ライフサイエンスコーパス: ultimate

1 strategies to improve these systems with the ultimate aim of developing materials for ultra-high-dens

2 The ultimate aim of flow sensing is to represent the perturb

3 ctors on which cancer cells depend, with the ultimate aim of targeting them.

4 ecause minimising time to reperfusion is the ultimate aim of treatment.

5 , and treatment of these disorders, with the ultimate aim to develop entirely new approaches to preve

6 with rapid point-of-care diagnostics as the ultimate aim.

7 inely "undetectable" transmission remain the ultimate aim.

8 Integrating these ultimate and proximate approaches, we introduce dual-pro

9 tention to the need to differentiate between ultimate and proximate explanation; the insurance hypoth

10 entary questions, avoiding the conflation of ultimate and proximate explanations that has long hinder

11 m the perspective of Allah (God), who is the ultimate arbitrator of religious belief, changes the rel

12 requency fluctuation processes determine the ultimate attainable resolution.

13 The ultimate benefit of weight reduction relates to the redu

14 is likely that the third cation provides the ultimate boost over the energy barrier to catalysis of D

15 termine how relativistic motion modifies the ultimate bound in the precision of the measurement of ti

16 y principle and the heat theorem), and place ultimate bounds on the speed at which information can be

17 In the field of nanofluidics, it has been an ultimate but seemingly distant goal to controllably fabr

18 residents, most develop an interest in their ultimate career before residency.

19 Most (65%) developed an interest in their ultimate career before residency.

20 We suggest that population density is the ultimate cause for Milu dispersal, whereas floods and hu

21 other environmental pressures which are the ultimate cause of decline.

22 Explanation of the ultimate causes of acute and chronic pancreatitis is cha

23 upports the connection between proximate and ultimate causes of masting: indeed, large-scale features

24 We also discuss proximate and ultimate causes of size variation and how variation in w

25 not distinguish clearly among proximate and ultimate causes.

26 stin complex in a manner that determines the ultimate cellular consequences of ss-arrestin signaling.

27 ence and avoiding differentiation may be the ultimate challenge to maintain the functions unique for

28 The ultimate challenge will be optimization of prevention st

29 The ultimate challenge will be to translate these findings t

30 exhibit a precision/recall tradeoff, and the ultimate choice of workflow should take into considerati

31 The World Health Assembly's ultimate choice will lead an organisation facing dauntin

32 nality is not predictive of an interneuron's ultimate circuit specificity.

33 ving robust cancer-specific lethality is the ultimate clinical goal.

34 diagnostic results, treatment decisions, and ultimate clinical outcomes, assuming use of the standard

35 complexes, coordinating the progression and ultimate closure of the phagocytic cup.

36 Our findings reveal that the ultimate coherence length of superlattices strongly depe

37 Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of

38 he nanoscale is architected to approach this ultimate combination.

39 tured composites (MINCs), which exhibit high ultimate compressive strengths (over 2 GPa), high compre

40 pared to other transition metal borides, and ultimate compressive strengths up to 1940 +/- 103 MPa we

41 The ultimate consequence of quantum many-body physics is tha

42 e tissue progenitors are predictive of their ultimate contributions to regenerated skeletal structure

43 water, shelter, and mate) while avoiding the ultimate cost of predation.

44 ds with eight novel residues that include an ultimate cysteine.

45 t that diffusive processes likely govern the ultimate decay of geomagnetic spikes.

46 In this model, the ultimate degradation of the mRNA is the last step in a c

47 each cell is fundamentally important for the ultimate delineation of organ formation and function.

48 the determination of advective transport and ultimate depocenters of MOSSFA material.

49 time scales in catchment soils prior to its ultimate deposition.

