ライフサイエンスコーパス: ubiquitinated protein

1 ic number of ATPs is consumed in degrading a ubiquitinated protein.

2 me is a large protease complex that degrades ubiquitinated proteins.

3 n family, which regulates the degradation of ubiquitinated proteins.

4 ased Bax by 140% (P<0.05) and also increased ubiquitinated proteins.

5 tions can affect proteasome interaction with ubiquitinated proteins.

6 perone proteins, proteasomal components, and ubiquitinated proteins.

7 basal ATP consumption and degradation of non-ubiquitinated proteins.

8 100 nM) and causes accumulation of cellular ubiquitinated proteins.

9 ning paralleled by accumulation of insoluble ubiquitinated proteins.

10 criteria necessary for the interpretation of ubiquitinated proteins.

11 led to exert protection or blunt the rise in ubiquitinated proteins.

12 damage sites in part through recognition of ubiquitinated proteins.

13 ivity, but significant affinity for cellular ubiquitinated proteins.

14 hat WRNIP1 plays a role in the metabolism of ubiquitinated proteins.

15 stability, function, and/or localization of ubiquitinated proteins.

16 nd occurrence of inclusion bodies containing ubiquitinated proteins.

17 disease, exhibit inclusion bodies containing ubiquitinated proteins.

18 ransport (ESCRT) [10-12], small GTPases, and ubiquitinated proteins.

19 a marked decrease in association of VCP with ubiquitinated proteins.

20 th dynein and induces marked accumulation of ubiquitinated proteins.

21 -mediated degradation and an accumulation of ubiquitinated proteins.

22 lexes that selectively degrade intracellular ubiquitinated proteins.

23 a proteasome inhibitor was used to stabilize ubiquitinated proteins.

24 on dissociation (IRMPD), for the analysis of ubiquitinated proteins.

25 ated factor that mediates the degradation of ubiquitinated proteins.

26 branched synthetic ubiquitin chains and from ubiquitinated proteins.

27 of high molecular weight TDP-43 species and ubiquitinated proteins.

28 assayed protein solubility and the amount of ubiquitinated proteins.

29 s accompanied by an increase in the level of ubiquitinated proteins.

30 , accompanied by an increase of oxidized and ubiquitinated proteins.

31 western blotting quantities of endogenously ubiquitinated proteins.

32 ysis and enhance proteasomal specificity for ubiquitinated proteins.

33 mployed unanchored ubiquitin chains and mono-ubiquitinated proteins.

34 ion, KO of ubqln also caused accumulation of ubiquitinated proteins.

35 ability to bind, deubiquitinate, and degrade ubiquitinated proteins.

36 ed p62-independent autophagic degradation of ubiquitinated proteins.

37 autophagic substrates such as p62, LC3II and ubiquitinated proteins.

38 ondrial impairment led to down-regulation of ubiquitinated-proteins, 26S proteasome disassembly, and

39 fication and quantification of more than 400 ubiquitinated proteins, a fraction of which were found t

40 nits resulted in significant accumulation of ubiquitinated proteins accompanied by cessation of cell

41 Our data indicate that ubiquitinated proteins accumulate in DvSnf7 dsRNA-fed la

42 If 20S proteasome activity is inhibited, ubiquitinated proteins accumulate in the parasites.

43 Significantly, ubiquitinated proteins accumulate in the TDP-43-depleted

44 n Clcc1-deficient granule cells in vivo, and ubiquitinated proteins accumulate in these neurons befor

45 the nervous system, pathologic aggregates of ubiquitinated proteins accumulate only in specific neuro

46 heat-shock or arsenite treatment, when poly-ubiquitinated proteins accumulate.

47 including potentially toxic aggregate-prone ubiquitinated proteins, accumulate in Pompe myofibers an

48 that they exhibit reduced ability to degrade ubiquitinated proteins, accumulate short-lived GFPu, and

49 Fewer ubiquitinated proteins accumulated in the swoF1 mutant c

50 lysis degradation pathway genes resulting in ubiquitinated protein accumulation in muscle.

