ライフサイエンスコーパス: ulceration

1 al outcomes (i.e., gastric cancer and peptic ulceration).

2 after treatment, without pain, crusting, or ulceration.

3 valves (VVs) prevent venous hypertension and ulceration.

4 significant linkage between PHIP levels and ulceration.

5 with a livedolike appearance and superficial ulceration.

6 n (PHIP) copy number and its relationship to ulceration.

7 ation-induced oral mucositis, a painful oral ulceration.

8 tients may develop bleeding caused by stress ulceration.

9 creased disease severity, and prevented skin ulceration.

10 digital images recording possible subsequent ulceration.

11 y begin in a wound, most often a neuropathic ulceration.

12 from mild erythema to moist desquamation and ulceration.

13 nostic information than the mere presence of ulceration.

14 tation and lipodermatosclerosis of skin, and ulceration.

15 he pathogenesis of gastric cancer and peptic ulceration.

16 major cause of gastric carcinoma and peptic ulceration.

17 P = 0.0053), but not among patients without ulceration.

18 nd epithelial cell exfoliation, erosion, and ulceration.

19 patients (n = 70) who denied any history of ulceration.

20 Most common toxicity was mild aphthous ulceration.

21 33% of patients reporting multiple sites of ulceration.

22 ammatory settings dominated by cell loss and ulceration.

23 ly correlated with cellular inflammation and ulceration.

24 ogenesis, weaker skin, and predisposition to ulceration.

25 icted chronic juvenile DM, particularly with ulceration.

26 formation, with strain 3A causing cutaneous ulceration.

27 pithelial barrier in the form of erosion and ulceration.

28 cting DSS, outperforming tumor thickness and ulceration.

29 al and regeneration after colonic epithelial ulceration.

30 to vary depending upon the state of vascular ulceration.

31 d did not have cutaneous or gastrointestinal ulceration.

32 a, low mitotic activity, focal necrosis, and ulceration.

33 rized by chronic inflammation and urothelial ulceration.

34 perficial vessel wall erosion induced by the ulceration.

35 almitis, and infectious keratitis or corneal ulceration.

36 constituents ameliorate ASA-induced gastric ulceration.

37 keratitis is characterized by severe corneal ulceration.

38 cosae of RAS patients not affected by active ulceration.

39 glycolysis (Warburg effect), associated with ulceration.

40 reviously unrecognised cause of chronic skin ulceration.

41 lerosis, postthrombotic syndrome, and venous ulceration.

42 tion, palmar violaceous papules, and digital ulcerations.

43 condition involving painful and deep mucosal ulcerations.

44 o pseudomembrane-covered, irregularly-shaped ulcerations.

45 0.14) was protective, for the development of ulcerations.

46 sis in the colonic epithelium and subsequent ulcerations.

47 tion, palmar violaceous papules, and digital ulcerations.

48 ish-red infiltrations to mutilating necrotic ulcerations.

49 proximal to mid jejunum and jejunal mucosal ulcerations.

50 The most common adverse events were mouth ulceration (25 [32%] in the everolimus group vs two [5%]

51 pulmonary embolus prevention (42%) or venous ulceration (25%).

52 Stomatitis (48 [43%] patients) and mouth ulceration (33 [30%] patients) were the most frequent tr

53 pithelial defects, 25%, 3 days; conjunctival ulceration, 39%, 3.5 days; symblepharon, 28%, 4 weeks; c

54 %), photosensitivity (60.9%), and oral/nasal ulcerations (43.5%), but a lower prevalence of hematolog

55 of 1769 patients were analyzed (1311 without ulceration, 458 with ulceration) with a median follow-up

56 [44%]), xerosis (8 [20%]), scrotal erythema/ulceration (6 [15%]), and nail splinter hemorrhages (5 [

57 prolong the existence of already established ulcerations, affecting tissue healing.

58 Foot ulceration affects a significant proportion of patients

59 thickness or < 0.8 mm Breslow thickness with ulceration) after a thorough discussion with the patient

60 ed with the year of publication, female sex, ulceration, age, and the quality score of the studies.

61 Factors analyzed included Breslow thickness, ulceration, anatomic site, sex, Clark level, age, mitoti

62 o hypochlorhydria and predisposes to gastric ulceration and adenocarcinoma.

