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1 ABCG1 is ubiquitinated and degraded via the ubiquitin proteasome system.
2 is under dual control via autophagy and the ubiquitin proteasome system.
3 ion of proatrophic genes and proteins of the ubiquitin proteasome system.
4 specific degradation is a key feature of the ubiquitin proteasome system.
5 a cells depends on the elaborately regulated ubiquitin proteasome system.
6 argeting proteins for degradation across the ubiquitin proteasome system.
7 quitination, followed by degradation via the ubiquitin proteasome system.
8 on of myofibrillar proteins primarily by the ubiquitin proteasome system.
9 viability under conditions that stressed the ubiquitin proteasome system.
10 mediate muscle protein breakdown through the ubiquitin proteasome system.
11 F1 is due to the selective inhibition of the ubiquitin proteasome system.
12 (ER) to the cytosol and are destroyed by the ubiquitin proteasome system.
13 stresses can reduce buffering effects in the ubiquitin proteasome system.
14 barrier dysregulation and disruption of the ubiquitin proteasome system.
15 proteins, priming their degradation via the ubiquitin proteasome system.
16 regulatory proteins for destruction via the ubiquitin proteasome system.
17 the nucleus, where they are targeted by the ubiquitin-proteasome system.
18 s is largely dependent on proteolysis by the ubiquitin-proteasome system.
19 protein levels are tightly regulated by the ubiquitin-proteasome system.
20 hway and that its degradation depends on the ubiquitin-proteasome system.
21 ation of RB family repressor potency and the ubiquitin-proteasome system.
22 ed to Tip110 protein degradation through the ubiquitin-proteasome system.
23 in degradation of wild type channels via the ubiquitin-proteasome system.
24 ifically inhibited protein processing by the ubiquitin-proteasome system.
25 unction by promoting its degradation via the ubiquitin-proteasome system.
26 es that control USP33 degradation within the ubiquitin-proteasome system.
27 ation, enhancing its degradation via the K48 ubiquitin-proteasome system.
28 ted into the cytosol for degradation via the ubiquitin-proteasome system.
29 Rad17 has been shown to be regulated by the ubiquitin-proteasome system.
30 g protein, is a versatile participant in the ubiquitin-proteasome system.
31 es that regulate protein degradation via the ubiquitin-proteasome system.
32 tain and modulate the dynamic balance of the ubiquitin-proteasome system.
33 e Entamoeba histolytica harbors an extensive ubiquitin-proteasome system.
34 sulin signaling extends to regulation of the ubiquitin-proteasome system.
35 teins that are slated for degradation by the ubiquitin-proteasome system.
36 were regulated by synaptic activity and the ubiquitin-proteasome system.
37 ocytes because of reduced degradation by the Ubiquitin-proteasome system.
38 idea that its stability is regulated by the ubiquitin-proteasome system.
39 wn that Tip60 is turned over in cells by the ubiquitin-proteasome system.
40 ith degradation of ELT-2 protein by the host ubiquitin-proteasome system.
41 HF8 protein stability to be regulated by the ubiquitin-proteasome system.
42 cts as a potential negative regulator of the ubiquitin-proteasome system.
43 cleus is due to its rapid degradation by the ubiquitin-proteasome system.
44 ion and induced clearance of Htt through the ubiquitin-proteasome system.
45 mutant alpha3 precursor was degraded by the ubiquitin-proteasome system.
46 a consequence of upregulated NEDD4-1 via the ubiquitin-proteasome system.
47 hypoxia induces VPS4B downregulation by the ubiquitin-proteasome system.
48 hat exocyst degradation is controlled by the ubiquitin-proteasome system.
49 we identify Spg5 as a novel component of the ubiquitin-proteasome system.
50 mponents, consistent with dysfunction of the ubiquitin-proteasome system.
51 y Insig-dependent protein degradation by the ubiquitin-proteasome system.
52 stability of Twist is also regulated by the ubiquitin-proteasome system.
53 l role in posttranslational targeting to the ubiquitin-proteasome system.
54 all cells is degraded by the ATP-dependent, ubiquitin-proteasome system.
55 D8-activating enzyme pathway involved in the ubiquitin-proteasome system.
56 through CSN8), and is known to regulate the ubiquitin-proteasome system.