51 over, the overexpression of PARK2 diminished ubiquitinated proteins accumulation, improves its target

52 A proteomics strategy was used to identify ubiquitinated proteins after preconditioning ischemia.

53 Ubiquitinated proteins aggregate upon proteasome failure

54 uction in AlaRS editing efficacy resulted in ubiquitinated protein aggregates and mitochondrial defec

55 autophagy defects including accumulation of ubiquitinated protein aggregates and p62/SQSTM1, deficie

56 t pressure overload promotes accumulation of ubiquitinated protein aggregates in the left ventricle,

57 sis in cerebellum as well as accumulation of ubiquitinated protein aggregates without any deficiency

58 changes, including gliosis, accumulation of ubiquitinated protein aggregates, lipofuscinosis, and en

59 Ubiquitinated protein aggregates, of which TDP-43 is a m

60 -weight alpha-synuclein, and the presence of ubiquitinated protein aggregates, recapitulating many of

61 autophagosomal protein LC3 and clearance of ubiquitinated protein aggregates.

62 rk, and Dark was observed to colocalize with ubiquitinated protein aggregates.

63 m conjugation to itself or a diffuse pool of ubiquitinated proteins already present in the microsomes

64 The absence of ubiquitinated proteins also argues against a model in wh

65 efoldin increased the level of SDS-insoluble ubiquitinated protein and reduced cell viability in lact

66 Here we report that MTA1 is an ubiquitinated protein and targeted by the RING-finger E3

67 Elevated levels of total ubiquitinated proteins and 19S and 20S proteasome subuni

68 hHR23A binds ubiquitinated proteins and acts as a shuttling factor to

69 nto a large centrosomal aggregate containing ubiquitinated proteins and alpha-synuclein.

70 The presence of increased ubiquitinated proteins and amyloid oligomers in failing

71 These inclusions contain insoluble ubiquitinated proteins and amyloid precursor-like protei

72 roteins and reduced the accumulation of both ubiquitinated proteins and APP/p-Tau proteins.

73 120G) overexpression-induced accumulation of ubiquitinated proteins and cellular injury.

74 ved from L110R MM-1alpha mice, the levels of ubiquitinated proteins and cytotoxicity were higher in L

75 ration was accompanied by an accumulation of ubiquitinated proteins and decreased xeroderma pigmentos

76 resistant parasites exhibit lower levels of ubiquitinated proteins and delayed onset of cell death,

77 Firstly, we observed a reduction in ubiquitinated proteins and E1 activity.

78 receptor hRpn13, triggering accumulation of ubiquitinated proteins and endoplasmic reticulum stress-

79 correlate with an increased accumulation of ubiquitinated proteins and expression of CIN85/RukL in p

80 Our data suggest that recruitment of both ubiquitinated proteins and LC3-II by p62 directs ubiquit

81 es the selectivity of the 26S proteasome for ubiquitinated proteins and links their deubiquitination

82 ssue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates

83 ormal accumulations of amyloid-beta peptide, ubiquitinated proteins and other autophagic substrates w

84 proteins containing the UBAb interacted with ubiquitinated proteins and polyubiquitin chains in vitro

85 Rad23 also binds ubiquitinated proteins and promotes their degradation by

86 f desmin filaments caused an accumulation of ubiquitinated proteins and rapid destruction of myofibri

87 easomal deubiquitinating enzyme that cleaves ubiquitinated proteins and releases ubiquitin chains.

88 A domains prevent efficient interaction with ubiquitinated proteins and result in poor suppression of

89 tion was associated with the accumulation of ubiquitinated proteins and reversible opacification of t

90 nd SW480 cell lines leads to accumulation of ubiquitinated proteins and several proteasome target pro

91 which resulted in ER stress, accumulation of ubiquitinated proteins and subsequent ER dilation, contr

92 hows that IBMPFD mutant expression increases ubiquitinated proteins and susceptibility to proteasome

93 d histone deacetylase 6 recognize aggregated ubiquitinated proteins and target them for autophagy in

94 We show that RNF114 associates with ubiquitinated proteins and that it is a soluble cytosoli

95 tylase 6, which serves as an adaptor between ubiquitinated proteins and the dynein motor.

96 ytic activity of the 20S proteasome, because ubiquitinated proteins and the peptidase activities of 2

97 We determined that eEF1A interacted with ubiquitinated proteins and the proteasome following ATP

98 ncer cells, resulting in the accumulation of ubiquitinated proteins and the proteasome target protein

99 , for the first time, an interaction between ubiquitinated proteins and the proteasome.

100 overexpression determines an accumulation of ubiquitinated proteins and this event requires the N-ter

101 sitive) cells results in the accumulation of ubiquitinated proteins and three natural proteasome subs

102 and in vivo by WA results in accumulation of ubiquitinated proteins and three proteasome target prote

103 R23B, were found to bind specifically to K48-ubiquitinated proteins and to stimulate proteasome bindi

104 n-binding domains, thereby bringing together ubiquitinated proteins and ubiquitin receptors to execut

105 y of brain 26S proteasomes, higher levels of ubiquitinated proteins and undegraded Ub-G76V-GFP.