63 the divergent trends in incidence of peptic ulceration and apparent trends in diagnosis of upper gas

64 with marked lethal toxin-induced intestinal ulceration and bleeding in neutrophil elastase(+/+) anim

65 e use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract.

66 een neutrophil presence at sites of melanoma ulceration and cell proliferation at these sites, which

67 omplications were as follows: for lid margin ulceration and corneal epithelial defects, 25%, 3 days;

68 non and its ischaemic complications (digital ulceration and critical ischaemia) and discusses possibl

69 ation in wild type mice, caused marked colon ulceration and delayed ulcer healing in GM-CSF(-/-) mice

70 oss changes to crypt architecture, including ulceration and denuding of the epithelial layer.

71 s the strongest known risk factor for peptic ulceration and distal gastric cancer, and adherence of H

72 Esophageal ulceration and fistula are complications of pulmonary ve

73 the human stomach and contributes to peptic ulceration and gastric adenocarcinoma.

74 Jup mutant mice also suffered skin ulceration and inflammation.

75 opment), hemochromatosis (involved in venous ulceration and iron absorption), and various types of co

76 djusting for significant prognostic factors (ulceration and lymph node status) and treatment.

77 th increasing Breslow thickness, presence of ulceration and male sex, predicts SLN metastasis in pati

78 first time, lichenoid esophagitis may cause ulceration and mucosal sloughing severe enough to result

79 Skin ulceration and necrosis due to Loxosceles spider envenom

80 ced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis.

81 stellate purpuric lesions that often undergo ulceration and necrosis, increasing the risk of infectio

82 hronic inflammatory complications, including ulceration and neovascularization.

83 edictive of positive non-SLNs; primary tumor ulceration and number of positive SLNs had no apparent i

84 atment include severe emesis and nausea, and ulceration and pain at the injection site.

85 involving nodular gingival enlargement with ulceration and periodontal tissue destruction.

86 Angiotropism in melanoma correlates with ulceration and poor prognosis.

87 Dose-limiting toxicities were rectal ulceration and proteinuria at the 7.0 mg/kg dose.

88 -dependent thermal injury model in mice with ulceration and scar formation that depended on nonredund

89 a increases epidermal injury with subsequent ulceration and scarring, both clinically and morphologic

90 n with complement activation that results in ulceration and scarring.

91 reatment significantly reduced the degree of ulceration and the time of healing.

92 nodal involvement, number of positive nodes, ulceration and tumor thickness, sex, and center.

93 and treat promptly to minimize the risk for ulceration and visual loss.

94 is involved in P. aeruginosa-induced corneal ulceration and whether it therefore can be targeted for

95 gures per 50 high power fields, while 11 had ulceration and/or necrosis of the lesion.

96 etidronate increased the risk for esophageal ulcerations and gastrointestinal perforations, ulceratio

97 n to a persistent, metastatic disease, where ulcerations and granulomatous nodules can affect multipl

98 ermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammat

99 w thickness >/= 0.75 mm, Clark level >/= IV, ulceration, and absence of regression differed significa

100 nodes, primary tumor thickness, patient age, ulceration, and anatomic site of the primary independent

101 corneal disease (vascularization, scarring, ulceration, and conjunctivalization), history of conjunc

102 g complications, including scleral thinning, ulceration, and delayed conjunctival epithelialization;

103 (FCL: 998) coincided with chronic intestinal ulceration, and finally 50 samples from 19 patients (FCL

104 opment and progression of gastritis, gastric ulceration, and gastric cancer, this dual regulatory rol

105 is, pulmonary arterial hypertension, digital ulceration, and gastro-oesophageal reflux, are now treat

106 ess more than 0.75 mm, MR >/= 1, presence of ulceration, and LVI (all P = .001) were significantly as

107 or larger, increasing Clark level, mitoses, ulceration, and lymphovascular invasion were independent

108 r MM only, melanoma type, Breslow thickness, ulceration, and mortality.

109 atient age, tumor size, mitotic index, tumor ulceration, and necrosis were statistically associated w

110 tients were stratified by Breslow thickness, ulceration, and nodal status.

