ライフサイエンスコーパス: ubiquitylation

1 ne or in combination with SCF(Skp2)-mediated ubiquitylation.

2 e that recruits T58-phosphorylated c-MYC for ubiquitylation.

3 radigm for understanding ribosome-associated ubiquitylation.

4 e, interacts with TOP2alpha and mediates its ubiquitylation.

5 cells responsible for regulation of NEIL1 by ubiquitylation.

6 post-translationally by phosphorylation and ubiquitylation.

7 part via its NTD, to target stalled NSPs for ubiquitylation.

8 be acetylated by TIP60 in vivo, blocking its ubiquitylation.

9 trates to regulate the functional outcome of ubiquitylation.

10 ions of effector fate-determining factors is ubiquitylation.

11 multaneous and joint regulation of substrate ubiquitylation.

12 show that CSB is regulated via site-specific ubiquitylation.

13 ID2-VHL interaction and preserves HIF2alpha ubiquitylation.

14 -translational modifications such as protein ubiquitylation.

15 hich is functionally analogous to eukaryotic ubiquitylation.

16 lular IAP1 and IAP2) regulate RIPK3 and MLKL ubiquitylation.

17 one of the degradation elements impairs this ubiquitylation.

18 nositide (PI) lipids is also a major site of ubiquitylation.

19 orms a CRL3(IBTK) complex promoting its self-ubiquitylation.

20 acts with APC/C, and it facilitates CYCLIN A ubiquitylation.

21 that the UBA domain enhances cIAP1 and cIAP2 ubiquitylation.

22 hereas RACK1 regulates RPS2, RPS3, and RPS20 ubiquitylation.

23 domains in both Slx5 and Slx8 for substrate ubiquitylation.

24 nd SLX4 to the ICL depends on FANCD2 and its ubiquitylation.

25 Upon synthesis, Csr2 becomes activated by ubiquitylation.

26 ly been assumed to be determined by rates of ubiquitylation.

27 vity towards the substrate and also the self-ubiquitylation.

28 half-life of PIM1, and markedly reduced its ubiquitylation.

29 and occurred independently of PRC1-catalyzed ubiquitylation.

30 or, cooperates with UBR5 in mediating MOAP-1 ubiquitylation.

31 lation of the Ub carboxyl terminus precludes ubiquitylation.

32 sites fails to recruit PRP19 and support RPA ubiquitylation.

33 bination factors dependent on HEI10-mediated ubiquitylation.

34 ious cellular proteins and render eukaryotic ubiquitylation a dynamic process.

35 teins in inclusions, the TRIM21-mediated p62 ubiquitylation abrogates p62 oligomerization and sequest

36 g and a significant increase in the in vitro ubiquitylation activity of UBE3B.

37 role in regulation of SAGA's histone H2B de-ubiquitylation activity.

38 o acids 758-1068) results in loss of UBE3B's ubiquitylation activity.

39 pond to S phase-specific CUL4(Ddb1)-mediated ubiquitylation alone or in combination with SCF(Skp2)-me

40 Finally, we provide evidence that H2A ubiquitylation also contributes to resistance to transcr

41 Inactivation of TLE by UBR5-dependent ubiquitylation also involves VCP/p97, an AAA ATPase regu

42 Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role of this res

43 d by dimerization, leading to both substrate ubiquitylation and autoubiquitylation, responsible for d

44 We show that Mcm7 ubiquitylation and CRL2(Lrr1) binding to chromatin are t

45 interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013).

46 sly, we reported that MOAP-1 is targeted for ubiquitylation and degradation by the APC/C(Cdh1) ubiqui

47 Thr182 phosphorylation not only controls BLM ubiquitylation and degradation during mitosis but is als

48 (CRBN) E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high gluta

49 erved CTE asparagine residue is required for ubiquitylation and degradation of a subset of Doa10 subs

50 Overexpression of beta-TrCP induced the ubiquitylation and degradation of DMRT1.

51 ognizes an acetyl degron of GS, resulting in ubiquitylation and degradation of GS in response to glut

52 phosphorylation process and also stimulates ubiquitylation and degradation of kinases in regular pro

53 d quality control (RQC) complex promotes the ubiquitylation and degradation of NCs remaining stalled

54 es substrate recognition for c-IAP1 mediated ubiquitylation and degradation of NIK.

