ライフサイエンスコーパス: ultimately

1 Ultimately, 1466 women (61.6%) received BCS, 508 (21.2%)

2 Ultimately, 1783 consecutive patients were included in t

3 Thus, the mineralogy of the USDW is ultimately a determining factor of arsenic fate and tran

4 These results suggest that LDE is ultimately a limited strategy for improving de novo enzy

5 ltiple markers, population substructure, and ultimately a requirement for replication.

6 Ultimately, a molecular understanding of gut microbial x

7 Ultimately, a perspective on the potential and limitatio

8 Ultimately, a phase develops where ventricular dilation

9 Ultimately, a total of 57 articles with 4,651 patients e

10 itogen-activated protein kinases (MAPKs) are ultimately accomplished by the substrate proteins where

11 Gulf of Mexico (nGoM), settled rapidly, and ultimately accumulated in the sediments of the nGoM.

12 ng towards achieving 120 x 20 is crucial for ultimately achieving the Sustainable Development Goals o

13 in inducing podocyte SDF-1 production, which ultimately activates PECs.

14 These collective functions of SR-B1 ultimately affect programmed cell death, female fertilit

15 ulating endogenous DNA lesions and how these ultimately affect the physiology of cells and tissues.

16 most studies focusing on indirect evidences, ultimately affecting our interpretation on hominin terri

17 The Lancet Countdown ultimately aims to report annually on a series of indica

18 point clouds can efficiently be processed to ultimately allow accurate remote quantification of fores

19 al resolution in remote sensing of spins may ultimately allow the structural imaging of individual ma

20 d 2D NMR, we synthesized (13)C-enriched FEC, ultimately allowing a detailed structural assignment of

21 the beginning of a much longer process which ultimately allows cells to determine their light exposur

22 nced Hg deposition, reduced Hg emission and, ultimately, an increase in snowpack and snowmelt runoff

23 rucial for cilia structure and function and, ultimately, animal development.

24 ss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death.

25 their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and s

26 This first proof of concept may ultimately be applicable to geofencing other types of pr

27 tly, these ocean-wide migration patterns can ultimately be linked with breeding performance: colony p

28 Angiosperms may ultimately be recognized from Jurassic or earlier rocks,

29 the biological roles of this isozyme and may ultimately be useful for treating specific diseases in w

30 cult to realize any other way and that could ultimately be utilized for making a wide variety of devi

31 y tethering a region of the substrate, which ultimately becomes an extracellular loop, to the lumen o

32 more than four kilometres below the surface ultimately becomes an order of magnitude more energetic

33 ral circuits affect auditory processing and, ultimately, behavior.

34 Ultimately, bioremediation strategies, in the studies re

35 of individual subpopulations of neurons and ultimately brain circuits is largely unknown.

36 tine practice and whether MRD assessment can ultimately bring us closer to the goal of personalized l

37 This method could ultimately, by characterizing the tumor microenvironment

38 nce (learning) affects such decisions, which ultimately can impact plant fitness.

39 l cells triggers chronic inflammation, which ultimately, causes growth plate and epiphyseal dysplasia

40 APC-expanding autoreactive T cell responses ultimately causing type 1 diabetes (T1D).

41 tanding neuronal and retinal development and ultimately cell-transplant therapy.

42 by phosphorylation and ubiquitination, which ultimately change the cell surface accumulation of Smo.

43 ationships, the study of brain disease, and, ultimately, clinical applications of neuroimaging.

44 killed in increasing proportions over time, ultimately comprising a quarter of civilian deaths in 20

45 Ultimately, conserving many of these species necessitate

46 Chemical defense of nectar is, however, ultimately constrained by pollinator gustatory sensitivi

47 ally where arrhythmia risk is increased, and ultimately contribute to clinical management.

48 tory coding mechanisms of bed bugs that will ultimately contribute to the design and development of n

49 heating energy in a cost-effective way, and ultimately contribute to the relief of global energy and

50 Such differences may ultimately contribute to their unique behavioral profile

51 lism in a fashion that promotes survival and ultimately contributes to metastatic outgrowth.