111 he number of tumor-containing nodes, primary ulceration, and patient age independently predicted surv

112 uction, amblyopia, or feeding difficulties), ulceration, and severe anatomic distortion, especially o

113 percentage of goal calories received, nasal ulceration, and sinusitis.

114 ugh workup ruled out other causes of genital ulceration, and the ulcers completely resolved after tre

115 f sensory loss, pain, autonomic dysfunction, ulcerations, and amputations.

116 ly experience pain and are at risk of falls, ulcerations, and amputations.

117 cerations and gastrointestinal perforations, ulcerations, and bleeding.

118 ccumulation, intraplaque hemorrhages, plaque ulcerations, and phosphoactivated endoplasmic reticulum

119 ng, hypercytokinemia, T cell cytopenia, skin ulcerations, and premature death.

120 Ulcerations appeared to be pathogenetically important, b

121 Skin infections with ulceration are a major health problem in countries of th

122 Plaque rupture and ulceration are common in women with myocardial infarctio

123 ts and decisions made by nurses managing leg ulceration are complex and uncertain and some of the var

124 nsertion and four cases of superficial nasal ulceration associated with the bridle.

125 We recommend that extent of ulceration be recorded in pathology reports for all ulce

126 IND administration induced significant ulceration, bleeding, and oedema in the stomach or small

127 Immunization with rTP0136 delayed ulceration but did not prevent infection or the formatio

128 was associated with the presence of gastric ulceration but not gastric cancer.

129 proliferation and cell migration at sites of ulceration compared to WT mice; these reductions correla

130 ninflamed corpus and predisposes to duodenal ulceration; corpus-predominant gastritis leads to hypoch

131 The slit-lamp characteristics of the corneal ulceration, corrected distance visual acuity, duration u

132 taract, trachoma control, infectious corneal ulceration, cytomegalovirus retinitis, and retinopathy o

133 icobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma, and gastric l

134 ere intestinal defects that included mucosal ulcerations, epithelial cell sloughing, and inflammation

135 was a statistically significant increase in ulceration for CM with a depth of approximately 1.4 per

136 er pylori infection, and prophylaxis against ulceration from nonsteroidal anti-inflammatory drugs.

137 ired NF-kappaB activation, develop cutaneous ulceration from TNF exposure, and exhibit severe dextran

138 audication (N=8128), rest pain (N=3056), and ulceration/gangrene (N=11,770) and Current Procedural Te

139 rest pain (P=0.061), and no improvement for ulceration/gangrene (P=0.65).

140 t environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other d

141 ich is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma.

142 Patients with open-foot and healed-foot ulceration had significantly longer RA disease duration,

143 To our knowledge, neurotrophic corneal ulceration has not previously been reported after retina

144 CI, 1.00-1.01; P = .02) and the presence of ulceration (HR, 1.21; 95% CI, 1.01-1.45; P = .04) were a

145 cterized by clinical inflammation, bleeding, ulceration, hyperplasia, and necrosis was observed aroun

146 loss of ATP2C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer f

147 g collagen turnover and stabilization before ulceration in "at risk" patients.

148 diameter was 85 mm (55-250 mm), with mucosal ulceration in 4 patients, preoperative capsular rupture

149 tiology of autosomal-dominant, mucocutaneous ulceration in a family whose proband was dependent on an

150 slands-Haemophilus ducreyi-as causes of skin ulceration in a yaws-endemic region.

151 The detection of ulceration in melanomas with thicker than 1 mm increased

152 1 significantly reduced the extent of tongue ulceration in mice receiving a single fraction, high dos

153 is needed to establish risk factors for foot ulceration in RA and to target foot health provision mor

154 e treatment as well as prevention of corneal ulceration in the developing world.

155 ll bowel, and the other had chronic ischemic ulceration in the ileum.

156 itis, which creates painful inflammation and ulceration in the oral cavity.

157 ouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring.

158 lted in little epithelial damage and mucosal ulceration in wild type mice, caused marked colon ulcera

159 ated superficial thermal lesions and thermal ulcerations in 1 of 50 (2%) and 5 of 50 (10%) patients,

160 se activity, and illness features, including ulcerations in children and pericarditis in adults.