57 roteolysis via SUMO-dependent control of the ubiquitin-proteasome system.
58 carefully orchestrated by ubiquitination and ubiquitin-proteasome system.
59 egradation of intracellular proteins via the ubiquitin-proteasome system.
60 aperone-associated misfolded proteins by the ubiquitin-proteasome system.
61 e abundance of four PIF proteins through the ubiquitin-proteasome system.
62 , the bacterial equivalent of the eukaryotic ubiquitin-proteasome system.
63 ed proteins is primarily accomplished by the ubiquitin-proteasome system.
64 ts SUMO-2 conjugation and degradation by the ubiquitin-proteasome system.
65 MI involve accelerated titin turnover by the ubiquitin-proteasome system.
66 eins are not targeted for degradation by the ubiquitin-proteasome system.
67 1-like (ASK) protein components of the plant ubiquitin/proteasome system.
68 a cellular stress response that engages the ubiquitin/proteasome system.
69 s in the induction of autophagy-lysosome and ubiquitin-proteasome systems.
70 ic connections between the transcription and ubiquitin-proteasome systems.
71 changes in the cancer cells, which makes the ubiquitin-proteasome system a potential target to enhanc
72 ced MuRF-1 levels, suggesting that it blocks ubiquitin-proteasome system activation and does so in bo
74 se isoforms were efficiently degraded by the ubiquitin proteasome system, an effect reversed by the a
79 ese chains, one can study their roles in the ubiquitin proteasome system and the DNA damage response
80 to coordinate the degradation of SLBP by the ubiquitin proteasome system and the exosome-mediated deg
81 BXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in
82 ytoplasmic DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-terminus fragment r
83 an increase of protein breakdown due to the ubiquitin-proteasome system and autophagy activation.
84 ased the expression of the components of the ubiquitin-proteasome system and autophagy in LLC-bearing
85 that p62 mediates the crosstalk between the ubiquitin-proteasome system and autophagy through its bi
86 One module includes genes involved in the ubiquitin-proteasome system and contains SCA genes usual
87 generative diseases and the link between the ubiquitin-proteasome system and neurodegeneration make t
88 combined exposure to HCV and HIV-1, that the ubiquitin-proteasome system and NF-kappaB contribute to
90 ns show abnormal protein degradation via the Ubiquitin-proteasome system and partially impaired trans
92 egulation of hepatic lipid metabolism by the ubiquitin-proteasome system and suggests COP1 as a poten
93 rate that HEV replication requires an active ubiquitin-proteasome system and that proteasome inhibito
94 utophagy-lysosome pathway, although both the ubiquitin-proteasome system and the autophagy-lysosome p
95 We therefore measured the activation of the ubiquitin-proteasome system and the lysosomal pathway of
96 nontraditional mitophagy pathways involving ubiquitin-proteasome system and the ubiquitin-binding pr
97 ation and to STUbL-mediated targeting to the ubiquitin-proteasome system and thereby implicate this p
98 levance for biomedical sciences, such as the ubiquitin-proteasome system and various human disease-as
99 that SUMOylation is an integral part of the ubiquitin proteasome system, and expression of the small
100 hways involving endo-lysosomal vesicles, the ubiquitin-proteasome system, and autophagy-based or endo
101 he Ca(2+)-dependent protease calpain and the ubiquitin-proteasome system, and causes attenuation and
102 sequence of the efficient degradation by the ubiquitin-proteasome system, and in response to hypoxia,
103 ular peptides are constantly produced by the ubiquitin-proteasome system, and many are probably funct
104 ubiquitination, protein trafficking, and the ubiquitin-proteasome system, and monitored P-gp protein
105 ligases catalyze protein degradation by the ubiquitin-proteasome system, and their activity is tight
106 this study, we show that Fbp1 is part of the ubiquitin-proteasome system, and we further investigated
107 this paper referred to as autophagy) and the ubiquitin-proteasome system are the two major catabolic
109 Taken together, these results reveal the ubiquitin-proteasome system as a novel regulatory mechan
110 ltogether, our results not only point to the ubiquitin-proteasome system as an important regulator of
112 nduced silencing exhibited dependence on the ubiquitin-proteasome system, as was shown previously for
113 factor Bag1 promotes hERG degradation by the ubiquitin-proteasome system at the endoplasmic reticulum
114 ive within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain
115 y to lead to its targeted degradation by the ubiquitin-proteasome system because degradation is blunt
116 inking cytosolic antibody recognition to the ubiquitin proteasome system brings this research into sh
117 other major degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasom
118 ibitors that target different aspects of the ubiquitin-proteasome system can be distinguished by thei
120 cultures and found altered levels of several ubiquitin proteasome system components, in particular de