52 n induces biochemical and molecular changes, ultimately contributing to retinal complications and vis

53 To understand and ultimately correct this deficiency, we quantified flavor

54 or-kappaB to the PTPRZ1 and Wnt8a promoters, ultimately decreasing Wnt/beta-catenin signaling activit

55 luate these potential applications, and will ultimately define the value of this terminology.

56 , thereby leading to auto-ubiquitination and ultimately degradation of the substrate recognition subu

57 rogenous nature of the soil environment, but ultimately demonstrates the maintenance of lineage-speci

58 retention and susceptibility to enemies may ultimately depend upon interactions among soil nutrients

59 xible membrane platform with dimensions that ultimately depend upon the target cargo.

60 isease processes, develop new therapies and, ultimately, design replacement tissues.

61 This cascade of events is ultimately detected with MRI using magnetic interaction

62 olution of a ptychographic reconstruction is ultimately determined by the diffraction limit for the w

63 erences between males and females, which are ultimately determined by the presence of an XX or XY sex

64 egulating the membrane sorting decision that ultimately determines the number of AMPARs on the cell s

65 , setting the ratio of alternative fates and ultimately determining color preference.

66 additive effects that herbivory will have on ultimately determining seedling success.

67 itude of acute T-cell responses, the patient ultimately developed long-term, polyfunctional memory T-

68 Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro.

69 nutrient availability during host infection, ultimately disseminating to colonize the purine-poor cen

70 time, with SVLPs present in such structures ultimately dominating.

71 by afferent light signals in the optic nerve ultimately drive iris-sphincter-muscle contraction via e

72 eakdown in the abyssal ocean, but a residual ultimately drives diverse assemblages of seafloor hetero

73 onse to the 2014-15 Ebola epidemic, although ultimately effective, was slow and expensive.

74 n unusually slow ( approximately 400 ps) but ultimately efficient charge generation mediated by inter

75 ired to understand normal cell function, and ultimately, elucidate the mechanism of disease.

76 Such regenerative strategies may ultimately enable the thymus to play as prominent a role

77 from vapor on real surfaces, where this will ultimately enable us to use topography to control crysta

78 ncer patients with oncogene-targeted therapy ultimately enables the emergence of drug-resistant clone

79 ctivity could be improved through evolution, ultimately enabling the synthesis of complete DNA genome

80 reincorporated into phosphatidylcholine, and ultimately enter seed triacylglycerol.

81 d their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG

82 in the center-surround pRF configuration and ultimately explain the range of visual deficits experien

83 r patient care, enhanced patient safety, and ultimately facilitate a more predictable, optimal treatm

84 High-temperature treatment ultimately facilitates the structural evolution of the k

85 Ultimately, FCIC studies do not provide robust measures

86 rmo-reception, acting as a thermo-opsin that ultimately feeds the local circadian clock in mouse mela

87 is important for blood vessel function and, ultimately, for organ homeostasis.

88 tails that participate in a homology search, ultimately forming double Holliday junctions (dHJs) that

89 radiation therapy and surgery subgroups, but ultimately found that a staging system consisting of sta

90 ty in the regulation of gene expression, and ultimately function.

91 generate cargo-laden transport carriers that ultimately fuse with an adjacent ER-Golgi intermediate c

92 become increasingly acidic and proteolytic, ultimately fusing with lysosomes, in a process termed "p

93 urnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma

94 specific consequences for the machinery that ultimately governs copper homeostasis, and further estab

95 uence cellular activity in growing bones and ultimately gross limb morphology, to generate phenotypic

96 d for research focused on understanding and, ultimately, halting transmission.

97 ging modalities are imperfect, and some will ultimately have no HCC on explant.

98 While the wounds were ultimately healed in all mice, histological analysis rev

99 e during seizures, PV+ and SOM+ interneurons ultimately help maintain ongoing seizures.

100 by constriction of the nascent bud neck and ultimately ILV generation by vesicle fission.

101 Such changes will in turn ultimately impact commercial fisheries' economic value.

102 mit the design of cellular assays, which can ultimately impact disparities in healthcare that exist i

103 compact inexpensive light source, which can ultimately impact many fields of science and engineering

104 ads to reduced control of energy metabolism, ultimately impacting mitochondrial membrane potential.