106 Herp is in a complex with ubiquitinated proteins and with the 26S proteasome, sugg

107 DsRed marker protein, (2) a higher level of ubiquitinated proteins, and (3) coordinated induced expr

108 ance of glycoconjugates, alpha-synuclein and ubiquitinated proteins, and abrogation of inflammatory r

109 1 aggregates contained inactive proteasomes, ubiquitinated proteins, and autophagosomes.

110 e main non-lysosomal degradative pathway for ubiquitinated proteins, and autophagy, a lysosome-mediat

111 ia increased their connectivity, accumulated ubiquitinated proteins, and decreased their respiration.

112 gulation of iron metabolism, accumulation of ubiquitinated proteins, and incorporation of elements of

113 (DUBs) proteolytically cleave ubiquitin from ubiquitinated proteins, and inhibition of DUBs that resc

114 The 26S proteasome degrades ubiquitinated proteins, and proteasomal degradation cont

115 of cullins and noncullin proteins, increased ubiquitinated proteins, and stabilized a surrogate subst

116 ulated reactive oxygen species (ROS) damage, ubiquitinated proteins, and the multi-functional adapter

117 oteins, including amyloid-beta (Abeta), tau, ubiquitinated-proteins, apolipoprotein E, and alpha-synu

118 Enrichment analysis demonstrated that 35% of ubiquitinated proteins are cell-cycle regulated.

119 Ubiquitinated proteins are degraded by the 26 S proteaso

120 Ubiquitinated proteins are degraded by the proteasome, a

121 Many ubiquitinated proteins are degraded by the proteasome, a

122 udies have shown that unfolded and misfolded ubiquitinated proteins are degraded not only by proteaso

123 y neurodegenerative disorders, aggregates of ubiquitinated proteins are detected in neuronal inclusio

124 Therefore, we investigated why K63-ubiquitinated proteins are not degraded by proteasomes.

125 Intrasarcoplasmic amyloidosis and increased ubiquitinated proteins are observed in human failing hea

126 Most poly-ubiquitinated proteins are recognized and degraded by th

127 Ubiquitinated proteins are sorted into distinct pathways

128 otein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and c

129 Most ubiquitinated proteins are then targeted for degradation

130 Large-scale analyses of ubiquitinated proteins are usually performed by combinin

131 Using ubiquitinated proteins as affinity ligands, we found tha

132 activity, which preceded the accumulation of ubiquitinated proteins as detergent/salt-insoluble aggre

133 s, a scaffold protein that co-localizes with ubiquitinated protein at the 30 days post irradiation ti

134 ation and aggregation of alpha-synuclein and ubiquitinated proteins at 20 months of age.

135 ydr049 mutant cells accumulate Cdc48p-bound ubiquitinated proteins at the ER membrane.

136 Degradation of ubiquitinated proteins by 26 S proteasomes requires ATP

137 The degradation of ubiquitinated proteins by 26 S proteasomes requires ATP

138 disorders associated with the aggregation of ubiquitinated proteins by impairing 26 S proteasome acti

139 compared the turnover dynamics of endogenous ubiquitinated proteins by proteasomes and autophagy by a

140 play synergistic roles in the recognition of ubiquitinated proteins by the proteasome, and loss of bo

141 has the capacity to delay the degradation of ubiquitinated proteins by the proteasome.

142 48 (K48) of ubiquitin mediate recognition of ubiquitinated proteins by the proteasome.

143 We report that ataxin-3 interacts with ubiquitinated proteins, can bind the proteasome, and, wh

144 deubiquitination and allows for selection of ubiquitinated proteins capable of being unfolded and eff

145 normal storage of carbohydrates, lipids, and ubiquitinated proteins, combined with marked accumulatio

146 that this lack of proteasomal processing of ubiquitinated proteins constitutes the primary defect in

147 We observed that high molecular weight ubiquitinated proteins constitutively coimmunoprecipitat

148 ion is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates

149 HDAC6 mutants, we show that HDAC6 binding to ubiquitinated proteins controls the duration of HSF1 act

150 revealed that this protein is essential for ubiquitinated protein degradation and for parasite survi

151 tinated proteins in the knock-out cells, but ubiquitinated protein degradation was decreased during s

152 ome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recyc

153 a role for autophagy in clearance of diffuse ubiquitinated proteins delivered by p62/SQSTM1.

