ライフサイエンスコーパス: ubiquitination

1 gase that negatively regulates p53 levels by ubiquitination.

2 20 during infection and also mediates TRP120 ubiquitination.

3 of Hsp70-interacting protein (CHIP)-mediated ubiquitination.

4 p53 through inhibiting the MDM2-mediated p53 ubiquitination.

5 MDM2/MDM4 interaction and inducing MDM2 self-ubiquitination.

6 AD3 and vitamin D receptor by altering SMAD3 ubiquitination.

7 f GP78 and PrP(C), thereby increasing PrP(C) ubiquitination.

8 rotein degradation through a reduction of de-ubiquitination.

9 tivation of TNF receptor-associated factor 2 ubiquitination.

10 mitochondrial translocation through inducing ubiquitination.

11 ands is required for Rnf20-mediated H2B mono-ubiquitination.

12 acterized by diffuse protein aggregation and ubiquitination.

13 d FANCG are dispensable for maximal in vitro ubiquitination.

14 0, Tyr-133, or Tyr-250 in PCNA abrogated its ubiquitination.

15 rain cancer treatment that targets PTEN mono-ubiquitination.

16 biquitination but also in Lys63-linked Nur77 ubiquitination.

17 enhances BRD4's stability by inhibiting its ubiquitination.

18 ulates chondrogenesis via modulation of SOX9 ubiquitination.

19 ns, and involves K48- rather than K63-linked ubiquitination.

20 e fetus with IP, leading to defective linear ubiquitination.

21 karyotic replication is orchestrated by PCNA ubiquitination.

22 itination as well as NEMO/IKKgamma substrate ubiquitination.

23 ks TRIM6 to promote EBOV replication through ubiquitination.

24 These results indicate that ubiquitination, a modification well known to target memb

25 Lys-63-ubiquitination activates the TGFbeta-activated kinase (T

26 carrying the p.V742G variant showed reduced ubiquitination activity in vitro and white blood cells f

27 In vitro and in vivo ubiquitination analyses indicated that CRL4B(DCAF11) E3

28 findings revealed a novel mechanism on EZH2 ubiquitination and an important signaling network of SKP

29 d depupylation have evolved independently of ubiquitination and are related to the family of ATP-bind

30 e presence of LATS, ERalpha was targeted for ubiquitination and Ddb1-cullin4-associated-factor 1 (DCA

31 ome human cancers, specifically triggers the ubiquitination and degradation of AMPK-alpha2.

32 In addition, p53 promoted ubiquitination and degradation of HIF-1alpha in partial

33 CRBN)) ubiquitin ligase that enable binding, ubiquitination and degradation of key therapeutic target

34 at serine 104 is required for the efficient ubiquitination and degradation of NRF2.

35 attributed to NA's ability to facilitate the ubiquitination and degradation of Snail1, a transcriptio

36 tin ligase regulates the CIA pathway through ubiquitination and degradation of the CIA-targeting prot

37 Here, we report that TcpB induces ubiquitination and degradation of the inflammatory caspa

38 either NLRP11 or RNF19A abrogates K48-linked ubiquitination and degradation of TRAF6, which promotes

39 This remodeling effect is mediated by the ubiquitination and degradation of XIAP (X-linked inhibit

40 we demonstrate that lenalidomide induces the ubiquitination and degradation of ZFP91.

41 ll transcription factor, PU.1, undergoes K63 ubiquitination and degradation through p62-dependent sel

42 interaction is transient, triggers receptor ubiquitination and degradation without signalling activa

43 ts the E3 ligase Itch to MAVS to trigger its ubiquitination and degradation, and loss of TAX1BP1 or I

44 y, UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes act

45 bitor coincidently abrogates endogenous KLF4 ubiquitination and degradation, as well as FBXO32-depend

46 esenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by whi

47 s (228-355 aa) and directly targets KLF4 for ubiquitination and degradation.

48 to IL-21 signalling as Grail promotes IL-21R ubiquitination and degradation.

49 ion factors Ikaros and Aiolos to cause their ubiquitination and degradation.

50 aam2 associates with VHL and facilitates its ubiquitination and degradation.

51 ncated C terminus that escapes FBW7-mediated ubiquitination and degradation.

52 t of eukaryotic biology by promoting protein ubiquitination and degradation.

53 domain is critical for FBXO32-dependent KLF4 ubiquitination and degradation.