50 n species' may serve as ideal models for the ultimate design of crops with enhanced drought tolerance

51 amilies empathized with the initial hope and ultimate despair of potential recipients who must contin

52 The exploration and ultimate detection of dark matter are led by experiments

53 o these guidelines to be voluntary, with the ultimate determination regarding their application to be

54 o these guidelines to be voluntary, with the ultimate determination regarding their application to be

55 o these guidelines to be voluntary, with the ultimate determination regarding their application to be

56 o these guidelines to be voluntary, with the ultimate determination regarding their application to be

57 o these guidelines to be voluntary, with the ultimate determinations regarding their application to b

58 results, and treatment of 3 patients with an ultimate diagnosis most consistent with facial EPD.

59 7.3% after implementation, regardless of the ultimate diagnosis or algorithm adherence.

60 6%) did not require hospitalization based on ultimate diagnosis, and 48 (92.3%) received unnecessary

61 colonic findings, subsequent investigations, ultimate diagnosis, and extracolonic cancer diagnoses 1

62 d guide the reader to discover the patient's ultimate diagnosis.

63 vanced technologies at driving maleness, the ultimate disease refractory phenotype, become possible a

64 for developing programmatic guidance for the ultimate disposal of all OPV after the eradication of po

65 (5hmC), which is enriched in brain, and its ultimate DNA demethylation.

66 The ultimate driver of CAR development and implementation fo

67 Plausibly, the ultimate driver of diversification was an increase in fo

68 ion associated with those nutrients, are the ultimate driver of DOC distributions across the Atlantic

69 roposed to explain these differences but the ultimate drivers remain unclear.

70 by brainstem neuronal connections, but their ultimate effect is invariably to minimize arterial PCO2

71 ural history of progressive MS, although its ultimate effect on therapeutic development and clinical

72 Critically, our findings argue that the ultimate effectiveness of vaccine booster schedules will

73 ers, but these CP-OLEDs are limited in their ultimate efficiencies by the type of emissive electronic

74 non-native disulfides requires NADPH as the ultimate electron donor, and a robust cytosolic thioredo

75 o, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation r

76 species' genomes de novo fail to achieve the ultimate endpoint to produce contigs, each representing

77 cribed as key processes in understanding the ultimate environmental fate of fullerene based materials

78 lthough IgE was discovered 50 years ago, the ultimate evidence for its role in human allergic disease

79 tradition of theoretical modeling has sought ultimate evolutionary explanations for this seemingly al

80 ch as a failure to distinguish proximate and ultimate explanations.

81 n many systems given that hydroperiod is the ultimate factor determining the presence of an aquatic s

82 Economies of scale (EOSs) provide the ultimate factor selecting for masting, but EOSs probably

83 The ultimate failure of medical treatment and procedural rev

84 rt plasma half-life of these drugs and their ultimate failure to permeate the blood brain barrier.

85 cean, but as yet little is known about their ultimate fate and their impact on marine ecosystems.

86 ctive toxicity, environmental transport, and ultimate fate of advanced nanoscale materials, including

87 onal results, the work demonstrates that the ultimate fate of DMMP hydrolysis at the Cs8[Nb6O19] cata

88 The ultimate fate of ER-entrapped MIDY mutants is unclear, b

89 reased sharply over the past decade, but the ultimate fate of those waste streams is poorly character

90 s arise and become differentiated, nor their ultimate fate within species.

91 to high levels within a generation, and the ultimate fixation of less-severe mutations that escape g

92 able in spectroscopy because they define the ultimate frequency precision that can be reached.

93 n dead patient whose 'phenotype' betrays the ultimate futility and lack of sustainability of the stat

94 e the view that stimulatory peptides are the ultimate gatekeepers of puberty.

95 tive electrodes (ISEs) that could become the ultimate, generally applicable SC, which in combination

96 ndings could be further developed toward the ultimate generation of therapeutic human HSCs.

97 d guide the reader to discover the patient's ultimate genetic diagnosis.

98 on of rigorous statistical methods, with the ultimate goal being the clinical treatment of epileptoge

99 An ultimate goal for those engaged in research to develop i

100 Although the ultimate goal has been to optimize sensitivity for detec

101 An ultimate goal in carbon nanoscience is to decipher forma

102 es using endogenous stem cells represents an ultimate goal in regenerative medicine.

