ライフサイエンスコーパス: ubiquitinated

1 unavailable, three nearby lysines may become ubiquitinated.

2 amount of Bid in the cytosol is mono- and bi-ubiquitinated.

3 ds, respectively, that are known to be oligo-ubiquitinated.

4 milar to the wild-type receptor, but was not ubiquitinated.

5 d in cells, is degradation-resistant and not ubiquitinated.

6 subunit intrinsic to the MCC (Cdc20(MCC)) is ubiquitinated, a process that results in APC/C reactivat

7 hibitors are known to prevent degradation of ubiquitinated AAV capsids, thereby leading to increased

8 tion by a stabilized XBAT35.2, the levels of ubiquitinated ACD11 increased considerably, and the abun

9 Both IL-4Ralpha and gammaC were ubiquitinated after 30 min of IL-4 treatment, suggesting

10 Tsa1 counteracted the accumulation of ubiquitinated aggregates during aging and the reduction

11 6 is involved in the autophagic clearance of ubiquitinated aggregates during which SQSTM1/p62 plays a

12 neurons form large autophagosomes containing ubiquitinated aggregates early in disease progression.

13 Many cargoes are ubiquitinated, allowing access to an ESCRT-dependent pat

14 proteasomal degradation study showed that di-ubiquitinated alpha-globin is rapidly degraded in contra

15 Ubiquitinated alpha-synuclein is targeted to proteasomal

16 TrkA is ubiquitinated, among other E3 ubiquitin ligases, by Nedd

17 g a role of Eps15 for the internalization of ubiquitinated AMPARs.

18 PRL ubiquitinated and accelerated poststimulatory decay of a

19 We show that KLHL41 is poly-ubiquitinated and acts, at least in part, by preventing

20 Although misfolded proteins are ubiquitinated and cleared by the proteasome, they can ac

21 other steroid receptors, which are typically ubiquitinated and degraded by proteasomes after ligand b

22 ting of the I-II loop of CaV2.2 was directly ubiquitinated and degraded by the proteasome system.

23 zed by binding to IP3Rs, that unbound Bok is ubiquitinated and degraded by the proteasome, and that b

24 Once exported from the nucleus, menin was ubiquitinated and degraded by the proteasome.

25 h-related proteins were identified that were ubiquitinated and degraded more rapidly after mTOR inhib

26 ng finger protein 41 (RNF41) as an E3 ligase ubiquitinated and degraded SGT1 in a phosphorylation-dep

27 These are subsequently ubiquitinated and degraded via the 26S proteasome, leadi

28 We found that during hypoxia, PKCzeta is ubiquitinated and degraded via the ubiquitin ligase HOIL

29 Previous studies reported that ABCG1 is ubiquitinated and degraded via the ubiquitin proteasome

30 uished from their assembled counterparts and ubiquitinated and degraded within the nuclear compartmen

31 n (ERAD), by which misfolded ER proteins are ubiquitinated and degraded.

32 multiple lysines within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.

33 Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding pr

34 Both the cytoplasmic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments a

35 ells were treated with proteasome inhibitor, ubiquitinated and insoluble TDP-43 species accumulated.

36 the cilium, and the receptor is subsequently ubiquitinated and internalized.

37 Furthermore, Est1 is ubiquitinated and its cell cycle-regulated abundance is

38 156A and K143R, but T156D was constitutively ubiquitinated and persistently localized to the nucleus.

39 version expressed in vivo, Lys-less IAA1 was ubiquitinated and rapidly degraded in vivo.

40 NALP7 is constitutively ubiquitinated and recruited to the endolysosome for degr

41 biquitinomes identified about 70 proteins as ubiquitinated and specifically modified with K63-linked

42 Upon S phase entry, Orc1 is ubiquitinated and targeted for destruction, with subsequ

43 p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degrada

44 er2 binding to hp53 prevents Mdm2 from being ubiquitinated and targeting hp53 by the proteasome.