55 e NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 d

56 main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-

57 c1), along with Def1, is known to facilitate ubiquitylation and degradation of RNA polymerase II (pol

58 CUL9 promotes the ubiquitylation and degradation of survivin and is inhibi

59 Ubiquitylation and degradation of the antioxidant transc

60 However, light still stimulates ubiquitylation and degradation of this mutant, implying

61 ll survival decisions by controlling protein ubiquitylation and degradation.

62 gh defined sequence motifs that promote CDC6 ubiquitylation and degradation.

63 L-associated Cullin 2, and impairs HIF2alpha ubiquitylation and degradation.

64 binding to Kelch-like 3, targeting WNK4 for ubiquitylation and degradation.

65 e in proximity of HIF1alpha and increase its ubiquitylation and degradation.

66 ed acetylation of Dnmt1 and subsequent Dnmt1 ubiquitylation and degradation.

67 11 as an important E3 that targets SNAIL for ubiquitylation and degradation.

68 te that stimulates Fbw7 binding and cyclin E ubiquitylation and degradation.

69 ing TRC35 from succumbing to RNF126-mediated ubiquitylation and degradation.

70 (CRL4(VprBP)), which we show regulate FoxM1 ubiquitylation and degradation.

71 nding region, acting as a trigger for cavin1 ubiquitylation and down-regulation.

72 conserved KEN box, mutation of which impedes ubiquitylation and downregulation of CtIP both during G1

73 by signaling pathways and warrant that cargo ubiquitylation and endocytosis appropriately respond to

74 between the RNF168/USP10 axis and TOP2alpha ubiquitylation and function, and suggest a role for RNF1

75 ulated genes independently of histone H2B de-ubiquitylation and further controls transcriptional elon

76 l half of the +1 nucleosome, whereas H2BK123 ubiquitylation and H3K9 acetylation are enriched on the

77 tin ligase activity also fail to support RPA ubiquitylation and HR.

78 and Spt16 is critical for both CENP-A(Cse4) ubiquitylation and its exclusion from euchromatin.

79 guanylate binding proteins, protein kinases, ubiquitylation and necroptosis related pathways that mod

80 nase inhibitor, WEHI-345, which delays RIPK2 ubiquitylation and NF-kappaB activation downstream of NO

81 r protein BRCA1, which acts upstream of MCM7 ubiquitylation and p97 recruitment.

82 uence of P62 accumulation, which impairs H2A ubiquitylation and perturbs ATM signaling.

83 ake up the kinetochore are regulated through ubiquitylation and phosphorylation.

84 s Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol eta recruitment to stalled replic

85 th the notion that the 148M variant disrupts ubiquitylation and proteasomal degradation of PNPLA3, re

86 a SPOP substrate that exhibited decreases in ubiquitylation and proteasomal degradation resulting fro

87 elongation, which is maintained by San1 via ubiquitylation and proteasomal degradation.

88 d ribosomal protein S6 (RpS6) to promote its ubiquitylation and proteasomal degradation.

89 SKP2 activates ERalpha ubiquitylation and proteolysis.

90 uitylase that negatively regulates TOP2alpha ubiquitylation and restrains its chromatin association.

91 While beta-TrCP1 promotes FBXW2 ubiquitylation and shortens its half-life, FBXW2 does th

92 This markedly inhibits p53 ubiquitylation and significantly stabilizes and activate

93 ovide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis

94 The light-induced ubiquitylation and subsequent degradation of PIF1 is red

95 ependent phosphorylation is required for the ubiquitylation and subsequent degradation of Vac17 and t

96 an important phosphorylation site for Atoh1 ubiquitylation and subsequent degradation.

97 plasma membrane, notably by regulating their ubiquitylation and subsequent endocytosis.

98 ing as an E3-ubiquitin ligase, IDOL promotes ubiquitylation and subsequent lysosomal degradation of t

99 PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.

100 ut the functional connection between protein ubiquitylation and this UBD remains unclear.

101 odulating AQP2 trafficking, phosphorylation, ubiquitylation, and degradation.

102 hat facilitate UHRF1 chromatin targeting, H3 ubiquitylation, and DNA methylation inheritance.