103 ontoxic, tumor-specific immunotherapy is the ultimate goal in the battle against cancer, especially t

104 The ultimate goal is the tailoring of single atoms for elect

105 The ultimate goal is to develop a full-scale focal plane arr

106 Building on this foundational study, the ultimate goal is to exploit the capabilities of ODD for

107 Down the road, the ultimate goal is to have clinical noninvasive in vivo im

108 The ultimate goal is to link the understanding of protein in

109 The ultimate goal is to obtain a material with desired elast

110 t also for computational neuroscience, whose ultimate goal is to understand how cognition is implemen

111 The ultimate goal of a staging model has to be to inform the

112 lls can be recognized and targeted, with the ultimate goal of achieving an HIV-1 cure.

113 The ultimate goal of any experiment is to understand the bio

114 ronment of inquiry and scholarship, with the ultimate goal of better alignment between education and

115 e, and much effort has been made towards the ultimate goal of chirality-controlled growth of SWNTs.

116 f heterogeneous clinical syndromes, with the ultimate goal of defining therapeutically homogeneous pa

117 immune responses against FL cells, with the ultimate goal of designing novel patient-specific vaccin

118 This study represents the first step to the ultimate goal of developing a cost-effective manufacturi

119 locks to HIV-1 in common marmosets, with the ultimate goal of developing a new animal model of HIV-1

120 Studies that work towards the ultimate goal of developing highly efficient TE material

121 synthesis of two-dimensional diamond is the ultimate goal of diamond thin-film technology.

122 Yet, the ultimate goal of directly correlating the function of th

123 exity, from molecules to organisms, with the ultimate goal of establishing predictive understanding o

124 ultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity

125 that will be fundamental to overcome if the ultimate goal of fully personalised clinical cardiac car

126 , but also in humans in order to provide the ultimate goal of giving the right drug at the right dose

127 Realizing the ultimate goal of identifying genome-wide signatures that

128 With the ultimate goal of improving drought resistance in turfgra

129 ortant policy and research efforts, with the ultimate goal of improving outcomes for patients with ki

130 iations with BMT clinical outcomes given the ultimate goal of improving patient outcomes.

131 to identify ways to treat CSA in HF with the ultimate goal of improving patient quality of life and c

132 e underlying biological mechanisms, with the ultimate goal of informing evidence-based dietary recomm

133 The ultimate goal of most biomedical research is to gain gre

134 The ultimate goal of our work is to develop, a cationic amph

135 s of patient response to treatment, with the ultimate goal of personalising therapeutic intervention

136 The ultimate goal of precision medicine is to use population

137 The ultimate goal of RealityConvert is to facilitate and boo

138 ial chicken and turkey populations, with the ultimate goal of refining surveillance in these populati

139 eation of functional and robust genomes, the ultimate goal of synthetic biology.

140 The ultimate goal of this conceptual perspective is to outli

141 ication of leukemia stem cells (LSCs) is the ultimate goal of treating acute myeloid leukemia (AML).

142 The ultimate goal should be to prohibit or more closely regu

143 receptors in the calcium flux assay with the ultimate goal to generate selective 5-HT2C agonists.

144 ation of plant and microbial traits with the ultimate goal to reinstate beneficial associations that

145 broadly neutralizing antibodies remains the ultimate goal, to date, vaccines continue to fail to ind

146 ts will continue the journey to achieve this ultimate goal.

147 nt for the success of malaria elimination as ultimate goal.

148 ck and regeneration of pancreatic islets are ultimate goals for the complete cure of type 1 diabetes

149 Among the ultimate goals of protein physics, the complete, experim

150 One of the ultimate goals of regenerative medicine is the generatio

151 The ultimate goals of the consortium are two-fold: to develo

152 sharing, reproducibility, and reusability as ultimate goals.

153 Because clinical events serve as the ultimate gold standard, the future of all diagnostic tes

154 hese reports will serve as the basis for the ultimate guideline development process to be conducted b

155 that they were adjusted to provide the same ultimate hardness.