45 forms and can be discovered phosphorylated, ubiquitinated and truncated.

46 lexes, where it is bound to cytosolic HSP70, ubiquitinated, and degraded via the proteasome.

47 BFRF1 is ubiquitinated, and elimination of possible ubiquitinatio

48 4.7 or human HEK293 cells, were endocytosed, ubiquitinated, and released via exosomes.

49 -1 from cultured rat hippocampal neurons was ubiquitinated, and the levels of ubiquitinated Tomo-1 dr

50 Homodimeric Plk4 has been shown to be ubiquitinated as a result of autophosphorylation, thus p

51 substrate bound tightly to the APC/C and was ubiquitinated at a low rate in the absence of activator.

52 ts that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assemble efficiently at centrome

53 Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitinat

54 Poleta has been shown to be ubiquitinated at one primary site.

55 onoubiquitinated poliota revealed that it is ubiquitinated at over 27 unique sites.

56 In Jurkat cells, ZAP-70 is ubiquitinated at several sites that are not sensitive to

57 uantities of pure human Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by geneticall

58 complex, and facilitates trafficking of the ubiquitinated beta2AR to autophagosomes, which fuse with

59 ss by nutrient starvation, agonist-activated ubiquitinated beta2ARs traffic to autophagosomes to colo

60 ic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cy

61 ytosis-deficient mutant (end4Delta) Pma1p is ubiquitinated but retained at the plasma membrane during

62 at upon the induction of DNA damage, EXO1 is ubiquitinated by a member of the Skp1-Cullin1-F-box (SCF

63 suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro

64 We identify a critical substrate ubiquitinated by CUL3-SPOPL as EPS15, an endocytic adapt

65 K6a in the cytosol is ubiquitinated by cullin-RING E3 ligases for subsequent p

66 PRMT5, beta-catenin, and UbxD8 are directly ubiquitinated by E6AP in vitro and in the cell.

67 Indeed, IFNAR1 was phosphorylated and ubiquitinated by IAV infection, which resulted in IFNAR1

68 the 60S-housed nascent polypeptides are poly-ubiquitinated by Listerin.

69 HIF-1alpha is constitutively ubiquitinated by pVHL (von Hippel-Lindau protein) follow

70 However, HIF-1alpha is not recognized and ubiquitinated by pVHL in IPMK KO (knockout) cells.

71 Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among

72 d misfolded proteins are then recognized and ubiquitinated by RNF4 and are subsequently targeted for

73 ERAD substrates are ubiquitinated by the action of the Hrd1 RING-H2 E3 ligas

74 Ret9 was not ubiquitinated by the CD2AP.Cbl-3/c complex, suggesting t

75 After phosphorylation, RECQL4 is ubiquitinated by the DDB1-CUL4A E3 ubiquitin ligase, whi

76 SIRT1 was ubiquitinated by the MDM2 E3 ligase in vitro and in vivo

77 n13 becomes extensively and selectively poly-ubiquitinated by the proteasome-associated ubiquitin lig

78 polypeptides trapped in the 60S subunit are ubiquitinated by the ribosome quality control (RQC) path

79 p analysis confirmed that both proteins were ubiquitinated by TRIM32 in vitro; however, only NDRG2 ac

80 o assemble with beta-globin were selectively ubiquitinated by UBE2O.

81 aptic vesicles, was shown to bind to, and be ubiquitinated by, the PD-linked E3 ubiquitin ligase Park

82 e we report that the human 26S proteasome is ubiquitinated, by which the ubiquitin receptors Adrm1 an

83 ns] mediate cargo degradation, concentrating ubiquitinated cargo and organizing the activities of ESC

84 CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes.

85 Inhibition of ubiquitinated cargo transport through the multivesicular

86 I, is able to associate stably with the mono-ubiquitinated cargo within a lipid bilayer.

87 ly select for the isolation membrane and the ubiquitinated cargo.