161 -FDG uptake was found in 87% of deep mucosal ulcerations in IBD patients, whereas mild endoscopic les

162 of NGF was introduced to treat neurotrophic ulcerations in patients.

163 neuropathy (DPN) often leads to neurotrophic ulcerations in the cornea and skin; however, the underly

164 f decompensated liver cirrhosis, varices and ulcerations in the upper gastrointestinal tract.

165 earance of intraplaque hemorrhage and tissue ulceration, in association with deregulation of smooth m

166 trointestinal anastomotic stenosis, marginal ulceration, incisional hernia.

167 The risk of incident venous leg ulceration increased for patients living in areas of hig

168 esions of the head and neck, the presence of ulceration, increasing Breslow thickness, older age, and

169 a histolytica kills human cells resulting in ulceration, inflammation and invasion of the colonic epi

170 0 treatment on wound heal-ing, the degree of ulceration, inflammation, angiogenesis, and collagen syn

171 rointestinal manifestations included gastric ulceration, intestinal bacterial overgrowth with villous

172 ts as endoscopically visible surface mucosal ulcerations, irregularities, or polyploidal masses.

173 Ulceration is a common negative prognostic marker of sol

174 While ulceration is a common, predominantly benign complicatio

175 Diabetic foot ulceration is a major complication of diabetes.

176 These data support the conclusion that ulceration is a predictive marker for response to adjuva

177 Diabetic foot ulceration is a severe complication of diabetes that lac

178 Ulceration is an adverse prognostic factor for clinicall

179 Tumor ulceration is an important prognostic factor for cutaneo

180 Ulceration is an important prognostic factor in melanoma

181 The signaling basis of ulceration is being elucidated.

182 The treatment of chronic mucocutaneous ulceration is challenging, and only some patients respon

183 eatment for Buruli ulcer, new or progressive ulceration is common before healing sets in.

184 al studies suggest that bleeding from stress ulceration is extremely uncommon in intensive care unit

185 Optimal management of digital ulceration is multidisciplinary including tissue viabili

186 errater reliability suggests that if digital ulceration is to be used as an end point in multicenter

187 nel of nurses with advanced knowledge of leg ulceration judged the same scenarios and provided a stan

188 Age, MR, ulceration, LVI, regression, and sentinel node status we

189 o age, Breslow thickness, mitotic rate (MR), ulceration, lymphovascular invasion (LVI), and regressio

190 Moreover, they suggest that ulceration may be driven by increased glycolysis and ang

191 Extent of ulceration (measured either as diameter or percentage of

192 Disease progression can lead to corneal ulceration, melt, and perforation.

193 h as following surgery, biopsy collection or ulceration, might impact on cancer progression.

194 6-13.23]); other independent predictors were ulceration, mitoses, and scalp location.

195 of the stomach and duodenum from injury and ulceration, most frequently caused by necrotic agents in

196 , segment wall hyperenhancement (n=18), deep ulceration (n=6), fistula (n=3), stenosis (n=7), mesente

197 Nonsexual acute genital ulceration (NAGU) is a rare vulvar skin condition typica

198 ination revealed a painful lesion with focal ulceration, necrosis and pus discharge with active infla

199 were noted, including corneal opacification, ulceration, neovascularization, and ectasia.

200 increased risk for the development of peptic ulceration, noncardia gastric adenocarcinoma, and gastri

201 icobacter pylori is a risk factor for peptic ulceration, noncardia gastric adenocarcinoma, and gastri

202 ted after adjusting for maximum thickness or ulceration of any melanoma regardless of the index tumor

203 coronary syndromes related to thrombosis and ulceration of atherosclerotic plaque within a coronary a

204 BK is characterized by excessive tearing and ulceration of the cornea.

205 N0 M0 tumor that was 2.7 mm in depth with no ulceration of the epidermal surface.

206 A newborn girl presented with an ulceration of the left forearm associated with an appare

207 ital inflammation of either partner, genital ulceration of the man, and first follow-up interval.

208 ntact lenses and produces exquisite pain and ulceration of the ocular surface.