154 rison with normal tissues by accumulation of ubiquitinated proteins despite elevated proteasome level

155 Excess p62 inhibits the clearance of ubiquitinated proteins destined for proteasomal degradat

156 ing in accumulation of oxidative lesions and ubiquitinated proteins during heat stress in CWD clams.

157 Usp14 are much more active in degrading non-ubiquitinated proteins (e.g. Sic1) than WT particles.

158 on-gamma: (1) that immunoproteasomes degrade ubiquitinated proteins faster than the constitutive prot

159 tein catabolism could induce accumulation of ubiquitinated proteins followed by significant cell stre

160 nizing the Lys--Gly-Gly (diGly) remnant from ubiquitinated proteins following trypsinolysis have prov

161 an autophagy receptor involved in targeting ubiquitinated proteins for degradation.

162 plex is evolutionarily conserved and targets ubiquitinated proteins for degradation.

163 A protocol to enrich K6-ubiquitinated proteins from cells identifies HUWE1 as a

164 entify 374 diglycine-modified lysines on 236 ubiquitinated proteins from HEK293 cells, including 80 p

165 acilitates the extraction and degradation of ubiquitinated proteins from larger structures.

166 which suggests a role for p97 in extracting ubiquitinated proteins from myofibrils.

167 p97/VCP aids in the extraction of ubiquitinated proteins from the endoplasmic reticulum (E

168 ing protein (VCP) subsequently dislodges the ubiquitinated proteins from the ER and chaperones them t

169 ubstrates, likely by facilitating release of ubiquitinated proteins from the OMM.

170 ged by the heterogeneity and sheer number of ubiquitinated proteins (>5,000).

171 tion of the proteasome's capacity to degrade ubiquitinated proteins has received little attention, al

172 Ubiquitin and ubiquitinated proteins have been shown to activate ExoU,

173 c complex responsible for the degradation of ubiquitinated proteins, have demonstrated remarkable the

174 wn role in mediating the degradation of poly-ubiquitinated proteins, HDAC6 selectively interacted wit

175 in-mediated processes such as degradation of ubiquitinated proteins (i.e. EGFR, Mdm-2, and Siah-1).

176 Accumulation of ubiquitinated protein in spheroids was evident in some b

177 f TUNEL staining and lack of accumulation of ubiquitinated protein in vacuoles of motor and sensory n

178 ation scheme for the isolation of a specific ubiquitinated protein in which affinity moieties are fus

179 tophagy, an accumulation of p62/SQSTM-1, and ubiquitinated proteins in autophagosomes.

180 gradation through suppressing neddylation of ubiquitinated proteins in cardiomyocytes.

181 When degradation of ubiquitinated proteins in cells was inhibited, levels of

182 tetraubiquitin chains in vitro and binds to ubiquitinated proteins in cellular lysates.

183 evalence of receptors such as agglutinin and ubiquitinated proteins in ciliary ectosomes suggests tha

184 tergent-resistant CryAB oligomers, and total ubiquitinated proteins in CryAB(R120G) TG hearts.

185 strate accumulation of P56S VAPB protein and ubiquitinated proteins in cytoplasmic inclusions, select

186 oteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma

187 es ATP-dependent degradation of unfolded and ubiquitinated proteins in eukaryotes.

188 veloped an approach for the visualization of ubiquitinated proteins in living cells designated ubiqui

189 with this view, NAC abolished an increase in ubiquitinated proteins in MG132-treated astrocytes.

190 f mutant desmin overexpression to accumulate ubiquitinated proteins in NRVMs.

191 utophagy inhibition (96 h) failed to elevate ubiquitinated proteins in rat cortical neurons, although

192 G treatment resulted in hyperaccumulation of ubiquitinated proteins in S. pombe cells.

193 formation of p62/SQTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-

194 The accumulation of ubiquitinated proteins in the autophagolysosome provides

195 ere we show that tau increased the levels of ubiquitinated proteins in the brain and triggered activa

196 e been described as transient aggregation of ubiquitinated proteins in the cytosol.

197 n, and the lactacystin-sensitive turnover of ubiquitinated proteins in the intact cells.