105 ighlighting new therapeutic opportunities to ultimately improve long-term lung transplant outcome.

106 more accurate arrival-time picking that will ultimately improve the localization accuracy.

107 AR research and (2) developing, testing, and ultimately improving drugs targeting AR.

108 ty turnover to local, species-level effects, ultimately improving our understanding of spatial commun

109 hetic devices to enhance their control, thus ultimately improving the amputees' quality of life.

110 Ultimately, in the face of a global environment marked b

111 M, regardless of whether ecosystem wealth is ultimately included in a broader wealth index.

112 l as degrade the host mucosa, processes that ultimately increase susceptibility to infections and con

113 mbrane can initiate a signaling pathway that ultimately increases nuclear CREB phosphorylation and, i

114 quality into these complex cellular systems, ultimately increasing patient access to living therapeut

115 high-grade gliomas eventually recur and are ultimately incurable.

116 activated DNA-damage-response signaling, and ultimately induced apoptosis.

117 tory perception and dietary preferences that ultimately influence human health and disease.

118 to the 5' end of the nascent U1 snRNA, which ultimately influences the utilization of U1 snRNP in spl

119 rupting faithful mitotic progression and may ultimately inform the design of therapies for a broad ra

120 dulate the magnitude of neuronal output and, ultimately, information processing.

121 acylation of ketones via C-C bond activation ultimately informed our choice to pursue and develop the

122 id ((M)MPA) product to the polyanions, which ultimately inhibits catalytic turnover.

123 se transcribed into double-stranded DNA that ultimately integrates into the host-cell genome to estab

124 ad to other individuals in the community and ultimately into the population.

125 -group necessarily leads to parochialism and ultimately is detrimental to global cooperation.

126 Ultimately, it is even possible to determine protein num

127 uency in the coming century - can stress and ultimately kill native coldwater fish in lakes where the

128 the United States, and 95% of food waste is ultimately landfilled.

129 the autophagy machinery to the phagosome and ultimately LC3 conjugation.

130 se following treatment interruption does not ultimately lead to better viral containment.

131 al control over the SP conformation that may ultimately lead to biological functions.

132 f downstream Ras family small GTPases, which ultimately lead to ERK, JNK, and p38 phosphorylation.

133 ypertrophy and fibrosis development that can ultimately lead to heart failure and arrhythmias.

134 pathological remodeling response, which can ultimately lead to heart failure.

135 utcomes impairing tissue function, which can ultimately lead to organ failure and death.

136 igger for the resultant cellular events that ultimately lead to photoreceptor death.

137 ore and identifiable chemical reactions that ultimately lead to switching between on and off states.

138 ver, it is unknown how downstream events can ultimately lead to T cell activation.

139 dles in the microscale which we predict will ultimately lead to the design of truly tailorable carbon

140 t reflect the series of cleavage events that ultimately lead to the fully active, substrate-bound sta

141 rity by forming membrane-spanning pores that ultimately lead to their death.

142 oth antigen presentation and T cell priming, ultimately leading to allograft rejection.

143 thrive, dilated cardiomyopathy and epilepsy, ultimately leading to death in early childhood.

144 cation end products (RAGE) on Kupffer cells, ultimately leading to increased thrombopoietin (TPO) pro

145 in complex 1 (mTORC1) and activation of Akt, ultimately leading to increases in autophagy enzyme prod

146 zation and phosphorylation during metaphase, ultimately leading to mitotic catastrophe, multinucleati

147 euronal oxidative stress and synapse damage, ultimately leading to neurodegeneration and memory impai

148 can profoundly affect food reward behavior, ultimately leading to obesity.

149 sible for both a carbon and an energy crisis ultimately leading to plant death.

150 n, and a rapid disorganization of RPE cells, ultimately leading to retinal degeneration.

151 lease by the relevant mechanistic processes, ultimately leading to the development of mechanism based

152 crystals during the rolling circle process, ultimately leading to the direct immobilization of prote

153 cally active complexes on the exposed lipid, ultimately leading to the formation of fibrin.