123 scription factor, NAC1, that is subjected to ubiquitin-proteasome system-dependent degradation in pla
124 n between the cytosolic Hsp70 system and the ubiquitin proteasome system during protein triage are no
125 iated factor-1 (FAF1) both have roles in the ubiquitin-proteasome system during NF-kappaB activation,
126 to the destruction of select targets by the ubiquitin-proteasome system (eg, SCF(Skp2)-directed dest
127 homeostasis of MCPH1 in association with the ubiquitin-proteasome system ensures mitotic entry indepe
130 in which a fungal effector targets the host ubiquitin proteasome system for the suppression of PAMP-
131 umber variation.Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of
132 he potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is
133 ised degradative mechanisms, we found normal ubiquitin-proteasome system function and only modest ine
135 g mechanisms are still unclear, although the ubiquitin-proteasome system has been involved in the deg
136 quitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of
137 hown that ST2L stability is regulated by the ubiquitin-proteasome system; however, its upstream inter
138 hesized proteins are rapidly degraded by the ubiquitin-proteasome system; however, the relationship o
139 me accumulation and occurred before a global ubiquitin-proteasome system impairment in Csn8-deficient
140 or the first time a fine-tuning of FACT by a ubiquitin proteasome system in promoting chromatin reass
141 alysis of RNA-sequencing data identified the ubiquitin proteasome system in the TNF-alpha signaling p
142 ts cellular proteins from degradation by the ubiquitin-proteasome system in conditions of stress.
144 ovide further evidence of dysfunction of the ubiquitin-proteasome system in schizophrenia, and sugges
147 dings identify an essential function for the ubiquitin-proteasome-system in spermiogenesis and define
148 ific branches of the endosomal-lysosomal and ubiquitin-proteasome systems, in maintaining the homeost
149 their demise by activating components of the ubiquitin proteasome system, including the E2 ligase LET
152 In this study, we provide evidence that the ubiquitin proteasome system is involved in the reduced d
153 crosstalk between protein ISGylation and the ubiquitin proteasome system is not fully understood.
162 es indicate that the overall activity of the ubiquitin-proteasome system is preserved in SBMA models.
171 protein ISGylation negatively regulates the ubiquitin-proteasome system, leading to increased produc
172 synapses, Pinto et al. show that the axonal ubiquitin-proteasome system locally regulates the accumu
173 tin-like domains in proteins not part of the ubiquitin proteasome system may bind the proteasome more
174 ation of organelle biogenesis factors by the ubiquitin-proteasome system may constitute an important
175 c deficiency disrupts their folding, and the ubiquitin-proteasome system may help manage this stress.
177 mino acids (aa261-270) that was required for ubiquitin-proteasome system-mediated degradation, among
182 iquitin ligase that functions to promote the ubiquitin-proteasome system of protein degradation and a
184 volving targeted protein removal through the ubiquitin-proteasome system, or selective, whole-chlorop
185 nes are involved in cytokinin signaling, the ubiquitin-proteasome system pathway, DNA repair and Cu t
186 gly evident that protein degradation via the ubiquitin proteasome system plays a fundamental role in
190 or studies of fertilization and wherever the ubiquitin-proteasome system plays a role in cellular fun
191 (eight patients), and one patient with FTLD-ubiquitin proteasome system positive inclusions (FTLD-UP
192 CR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 u
194 nd is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comp
195 ll ubiquitin-like modifier)-modification and ubiquitin-proteasome systems regulate the major events o
196 ng through polycomb-repressive complex 1.The ubiquitin-proteasome system regulates cellular reprogram
198 depletion of the ubiquitin ligase SYVN1, the ubiquitin/proteasome system regulator NEDD8, or the F-bo
201 The treatment with MG132, an inhibitor of ubiquitin proteasome system, rescues the expression leve
202 report that EXO1 is rapidly degraded by the ubiquitin-proteasome system soon after DSB induction in
204 ligases or E3 enzymes are components of the ubiquitin proteasome system that function during the tra
205 ion of a naturally-occurring mutation of the ubiquitin proteasome system that is associated with a di
207 anical ventilation-induced activation of the ubiquitin-proteasome system, the autophagy/lysosomal sys
208 The stability of Atoh1 was regulated by the ubiquitin proteasome system through the action of Huwe1,
209 cal intervention on E3 ligases.Targeting the ubiquitin proteasome system to modulate protein homeosta
210 Both processes utilize chaperones and the ubiquitin-proteasome system to aid in protein eliminatio
211 ss that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived protei
212 that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence.