156 lly promising novel tuberculosis vaccines to ultimate human applications has been challenged by the l

157 inct developmental gene networks governs the ultimate identity of a cell, but the mechanisms involved

158 upt the functioning of boreal forests, their ultimate implications for forest composition are uncerta

159 rticle discusses mediation analysis with the ultimate intention of helping nutrition researchers to c

160 Progress on this issue will be an ultimate judge of sustainable development.

161 Here, we demonstrate that ultimate lateral confinement and delocalization of surfa

162 oplasmatron source, which resulted in higher ultimate lateral resolutions down to 37 nm and which pro

163 d the charge separation needed to access the ultimate length scales necessary for future electronic a

164 ing for flexible transparent electronics and ultimate length scaling.

165 hypothesis (IH) needs to be understood as an ultimate-level argument, although we welcome the various

166 Diffraction is the ultimate limit at which details of objects can be resolv

167 als design and molecular modelling, with the ultimate limit being a universal quantum computer that c

168 We characterize the ultimate limit of how much data can be reliably and cove

169 l that, through desktop parallelization, the ultimate limit of real-time processing is possible.

170 A decrease in film thickness to the ultimate limit of the atomic, sub-nanometre length scale

171 The single-atom bit represents the ultimate limit of the classical approach to high-density

172 al silicon-based electronics is reaching its ultimate limit, considerable effort has been devoted to

173 explain such high charging, and what is the ultimate limit?

174 Exploring the ultimate limits of the technology by experimental measur

175 es to improve replication fidelity, with the ultimate limits to what can be achieved set by the power

176 the experimental concrete samples under the ultimate load, and hence the effective crack length is c

177 , yield strain, yield load, ultimate strain, ultimate load, resilience, and toughness in both stance

178 d arginine could serve as good predictors of ultimate meat quality parameters, even though further st

179 Thus, understanding how diabetes alters the ultimate mechanical properties of healed wounds will be

180 ds in temperature variability may not be the ultimate mechanism underlying latitudinal and elevationa

181 al questions: (i) what are the proximate and ultimate mechanisms underlying age-related brain atrophy

182 zed by CYP9M10/CPR and CYP6AA7/CPR, with the ultimate metabolite identified here as PBCOOH, which is

183 as they interact strongly with light at the ultimate monolayer limit.

184 gested that a 'flat' competition between the ultimate motor actions might also explain these results.

185 Tooth loss is the ultimate negative consequence of periodontitis, and repo

186 emical potential, has been recognized as the ultimate negative electrode material for next-generation

187 , where they expand, before they reach their ultimate niche, the kidney marrow.

188 indicate that strength (defined here as the ultimate number of intracellular domain molecules reachi

189 The ultimate objective for these types of studies is predict

190 exploited challenges in their work, with the ultimate objective making chemistry more accessible for

191 The ultimate objective of this collaborative exchange is to

192 The ultimate outcome of alloreactivity versus tolerance foll

193 mical signatures related to the severity and ultimate outcome of the infection.

194 tations are reflected in the relatively poor ultimate outcomes of patients with MCL treated in the re

195 relying on green oxidants H2O2 and O2 as the ultimate oxygen source.

196 that their focus on "appraisal style" as the ultimate path to resilience may be too narrow.

197 st rates, limiting our ability to assess the ultimate performance and scalability of this technology.

198 The fundamental properties and ultimate performance limits of organolead trihalide MAPb

199 losses is critical to fully characterize the ultimate performance of Ag as a plasmonic material, and

200 However, the ultimate performance of graphene composites will depend,

201 provides a useful strategy for exploring the ultimate performance of organic solar cells.

202 ment systems should be designed based on the ultimate pharmaceutical concentration in ureolyzed urine

203 cornea arise from genetic defects where the ultimate phenotype can be influenced by cross talk betwe

204 the thickness of the diffraction mask to its ultimate physical limit, that is, the thickness of a sin

205 However, the ultimate physiological influence of manipulating a pepti

206 ntogeny, from newly formed B cells until the ultimate plasma cell stage.

