ライフサイエンスコーパス: ubiquitin-protein ligase

1 ase due to a loss of function mutation in an ubiquitin protein ligase.

2 ecognizing component of the SCF(HOS)-Roc1 E3 ubiquitin protein ligase.

3 , the anaphase promoting complex (APC), is a ubiquitin protein ligase.

4 me, and, frequently, a substrate-specific E3 ubiquitin-protein ligase.

5 anaphase-promoting complex/cyclosome (APC/C) ubiquitin-protein ligase.

6 ne encoding the E6-associated protein (E6AP) ubiquitin-protein ligase.

7 utations of the parkin gene, which encodes a ubiquitin-protein ligase.

8 , presumably through its ability to act as a ubiquitin-protein ligase.

9 isiae RSP5 gene encodes an essential HECT E3 ubiquitin-protein ligase.

10 gnaling, has recently been shown to act as a ubiquitin-protein ligase.

11 nd degradation of p53, dependent on the E6AP ubiquitin-protein ligase.

12 ns and functionally classifies Rsp5 as an E3 ubiquitin-protein ligase.

13 uitination of active RTKs by acting as an E3 ubiquitin-protein ligase.

14 tions in the UBE3A locus which encodes E6-AP ubiquitin-protein ligase.

15 ndent functions, as both a coactivator and a ubiquitin-protein ligase.

16 allelic to RSP5, which encodes an essential ubiquitin-protein ligase.

17 1 maps to RSP5, a gene encoding an essential ubiquitin-protein ligase.

18 romyces cerevisiae, encodes a hect domain E3 ubiquitin-protein ligase.

19 Rad17 oscillation is mediated by Cdh1/APC, a ubiquitin-protein ligase.

20 bsentia homologue-1 (Siah-1), a RING-type E3 ubiquitin-protein ligase.

21 ermeabilized cells, likely by membrane-bound ubiquitin protein ligases.

22 region of Gag with cellular Nedd4-family E3 ubiquitin protein ligases.

23 it of the SCF (SKP1, Cullin, F-box) class of ubiquitin protein ligases.

24 omponents of SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligases.

25 n Cul-3, a member of the cullin family of E3 ubiquitin-protein ligases.

26 main of Rsp5p that is highly conserved among ubiquitin-protein ligases.

27 xy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases.

28 xy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases.

29 pathway analysis identified SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) as a key miR-140-5p

30 SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) belongs to the Nedd4

31 The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is a homologous to the

32 ion also depends on SMURF1 (SMAD specific E3 ubiquitin protein ligase 1), which promotes RhoA degrada

33 Siah-1 [seven in absentia homolog 1 (Siah E3 ubiquitin protein ligase 1)] interacting protein] is a m

34 ting ducts in mice deficient for mindbomb E3 ubiquitin protein ligase 1, a key regulator of the Notch

35 HECT domain and ankyrin repeat-containing E3 ubiquitin protein ligase 1-null mouse hearts was associa

36 ECT) domain and Ankyrin repeat containing E3 ubiquitin-protein ligase 1 (HACE1) plays a protective ro

37 HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) as an E3 ubiquitin ligase re

38 ) and ENHANCER OF GL3 (EGL3), is mediated by ubiquitin protein ligase 3 (UPL3).

39 Absence of the maternal copy of ubiquitin protein ligase 3A (UBE3A) results in Angelman

40 ome (AS) result from loss or inactivation of ubiquitin protein ligase 3A (UBE3A), a gene displaying m

41 ersion and show that Itch encodes a novel E3 ubiquitin protein ligase, a protein involved in ubiquiti

42 In addition to the well-characterized E6AP ubiquitin-protein ligase, a second HECT domain protein (

43 Protein complexes and pathways involved in ubiquitin-protein ligase activities, sphingolipid metabo

44 efine a mechanism by which TNF-RII-regulated ubiquitin protein ligase activity can potentiate TNF-ind

45 E6AP and E6 together provide the E3-ubiquitin protein ligase activity in the transfer of ubi

46 The ubiquitin protein ligase activity of c-Cbl (abbreviated

47 Thus, the ubiquitin protein ligase activity of c-IAP1 is responsib

48 etic and functional analysis suggests the E3 ubiquitin protein ligase activity of parkin, and the ubi

49 form of DRONC for degradation through its E3 ubiquitin protein ligase activity.