103 protein retrotranslocation into the cytosol, ubiquitylation, and proteasomal degradation.

104 The function of Cdc48 in controlling H2B ubiquitylation appears conserved in human cells because

105 Among others, phosphorylation and ubiquitylation are known to regulate proximal T-cell rec

106 The kinetics of protein ubiquitylation are paramount as a balance must be achiev

107 hese results reveal regulatory 40S ribosomal ubiquitylation as an important facet of eukaryotic trans

108 plays a central role in shaping H2AK119 mono-ubiquitylation at PcG targets and underpins an activity-

109 eview, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plast

110 FR target genes, from EGFR pathway-dependent ubiquitylation by a Cullin 1/SKP1-related A/Archipelago

111 is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the prot

112 ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cu

113 Thus, Groucho/TLE ubiquitylation by Hyd/UBR5 is a key prerequisite that en

114 maged organelles are marked for disposal via ubiquitylation by Parkin.

115 how that PALB2 indirectly recognizes histone ubiquitylation by physically associating with ubiquitin-

116 yclin B1 takes place in the proteasome after ubiquitylation by the anaphase-promoting complex/cycloso

117 ind to DDB1 and that Gbeta2 targets GRK2 for ubiquitylation by the DDB1-CUL4A-ROC1 ubiquitin ligase.

118 including phosphorylation-dependent cyclin E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

119 as a functionally relevant substrate, whose ubiquitylation by UBR5 is induced by Wnt signaling and c

120 e methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover,

121 Regulation of ubiquitylation can occur at each stage of the stepwise U

122 early-acting regulators of the three-enzyme ubiquitylation cascade are unknown.

123 modification system, mediating a sequential ubiquitylation cascade reminiscent of the eukaryotic pro

124 DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway

125 tin ligases provide substrate selectivity in ubiquitylation cascades and are therefore considered to

126 RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation an

127 ate through the localization of the ART/Rsp5 ubiquitylation complex at the TGN.

128 Ubiquitylation controls protein function and degradation

129 in mpkCCD14 cells resulted in increased AQP2 ubiquitylation, decreased AQP2 protein half-life, and re

130 ajor roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrat

131 in clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR by IDOL

132 and rodent cells as the underlying cause for ubiquitylation-dependent lysosomal degradation of the LD

133 interaction is lost and beta-catenin escapes ubiquitylation-dependent proteasomal degradation.

134 capping factors, enzymes involved in protein ubiquitylation/deubiquitylation and cellular detoxificat

135 Ubiquitylation drives formation of a TCOF1-NOLC1 platfor

136 are ensured through the timely activation of ubiquitylation enzymes.

137 e cell division depends on tightly regulated ubiquitylation events catalyzed by the anaphase-promotin

138 , cell-cycle timing depends on a sequence of ubiquitylation events mediated by the anaphase-promoting

139 CUL3 co-adaptors as important regulators of ubiquitylation events that control human development.

140 yriad of interconnecting phosphorylation and ubiquitylation events.

141 nct and overlapping regulatory 40S ribosomal ubiquitylation events.

142 Tethered Set1 still requires histone H2B ubiquitylation for activity.

143 study we reveal the importance of K63-linked ubiquitylation for the assembly of decapping factors, P-

144 The initial ubiquitylation greatly enhances the substrate's binding

145 romatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation

146 pects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases

147 Although ubiquitylation has been suggested to signal cotranslatio

148 Many targets and functions of ubiquitylation have been described; by contrast, few tar

149 thylation, phosphorylation, SUMOylation, and ubiquitylation, have emerged as important contributors i

150 Current chemical strategies for protein ubiquitylation, however, employ temporary ligation auxil

151 vealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these a

152 We show that MLN7243 rapidly inhibits ubiquitylation in a variety of cell lines and can profou

153 mechanism and results in unrestrained FGFR1 ubiquitylation in cells.

154 ly manner, suggesting a requirement for K991 ubiquitylation in CSB activation.

155 ng, we identify the sites of KEAP1-dependent ubiquitylation in MCM3, and these sites are on predicted

156 indings demonstrate that the requirement for ubiquitylation in MHC class I-restricted Ag processing v

157 Here, we report the reconstitution of NSP ubiquitylation in Neurospora crassa cell extracts.

158 gram of PARKIN recruitment and mitochondrial ubiquitylation in response to mitochondrial damage.