207 Though the ultimate pMMO active oxidant is still debated, C-H oxida

208 dings set an upper bound on the accuracy and ultimate predictability of human choices in uncertain en

209 The fate of this peroxide dictates the ultimate product selectivity.

210 gy cascades, an essential step towards their ultimate programmability.

211 ssemblies modulate reaction kinetics and the ultimate propagation of signals.

212 However, the path from the CUL3 complex to ultimate proteasomal degradation was previously unknown.

213 onsidered the most distal stop and hence the ultimate protein-sorting station for distinct apical and

214 e nature of evidence in epidemiology and the ultimate purpose of epidemiologic inquiry.

215 adapts it to the microfluidic level for the ultimate purpose of total bilirubin quantitation.

216 novel targets for strain improvement in the ultimate quest to enhance plant productivity and agricul

217 se two-way assisted capacities represent the ultimate rates that are reachable without quantum repeat

218 reversal with one or more relapses, but with ultimate recovery (22.5%); and relapsing without recover

219 by the amount of oil produced, or estimated ultimate recovery (EUR); (4) estimating domestic water d

220 nction differ among patients with respect to ultimate recovery.

221 econd time scales and thus elucidating their ultimate relationship.

222 it has been challenging to disentangle their ultimate relationships.

223 studies have demonstrated that bats are the ultimate reservoir hosts for a number of coronaviruses (

224 treated breads differed widely in early and ultimate resilience, despite the fact that they were adj

225 ration of the optical-frequency axis with an ultimate resolution limited by the micro-resonator reson

226 improving host immunity may prove to be the ultimate resource.

227 sent useful molecular markers to predict the ultimate response of pituitary adenomas to BIM-23A760.

228 ter IC1, are early predictive biomarkers for ultimate response to subsequent chemoradiotherapy.

229 gen atom transfer, radical fluorination, and ultimate restoration of the enone.

230 ased on high-resolution density maps are the ultimate result of the cryo-EM structure determination p

231 nultimate rib-bearing level, rather than the ultimate rib-bearing level, as in most humans and extant

232 this transition, one segment cranial to the ultimate rib-bearing vertebra, also occurs in all other

233 roduction, are outlined to shed light on the ultimate role of artificial photosynthesis in achieving

234 pen questions in the signaling networks, the ultimate role of p21 in the p53-deficiency phenotype in

235 lm sub-5 nm magnetic skyrmions constitute an ultimate scaling alternative for future digital data sto

236 tate protein sorting to lysosomes to support ultimate secretion; (2) impaired secretion of alpha gran

237 Gain of HREs does not always provide an ultimate selective advantage for TEs, but may increase t

238 ues now elegantly twist the plot and achieve ultimate selectivity: They target MMP-9 by allostericall

239 The ultimate sensitivity achieved through examining the spec

240 rs at the single molecule level promises the ultimate sensitivity in clinical diagnosis.

241 uired for maximum enhancement as well as the ultimate sensitivity of the technique.

242 hanisms by which these factors determine the ultimate severity of ASD are still poorly understood.

243 We find that peatlands reach their ultimate shape first at the edges of peat domes where th

244 ilience either in situ (surface soils) or in ultimate sinks (marine sediments).

245 then through the anterior forebrain to their ultimate site of differentiation in the olfactory bulbs

246 d into the ice phase plays a key role in the ultimate size of the ice grains after recrystallization.

247 pin chains made of few magnetic ions are the ultimate-size structures that can be engineered to perfo

248 egardless of alginate fouling, suggesting an ultimate solution to eliminating the irreversible membra

249 is described in this study, has provided an ultimate solution to this intrinsic colloid formation di

250 Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why

251 The ultimate source of CF3 is the inexpensive industrial was

252 Carbon dioxide is the ultimate source of the fossil fuels that are both centra

253 oans in deriving additional ancestry from an ultimate source related to the hunter-gatherers of easte

254 is a critical requirement for achieving the ultimate spatio-temporal resolution with either method.