50 g by regulating IRAK degradation through its ubiquitin protein ligase activity.

51 The ubiquitin-protein ligase activity associated with the E1

52 sed full-length XIAP, which is known to have ubiquitin-protein ligase activity for active caspase-3.

53 Parkin has ubiquitin-protein ligase activity in the presence of Ubc

54 e Parkinson's disease due to the loss of the ubiquitin-protein ligase activity of Parkin protein.

55 vivo function, strongly suggesting that the ubiquitin-protein ligase activity of Rsp5 is intrinsical

56 xport by E1B-55K and E4orf6 results from the ubiquitin-protein ligase activity of the adenovirus ubiq

57 viral late mRNA nuclear export requires the ubiquitin-protein ligase activity of this viral ubiquiti

58 tro experiments indicate that Rkr1 possesses ubiquitin-protein ligase activity.

59 mutant proteins to coactivate PR or provide ubiquitin-protein ligase activity.

60 teins, including Rsp5 and Nedd-4, which have ubiquitin-protein ligase activity.

61 (HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase), an E3 ligase implicated in ca

62 ue mutations in PEX2 and PEX10, which encode ubiquitin-protein ligases anchored in the peroxisomal me

63 associated protein, E6AP, acts both as an E3 ubiquitin-protein ligase and as a coactivator of steroid

64 RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and

65 The UBE3A gene encodes the E6-AP ubiquitin-protein ligase and has recently been shown to

66 n SH2-containing protein that functions as a ubiquitin-protein ligase and thus provide a distinct mec

67 NEDD8 acts predominantly as a regulator of ubiquitin-protein ligases and as a decoy for proteins ta

68 SCF complexes are the largest family of E3 ubiquitin-protein ligases and mediate the ubiquitination

69 (HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase) and NEDD4-1 (Neural precursor

70 zymes), E2 (ubiquitin-carrier proteins), E3 (ubiquitin-protein ligases), and E4 (ubiquitin chain asse

71 MDP1 is identical to RSP5, which encodes ubiquitin-protein ligase, and mdp1 mutations are suppres

72 Hsp70-type molecular chaperones, the Pib1 E3 ubiquitin-protein ligase, and the deubiquitylating enzym

73 utations of the parkin gene, which encodes a ubiquitin-protein ligase, are a common cause of autosoma

74 dentification of the Nedd4-like family of E3 ubiquitin protein ligases as proteins that specifically

75 en shown to physically associate with two E3 ubiquitin protein ligases as well as proteasomes, we inv

76 mone receptor-interacting protein 12), an E3 ubiquitin-protein ligase as a new partner of PTF1a.

77 ction but not the placement of the Rad6-Bre1 ubiquitin-protein ligase at the promoters of active gene

78 ription factors, and robust induction of the ubiquitin-protein ligase atrogin-1/MAFbx.

79 Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regu

80 vity of beta-transducin repeat containing E3 ubiquitin protein ligase, betaTrCP.

81 oxidation, and also RNF146, which encodes a ubiquitin protein ligase, both known pathways in breast

82 te Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated l

83 plex, indicating that it inhibited the viral ubiquitin-protein ligase but had no effect on viral earl

84 tly, evidence has started to emerge that the ubiquitin-protein ligase c-Cbl is involved in CSF-1 rece

85 Degradation required the ubiquitin protein ligase called the anaphase-promoting c

86 ox proteins [2] are components of modular E3 ubiquitin protein ligases called SCFs, which function in

87 box proteins are one of the four subunits of ubiquitin protein ligases called SCFs.

88 Parkin, an E2-dependent ubiquitin protein ligase, carries pathogenic mutations i

89 Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step

90 ondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism.

91 A1 also interacted with FBXW7, subunit of E3 ubiquitin protein ligase complex SCF, and the latter was

92 yeast Hs-CUL-2 homolog, Cdc53, is part of a ubiquitin protein ligase complex that targets cell cycle

93 mycin to downregulate Skp2, a subunit of the ubiquitin protein ligase complex, identifies tumors that

94 ndau tumor suppressor protein to form the E3 ubiquitin protein ligase complex, required for HIF-1alph

95 CCNF encodes cyclin F, a component of an E3 ubiquitin-protein ligase complex (SCF(Cyclin F)).

96 The S. cerevisiae SCFCdc4p ubiquitin-protein ligase complex promotes cell cycle tra

97 quitin-protein ligase activity of this viral ubiquitin-protein ligase complex, we designed and expres

98 in-protein ligase activity of the adenovirus ubiquitin-protein ligase complex.