198 ditions there was no effect on the levels of ubiquitinated proteins in the knock-out cells, but ubiqu

199 e and protein level approaches to enrich for ubiquitinated proteins in the presence and absence of HR

200 profiling both the entire yeast proteome and ubiquitinated proteins in wild-type and ubiquitin K11R m

201 By determining the differential abundance of ubiquitinated proteins in yeast mutated for NPL4 and UBC

202 e observed the corresponding accumulation of ubiquitinated-proteins in NSCLC cell lines and tissues a

203 Major classes of identified ubiquitinated proteins include ER-resident membrane prot

204 uitinated proteins and LC3-II by p62 directs ubiquitinated proteins, including I-kappaBalpha, to the

205 abnormal ubiquitination and accumulation of ubiquitinated proteins, including TDP-43 and a SCF(Cycli

206 P-43) accumulation is the major component of ubiquitinated protein inclusions found in patients with

207 The well described accumulation of ubiquitinated protein inclusions in neurodegenerative di

208 in 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tiss

209 Ubiquitinated proteins increased dramatically in HEK-v c

210 hibition, the cellular content of K48-linked ubiquitinated proteins increased without any change in p

211 ytes exhibit higher than wild-type levels of ubiquitinated proteins, increased levels of protein oxid

212 es growth retardation and an accumulation of ubiquitinated proteins, indicative of a cellular stress

213 However, the endosomal accumulation of ubiquitinated proteins induced by dysfunctional ESCRT-II

214 t that this early and persistent increase in ubiquitinated proteins induced by IBMPFD mutations in p9

215 other potentially neighboring proteins, and ubiquitinated proteins into centrosomal aggregates.

216 duces neuronal death and the accumulation of ubiquitinated proteins into distinct aggregates.

217 eraction motif-containing protein that sorts ubiquitinated proteins into endosomes.

218 respect to endosomal movement and sorting of ubiquitinated proteins into lysosomes, its function in m

219 proteins might participate in the sorting of ubiquitinated proteins into multivesicular bodies (MVBs)

220 he defect resides apparently in the entry of ubiquitinated proteins into the 20S proteasome.

221 or K63-ubiquitin chains determine whether a ubiquitinated protein is targeted for proteasomal degrad

222 ubiquitin, indicating that incorporation of ubiquitinated proteins is a later event in the disease p

223 ng a clearer understanding of how sorting of ubiquitinated proteins is achieved.

224 re that the proteasome's capacity to degrade ubiquitinated proteins is also tightly regulated.

225 of trafficking machinery components to bind ubiquitinated proteins is known to have a function in ca

226 requency, demonstrating that accumulation of ubiquitinated proteins is not required.

227 Here, using shotgun proteomics, we map the ubiquitinated protein landscape during embryonic stem ce

228 atment with a proteasome inhibitor increases ubiquitinated protein levels and shortens the life span

229 The proteasome inhibitor epoxomicin raised ubiquitinated protein levels at least 3-fold higher than

230 ed production of reactive oxygen species and ubiquitinated protein levels, while the de-ubiquitinatio

231 ride, and 3-methyladenine failed to increase ubiquitinated protein levels.

232 we investigated the proteasome function and ubiquitinated protein levels.

233 ecreased proteasome activities and increased ubiquitinated protein levels.

234 overexpression had no impact on steady-state ubiquitinated protein levels.

235 Furthermore, many ubiquitinated proteins localize to the cytoskeleton and

236 protein inclusions and high-molecular-weight ubiquitinated proteins, markers of UPS dysfunction.

237 HC class I presentation, they do not degrade ubiquitinated proteins more efficiently than constitutiv

238 ions in Drosophila caused an accumulation of ubiquitinated proteins, neurodegeneration, larval-crawli

239 This accumulation of ubiquitinated proteins occurs primarily in the cell nucl

240 berrant membrane structures, accumulation of ubiquitinated proteins on membranes, and axon degenerati

241 If so, one would expect to find ubiquitinated proteins on vacuolar membranes.

242 e we describe UbiCRest, in which substrates (ubiquitinated proteins or polyubiquitin chains) are trea

243 rected to the LDs via SQSTM1, which bound to ubiquitinated proteins, possibly including perilipin 1,

244 Ubiquitin remnant profiling of the multi-ubiquitinated proteins proliferating cell nuclear antige

245 V), mutant profilin1 aggregation, abnormally ubiquitinated proteins, reduced choline acetyltransferas

246 inant protein species in the inclusions, and ubiquitinated proteins represent only a minor component;

247 e, suggesting that the increase in levels of ubiquitinated proteins resulting from avicin G treatment

248 s with CB-5083 leads to accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticul

249 nated substrate protein(s) possibly allowing ubiquitinated protein(s) to be degraded by the proteosom

250 with tau and were less active in hydrolyzing ubiquitinated proteins, small peptides and ATP.

251 control cells and treated with PKA degraded ubiquitinated proteins, small peptides, and ATP more rap

252 Although the identity of the ubiquitinated protein specific to either disorder was un

253 ry, including Ub(G76V)-GFP, a representative ubiquitinated protein substrate that is accumulated in t

254 Through their multiple contacts with ubiquitinated protein substrates involved in these pathw

255 re to activate it and confer specificity for ubiquitinated protein substrates.

256 yeast Ggas is required to direct sorting of ubiquitinated proteins such as general amino acid permea

257 There was no overall increase in ubiquitinated proteins, suggesting the ubiquitin-proteas

258 e that is responsible for the degradation of ubiquitinated protein targets in all eukaryotic cells.

259 l signature of cytoplasmic inclusions of the ubiquitinated protein TDP-43.

260 F1;ssfA1 mutant accumulated higher levels of ubiquitinated proteins than wild-type.

261 or expanded ataxin-3 binds a broad range of ubiquitinated proteins that accumulate when the proteaso

262 anded ataxin-3 both co-precipitate with poly-ubiquitinated proteins that accumulate when the proteaso

263 oquine (CQ) led to a massive accumulation of ubiquitinated proteins that correlated with increased ce

264 one resulted in an accumulation of puncta of ubiquitinated proteins that was further enhanced by the

265 Additionally, ubiquitinated proteins that were detected in proteasomes

266 he Rad23 family of proteins is known to bind ubiquitinated proteins through its two ubiquitin-associa

267 gnificant efforts have been made to identify ubiquitinated proteins through proteomics studies, but t

268 nactive ataxin-3 (normal or expanded) causes ubiquitinated proteins to accumulate in cells, even in t

269 Instead, expression of p97(E578Q) causes ubiquitinated proteins to accumulate on ER membranes and

270 adaptor protein p62, which normally targets ubiquitinated proteins to autophagosomes.

271 potentially allowing for the recruitment of ubiquitinated proteins to Cdc48.

272 Moreover, adding ubiquitinated proteins to cell extracts stimulated prote

273 a new strategy for the chemical synthesis of ubiquitinated proteins to generate a set of well-defined

274 id assay, we analyzed the initial binding of ubiquitinated proteins to purified 26S particles as an i

275 Recruitment of ubiquitinated proteins to the 26S proteasome lies at the

276 al protein and a signaling hub that shuttles ubiquitinated proteins to the lysosome during autophagy.

277 te ubiquitin recognition and the delivery of ubiquitinated proteins to the proteasome by autoinhibiti

278 e the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation

279 a variety of cellular processes by targeting ubiquitinated proteins to the proteasome for degradation

280 The delivery of ubiquitinated proteins to the proteasome for degradation

281 ains, and may participate in the delivery of ubiquitinated proteins to the proteasome through docking

282 face affects the ability of Rad23 to deliver ubiquitinated proteins to the proteasome.

283 ned Hspa1B (heat shock protein 1B hsp70) and ubiquitinated proteins, trapped other cytoskeletal prote

284 tant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-

285 tic inhibition of autophagy fails to elevate ubiquitinated proteins unless the proteasome is affected

286 th their associated components, also contain ubiquitinated proteins, vimentin, heat-shock protein 72,

287 Furthermore, VCP association with ubiquitinated proteins was demonstrated in vector-transf

288 The binding site for these ubiquitinated proteins was mapped to the UBA domain of C

289 In wild-type mice, an elevated level of ubiquitinated proteins was observed during muscle reload

290 in both ventilated groups, and the amount of ubiquitinated proteins was significantly and similarly e

291 actories that were regularly associated with ubiquitinated proteins, we conclude that reovirus factor

292 The increased levels of ubiquitinated protein were accompanied by increased leve

293 However, increased levels of ubiquitinated proteins were found associated with shuttl

294 Furthermore, levels of ubiquitinated proteins were higher in endosomal/lysosoma

295 Furthermore accumulating ubiquitinated proteins were observed primarily in insolu

296 y WT proteasomes is activated if they bind a ubiquitinated protein, which is loosely folded.

297 sulted in the dual accumulation of viral and ubiquitinated proteins, which led to enhanced ER stress,

298 c capability to extract, unfold, and degrade ubiquitinated proteins while releasing bound partners un

299 The digestion of ubiquitinated proteins with trypsin yields a glycine-gly

300 reduced PSMD12 levels and an accumulation of ubiquitinated proteins without any impairment of proteas