214 g the cellular quality-control machinery-the ubiquitin-proteasome system-to remove specific cancer-ca
216 at accelerated cMLCK protein turnover by the ubiquitin-proteasome system underlies the transition fro
217 plications are linked to the function of the ubiquitin-proteasome system, understanding its mechanism
218 applying inhibitors to selectively block the ubiquitin proteasome system (UPS) and autophagy-lysosoma
219 s a poorly understood alternative arm of the ubiquitin proteasome system (UPS) and is required for mo
220 two most prominent proteolytic systems, the ubiquitin proteasome system (UPS) and the autophagosomal
221 ded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to auto
222 t not only is DISC1 turnover elicited by the ubiquitin proteasome system (UPS) but that it is orchest
228 isorders, implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis.
231 demonstrated that protein regulation via the ubiquitin proteasome system (UPS) is crucial for normal
236 his study was undertaken to characterize the ubiquitin proteasome system (UPS) response to varied die
237 ental mechanisms of protein homeostasis, the ubiquitin proteasome system (UPS), as it relates to lung
238 er, it is unclear whether proteolysis by the ubiquitin proteasome system (UPS), which catalyzes most
240 Here, we report the rapid ubiquitination and ubiquitin proteasome system (UPS)-mediated degradation o
241 strains revealed a broad down-regulation of ubiquitin proteasome system (UPS)-related genes, in part
246 Degradation of maternal proteins by the ubiquitin-proteasome system (UPS) accompanies the matern
249 induced unfolded protein response (UPR), the ubiquitin-proteasome system (UPS) and autophagy, appear
251 n of genes involved in mitochondrial (MT) or ubiquitin-proteasome system (UPS) functions were markedl
258 egulated protein degradation mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryo
260 mechanisms of protein homeostasis, including ubiquitin-proteasome system (UPS) mediated protein degra
261 ders and may be caused by alterations in the ubiquitin-proteasome system (UPS) or the autophagy-lysos
264 ulation of p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesi
267 es and various proteolytic processes such as ubiquitin-proteasome system (UPS) to avoid a build-up of
268 for antifouling paint biocides, inhibits the ubiquitin-proteasome system (UPS) via targeting both 19S
269 Targeted degradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of
270 At the molecular level, an activation of the ubiquitin-proteasome system (UPS) was detected which res
271 lso known as dendrite pruning-depends on the ubiquitin-proteasome system (UPS), but the specific proc
274 influences cellular survival and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis f
286 ardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome
287 st plant interaction is the role of the host ubiquitin/proteasome system (UPS) in the infection proce
288 r HDAC, which is functionally related to the ubiquitin proteasome system via its ubiquitin binding do
289 sponse to mitogens, Tiam1 is degraded by the ubiquitin-proteasome system via the SCF(betaTrCP) ubiqui
291 effect on bona fide native substrates of the ubiquitin-proteasome system was observed from PKG manipu
292 tose-1,6-bisphosphatase are degraded via the ubiquitin proteasome system when cells are replenished w
293 xcitation removes GKAP from synapses via the ubiquitin-proteasome system, whereas inactivity induces
294 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitin
295 ism of regulation that is independent of the ubiquitin proteasome system, which can become occupied w
296 PN1 protein accumulation is regulated by the ubiquitin proteasome system, which is highly dysregulate
298 y the EWS-FLI1 protein as a substrate of the ubiquitin-proteasome system with a characteristic polyub
299 y pathways impact RB function, including the ubiquitin-proteasome system with deregulated RB destruct
300 maps out the roles of the components of the ubiquitin-proteasome system with emphasis on areas where
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