99 tion of Bim through the Cullin2/ElonginB-CIS ubiquitin-protein ligase complex.

100 ty to components of cellular multisubunit E3 ubiquitin-protein ligase complexes, including 9 proteins

101 d protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive photomorphogenesis

102 demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signalin

103 educes expression of RSP5/NPI1, a postulated ubiquitin-protein ligase, dramatically reduces the rate

104 ified a HECT domain-containing protein UBR5 (ubiquitin protein ligase E3 component n-recognin 5) as a

105 the 15q15.2 locus involved regulation of the ubiquitin protein ligase E3 component UBR1.

106 Addition of ubiquitin protein ligase E3 substantially enhanced the E

107 th RING-H2 and leucine zipper motifs showing ubiquitin protein ligase (E3) activity and is exposed on

108 bset of IAPs that contain a RING domain have ubiquitin protein ligase (E3) activity implied the prese

109 some pathway, at least partially through the ubiquitin protein ligase (E3) activity of SKP2.

110 main-containing IAPs, c-IAP1 and c-IAP2 have ubiquitin protein ligase (E3) activity.

111 -IAP2, which also have RING domain-dependent ubiquitin protein ligase (E3) activity.

112 ation by promoting the interaction between a ubiquitin protein ligase (E3) called SCF(TIR1) and the A

113 dation, Rad6 interacts with the UBR1-encoded ubiquitin protein ligase (E3) enzyme.

114 We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activ

115 E6-associated protein (E6AP) functions as a ubiquitin protein ligase (E3) in the E6-mediated ubiquit

116 tablish that gp78 is a RING finger-dependent ubiquitin protein ligase (E3) of the endoplasmic reticul

117 Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of

118 e containing the C2 domain of mouse Nedd4, a ubiquitin protein ligase (E3) that also contains a hect

119 (E1), a ubiquitin-conjugating enzyme (E2), a ubiquitin protein ligase (E3), and a de-ubiquitinating e

120 report that CARP-2, a RING domain-containing ubiquitin protein ligase (E3), is a negative regulator o

121 ves ubiquitin carrier protein (E2) E214k and ubiquitin-protein ligase (E3) E3alpha, have remained unc

122 it was shown that E6-AP serves the role of a ubiquitin-protein ligase (E3) in the presence of the E6

123 The E6AP ubiquitin-protein ligase (E3) mediates the human papillo

124 cH5A, a 120-kDa protein(s) that behaves as a ubiquitin-protein ligase (E3), and ubiquitin-activating

125 The ubiquitin-protein ligase (E3), hRPF1/Nedd4, is a compone

126 y represent a core component of a CUL3-based ubiquitin-protein ligase (E3), we hypothesize that the p

127 , a ubiquitin-conjugating enzyme (E2), and a ubiquitin-protein ligase (E3).

128 e ubiquitin-conjugating enzyme (E2), and the ubiquitin-protein ligase (E3).

129 l nuclear ribonucleoprotein N (Snrpn (S)) to ubiquitin protein ligase E3A (Ube3a (U)) (mouse model re

130 esults from loss of function of the maternal ubiquitin protein ligase E3A (UBE3A) allele.

131 AS results from loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, whereas the g

132 al active maternal copy of the gene encoding ubiquitin protein ligase E3A (UBE3A).

133 on or mutation of the maternal allele of the ubiquitin protein ligase E3A (UBE3A).

134 Paramount among changing genes was ubiquitin protein ligase E3A (UBE3A; 15q11-q13), which w

135 ulating P16, accompanied by up-regulation of ubiquitin protein ligase E3A and human ubiquitin-related

136 maternally inherited UBE3A allele (encoding ubiquitin protein ligase E3A).

137 nal mRNA transcripts including sirtuin 1 and ubiquitin protein ligase E3a, two genes with established

138 caused by deficiency of maternally expressed ubiquitin-protein ligase E3A (UBE3A), an E3 ligase that

139 e both type III substrates for the mammalian ubiquitin-protein ligase E3alpha.