255 ty and physiological changes and what is the ultimate specificity of fMRI for functional mapping of m

256 essible by lasers and constitutes the key to ultimate-speed signal manipulation.

257 Ultimate speeds can be obtained by exploiting third-orde

258 ging, among other routes, with regard to the ultimate stability and environmental fate of surface fun

259 pecifies, under a given rainfall regime, the ultimate, stable morphology, and hence carbon storage, o

260 o be overcome for this technique to make the ultimate step from the academic world into forensic inst

261 The ultimate step in chloramphenicol (CAM) biosynthesis is a

262 The ultimate step in lysine biosynthesis, the NAD(+)-depende

263 e precursor suggests that CmlI catalyzes the ultimate step in the biosynthetic pathway and that the p

264 ate that this is caused by alteration of the ultimate step of cytokinesis, abscission.

265 se two materials significantly enhances both ultimate strain (250%), reversible rotation (9700 degree

266 reover, we observed a negative trend for the ultimate strain versus time, attesting a general decreme

267 l femur stiffness, yield strain, yield load, ultimate strain, ultimate load, resilience, and toughnes

268 GPa, versus ~30 GPa for human bone) and high ultimate strength (853 MPa) was fabricated.

269 biomaterials and textiles due to their high ultimate strength and stiffness resulting from a highly

270 their facile dispersion, these NTs, with an ultimate strength of about 20 GPa, are likely to find nu

271 (oim/+)sires had a 15% increase in torsional ultimate strength, a 29% increase in tensile strength, a

272 es in the mechanical properties of the silk (ultimate stress and strain, Young's modulus, toughness)

273 The ultimate success of any treatment may well rest on CSC e

274 There is growing recognition that the ultimate success of China's ambitious health reform (ena

275 The ultimate success of immunotherapy in the CNS will requir

276 However, the ultimate success of PrEP will depend on achieving sustai

277 sease phenotype between patients and predict ultimate success of TNF inhibitor therapy.

278 , maximizing cost-effectiveness, and raising ultimate success rates.

279 s, but may be an unreliable indicator of the ultimate survival and distribution of mobile stenotherma

280 ith tensile moduli of approximately 9.1 MPa, ultimate tensile strains of approximately 325%, compress

281 tensile load (+17%, P = 0.03 vs. RestTx) and ultimate tensile strength (+10%, P = 0.15 vs. RestTx).

282 gh yield strength (sigma y) of 1260 MPa, and ultimate tensile strength (sigma UTS) of 1400 MPa.

283 We present estimates of ultimate tensile strength (UTS) for two engineered beta-

284 dog-bone shaped specimens yielded an average ultimate tensile strength of 6.60 MPa and an average fai

285 An ultimate test of our understanding of E degrees ' is to

286 towards a parasitic lifestyle - will be our ultimate test of truly understanding the genetic and gen

287 eceptors will be critical to unlocking their ultimate therapeutic potential.

288 , two-dimensional materials, as an option of ultimate thin channels, receive wide attention.

289 The ultimate thinness of the vertical p-n homogeneous juncti

290 ents in bone anatomy, mobility patterns, and ultimate tooth survival)?

291 weathering stages that are important in the ultimate transformation of spilled crude oil.

292 e in the TIPS-Pn films greatly decreased the ultimate triplet diffusion length, suggesting that pure

293 ion is avoided--they might be considered the ultimate, uniform solids, without the microstructural fe

294 as the first evidence of replacement of the ultimate upper premolar and a unique paleopathological c

295 cell across the periarbuscular membrane for ultimate use by the fungus.

296 remain as two major challenges towards their ultimate utility, especially for highly reactive materia

297 te the ongoing collection of trial data, and ultimate validation of the guideline.

298 Stroke theranostics, the ultimate vision of synchronising tailored therapeutic st

299 TZD usage had no effect on the ultimate visual acuity outcome.

300 As graphene nanoribbons of ultimate width, they are valuable atom-precise model sys