88 which is crucial in determining the fate of ubiquitinated cargo.

89 ls suggest that ESCRT-III complexes surround ubiquitinated cargoes to trap them at the site of ILV bu

90 underlying initial cargo recognition of mono-ubiquitinated cargos remain poorly defined.

91 hows stronger interaction with SUG1 and with ubiquitinated cellular proteins.

92 is rapidly degraded in contrast to the mono-ubiquitinated counterpart, highlighting the importance o

93 howed proteasome-independent accumulation of ubiquitinated CPAP and abnormal, ubiquitin-positive, elo

94 r results show that centrobin interacts with ubiquitinated CPAP and prevents its degradation for norm

95 Furthermore, we show that ubiquitinated CRBN is targeted for proteasomal degradati

96 ction allows accumulation of both native and ubiquitinated CSB and results in an increase of UBXD7, p

97 CP/p97 segregase in the timely processing of ubiquitinated CSB from damaged chromatin.

98 ha proteasome and PR1a, and the detection of ubiquitinated CTB polypeptides revealed that N-glycosyla

99 fication cycle caused by the accumulation of ubiquitinated cyclin E.

100 es recruitment and retention of OPTN/TBK1 on ubiquitinated, damaged mitochondria.

101 EX5 and PMP70 as substrates of PEX2 that are ubiquitinated during amino acid starvation.

102 it), which inhibits the Hrs association with ubiquitinated EGFR.

103 teracting specifically with the UIM and with ubiquitinated epsin.

104 Cdc48 binding to retrotranslocated, ubiquitinated ERAD-M substrates is required for their so

105 9X knockdown resulted in increased levels of ubiquitinated ERG and was coupled with depletion of ERG.

106 mbrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded

107 Similarly, non-ubiquitinated FANCD2 can still support proliferation cel

108 ZAPL-associated PB2 and PA proteins are then ubiquitinated, followed by proteasomal degradation.

109 The ubiquitinated form of Rad18 does not interact with SNF2

110 lded alpha-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy b

111 chemical inhibition leads to accumulation of ubiquitinated forms of XPC, whereas complete USP7 defici

112 r interaction-defective mutants, reduces the ubiquitinated forms of XPC.

113 rons increased the fraction of Lys-63-linked ubiquitinated GABAB receptors and enhanced the expressio

114 iated knockdown of TRIM37 results in loss of ubiquitinated H2A, dissociation of PRC1 and PRC2 from ta

115 moters were bound by TRIM37 and enriched for ubiquitinated H2A.

116 m components, leading to global increases in ubiquitinated H2B (H2Bub) levels.

117 n the rapid and efficient synthesis of Lys34-ubiquitinated H2B and for the first time neddlyated pept

118 ue, together with semisynthetically prepared ubiquitinated H2B, enabled us to provide direct evidence

119 of USP7 leads to a reduction in the level of ubiquitinated histone H2A (H2Aub), the catalytic product

120 the UDR motif with mononuclesomes containing ubiquitinated histone H2A and impedes binding of 53BP1 t

121 1) transheterozygous animals accumulate mono-ubiquitinated histone H2B (ubH2B) and histone H3 tri-met

122 We found that Nedd4-2 ubiquitinated human NHE3 (hNHE3) and altered its express

123 ons from aged monkey brain increase in vitro ubiquitinated huntingtin, whereas depletion of UBE2N mar

124 Additionally, base-resistant forms of ubiquitinated IAA1 were observed for HIS(6x)-HA(3x)-IAA1

125 Ubiquitinated Id-1/Id-2 can then bind to p62 and be tran

126 protein complex specifically associates with ubiquitinated IkappaBalpha via the interactions between

127 , the PDGF beta receptor (PDGFRbeta) becomes ubiquitinated in a manner requiring both the c-Cbl and C