140 ense SNV, rs7739323, which is located in the ubiquitin protein ligase E3D (UBE3D) gene (Pmeta=1.46 x

141 Nedd4 family ubiquitin protein ligases (E3s) specifically associate w

142 of Apoptosis 1 and 2 (c-IAP1 and c-IAP2) are ubiquitin protein ligases (E3s) that constitutively ubiq

143 c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress noncanonica

144 The cullin CUL1 is a subunit in SCF-type ubiquitin protein ligases (E3s), including the SCF(TIR1)

145 arget proteins is catalyzed by the action of ubiquitin protein ligases (E3s).

146 d to be dictated by specific combinations of ubiquitin-protein ligases (E3s) and ubiquitin-conjugatin

147 Ubiquitin-protein ligases (E3s) of the HECT family share

148 Ubiquitin-protein ligases (E3s) regulate diverse cellula

149 mammalian homologue, Nedd4, are hect domain ubiquitin-protein ligases (E3s) required for the ubiquit

150 al step in this modification is performed by ubiquitin-protein ligases (E3s) that promote Ub transfer

151 Ubiquitin-protein ligases (E3s) that ubiquitinate substr

152 We have demonstrated that Nedd4 family ubiquitin-protein ligases (E3s), AIP4, WWP2/AIP2, and Ne

153 quitin-conjugating enzymes (Ubcs or E2s) and ubiquitin-protein ligases (E3s).

154 strates or with trans-acting factors such as ubiquitin-protein ligases (E3s).

155 eins Hrd1 and Doa10 are the predominant ERAD ubiquitin-protein ligases (E3s).

156 jugating enzymes (E2s) in collaboration with ubiquitin-protein ligases (E3s).

157 as BRG-1, and the less well-characterized E3 ubiquitin-protein ligases E6 papillomavirus protein-asso

158 man papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which cause

159 to E6-associated protein (E6AP), a cellular ubiquitin-protein ligase, enables E6AP to ubiquitinate p

160 was recently shown to interact with Nedd4, a ubiquitin-protein ligase expressed in epithelia.

161 es a member of the hect-domain-containing E3 ubiquitin-protein ligase family that is required for gro

162 by members of the hect-domain-containing E3 ubiquitin-protein ligase family.

163 c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and st

164 Cbl proteins function as ubiquitin protein ligases for the activated epidermal gr

165 Our results suggest that the ubiquitin protein ligase function of Cbl-b is regulated

166 The loss of Parkin's ubiquitin-protein ligase function in familial-linked mut

167 Our data show that the ubiquitin-protein ligase function of E6-AP is dispensabl

168 he majority of the AS patients examined, the ubiquitin-protein ligase function of E6-AP was defective

169 Familial-linked mutations disrupt the ubiquitin-protein ligase function of Parkin and impair P

170 Here, we report that PINK1 regulates the E3 ubiquitin-protein ligase function of parkin through dire

171 n induces apoptosis in part by disabling the ubiquitin-protein ligase function of XIAP and by stabili

172 correlate the E6-AP coactivator function and ubiquitin-protein ligase functions with the AS phenotype

173 cells that express mutant ataxin-1 but not a ubiquitin-protein ligase have significantly fewer NIs.

174 DSmurf encodes a HECT domain ubiquitin-protein ligase, homologous to vertebrate Smurf

175 tally down-regulated 4 (Nedd4) was the first ubiquitin protein ligase identified to interact with con

176 sine kinase family as substrates of the E6AP ubiquitin-protein ligase implicates a role for the ubiqu

177 The cellular protein E6AP functions as an E3 ubiquitin protein ligase in the E6-dependent ubiquitinat

178 e c-IAPs represent a pair of TNFR-associated ubiquitin protein ligases in which one regulates the exp

179 Three peroxisome-associated ubiquitin-protein ligases in the Really Interesting New

180 /hHYD, encoding a progestin induced putative ubiquitin-protein ligase) in mammary ductal carcinoma.

181 Certain ubiquitin protein ligases, including the SCF complex and

182 fication of cellular targets for E6AP, an E3 ubiquitin protein ligase involved in ubquitin-mediated d

183 of RTF1 is lethal in the absence of Rkr1, a ubiquitin-protein ligase involved in the destruction of

184 d protein that binds to Nedd4 protein, an E3 ubiquitin-protein ligase involved in ubiquitin-dependent

185 Cbl-b, a ring-type E3 ubiquitin protein ligase, is implicated in setting the t

186 des a member of the cullin family subunit of ubiquitin-protein ligases, is expressed at abnormally hi

187 In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing co

188 with and is ubiquitylated on K1413 by the E3 ubiquitin-protein ligase Itchy homolog (Itch), a Nedd4 f

189 A key step in this process is catalyzed by a ubiquitin-protein ligase known as the anaphase-promoting

190 dentified a novel missense variant in the E3 ubiquitin-protein ligase LRSAM1 (p.Cys694Tyr).