159 er that RNF168 links the HR machinery to H2A ubiquitylation in S/G2 cells.

160 RNF11 and SMURF2 dramatically reduced SMURF2 ubiquitylation in the cell.

161 mediated degradation of HY5 through enhanced ubiquitylation in the darkness.

162 ogical significance of Itch-promoted protein ubiquitylation in the immune and other systems and in It

163 a large group of proteins showing increased ubiquitylation in the proteasome mutant at low temperatu

164 lity of p.G195D is associated with increased ubiquitylation in the vicinity of the mutation site.

165 ieved, it remains unclear how RNF168-induced ubiquitylation influences HR.

166 We find that the APC-mediated ubiquitylation involves a highly processive initial reac

167 Ubiquitylation is a cardinal cellular modification and i

168 Ubiquitylation is a tightly regulated process that is es

169 kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be u

170 The misregulation of protein ubiquitylation is associated with many human diseases, a

171 Herein, the role of ubiquitylation is emerging as an important post-translat

172 translation termination factor GSPT1] whose ubiquitylation is induced by immunomodulatory drugs.

173 Its ubiquitylation is Ltn1 dependent and Ubp3 reversed, and

174 a mutant NEIL1 protein lacking residues for ubiquitylation is more stable than the wild type protein

175 tion with HJURP, indicating that "signaling" ubiquitylation is required for CENP-A loading at centrom

176 r to other post-translational modifications, ubiquitylation is reversible in a process dependent on a

177 t al. report that protein misfolding without ubiquitylation is sufficient for translocation into incl

178 A key feature of ubiquitylation is that the identity of UB chain linkage

179 se that competitive binding to alpha2 by the ubiquitylation machinery and alpha2 cofactors is balance

180 We show that the ubiquitylation machinery and the proteasome control diff

181 D8 can trigger NEDD8 conjugation through the ubiquitylation machinery.

182 mechanisms that control the activity of the ubiquitylation machinery.

183 Together, our data suggest that non-lysine ubiquitylation may be more prevalent than currently cons

184 This mutually exclusive PI-binding/ubiquitylation mechanism may help maintain low levels of

185 ytosis of transporters is triggered by their ubiquitylation mediated by the Rsp5 ubiquitin-ligase, re

186 Thus, CENP-A K124R ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex

187 ion of nascent polypeptides, cotranslational ubiquitylation occurs at a low level, suggesting the exi

188 ish that regulation of interactor binding by ubiquitylation occurs more generally among USP-family en

189 R stress-stimulated regulatory 40S ribosomal ubiquitylation occurs on a timescale similar to eIF2alph

190 ionarily conserved, site-specific regulatory ubiquitylation of 40S ribosomal proteins.

191 SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-neg

192 cupancy by Gcn4 and support a model in which ubiquitylation of activators-not their destruction-is im

193 k between CRL5 and CRL1 through SAG mediated ubiquitylation of beta-TrCP1.

194 ubiquitin ligase known as SCF(Dia2) promotes ubiquitylation of CMG during the final stages of chromos

195 of specific peptide generation reveals that ubiquitylation of defective ribosomal products is rate l

196 ling pathways are regulated by Itch-promoted ubiquitylation of diverse target proteins.

197 tylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I by Cul4-DDB1 and DCAF7.

198 ns, as well as levels of phosphorylation and ubiquitylation of EGFR in tumors in vivo closely resembl

199 lates Wnt receptor surface levels via lysine ubiquitylation of Frizzled to coordinate spatial and tem

200 hat targeting MUC1-C suppresses BMI1-induced ubiquitylation of H2A and thereby derepresses homeobox H

201 Ubiquitylation of H2AK15 by RNF168 inhibits chromatin ac

202 PIF1 enhances the poly-ubiquitylation of HFR1 by COP1 in vivo and in vitro In a

203 creases HIF1alpha stability and enhances the ubiquitylation of HIF1alpha by a von Hippel-Lindau prote