209 Ulceration of the oesophageal squamous mucosa (ulcerativ

210 lymph node staging procedure, Breslow depth, ulceration of the primary lesion, and disease stage.

211 umber of metastatic nodes, tumor burden, and ulceration of the primary melanoma.

212 2.90 mm; 95% CI, 2.87-4.54 mm; P = .54), or ulceration of the primary tumor (difference, -8.00%; 95%

213 N stage according to AJCC staging criteria, ulceration of the primary tumour, and patient sex.

214 A common feature of human wounds and ulcerations of any form is the expression of matrix meta

215 enucleation, and (iii) the impact of mucosal ulceration on outcome.

216 analysis, endoscopic abnormalities, that is, ulceration or nodularity (P = 0.0002; relative risk [RR]

217 patients; large complex plaques (those with ulcerations or mobile components) were seen in 8.5%.

218 interval [CI]: 1.3 to 4.6), especially when ulcerations or superimposed thrombus were present (adjus

219 6.1; >4 mm: OR, 12.6; 95% CI, 7.5-21.1), and ulceration (OR, 2.0; 95% CI, 1.5-2.7).

220 lder than 75 years; had T1b tumors, no tumor ulceration, or head/neck or truncal lesions; were covere

221 however, regardless of insult: inflammation, ulceration, or metaplasia/dysplasia.

222 cal presentation characterized by a stellate ulceration over the upper extremities and reported assoc

223 Tumor thickness (P < .001), ulceration (P < .001), satellitosis (P < .001), mitotic

224 ), greater Breslow thickness (P < .001), and ulceration (P < .02).

225 have primary tumor regression (P = 0.0054), ulceration (P < 0.0001), and axial primary tumor locatio

226 al infection which includes infiltration and ulceration (P < 0.05) and shortened the duration of the

227 led that only Breslow thickness (P < .0001), ulceration (P = .0004), male sex (P = .03), and absent T

228 (P < .001), decreasing TIL grade (P < .001), ulceration (P = .003), increasing tumor thickness (P = .

229 (P = .03), Clark level >/= IV (P = .05), and ulceration (P = .01) significantly predicted SLN metasta

230 ted with primary tumor thickness (P = .011), ulceration (P = .018), and SLN tumor burden (P = .018).

231 s, age (P = 0.0002), thickness (P < 0.0001), ulceration (P = 0.015), and location (P < 0.0001) remain

232 body changes with posterior pharyngeal wall ulceration (P<.01).

233 icin is applied to skin surfaces at risk for ulceration, particularly in neuropathic conditions chara

234 /=2 mitoses/mm(2) (40 ulcerated; 289 without ulceration), patients with diabetes had significantly ra

235 Major gastrointestinal complications are ulceration, perforation, hemorrhage, and obstruction.

236 usted for age, Breslow thickness, body site, ulceration, performed lymph node dissection, and treatme

237 ment of the amount and type of inflammation, ulceration, perineural invasion, and depth of invasion).

238 The ulceration phenotype likely represents the genotype of t

239 ing for the large numbers of people with leg ulceration play a key role in promoting quality in healt

240 urgery; no diabetes and no venous edema with ulcerations postsurgery (either no history or remission)

241 performed to investigate the hypothesis that ulceration predicts improved response to adjuvant interf

242 er was 40 mm (18-65 mm), without any mucosal ulceration, preoperative capsular ruptures, or incomplet

243 ess more than 0.75 mm, MR >/= 1, presence of ulceration, presence of LVI, and regression >/= 50%.

244 t diabetes who developed neuropathic corneal ulceration presumed secondary to long ciliary nerve comp

245 cludes pulmonary hypertension, cutaneous leg ulceration, priapism, and ischemic stroke.

246 hose regions, and chemically induced colonic ulcerations promoted bacterial colonization.

247 4000 patients with a diagnosis of venous leg ulceration, prospectively recorded between the years 200

248 y of stomatitis, mucosal inflammation, mouth ulceration, rash, and fatigue.

249 greater than 2.00 mm in women, and relative ulceration rates (95% CI) declined in both sexes (EAPCs,

250 agrammatic questionnaire data to exclude leg ulceration reduced the rate to 10.76%.

251 the prognostic significance of the extent of ulceration remains unclear.