191 utation in the gene encoding the putative E3 ubiquitin-protein ligase Mahogunin causes spongiform neu

192 lin-3, a small molecule antagonist of the E3 ubiquitin protein ligase MDM2, inhibited angiogenesis in

193 he 3'UTR of two oncoproteins: BRAF and an E3 ubiquitin protein ligase, MDM2.

194 ial transport through phosphorylation of the ubiquitin protein ligase Nedd4-2 (neuronal precursor cel

195 enhanced channel surface expression and the ubiquitin-protein ligase Nedd4-2 has emerged as a centra

196 Here, we investigated the role of ubiquitin-protein ligase NEDD4-2, which negatively regul

197 ing a significant upregulation of another E3 ubiquitin-protein ligase, NEDD4L, and of TNFRSF21, a key

198 on, ii) beta-transducin repeat containing E3 ubiquitin protein ligase nuclear accumulation, and iii)

199 Rsp5 is an E3 ubiquitin-protein ligase of Saccharomyces cerevisiae tha

200 s reflect the properties of enzymes known as ubiquitin-protein ligases or E3s.

201 Ubiquitin-protein ligases (or E3s) are the components of

202 proteins is directed by diverse families of ubiquitin-protein ligases (or E3s) in plants.

203 ination of various intracellular proteins by ubiquitin-protein ligases (or E3s) plays an essential ro

204 ity of ubiquitination is often controlled by ubiquitin-protein ligases (or E3s), which facilitate the

205 itination is directed by diverse families of ubiquitin-protein ligases (or E3s).

206 Mutations in the ubiquitin-protein ligase Parkin are associated with auto

207 owed that the genetic invalidation of the E3 ubiquitin-protein ligase parkin PD gene leads to exagger

208 The Parkinson's disease-associated ubiquitin-protein ligase, Parkin, is important in the el

209 The E3 ubiquitin-protein ligases play an important role in cont

210 TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cel

211 We have identified that Cdh1/APC, a critical ubiquitin protein ligase, plays an important role in reg

212 Here we report that Cbl, a RING-type E3 ubiquitin-protein ligase, promotes ubiquitination of TCR

213 he exact feature of misfolding that each PQC ubiquitin-protein ligase recognizes in their substrates

214 ting complex/cyclosome (APC/C), an essential ubiquitin protein ligase, regulates mitotic progression

215 TIR1 is part of a ubiquitin protein ligase required for degradation of Aux

216 expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal d

217 ally localized serine/threonine kinase and a ubiquitin-protein ligase, respectively, result in recess

218 The subsequent recruitment of E3 ubiquitin-protein ligase RING finger protein 4 resulted

219 ge checkpoint protein 1 (phospho-MDC1) or E3 ubiquitin-protein ligase ring finger protein 8 (RNF8), t

220 d at recombination junctions derived from E3 ubiquitin-protein ligase RNF168-deficient, Fanconi anemi

221 s include the yAP180 proteins, clathrin, the ubiquitin-protein ligase Rsp5p, End3p, and synaptojanin.

222 nism, in which APP acts as a modulator of E3 ubiquitin-protein ligase(s), shared by distinct neuronal

223 revious studies of the budding yeast nuclear ubiquitin-protein ligase San1 indicated that it recogniz

224 Because AtCUL1 is a component of the ubiquitin protein ligase SCF(TIR1), a complex that also

225 ptional repressors through the action of the ubiquitin protein ligase SCF(TIR1).

226 response proteins through the action of the ubiquitin protein ligase SCF(TIR1).

