growth and that the ubiquitin proteasome pathway functions in mature neurons
173 uggest that the nuclear N terminus-dependent ubiquitin proteasome pathway governs PGC-1alpha cellular
174 ur recent studies have demonstrated that the ubiquitin proteasome pathway has an important role in th
183 ein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mech
188 use models, as well as investigations of the ubiquitin-proteasome pathway in disease pathogenesis.
189 of this work was to explore the role of the ubiquitin-proteasome pathway in eliminating S-glutathiol
190 irpin RNA screen targeting components of the ubiquitin-proteasome pathway in human cells, we identifi
191 rovide very appealing tools for studying the ubiquitin-proteasome pathway in intact mammalian cells b
193 ere we show that GSK3beta is degraded by the ubiquitin-proteasome pathway in murine lung epithelial c
195 In this study we examined the role of the ubiquitin-proteasome pathway in the degradation of the L
196 ut mouse model, we evaluated the role of the ubiquitin-proteasome pathway in the development of contr
197 has led to investigations of the role of the ubiquitin-proteasome pathway in the pathogenesis of myel
198 f studies now indicate multiple roles of the ubiquitin-proteasome pathway in the regulation and maint
200 celerated muscle proteolysis mediated by the ubiquitin-proteasome pathway in various catabolic condit
202 cell signaling causes Bok degradation by the ubiquitin-proteasome pathway, in a manner that parallels
203 corroborated using several inhibitors of the ubiquitin proteasome pathway, including PS-341, an antic
204 hese damaged cytosolic proteins requires the ubiquitin-proteasome pathway, including the E2s UBC4/UBC
205 ion of caspase-8 and -9 and caspase-mediated ubiquitin-proteasome pathway-independent loss of cyclin
206 therapy suggest that drugs that disrupt the ubiquitin/proteasome pathway induce apoptosis and sensit
207 s aspects of nucleic acid metabolism and the ubiquitin-proteasome pathway intersect in several direct
208 kp1-cullin-F-box complex associated with the ubiquitin-proteasome pathway involved in auxin signaling
209 regulation of histone protein levels by the ubiquitin-proteasome pathway involving the E2 ubiquitin
213 indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell
217 rophy and contractile weakness, and that the ubiquitin-proteasome pathway is activated in the diaphra
224 of the regulation of TRAIL signaling in the ubiquitin-proteasome pathway is mediated by the inhibito
226 The data show that proteolysis through the ubiquitin-proteasome pathway is required for bFGF-induce
229 teins is a highly regulated process, and the ubiquitin-proteasome pathway is the major proteolytic sy
230 Accelerated protein degradation via the ubiquitin-proteasome pathway is the principal cause of s
232 tion as regulated protein degradation by the ubiquitin/proteasome pathway is essential for neuronal s
233 the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for
234 omplexes arrest transcription and activate a ubiquitin-proteasome pathway leading to the degradation
235 y proteins that are normally degraded by the ubiquitin-proteasome pathway like cyclins, p53, and Ikap
236 tion of cell death-promoting proteins by the ubiquitin-proteasome pathway may represent a novel thera
237 ethylene, EIN3 is quickly degraded through a ubiquitin/proteasome pathway mediated by two F box prote
238 ethylene, EIN3 is quickly degraded through a ubiquitin/proteasome pathway mediated by two F-box prote
239 plexes by molecular chaperones, or a slower, ubiquitin-proteasome-pathway-mediated turnover of DNA-bo
241 Consistently, a chemical inhibitor of the ubiquitin proteasome pathway mitigated the disrupting ef
242 ved and linked to an early activation of the ubiquitin proteasome pathway, myosin:actin ratios were n
244 urther shown that HDACs are degraded via the ubiquitin/proteasome pathway, opening up a search for th
245 fted either through DELLA proteolysis by the ubiquitin-proteasome pathway or through proteolysis-inde
253 MG132 and lactacystin, inhibitors of the ubiquitin-proteasome pathway, prevented the calmodulin a
257 n, Calnexin, and FGFR-3; stress response and ubiquitin/proteasome pathway-related genes and various r
258 epidopteran RNAi, Nuclear Factor-kappaB, and ubiquitin-proteasome pathways restrict RNA virus infecti
259 ions, these repressors are destroyed via the ubiquitin-proteasome pathway, resulting in derepression/
260 lts, these data support the concept that the ubiquitin-proteasome pathway serves as a general protein
262 plexities of ubiquitination of an endogenous ubiquitin-proteasome pathway substrate in unperturbed ma
264 erg1a in mouse skeletal muscle activates the ubiquitin proteasome pathway that is responsible for the
265 ced down-regulation of FLIP is mediated by a ubiquitin-proteasome pathway that is negatively regulate
267 that Sts1 is a new regulatory factor in the ubiquitin/proteasome pathway that controls the turnover
268 suggested many novel roles, including in the ubiquitin proteasome pathway, that warrant further explo
269 the level of MutSalpha can be reduced by the ubiquitin-proteasome pathway, the detailed mechanisms of
270 REBP and cleavage requires components of the ubiquitin-proteasome pathway: the E2-conjugating enzyme
271 n, inhibiting the degradation induced by the ubiquitin-proteasome pathway, thereby increasing Drosha
272 ized beta-catenin expression by blocking the ubiquitin-proteasome pathway, thereby promoting CRC deve
273 an be controlled post-translationally by the ubiquitin-proteasome pathway through a mechanism that de
274 xported to the cytoplasm and degraded by the ubiquitin-proteasome pathway through a process called ER
277 the GeneChip included genes involved in the ubiquitin proteasome pathway (UPP), metallothionein func
278 We investigated herein the involvement of ubiquitin-proteasome pathway (UPP) and autophagy, two ma
279 present study was to explore the role of the ubiquitin-proteasome pathway (UPP) in degrading C-termin
289 Although rates of protein degradation by the ubiquitin-proteasome pathway (UPS) are determined by the
290 is rapidly induced and then targeted to the ubiquitin-proteasome pathway via a mechanism that requir
292 rminal hydrolase L1 (UCHL1), a member of the ubiquitin proteasome pathway, was consistently up-regula
294 In old mice, genes that are involved in the ubiquitin-proteasome pathway were significantly down-reg
296 system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to m
297 system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to m
298 E1 (COI1) causes degradation of JAZs via the ubiquitin-proteasome pathway, which in turn activates th
299 expressed functional gene categories was the ubiquitin-proteasome pathway, which was upregulated in b
300 ation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underly
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