252 with intravascular hemolysis, cutaneous leg ulceration, renal insufficiency, iron overload, and live

253 caused corneal epithelial loss, and stromal ulceration resulting in decreased CCT.

254 The corneal ulceration's width and length was significantly bigger i

255 Ulceration, scarring, and disfigurement are significant

256 ek recovery period, colonic inflammation and ulceration scores returned to pretreatment levels compar

257 ice demonstrated that the severe DSS-induced ulceration seen in Mtgr1-null mice was due to a colonic,

258 range, 79%-80%; herpes simplex virus, vulvar ulcerations: sensitivity, 20%; specificity, 98%; PPV, 88

259 ickness >/= 0.75 mm, Clark level >/= IV, and ulceration significantly predict SLN disease in thin mel

260 stic factors were thickness, anatomic level, ulceration, site, sex, and age; PLG prognostic factors a

261 copy number was an independent predictor of ulceration status (P=0.04).

262 node-negative and node-positive patients by ulceration status revealed that the only significant imp

263 ed PHIP copy number and tumor vascularity on ulceration status was highly significant (P<0.0001).

264 ad no significant impact on OS regardless of ulceration status, however.

265 rates of < 5% regardless of Clark level and ulceration status.

266 of causing difficult-to-manage toxicity (eg, ulceration, stenosis, fibrosis, and even necrosis) that

267 smitted disease chancroid and a chronic limb ulceration syndrome in children.

268 neficial for the prevention of diabetic foot ulceration, the effect of foot self-care behavior on the

269 been recognized as being present in herpetic ulcerations, their role in subclinical reactivation and

270 ated with a large reduction in the hazard of ulceration, there was a high degree of uncertainty aroun

271 In addition to protection against stomach ulceration, these prodrugs exhibited significantly enhan

272 nes should consider the interaction among CM ulceration, thickness, sex, and age at diagnosis.

273 with fistula formation (11.6%) and four with ulceration/tissue necrosis (9.3%).

274 Gastric ulceration triggered an approximately threefold increase

275 ing validation, the point prevalence of foot ulceration was 3.39% and the overall prevalence was 9.73

276 The presence of ulceration was also an independent predictor of poorer M

277 Endoscopic mucosal ulceration was associated with more aggressive tumors.

278 Ulceration was associated with significantly worse DFS a

279 The baseline degree of mucosal ulceration was documented by ileocolonoscopy.

280 owever, a potentially fatal gastrointestinal ulceration was recently found and herein reported.

281 The incidence of tumor ulceration was stable across all tumor depths among youn

282 ables (patient age, Breslow depth, and tumor ulceration) was significantly greater than a model that

283 ific junctional pattern, basaloid cords, and ulceration were associated with basal cell carcinomas.

284 icular soft tissues, edema, enhancement, and ulceration were common in both groups.

285 Both the presence and extent of ulceration were independent predictors of survival.

286 The most common sites for ulceration were the dorsal aspect of hammer toes, the me

287 istologically defined as mitoses/mm(2)), and ulceration were the most dominant prognostic factors.

288 No epithelial erythema, erosions, or ulcerations were seen.

289 f landmarks and visible lesions (nodularity, ulceration) when present.

290 early responders related to inflammation and ulceration, whereas NF-kappaB and ISRE were late respond

291 . rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the b

292 ex, deeper Breslow thickness, and with tumor ulceration while decreasing with greater PSM (P < .001).

293 ickness of 4.8 mm, Clark level IV, and tumor ulceration with a mitotic rate of 37 mitoses/mm(2).

294 eocolonoscopy findings of extensive aphthous ulceration with skip lesions extending to the terminal i

295 analyzed (1311 without ulceration, 458 with ulceration) with a median follow-up of 71 months.

296 reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity,

297 satory proliferation in crypts and extensive ulcerations without significant changes in inflammatory

298 alopecia, epidermal hyperproliferation, and ulceration, without obvious effects on epidermal differe

299 f eosinophils (present vs absent; P = .007), ulceration (yes vs no; P = .003), perineural invasion (y

300 enotypic variables (e.g., depth of invasion, ulceration) yields a wide range of 10-year melanoma-spec