54 ), which associates with RAGE to mediate its ubiquitination and degradation.

55 ation end products is targeted by FBXO10 for ubiquitination and degradation.

56 via its RING domain to promote MYOD protein ubiquitination and degradation.

57 he latter was functionally involved in NICD1 ubiquitination and degradation.

58 new E3 ligase, which is responsible for KLF4 ubiquitination and degradation.

59 , as well as FBXO32-dependent exogenous KLF4 ubiquitination and degradation.

60 n patients with azoospermia that prevent its ubiquitination and degradation.

61 pts binding to CDH1 and protects RNF157 from ubiquitination and degradation.

62 e complex and facilitating Nox2 (gp91(phox)) ubiquitination and degradation.

63 binds to HMGCR and triggers its accelerated ubiquitination and degradation.

64 at Thr28 within its PBM, which leads to its ubiquitination and degradation.

65 nd targeted TBK1 (TANK binding kinase 1) for ubiquitination and degradation.

66 racts with CHS and specifically mediates its ubiquitination and degradation.

67 er demonstrated that Klhl31 targets FlnC for ubiquitination and degradation.

68 The ubiquitination and deubiquitination status of PRP31 regu

69 ion suppressor, and FMRP is required for its ubiquitination and down-regulation upon Gp1 mGluR activa

70 r hinder conformational changes required for ubiquitination and endocytosis of Fpn.

71 icrodomains and protects the channel against ubiquitination and endocytosis.

72 ity to oxidative stress and elevated protein ubiquitination and exhibited disease-associated changes

73 3 ligase complex responsible for histone H2A ubiquitination and gene silencing.

74 n implicated in cancer, inflammation, linear ubiquitination and integrin activity inhibition; however

75 l and Cbl-b and is required for Cbl-mediated ubiquitination and internalization of PDGFRalpha for fee

76 host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination and is important for efficient virus repl

77 e TNF-RSC is modulated by different types of ubiquitination and may lead to cell death, including apo

78 SUMOylation reactions, and increased MTHFD1 ubiquitination and MTHFD1 and SHMT1 degradation.

79 pendent on the duration of AM stimulation or ubiquitination and occurred via a mechanism that was par

80 Together, they act downstream of K63-linked ubiquitination and p62 recruitment, and selectively remo

81 ion of the dynamic cross-modulation of GluA1 ubiquitination and phosphorylation, a process that is pe

82 re, we revealed the cross-talk between GluA1 ubiquitination and phosphorylation, in particular phosph

83 hrocyte ADORA2B induces PKA phosphorylation, ubiquitination and proteasomal degradation of eENT1.

84 ligase to a target protein, PROTACs promote ubiquitination and proteasomal degradation of the target

85 in F) E3 ligase, where cyclin F mediates the ubiquitination and proteasomal degradation of Vif throug

86 GK1 can directly bind to SOX9 to inhibit its ubiquitination and proteasomal degradation.

87 ents-including Tsc2-thereby preventing their ubiquitination and proteasomal degradation.

88 aB2, and proteins involved in NFkappaB2 p100 ubiquitination and proteasomal processing to p52, as upr

89 gene exhibited increased Mcl-1 and inclusion ubiquitination and reduced Mcl-1 stabilization.

90 ritical for OGT-mediated regulation of FOXM1 ubiquitination and reducing SIRT1 activity reverses OGT-

91 SUG1-mediated signaling results in enhanced ubiquitination and regulates FADD-dependent caspase-8 ac

92 nal mutations in different genes involved in ubiquitination and related to immune system function wer

93 rate that key RQC activities-Ltn1p-dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alani

94 fense through cascades controlled by protein ubiquitination and Ser/Thr phosphorylation.

95 of the PI3K and MAPK pathways influences the ubiquitination and stability of RNF157 during the cell c

96 ise, DHA treated to JB6 cells inhibited Nrf2 ubiquitination and stabilized it.

97 E3 ligase to a target protein to facilitate ubiquitination and subsequent degradation of that protei

98 f1, Smurf1 T306D, prevents PIPKIgammai2 from ubiquitination and subsequent degradation similar to the

99 ligase complex, targeting PIF4 proteins for ubiquitination and subsequent degradation.

100 sterol synthesis by mediating sterol-induced ubiquitination and subsequent endoplasmic reticulum-asso

101 unit of hypoxia inducible factors (HIFs) for ubiquitination and subsequent proteasomal degradation.