204 This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and t

205 Dynamic regulation of RNF168-mediated ubiquitylation of histone H2A Lys13,15 (H2AK13,15ub) at

206 hromatin by recognizing RNF168-mediated mono-ubiquitylation of histone H2A Lys15 in the nucleosome co

207 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of oth

208 A central player in these events is the mono-ubiquitylation of histone H2B (H2Bub1), which has been s

209 Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a

210 MT1 to sites of newly replicated DNA through ubiquitylation of histone H3.

211 IL-1-induced formation of K63-Ub chains and ubiquitylation of IRAK1, IRAK4, and MyD88 was abolished

212 CMG unloading involves ubiquitylation of its Mcm7 subunit and the action of the

213 Itch induces the ubiquitylation of K1413, the reduction of PTCH1 levels a

214 t PARKIN phosphorylation and activation, and ubiquitylation of Lys residues on a cohort of MOM protei

215 Ubiquitylation of lysines within this site leads to rapi

216 Residual ubiquitylation of Mcm7 in dia2-DeltaTPR cells is still C

217 o the mitochondrial outer membrane (MOM) for ubiquitylation of MOM proteins with canonical and noncan

218 ating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysin

219 Molecular dynamics simulations revealed that ubiquitylation of one site, K301, do not only target pod

220 Here, we present evidence that Asr1-mediated ubiquitylation of pol II is required for silencing of su

221 Asr1-mediated oligo-ubiquitylation of pol II leads to ejection of two core s

222 Non-lysine ubiquitylation of proteasomal substrates has been consid

223 Ubiquitylation of receptor tyrosine kinases (RTKs) regul

224 The ubiquitylation of RPA by PRP19 and RFWD3 facilitates ATR

225 ZNF598 primarily mediates regulatory ubiquitylation of RPS10 and RPS20, whereas RACK1 regulat

226 biquitin ligases MULAN and MARCH5 coordinate ubiquitylation of SLC25A46 L341P, leading to degradation

227 he CTE is involved in the recognition and/or ubiquitylation of specific protein substrates.

228 n-RING ubiquitin ligases (CRLs) catalyze the ubiquitylation of substrates many of which are degraded

229 The ubiquitylation of Sufu, mediated by Fbxl17, allows the r

230 tic pathway in yeast, facilitating selective ubiquitylation of target proteins by the E3 ubiquitin li

231 We here report that transport-elicited ubiquitylation of the arginine transporter Can1 is promo

232 budding yeast, the F-box protein Dia2 drives ubiquitylation of the CMG helicase at the end of replica

233 oteasome inhibition stimulates comprehensive ubiquitylation of the complex, with the ensuing proteaph

234 ITSN1 stimulates ubiquitylation of the epidermal growth factor receptor (

235 gression complex increases the efficiency of ubiquitylation of the Mcm7 subunit of CMG, both in vitro

236 ificantly reduced, associated with increased ubiquitylation of VEGF protein.

237 domain alpha1-helix, which further undergoes ubiquitylation on a conserved lysine residue.

238 S8 E3 ligase activity is required for CENP-A ubiquitylation on lysine 124 (K124) and CENP-A centromer

239 examine the role of NCC phosphorylation and ubiquitylation on NCC endocytosis.

240 s in the ubiquitin ligase that mediates Gcn4 ubiquitylation or by inhibition of the proteasome, leadi

241 further define a feed-forward mitochondrial ubiquitylation pathway involving PARKIN activation upon

242 is is, in part, due to the complexity of the ubiquitylation pathways and the lack of robust quantitat

243 Site-specific histone ubiquitylation plays a central role in orchestrating the

244 icate that ZNF598, RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosom

245 Reversible protein ubiquitylation plays important roles in various processe

246 vating Ltn1 or by analyzing NCs with limited ubiquitylation potential, suggesting that inefficient ta

247 r calcium signaling in mitochondrial protein ubiquitylation, protein turnover, and disease.

248 est that control of pol II by nonproteolytic ubiquitylation provides a mechanism to enforce silencing

249 er the molecular basis for how PQC substrate ubiquitylation rates are controlled, the reaction cataly

250 The processivity of the ubiquitylation reaction necessitates transient physical

251 tification of the kinetics of San1-catalyzed ubiquitylation reactions.