128 We further show that SnRK1 is ubiquitinated in a SIZ1-dependent manner, causing its de

129 Indeed, EPS15 is ubiquitinated in a SPOPL-dependent manner, and accumulat

130 Finally, we show that Dock2 is directly ubiquitinated in CD4(+) T cells and that Elmo1 expressio

131 inically relevant AR-variants it can only be ubiquitinated in cells when AR retains LBD suggesting a

132 es and that multiple proteasome subunits are ubiquitinated in cells, especially the ubiquitin recepto

133 FDH is ubiquitinated in planta and degraded by the 26S proteaso

134 We show here that hD4R is ubiquitinated in primary neurons.

135 how that SIRT1 is dynamically and distinctly ubiquitinated in response to DNA damage.

136 5, and the deubiquitinating enzyme Uch37 are ubiquitinated in situ by proteasome-associating ubiquiti

137 quence AR variants lacking the LBD cannot be ubiquitinated in the cellular environment and their prot

138 We show that MutYH is ubiquitinated in vitro and in vivo by the E3 ligase Mule

139 The DIX domain is ubiquitinated in vivo at multiple lysines, which can be

140 Pma1p is ubiquitinated in vma mutants, and ubiquitination depends

141 om frontotemporal lobar dementia (FTLD) with ubiquitinated inclusion bodies show TDP-43 pathology, th

142 in 43 (TDP-43) is the principal component of ubiquitinated inclusions characteristic of most forms of

143 ients shows degeneration of the striatum and ubiquitinated inclusions immunoreactive for polyglutamin

144 N proteins from the CGG repeat accumulate in ubiquitinated inclusions in FXTAS patient brains and eli

145 generates novel proteins that accumulate in ubiquitinated inclusions in FXTAS patients.

146 d-stage disease revealed the accumulation of ubiquitinated inclusions in the brain and spinal cord, a

147 myopathy, with scattered myocytes containing ubiquitinated, intracellular prion inclusions that were

148 (MDBs) are protein aggregates consisting of ubiquitinated keratins 8/18 (K8/K18).

149 d quantitative mass spectrometry to identify ubiquitinated kinases and the sites of ubiquitination in

150 Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-acc

151 p1 transmembrane domain, and 3) close to the ubiquitinated lysines.

152 ed for transport (ESCRTs) mediate sorting of ubiquitinated membrane proteins into multivesicular bodi

153 ransport (ESCRTs) mediate the degradation of ubiquitinated membrane proteins via multivesicular bodie

154 allowing optineurin to stably associate with ubiquitinated mitochondria via its ubiquitin binding dom

155 SQSTM1 can bind to LC3 on autophagosomes and ubiquitinated molecules on cargos, thus facilitating the

156 gs Dom34-Hbs1 affect the total population of ubiquitinated nascent chains associated with yeast ribos

157 es are enriched in activated IKK kinases and ubiquitinated NEMO molecules, which suggests that they s

158 teasome inhibition, a consequent increase in ubiquitinated neurofilaments and other proteins, and dec

159 on (Co-IP) analysis indicated an increase in ubiquitinated neurofilaments in midbrain of KO mice, whe

160 egates in FXTAS patients and colocalize with ubiquitinated neuronal inclusions.

161 a2 GABAAR subunit by increasing the ratio of ubiquitinated/nonubiquitinated gamma2.

162 id responses, leading to the accumulation of ubiquitinated NPR1, which likely interferes with the ful

163 Normally ubiquitinated Nrf1 is rapidly degraded, but when partial

164 Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to a ubiquitinated nucleosome reveals that the DUB module pri

165 Under inflammatory conditions, ubiquitinated Nur77 resides at mitochondria, rendering t

166 cipitation assays, we show here that VP35 is ubiquitinated on lysine 309 (K309), a residue located on

167 the mechanisms of proteasomal recognition of ubiquitinated p53 and Mdm2.

168 that S5a participates in the recognition of ubiquitinated p53 by the proteasome.

169 gradation and results in the accumulation of ubiquitinated p53.