102 t to post-translational modification through ubiquitination and targeting for proteosomal degradation

103 -terminal lysines with arginine disrupts APP ubiquitination and that an increase in the number of sub

104 a reaction that requires the protein's prior ubiquitination and the presence of the Insig-2 protein.

105 duces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization an

106 s a multistep biochemical pathway to control ubiquitination and tubular ER function independently of

107 a hyperactive state, thereby leading to auto-ubiquitination and ultimately degradation of the substra

108 from HSP90, and causes the internalization, ubiquitination, and degradation of HER2.

109 acetylation, phosphorylation, glycosylation, ubiquitination, and many more have been linked to the re

110 unctional interplay between host E3 ligases, ubiquitination, and regulation of EBOV VP40-mediated egr

111 at ZBP1 activation requires RIG-I signaling, ubiquitination, and vRNP sensing to trigger activation o

112 Moreover, Tomo-1 ubiquitination appeared to be mediated through an intera

113 n, actin filament-based process, and protein ubiquitination are associated with meat tenderness where

114 ified thus far in association with defective ubiquitination are discussed in more detail.

115 enzymes (DUBs), which reverse the process of ubiquitination, are important regulators of the ubiquiti

116 stimulation, thereby facilitating TRAF6 auto-ubiquitination as well as NEMO/IKKgamma substrate ubiqui

117 ighlights the importance of linkage-specific ubiquitination at DNA damage sites, and it reveals that

118 Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53

119 RORgammat(M) showed less ubiquitination at Lys69 that was selectively required fo

120 02, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of

121 results not only in the inhibition of TRAF2 ubiquitination but also in Lys63-linked Nur77 ubiquitina

122 c autophagy, a process that depended on poly-ubiquitination, but not the E3 ubiquitin ligase Siah1.

123 to EGFR and blocks its interaction with and ubiquitination by c-CBL, stabilizing it and augmenting a

124 ein p53 is kept at low levels in part due to ubiquitination by MDM2, a process initiated by binding o

125 RING ligases (MRLs) and act as regulators of ubiquitination by modulating ligase activity, substrate

126 tate tumorigenesis as a context in which p27 ubiquitination by SCF(Skp2/Cks1) is required for p27 dow

127 in, leading to a decrease in alpha-synuclein ubiquitination by SIAH and Nedd4 ubiquitin ligases, and

128 eukaryotic cells, including as a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbL

129 band-bound thin filaments are degraded after ubiquitination by the ubiquitin ligase tripartite motif-

130 uccessive fashion to the substrate, and that ubiquitination by WWP1 requires the presence of a low-af

131 Functionally, we show that NEDD4-mediated H3 ubiquitination, by transcriptionally activating IL1alpha

132 Thus, ribosome ubiquitination can modulate translation elongation and i

133 onally, an analysis of quantitative study of ubiquitination changes in response to proteasome inhibit

134 cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional r

135 Ubiquitination controls a plethora of cellular processes

136 Ubiquitination controls the stability of most cellular p

137 aling by the transcription factor NF-kappaB, ubiquitination, cytokine signaling, protein folding, typ

138 ss of RRM domain ubiquitination - RRM domain ubiquitination decreases in response to proteasome inhib

139 of a dephosphomimetic of Mdm2 rescues PSD-95 ubiquitination, degradation and synapse elimination in F

140 through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells

141 Collectively, our study reveals a GbetaL-ubiquitination-dependent switch that fine-tunes the dyna

142 ediated internalization of group I mGluRs is ubiquitination-dependent.

143 m canonical translation, that Ltn1p-mediated ubiquitination depends on the poorly characterized RQC c

144 cidin binding or impaired hepcidin-dependent ubiquitination despite intact hepcidin binding.

145 Ubiquitination-directed proteasomal degradation of synap

146 Thus ubiquitination directs a variety of substrate fates incl

147 e activity of the cullin-RING-ligase type of ubiquitination E3s by promoting neddylation of cullin fa

148 Engineered CHIP enhanced KCNQ1 ubiquitination, eliminated KCNQ1 surface-density, and ab

149 Together, cellular ubiquitination events form a sophisticated and versatile

150 ecipitation experiments suggested that these ubiquitination events may be mediated by DDT-dependent E

151 iew specific ubiquitin-modifying enzymes and ubiquitination events that orchestrate inflammatory resp

152 adipose tissue through modulation of Lys(63) ubiquitination events.

153 depletion of CBL/CBL-B or LNK abrogated JAK2 ubiquitination, extended JAK2 half-life, and enhanced JA

154 Histone H2B lysine 120 mono-ubiquitination (H2Bub1) catalyzed by Rnf20 has been impl

155 , however, many non-proteolytic functions of ubiquitination have emerged as key regulators of cellula

156 stability as substrate-specific adaptors for ubiquitination, have been implicated in sarcomere format

157 Ubiquitination hinders Dvl binding to phosphatidic acid,

158 has demonstrated a central role for receptor ubiquitination in endocytic sorting.

159 gy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation.

160 These results suggest a role for ubiquitination in senescence and imply a common node dow

161 These studies reveal a novel function of ubiquitination in the regulation of group I mGluRs, as w

162 Understanding the molecular mechanism of ubiquitination in these events is the basis for unraveli

163 2 in a BR-dependent manner and promoted BIN2 ubiquitination in vitro.

164 ort that ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19

165 TAK1-null BMMs compared to elevated K48-poly-ubiquitination in WT cells, indicating increased stabili

166 reported disease mechanism (defective linear ubiquitination) in patients with IP.

167 Moreover, promoting mono-ubiquitination increases protein stability and nuclear l

168 Our results reveal that FANCD2 has a ubiquitination-independent role in countering endogenous

169 gulation of PRC1 components CBX4 and CBX6 by ubiquitination influences reprogramming.

170 Btbd7 can enhance E-cadherin ubiquitination, internalization, and degradation in MDCK

171 the ABA-signaling pathway are controlled by ubiquitination involving really interesting new genes (R

172 Linear ubiquitination is a key posttranslational modification t

173 Ubiquitination is a posttranslational modification that

174 Ubiquitination is a widespread post-translational modifi

175 Targeted protein degradation through ubiquitination is an important step in the regulation of

176 Commitment to ubiquitination is dictated primarily by comparatively sl

177 Here, we report that ubiquitination is essential for the assembly of a mitoph

178 wever, the biochemical mechanism by which E3 ubiquitination is impaired by IKK-driven phosphorylation

179 d array of cellular processes, and defective ubiquitination is implicated in several neurological dis

180 Protein ubiquitination is mediated sequentially by ubiquitin act

181 Protein ubiquitination is one of the most powerful posttranslati

182 We show here that LUBAC-mediated linear ubiquitination is required for LMP1 activation of NF-kap

183 Modulation of TRAF2 activity by ubiquitination is well studied; however, the deubiquitin

184 g short hairpin RNAs (shRNAs) attenuated the ubiquitination level of p21(Cip1), inhibited osteosarcom

185 USP36 reduces the ubiquitination levels and increases the stability of the

186 vely regulates Stat1 and Stat2 isgylation, a ubiquitination-like protein modification.

187 does not require an E2 enzyme for substrate ubiquitination, lysine selection, and polyubiquitin chai

188 y combining pex26 with peroxisome-associated ubiquitination machinery mutants, suggesting that ubiqui

189 directly modifying histones or hijacking the ubiquitination machinery to take control of several host

190 component of hypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing t

191 The ubiquitination mediated by ubiquitin activating enzyme (

192 f La promotes cell proliferation by averting ubiquitination-mediated degradation of the STAT3 protein

193 proteins, including BRD2, BRD3 and BRD4, for ubiquitination-mediated degradation.

194 x to enhance HBx stability by preventing its ubiquitination-mediated degradation.

195 Increased RAD6 levels cause histone 2B ubiquitination-mediated epigenetic changes that stimulat

196 oss-of-function mutations in SPOP compromise ubiquitination-mediated PD-L1 degradation, leading to in

197 ication of proteins by ubiquitin (Ub), i.e., ubiquitination, mediates a variety of cellular processes

198 tionally modified by ubiquitin (Ub) and that ubiquitination occurs through intrinsic and host-mediate

199 Ubiquitination of a subset of proteins by ubiquitin chai

200 increased mitochondrial fission by increased ubiquitination of AKAP121 (A-kinase anchor protein 121)

201 t reduced binding with Nedd4-1 and hence the ubiquitination of AMPARs.

202 een the MCC and APC/C, are defective in poly-ubiquitination of Cdc20, and are checkpoint defective.

203 ulation of nutrient storage can occur by the ubiquitination of certain transporters that are then sor

204 AM-induced activation of CLR*RAMP2 promoted ubiquitination of CLR.

205 al modifications affecting APP accumulation, ubiquitination of cytodomain lysines may represent a key

206 tes DCC multimerization, but TRIM9-dependent ubiquitination of DCC is reduced, which promotes an inte

207 uscles, phosphorylation and Trim32-dependent ubiquitination of desmin filaments increased rapidly and

208 on of TRAF6-mediated and lysine(K) 63-linked ubiquitination of EZH2 for degradation.

209 expression of TRAF6 promoted the K63-linked ubiquitination of EZH2 to decrease EZH2 and H3K27me3 lev

210 Ubiquitination of GABARAP occurs in the N terminus, a do

211 trate-binding region and promotes K48-linked ubiquitination of GABARAP.

212 of lineage-specific genes via RYBP-dependent ubiquitination of H2AK119.

213 findings indicate an important role for the ubiquitination of H4K91 in genomic stability during embr

214 Lys63-linked ubiquitination of HIF1alpha by XIAP is dependent on the

215 TRAF6 ubiquitination of hnRNPA1 regulated alternative splicing

216 ssays through aberrant transcription and H2B ubiquitination of Hoxa9 and Meis1 Mechanistically, H3 an

217 eanwhile, CaMKII can also promote K63-linked ubiquitination of inhibitor of differentiation 1/2 (Id-1

218 During antibacterial autophagy, ubiquitination of intracellular bacteria recruits protei

219 pathway may be implicated in FBXO32-mediated ubiquitination of KLF4, as p38 kinase inhibitor coincide

220 This mechanism requires ubiquitination of Kv1.3, catalyzed by the E3 ubiquitin-l

221 and Drp1 depletion on degradation rates and ubiquitination of Mcl1 and MiD49 were eliminated in Drp1

222 Our analyses suggest that Mot2 directs ubiquitination of Mei2 to preserve the activity of Mmi1

223 Ubiquitination of MET was also decreased in CBL mutant c

224 he core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane protein

225 Post-translationally, K48-linked poly-ubiquitination of NUMBL is diminished in TAK1-null BMMs

226 cotreatments synergistically triggered mono-ubiquitination of PCNA and apoptosis in a RAD18-dependen

227 iquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasom

228 also show that SDHD-G12S/H50R promotes mono-ubiquitination of PTEN, causing its translocation into t

229 e-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin

230 lobal ribosome collision in vivo resulted in ubiquitination of ribosomal proteins, suggesting that co

231 Here we show that ZNRF4 induces K48-linked ubiquitination of RIP2 and promotes RIP2 degradation.

232 Spata2 deficiency promotes M1 ubiquitination of RIPK1 to inhibit RIPK1 kinase activity

233 Mechanistically, TRIM29 induces K48-linked ubiquitination of Stimulator of interferon genes, a key

234 This suggests that ubiquitination of Stx3 leads to removal from the basolat

235 Here we report that ubiquitination of the 40S ribosomal protein uS10 by the

236 revealed that unconventional K27-linked auto-ubiquitination of the ARF domain is essential for the GT

237 at the process of CAT tailing enables robust ubiquitination of the nascent polypeptide.

238 Toxoplasma vacuoles, leading to Lys63-linked ubiquitination of the vacuole and restriction of parasit

239 Ubiquitination of this site plays a role in AR stability

240 with S Typhimurium specifically induces the ubiquitination of tumor necrosis factor receptor-associa

241 with Twist and promoted the non-degradative ubiquitination of Twist.

242 This effect is mediated by the ubiquitination of XIAP (X-linked inhibitor of aptosis pr

243 IAV infection induces ubiquitination of ZBP1, suggesting potential regulation

244 have been observed to trigger site-specific ubiquitination on several ribosomal proteins.

245 ation reactions identified two sites of mono-ubiquitination on the 40S protein eS10 as the primary ri

246 tituted protein exhibited diminished in vivo ubiquitination, overexpression of GDU1 lysine mutants st

247 Here, we identify a PML ubiquitination pathway that is mediated by WD repeat 4-c

248 proteins associated with the BMI1 dependent ubiquitination pathway.

249 on-mimics promote TDP-43 phosphorylation and ubiquitination, perturb mitochondria, and initiate degen

250 Protein ubiquitination plays a role in essentially every process

251 evidence indicate that LUBAC-mediated linear ubiquitination plays crucial roles in regulating LMP1 si

252 years, our knowledge of the varied role that ubiquitination plays in promoting signal amplification,

253 Ubiquitination powerfully regulates multiple steps in th

254 ow that SIAH2 binds to Plk3 and mediates its ubiquitination primarily through its polo-box domain.

255 Ubiquitination-promoted turnover of Aurora B at the midb

256 CHD1 degradation via the beta-TrCP-mediated ubiquitination-proteasome pathway.

257 Analogous to eukaryotic ubiquitination, proteins in actinobacteria can be post-t

258 s, coupled with the complexity of the native ubiquitination reaction that requires ATP and E1 and E2

259 Biochemical ubiquitination reactions identified two sites of mono-ub

260 conclude that both isopeptide and ester bond ubiquitination regulate proteasomal degradation of hD4R.

261 Ubiquitination regulates a broad array of cellular proce

262 of rs9517723 could induce overactivation of ubiquitination-related pathway, resulting in the develop

263 ure indicated that (1) mutations that caused ubiquitination-resistance were positioned at helix-helix

264 Cells lacking ZNF598 activity or containing ubiquitination-resistant eS10 ribosomes failed to stall

265 netic variation enabling chemical control of ubiquitination revealed KCNQ1 surface-density declined w

266 tion highlights the uniqueness of RRM domain ubiquitination - RRM domain ubiquitination decreases in

267 Here, we report a novel N-terminal ubiquitination site at lysine 311.

268 y lysine 477 (K477) of HIF-1alpha as a major ubiquitination site for Parkin.

269 ation (IAP) and subsequent identification of ubiquitination sites by mass spectrometry.

270 TRP120 ubiquitination sites were mapped using a high-density mi

271 of liver homeostasis and the role of linear ubiquitination specifically in liver parenchymal cells,

272 nteracted with Topo IIalpha and modified its ubiquitination status to protect Topo IIalpha from the p

273 effectors of ERK5 and also by modulating its ubiquitination status.

274 We developed a novel ubiquitination system, Rapamycin-Induced Degradation (Ra

275 ibosylation of ubiquitin in the absence of a ubiquitination target.

276 n transfer (OUT) technology to profile their ubiquitination targets in mammalian cells.

277 cysteines are (on average) closer to lysine ubiquitinations than are unmodified cysteines, indicatin

278 Ubiquitination, the crucial posttranslational modificati

279 1 greatly reduced cMyc-FBW7 binding and cMyc ubiquitination, thus providing novel insight into how EY

280 Additionally, we identified protein ubiquitination to be associated among East-Asian beta-ce

281 ion of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes n

282 hifts the balance of EGFR modifications from ubiquitination to neddylation, inhibiting EGFR dynamics

283 ncoprotein that negatively regulates PML via ubiquitination to promote lung cancer progression by fos

284 rk reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chai

285 Lastly, we assessed NEMO linear ubiquitination using immunoblotting and investigated the

286 Ubiquitination was increased in the absence of the Bre5-

287 ance to exogenous amino acids, and LOG2 self-ubiquitination was markedly stimulated by the GDU1 cytos

288 Conversely, when protein ubiquitination was prevented, or when purified proteasom

289 To better understand the mechanism of KLF4 ubiquitination, we performed a genome-wide screen of E3

290 Silencing MKP-1 promoted PARP-1 ubiquitination, which decreased PARP-1 protein levels.

291 Ubiquitination, which is essential to almost all biologi

292 cer that is regulated by phosphorylation and ubiquitination, which ultimately change the cell surface

293 erminal kinase 1/2 (JNK1/2) decreased PARP-1 ubiquitination while increasing total PARP-1 protein lev

294 , TRAF6 knockdown resulted in a reduced EZH2 ubiquitination with an increase of EZH2 and H3K27me3 lev

295 Artificial APP ubiquitination with rapalog-mediated proximity inducers

296 Inhibition of ubiquitination with small molecules also significantly d

297 NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal s

298 ibe the various non-traditional functions of ubiquitination, with particular focus on how they can be

299 Specifically, TRAF6 mediates lysine-63 ubiquitination within the Src homology 2 (SH2) domain of

300 at negatively regulate the Hippo pathway via ubiquitination, yet few deubiquitinating enzymes (DUB) h