252 e fluorescence assays that capture transient ubiquitylation reactions.

253 Phosphorylation and ubiquitylation regulate the GH receptor (GHR) at the cel

254 iew details our current understanding of how ubiquitylation regulates CD4(+) T cell effector identity

255 o support the emerging view that transporter ubiquitylation relies on combinatorial interaction rules

256 ability to interact with Fbxl7 (E126A) and a ubiquitylation-resistant double point mutant (KK90RR/KK9

257 Expression of an ubiquitylation-resistant form of RAD51 in human cells le

258 e enhanced nuclear matrix association of the ubiquitylation-resistant RAD51.

259 ction or mutations that block RPS10 or RPS20 ubiquitylation result in defective resolution of stalled

260 increased AQP2 protein t1/2 and reduced AQP2 ubiquitylation, resulting in greater levels of AQP2 and

261 ich catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 comp

262 pport the hypothesis that complex eukaryotic ubiquitylation signalling pathways have developed from c

263 the genome and is controlled by a variety of ubiquitylation signals on substrate proteins.

264 Like Itch depletion, mutation of the ubiquitylation site (K1314R) resulted in the accumulatio

265 ndent and Ubp3 reversed, and mutation of its ubiquitylation site rendered ribophagy less dependent on

266 alysis of CSB identified lysine (K) 991 as a ubiquitylation site.

267 vin1 but not mutant cavin1 lacking the major ubiquitylation site.

268 tylated, we used a proteomic approach to map ubiquitylation sites and screen for DNA ligase I-associa

269 itin-ligase activity of Asr1--or mutation of ubiquitylation sites within Rpb1--induces transcription

270 s include 18 548 phosphorlyation sites, 3412 ubiquitylation sites, 2316 acetylation sites, 685 methyl

271 Therefore, TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal

272 ified a number of influential proteins whose ubiquitylation status is modified during this switch.

273 suppressor Pdcd4 as IBtkalpha interactor and ubiquitylation substrate of CRL3(IBTK) for proteasomal d

274 Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b.

275 PALB2 ubiquitylation suppresses its interaction with BRCA1 and

276 eins it is less clear how complex eukaryotic ubiquitylation system arose and diversified from these p

277 eased degradation of the Mfn2 protein, a key ubiquitylation target of Parkin on mitochondria.

278 overall protein levels of LRSAM1, nor of its ubiquitylation target TSG101.

279 Collectively, we expand the catalog of ubiquitylation targets in Arabidopsis and show that this

280 ng models (acetylation, phosphorylation, and ubiquitylation), the resulting models yielded high overa

281 adation, despite increased CUL3-mediated WNK ubiquitylation; therefore, CUL3 loss in kidney should ph

282 ent of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 an

283 mately 6 h in HeLa cells and is targeted for ubiquitylation through actions of the F-box protein FBXO

284 replication via orchestration of histone H2B ubiquitylation, thus providing distinct functional insig

285 show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole.

286 decades of study, the importance of protein ubiquitylation to peptide generation remains uncertain.

287 hat RNF168 couples PALB2-dependent HR to H2A ubiquitylation to promote DNA repair and preserve genome

288 HeDNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail a

289 Ubiquitylation triggers a rapid redistribution of Perfor

290 emplate switching (TS), are activated by the ubiquitylation (ub) of PCNA through components of the RA

291 Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1)

292 ilized reporters that undergo misfolding and ubiquitylation upon removal of a stabilizing ligand to e

293 its protein half-life through promoting its ubiquitylation via atypical K11-linkage.

294 modifications, including phosphorylation and ubiquitylation, which are fundamental for controlling AQ

295 ic calcium levels into more persistent SEC31 ubiquitylation, which in turn triggers formation of larg

296 gulators of phosphorylation, acetylation and ubiquitylation, which suggest regulatory crosstalk betwe

297 ce receptors resulted in an increase in EGFR ubiquitylation with sustained ligand incubation.

298 and its application towards native chemical ubiquitylation with the ligation auxiliary 2-aminooxyeth

299 ctive 60S binding also lead to defective NSP ubiquitylation, without affecting Ltn1's intrinsic E3 li

300 phorylation is often used to promote protein ubiquitylation, yet we rarely understand quantitatively