170 Ubiquitinated PalF triggers downstream signalling events

171 A widely-accepted model purports that ubiquitinated PCNA recruits TLS polymerases such as pol

172 PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the peroxisomal membrane.

173 itination machinery mutants, suggesting that ubiquitinated PEX5 is degraded by the proteasome when th

174 Ubiquitinated plasma membrane proteins (cargo) are deliv

175 up45-Sup35 strongly influences the amount of ubiquitinated polypeptides associated with 60S ribosomal

176 lysis degradation pathway genes resulting in ubiquitinated protein accumulation in muscle.

177 uction in AlaRS editing efficacy resulted in ubiquitinated protein aggregates and mitochondrial defec

178 changes, including gliosis, accumulation of ubiquitinated protein aggregates, lipofuscinosis, and en

179 Ubiquitinated protein aggregates, of which TDP-43 is a m

180 autophagosomal protein LC3 and clearance of ubiquitinated protein aggregates.

181 s, a scaffold protein that co-localizes with ubiquitinated protein at the 30 days post irradiation ti

182 The well described accumulation of ubiquitinated protein inclusions in neurodegenerative di

183 in 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tiss

184 ry, including Ub(G76V)-GFP, a representative ubiquitinated protein substrate that is accumulated in t

185 Through their multiple contacts with ubiquitinated protein substrates involved in these pathw

186 y WT proteasomes is activated if they bind a ubiquitinated protein, which is loosely folded.

187 Usp14 are much more active in degrading non-ubiquitinated proteins (e.g. Sic1) than WT particles.

188 n Clcc1-deficient granule cells in vivo, and ubiquitinated proteins accumulate in these neurons befor

189 heat-shock or arsenite treatment, when poly-ubiquitinated proteins accumulate.

190 over, the overexpression of PARK2 diminished ubiquitinated proteins accumulation, improves its target

191 Ubiquitinated proteins aggregate upon proteasome failure

192 hHR23A binds ubiquitinated proteins and acts as a shuttling factor to

193 roteins and reduced the accumulation of both ubiquitinated proteins and APP/p-Tau proteins.

194 ration was accompanied by an accumulation of ubiquitinated proteins and decreased xeroderma pigmentos

195 resistant parasites exhibit lower levels of ubiquitinated proteins and delayed onset of cell death,

196 receptor hRpn13, triggering accumulation of ubiquitinated proteins and endoplasmic reticulum stress-

197 correlate with an increased accumulation of ubiquitinated proteins and expression of CIN85/RukL in p

198 f desmin filaments caused an accumulation of ubiquitinated proteins and rapid destruction of myofibri

199 y of brain 26S proteasomes, higher levels of ubiquitinated proteins and undegraded Ub-G76V-GFP.

200 Enrichment analysis demonstrated that 35% of ubiquitinated proteins are cell-cycle regulated.

201 ing in accumulation of oxidative lesions and ubiquitinated proteins during heat stress in CWD clams.

202 nizing the Lys--Gly-Gly (diGly) remnant from ubiquitinated proteins following trypsinolysis have prov

203 plex is evolutionarily conserved and targets ubiquitinated proteins for degradation.

204 A protocol to enrich K6-ubiquitinated proteins from cells identifies HUWE1 as a

205 ubstrates, likely by facilitating release of ubiquitinated proteins from the OMM.

206 tion of the proteasome's capacity to degrade ubiquitinated proteins has received little attention, al

207 gradation through suppressing neddylation of ubiquitinated proteins in cardiomyocytes.

208 When degradation of ubiquitinated proteins in cells was inhibited, levels of

209 evalence of receptors such as agglutinin and ubiquitinated proteins in ciliary ectosomes suggests tha

210 strate accumulation of P56S VAPB protein and ubiquitinated proteins in cytoplasmic inclusions, select

211 with this view, NAC abolished an increase in ubiquitinated proteins in MG132-treated astrocytes.

212 formation of p62/SQTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-

213 hibition, the cellular content of K48-linked ubiquitinated proteins increased without any change in p

214 respect to endosomal movement and sorting of ubiquitinated proteins into lysosomes, its function in m

215 re that the proteasome's capacity to degrade ubiquitinated proteins is also tightly regulated.

216 Furthermore, many ubiquitinated proteins localize to the cytoskeleton and

217 berrant membrane structures, accumulation of ubiquitinated proteins on membranes, and axon degenerati

218 e we describe UbiCRest, in which substrates (ubiquitinated proteins or polyubiquitin chains) are trea

219 Moreover, adding ubiquitinated proteins to cell extracts stimulated prote

220 a new strategy for the chemical synthesis of ubiquitinated proteins to generate a set of well-defined

221 e the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation

222 The digestion of ubiquitinated proteins with trypsin yields a glycine-gly

223 reduced PSMD12 levels and an accumulation of ubiquitinated proteins without any impairment of proteas

224 DsRed marker protein, (2) a higher level of ubiquitinated proteins, and (3) coordinated induced expr

225 ance of glycoconjugates, alpha-synuclein and ubiquitinated proteins, and abrogation of inflammatory r

226 ia increased their connectivity, accumulated ubiquitinated proteins, and decreased their respiration.

227 The 26S proteasome degrades ubiquitinated proteins, and proteasomal degradation cont

228 ulated reactive oxygen species (ROS) damage, ubiquitinated proteins, and the multi-functional adapter

229 normal storage of carbohydrates, lipids, and ubiquitinated proteins, combined with marked accumulatio

230 abnormal ubiquitination and accumulation of ubiquitinated proteins, including TDP-43 and a SCF(Cycli

231 es growth retardation and an accumulation of ubiquitinated proteins, indicative of a cellular stress

232 rected to the LDs via SQSTM1, which bound to ubiquitinated proteins, possibly including perilipin 1,

233 V), mutant profilin1 aggregation, abnormally ubiquitinated proteins, reduced choline acetyltransferas

234 s with CB-5083 leads to accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticul

235 with tau and were less active in hydrolyzing ubiquitinated proteins, small peptides and ATP.

236 control cells and treated with PKA degraded ubiquitinated proteins, small peptides, and ATP more rap

237 There was no overall increase in ubiquitinated proteins, suggesting the ubiquitin-proteas

238 ned Hspa1B (heat shock protein 1B hsp70) and ubiquitinated proteins, trapped other cytoskeletal prote

239 tant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-

240 of high molecular weight TDP-43 species and ubiquitinated proteins.

241 , accompanied by an increase of oxidized and ubiquitinated proteins.

242 ysis and enhance proteasomal specificity for ubiquitinated proteins.

243 western blotting quantities of endogenously ubiquitinated proteins.

244 mployed unanchored ubiquitin chains and mono-ubiquitinated proteins.

245 ion, KO of ubqln also caused accumulation of ubiquitinated proteins.

246 ability to bind, deubiquitinate, and degrade ubiquitinated proteins.

247 basal ATP consumption and degradation of non-ubiquitinated proteins.

248 led to exert protection or blunt the rise in ubiquitinated proteins.

249 ransport (ESCRT) [10-12], small GTPases, and ubiquitinated proteins.

250 n ubiquitin-binding protein that targets the ubiquitinated receptor to lysosomal degradation and prom

251 correlated with higher detectable levels of ubiquitinated receptor.

252 rt (ESCRT) machinery responsible for sorting ubiquitinated receptors into intraluminal vesicles (ILVs

253 trafficking and sorting of internalized and ubiquitinated receptors.

254 Once ubiquitinated, reductase becomes dislocated from ER memb

255 We identified K125 as the ubiquitinated residue on CARD9 and demonstrated that thi

256 in Myb3 were found to be phosphorylated and ubiquitinated, respectively.

257 on, leading to prolonged accumulation of K63-ubiquitinated RIP within the TNFR1 signaling complex.

258 inhibition led to accumulation of K48-linked ubiquitinated RIPK3, which was partially reduced when Ly

259 Ubiquitinated RNAPII showed similar enrichment.

260 deling activity promotes the dissociation of ubiquitinated Rpb1 from chromatin to protect the integri

261 pb1 degradation and accumulate tightly bound ubiquitinated Rpb1 on chromatin.

262 tosome (SQSTM1, p62) mediated association of ubiquitinated SLiPs to the autophagy gene product LC3.

263 causes ER accumulation of NAT1 R64W and its ubiquitinated species, and that these products are clear

264 VCP-mediated dislocation and presentation of ubiquitinated sperm mitochondrial proteins to the 26S pr

265 Thus, without a ubiquitinated substrate present, Usp14 suppresses multip

266 f the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate.

267 t, the regulation of Rad23 interactions with ubiquitinated substrates and the proteasome is unknown.

268 ) is the movement, or retrotranslocation, of ubiquitinated substrates from the ER lumen or membrane t

269 by the accumulation of LC3, SQSTM1/p62, and ubiquitinated substrates in an expanded population of au

270 ase Substrate Trapping, for the isolation of ubiquitinated substrates in complex with their ubiquitin

271 th accumulation of free ubiquitin chains and ubiquitinated substrates in the leon mutant.

272 on and off proteasomes, and the presence of ubiquitinated substrates promotes their association.

273 By using this protocol, ubiquitinated substrates that are specific for a given l

274 talloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for

275 nt of single-molecule sensing of differently ubiquitinated substrates with different biological signi

276 ain(s) that interact with the proteasome and ubiquitinated substrates, respectively.

277 system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differe

278 his is especially adequate because, for most ubiquitinated substrates, Ub modifies only a few molecul

279 inding domain, which allows the isolation of ubiquitinated substrates.

280 Conversely, ectopic expression of Mex3b ubiquitinated SUZ12, displaced DDX5 from HOTAIR, and ind

281 Subsequently, ubiquitinated Syn5 recruits p97/p47 to the mitotic Golgi

282 re we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb

283 Cif selectively increased the amount of ubiquitinated TAP1 and increased its degradation in the

284 We identify RIPK1 and caspase-8 as linearly ubiquitinated targets of LUBAC following TRAIL stimulati

285 Here we show that a family of highly ubiquitinated tetraspan Cos proteins provides a Ub signa

286 a roadblock for RNAPII, which pauses and is ubiquitinated, thus triggering termination.

287 Furthermore, we found that accumulation of ubiquitinated TLR4 and binding of E3 ubiquitin ligase Tr

288 iCRest can be used to show that a protein is ubiquitinated, to identify which linkage type(s) are pre

289 neurons was ubiquitinated, and the levels of ubiquitinated Tomo-1 dramatically increased upon pharmac

290 ESCRT dysfunction causes ubiquitinated transmembrane proteins to accumulate at en

291 ired for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2.

292 me transgenes encoding wild-type (stable) or ubiquitinated (unstable) forms of IGRP in IGRP-deficient

293 the replication stress response, is multiply ubiquitinated upon replication fork stalling.

294 These tests revealed that ubiquitinated vacuole membrane proteins recruit ESCRTs t

295 , namely Tau and apoE, interact with and are ubiquitinated via the ACR in vitro This, and the evidenc

296 stocompatibility complex class II (MHCII) is ubiquitinated via the evolutionarily conserved lysine in

297 As pathological TDP-43 is ubiquitinated, we focused on the ubiquitin-conjugating e

298 ults in a drastic reduction in the levels of ubiquitinated XBAT35.2 and an increase in the abundance

299 interaction is crucial for trafficking of a ubiquitinated yeast SNARE (Snc1).

300 SCRT machinery is then recruited to sort the ubiquitinated Ypq1 into intraluminal vesicles (ILVs).