227 Two different ubiquitin protein ligases, SCF(SKP2) and the RING protei

228 er, in females doubly mutant for bam and the ubiquitin protein ligase Smurf, the number of germ cells

229 responsiveness via up-regulation of SKI, E3 ubiquitin-protein ligase SMURF2, and SMAD7 (mothers agai

230 proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 ter

231 REM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which

232 Cullin-RING ubiquitin-protein ligases such as the Skp1, cullin, F-bo

233 The APC/C ubiquitin-protein ligase targets proteins by appending p

234 i's sarcoma-associated herpesvirus encodes a ubiquitin-protein ligase termed K3, which functions as a

235 ese domains bind Rhp18/Rad18, which is an E3 ubiquitin protein ligase that has crucial functions in p

236 Pellino 3b is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked

237 This complex functions as a ubiquitin protein ligase that targets members of the aux

238 re the largest and best studied family of E3 ubiquitin protein ligases that facilitate the ubiquityla

239 The E6-AP gene (UBE3A) encodes an E3 ubiquitin-protein ligase that binds the human papillomav

240 se-promoting complex (APC) is a multisubunit ubiquitin-protein ligase that catalyzes the polyubiquiti

241 moting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiqu

242 Triad3A is an E3 ubiquitin-protein ligase that interacts with the Toll/in

243 arboxyl terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti

244 ble, and their degradation is triggered by a ubiquitin-protein ligase that is regulated by modificati

245 n is likely a recognition element for the E3 ubiquitin-protein ligase that modifies Gal4.

246 d additional cellular proteins to form an E3 ubiquitin-protein ligase that polyubiquitinates p53 and

247 +) absorption is regulated by Nedd4-2, an E3 ubiquitin-protein ligase that reduces expression of the

248 by disrupting its binding to Nedd4-2, an E3 ubiquitin-protein ligase that targets ENaC for degradati

249 by inhibiting the function of Nedd4-2, an E3 ubiquitin-protein ligase that targets ENaC for degradati

250 findings suggest that Staring is a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for deg

251 SGK phosphorylates Nedd4-2, an E3 ubiquitin-protein ligase that targets the epithelial Na+

252 complex (APC) or cyclosome is a multisubunit ubiquitin-protein ligase that ubiquitinates and thereby

253 Rsp5 is the sole yeast ubiquitin-protein ligase that ubiquitylates RNA pol II L

254 It is defined by San1p, a ubiquitin-protein ligase that, in conjunction with the u

255 degradation typically proceeds via multiple ubiquitin-protein ligases that act throughout the cell t

256 Two E3 ubiquitin-protein ligases that recognize the encephalomy

257 As part of a ubiquitin-protein ligase, these viral proteins stimulate

258 C proteins can also interact with certain E3 ubiquitin protein ligases, they may provide a link betwe

259 sults suggest that Parkin functions as an E3 ubiquitin-protein ligase through its ring domains and th

260 Although p19Arf binds to the Mdm2 E3 ubiquitin protein ligase to activate p53, neither of the

261 ) family proteins themselves can function as ubiquitin protein ligases to ubiquitinate their target p

262 These results suggest that Triad3A is an E3 ubiquitin-protein ligase to RIP1 and that Hsp90 and Tria

263 s indicate that Siah proteins function as E3 ubiquitin-protein ligases to regulate the ubiquitination

264 somerase I-binding, arginine/serine-rich, E3 ubiquitin protein ligase (Toporsa); and POU class 6 home

265 s a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to bal

266 FOXM1 prevented the E3 ubiquitin-protein ligase transcriptional intermediary fa

267 with LPS increased the expression of the E3 ubiquitin-protein ligase tripartite motif -: containing

268 Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome.

269 st one other gene, the E6-associated protein ubiquitin-protein ligase (UBE3A) gene, has been implicat

270 Although the gene for E6-AP ubiquitin-protein ligase (UBE3A) was mapped to the criti

271 n mutations of E6-associated-protein (E6-AP) ubiquitin-protein ligase (UBE3A).

272 Both Rad23 and Cdc48 bind a ubiquitin protein ligase ubiquitin fusion degradation-2

273 Two multiprotein E3 (ubiquitin-protein ligase) ubiquitin ligases, the SCF (Sk

274 protein degradation via interaction with the ubiquitin-protein ligase Ubr1 and in DNA repair via inte

275 identified a family of seven HECT-containing ubiquitin-protein ligases (UPL1-UPL7) in Arabidopsis tha

276 city of the pathway is determined by E3s (or ubiquitin-protein ligases, UPLs), little is known about

277 two-hybrid screen, mouse Nedd4 (mNedd4-1), a ubiquitin protein ligase, was previously isolated as an

278 utations in the parkin gene, which encodes a ubiquitin-protein ligase, were found to underlie a famil

279 Cbl proteins are ubiquitin protein ligases, which ubiquitinate activated

280 is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a varie

281 d/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulate