ライフサイエンスコーパス: ubiquitin-specific protease

1 lation apparatus, with cyclin D3, and with a ubiquitin-specific protease.

2 ses the proportion of ND10 which contain the ubiquitin-specific protease.

3 lent adduct with the active site cysteine of ubiquitin-specific proteases.

4 of GPCRs by ubiquitin ligases and removed by ubiquitin-specific proteases.

5 Here, we show that the DUB ubiquitin specific protease 1 (USP1) deubiquitinates the

6 The ubiquitin-specific protease 1 (USP1) is a known critical

7 stitutively antagonized by the action of the ubiquitin-specific protease 1 (USP1).

8 The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1

9 ity, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (USP1-associated fac

10 regulates p53 expression by interacting with ubiquitin-specific protease 10 (USP10), a deubiquitinati

11 irway epithelial cells, we demonstrated that Ubiquitin Specific Protease-10 (USP10) is located in ear

12 h, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-comp

13 ing enzymes that regulate AR; in that screen ubiquitin-specific protease 12 (Usp12) was identified as

14 fication of a deubiquitinating enzyme, named ubiquitin-specific protease 13 (USP13) that appears to b

15 regulating receptor fate, we report that the ubiquitin-specific protease 14 (USP14) interacts with th

16 Ubiquitin-specific protease 14 (USP14) is a component of

17 The axJ gene encodes ubiquitin-specific protease 14 (Usp14), a deubiquitinati

18 this study, we investigated the role of the ubiquitin-specific protease 14 (Usp14), a proteasome-ass

19 axia (ax(J)) mice have reduced expression of ubiquitin-specific protease 14 (Usp14), resulting in sev

20 Here we show that ax encodes ubiquitin-specific protease 14 (Usp14).

21 LX1570 binds to and inhibits the activity of ubiquitin-specific protease-14 (USP14) in vitro, with co

22 ssful capture of the TRIM-25-associated DUB, ubiquitin specific protease 15, demonstrated the versa-t

23 The induction of ubiquitin-specific protease 15 was dependent on calcium

24 ted induction of the deubiquitinating enzyme ubiquitin-specific protease 15 was observed, which is kn

25 the murine USP18 (Ubp43) gene and the human ubiquitin specific protease 18 (USP18) gene and encodes

26 The negative feedback regulator ubiquitin-specific protease 18 (USP18) potently interfer

27 fied a member of the deubiquitinases family, ubiquitin-specific protease 18 (USP18), as a novel negat

28 d genes included IFN-induced 15-kDa protein, ubiquitin-specific protease 18, glucocorticoid attenuate

29 Here, we identified ubiquitin-specific protease 19 (USP19) as a positive reg

30 Here we show that the ubiquitin-specific protease-19 (USP19) interacts with co

31 genetic screening approach, we identify the ubiquitin-specific protease 2 (USP2) as a post-transcrip

32 In this study, we identified ubiquitin-specific protease 2 (USP2) as an inducible reg

33 be impeded by deubiquitinating enzymes like ubiquitin-specific protease 20 (USP20), which can revers

34 1-interacting protein 5 via association with ubiquitin specific protease 21 (USP21) debiquitinase.

35 report that the histone ubiquitin hydrolase ubiquitin-specific protease 22 (USP22) is a critical epi

36 d, we identified the deubiquitinating enzyme ubiquitin-specific protease 22 (USP22), a component of t

37 cal studies reveal that depletion of Gcn5 or ubiquitin-specific protease 22 (Usp22), which is another

38 ncreasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase

39 ore significant in the linked subset and the ubiquitin-specific protease 24 gene (USP24).

40 Here, we identify ubiquitin-specific protease 25 (USP25) as a positive reg

41 findings have revealed an essential role for ubiquitin-specific protease 26 in cellular reprogramming

42 Here we report for the first time that ubiquitin-specific protease 26 negatively regulates soma

43 HIF-1alpha degradation can be antagonized by ubiquitin-specific protease 28 (USP28).

44 USP28 (ubiquitin-specific protease 28) is a deubiquitinating en

45 reased p53 levels in two ways: by decreasing ubiquitin specific protease 2a (USP2a) expression leadin

46 emonstrated that the deubiquitinating enzyme ubiquitin-specific protease 2a (USP2a) has oncogenic pro

47 It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of

48 Deubiquitination by ubiquitin-specific protease 2a and AKT-mediated phosphor

49 e discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrest

50 We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally

51 Among them, the ubiquitin-specific protease 36 (USP36) has been implicat

52 dentified the deubiquitinating enzyme USP44 (ubiquitin-specific protease 44) as a critical regulator

53 re, we show that the deubiquitinating enzyme ubiquitin-specific protease-46 (USP-46) regulates the ab

54 RNA screen, we identified the deubiquitylase ubiquitin-specific protease 6 (USP6) as a potent activat

55 We recently identified the TRE17/ubiquitin-specific protease 6 (USP6) oncogene as the fir

56 Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, whi

57 Ubiquitin specific protease 7 (USP7) is a known deubiqui

58 Ubiquitin specific protease 7 (USP7), the most widely st

59 Ubiquitin-specific protease 7 (USP7) deubiquitinates p53

60 The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation o

61 Human ubiquitin-specific protease 7 (USP7) is a deubiquitinati

62 Ubiquitin-specific protease 7 (USP7) is a deubiquitinati

63 For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degr

64 dentified the deubiquitinating enzyme (DUB), ubiquitin-specific protease 7 (USP7), as a novel regulat

65 ORF45: the viral protein ORF33 and cellular ubiquitin-specific protease 7 (USP7).

66 ded by herpes simplex virus 1 (HSV-1), binds ubiquitin-specific protease 7 (USP7).

67 Here we have identified ubiquitin-specific protease 7 (USP7; also known as HAUSP

68 33 and the 130-kDa protein is cellular USP7 (ubiquitin-specific protease 7).

69 We have identified the deubiquitinase Ubiquitin Specific Protease-7 (USP7) as a regulator of N

70 and are implicated in disease; for example, ubiquitin-specific protease-7 (USP7) regulates stability

71 Using an in vivo RNAi screen, we identified ubiquitin-specific protease 8 (USP8) as a deubiquitinase

72 Ubiquitin-specific protease 8 (USP8) has previously been

73 econd regulator of ubiquitin metabolism, the ubiquitin-specific protease 8 (USP8), is a downstream ta

74 o reduced expression of the de-ubiquitinase, ubiquitin-specific protease 8 (USP8).

75 The deubiquitinating enzyme ubiquitin-specific protease 8 (USP8/UBPy) has been previ

76 Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the mos

77 Additionally, we determined that the ubiquitin-specific protease activity of the ORF UL48 pro

78 deubiquitinase HAUSP (herpesvirus-associated ubiquitin-specific protease; also named USP7) and blocke

79 lyQ disease protein, ataxin-3, has predicted ubiquitin-specific protease and ubiquitin-binding domain

80 s significant homology to well characterized ubiquitin-specific proteases and previously was shown to

81 tion structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ub

82 tein homology domain at its N terminus and a ubiquitin-specific protease at its C terminus.

83 ic DUBs makes this new family of herpesvirus ubiquitin-specific proteases attractive targets for sele

84 Until now, whether deubiquitination by ubiquitin-specific proteases can regulate the clock prot

85 tyltransferase complex, including a putative ubiquitin-specific protease component.

86 interferon-stimulated gene encoding a 43-kDa ubiquitin-specific protease, designated ISG43, was ident

87 Here, we report that USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, revers

88 USP53 contains a catalytically inactive ubiquitin-specific protease domain and is expressed in c

89 2s were similar, with a conserved N-terminal ubiquitin-specific protease domain separated from an int

90 ration of the inhibitory signal requires the ubiquitin-specific protease encoded by the fat facets ge

91 Recently, a ubiquitin-specific protease enzyme (named HAUSP) and a u

92 chromosome 1q21 and encodes a member of the ubiquitin-specific protease family with highly conserved

93 Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates u

94 ne of these genes, Usp18, is a member of the ubiquitin-specific protease family.

95 the 135 kDa protein as a novel member of the ubiquitin-specific protease family.

96 an ecdysteroid-response gene, cabut, and an ubiquitin-specific protease gene, fat facets, with known

97 0 reported to abolish the interaction with a ubiquitin-specific protease has no effect on the functio

98 The ubiquitin-specific protease HAUSP is a critical componen

99 s, we have identified herpesvirus-associated ubiquitin-specific protease (HAUSP) as a novel p53-inter

100 the ability of Vmw110 to bind to a cellular ubiquitin-specific protease (HAUSP) is not required.

101 In this study, herpesvirus-associated ubiquitin-specific protease (HAUSP) was isolated as a bi

102 deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabili

103 quitinylating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7),

104 Doa4 is a ubiquitin-specific protease in Saccharomyces cerevisiae

105 protein 1, a ubiquitin-like 17-kDa protein, ubiquitin-specific protease ISG43, an RNA helicase DEAD

106 Vmw110 binds strongly and specifically to a ubiquitin-specific protease known as HAUSP, itself a com

107 hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function.

108 ed with and regulated by two isoforms of the ubiquitin-specific protease otubain 1.

109 Thus, USP21 is the first ubiquitin-specific protease shown to have dual specifici

110 r the influence of different combinations of ubiquitin-specific proteases, suggesting that they have

111 The B. mallei tssM gene encodes a putative ubiquitin-specific protease that is physically linked to

112 The ubiquitin-specific proteases (UBP) are a family of enzym

113 nalysis shows that it belongs to a family of ubiquitin-specific proteases (UBP), and its molecular ma

114 These studies identified a ubiquitin-specific protease, Ubp3, as having an essentia

115 lts broaden the understanding of a new human ubiquitin-specific protease, UBP43, and suggest that thi

116 sing after the first di-glycine motif by the ubiquitin-specific proteases Ubp5 and Ubp15 generates a

117 uitinating module (DUBm), which contains the ubiquitin-specific protease Ubp8, bound to Sgf11, Sus1,

118 Ubiquitin-specific proteases (UBPs) are a family of uniq

119 re released and subsequently disassembled by ubiquitin-specific proteases (UBPs) to regenerate free u

120 erference screening to identify a human DUB, ubiquitin-specific protease (USP) 13, whose expression m

121 zyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specific protease (USP) 14 in mammals] is the

122 TRE17 encodes a ubiquitin-specific protease (USP) and a TBC (TRE2-Bub2-C

123 rticularly key deubiquitinases (DUBs) of the ubiquitin-specific protease (USP) class.

124 ultispecificity, particularly binding to the ubiquitin-specific protease (USP) family of deubiquitina

125 The herpesvirus ubiquitin-specific protease (USP) family, whose founding

126 TRE17 encodes a ubiquitin-specific protease (USP), and a TBC domain that

127 ed growth, we identified and characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a

128 We also showed that ubiquitin-specific protease (USP)15 interacted with RORg

129 Ubiquitin-specific proteases (USP) are one class of DUBs

130 Here, we identify the ubiquitin-specific protease USP21 as a positive regulato

131 In this study, we identified the ubiquitin-specific protease USP25 as a negative regulato

132 iated bivalent interactions with p53 and the ubiquitin-specific protease USP28.

133 l. merge these two themes by identifying the ubiquitin-specific protease Usp4 as a partner for the ca

134 We have now identified the cytoplasmic ubiquitin-specific protease USP47 as the major enzyme in

135 region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence

136 we show that Hh stimulates the binding of a ubiquitin-specific protease Usp7 to Ci, which positively

137 ins had no effect on the distribution of the ubiquitin-specific protease USP7 within the cell, consis

138 tes resulting from our analysis included the ubiquitin-specific protease USP7, the transcriptional re

139 Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify

140 entify a novel mTOR interacting protein, the ubiquitin-specific protease USP9X, which acts as a negat

141 d that Themis stability is controlled by the ubiquitin-specific protease USP9X, which removes ubiquit

142 is reversed by two deubiquitinating enzymes, ubiquitin-specific proteases (USPs) 20 and 33, thus, inh

143 Ubiquitin-specific proteases (USPs) constitute the large

144 Ubiquitin ligases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose e

145 tant role in immune regulation; however, the ubiquitin-specific proteases (USPs) that carry out deubi

146 Ubiquitin-specific proteases (USPs) USP15 and USP4 belon

147 Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germli