154 ity within confined regions of the membrane, ultimately leading to the formation of water-permeable p

155 s driven by a systematic mutational bias and ultimately leads to an unusual level of microstructural

156 responses to hypercarbia and hypoxia, which ultimately leads to asphyxia.

157 ication, accumulates genomic instability and ultimately leads to cell death.

158 hey cause extensive neurodegeneration, which ultimately leads to death.

159 ell as improvements in face recognition, and ultimately leads to differentiated tissue properties bet

160 jury causes irreversible loss of neurons and ultimately leads to permanent visual impairment and blin

161 in BTN3A1 is a key event of pAg sensing that ultimately leads to T cell activation.

162 s on signaling within the synergid cell that ultimately leads to the degeneration of the receptive sy

163 PPR wetlands biogeochemical hotspots, which ultimately leads to their critical, but poorly recognize

164 ally small adverse effects on consumers, but ultimately led to population extinction and loss of ecos

165 ed program in these neonatal iNKT cells that ultimately led to their malignant transformation.

166 tes a series of intracellular responses that ultimately limit bacterial growth.

167 ons or complex chemical manipulations, which ultimately limit functional group compatibility and broa

168 tolerated and initially efficacious but were ultimately limited by their immunogenicity.

169 educed tumor invasiveness and size, but were ultimately limited in reducing tumor size because GECs m

170 protective response to mutant rhodopsin that ultimately limits photoreceptor cell death.

171 ermal conductivity of the surface structures ultimately limits the CHF; and a maximum CHF of 7-8 kW/c

172 but how these properties can be accessed and ultimately manipulated in real time is not well understo

173 vided agriculture with reactive nitrogen and ultimately mankind with nourishment for a population of

174 n epithelial or dendritic cells by HDMs that ultimately mediates said innate and adaptive allergic re

175 otional, more intense, more interesting, and ultimately more rewarding.

176 We report ion transport through ultimately narrow slits that are fabricated by effective

177 unctions in stem cell niche organization and ultimately neuroblast migration in the anterior forebrai

178 ulators of persistent pain in EAE, which may ultimately offer new therapeutic targets for mitigating

179 further elucidate this disease, which could ultimately offer precious insights for immunotherapeutic

180 OVOC and SOA burdens in the atmosphere, and ultimately on climate.

181 life, as online security and privacy depend ultimately on the quality of random numbers.

182 the progress of both organelle expansion and ultimately organelle closure around a particular cargo.

183 Throughout animals, embryonic cells must ultimately organize into polarized epithelial layers tha

184 Ultimately, our results are consistent with the social t

185 Ultimately, our work demonstrates proof-of-concept that

186 Ultimately, our work informs future studies about functi

187 Ultimately, people with SMI can be transinstitutionalise

188 on of proinflammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregn

189 orylation, visual chromophore recycling, and ultimately photoreceptor dark adaptation.

190 eterogeneous environmental viscosity and may ultimately play a role in surface-sensing during swarmin

191 mine pollinator abundance and diversity, and ultimately pollination services.

192 s with endometrial carcinoma progression and ultimately poor survival from disease.

193 nt in the pores will be driven to adsorb and ultimately precipitate on solid surfaces.

194 he case of palmitate, its accelerated uptake ultimately precipitates into cardiac insulin resistance

195 cancer biology, bioinformatics analyses, and ultimately precision medicine.

196 Understanding and ultimately predicting these conformational preferences w

197 ericans and potential interventions that may ultimately prevent myopia-related disease.

198 fically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation wit

199 ape, storing and processing information, and ultimately probing and controlling behaviour at the quan

200 ains challenging to treat, and most patients ultimately progress on therapy.

201 ould lead to an expanded B1 cell subset and, ultimately, progression to CLL.

202 LRRK2 ultimately promoted 6-OHDA-induced cell death via positi

203 ing, stabilizes protofilament curvature, and ultimately promotes microtubule disassembly.

204 ions in a concentration-dependent manner and ultimately promotes outer coat dissociation.

205 Ultimately, prospective, long-term outcome studies focus

206 ant traits are coordinated or decoupled will ultimately provide a powerful tool for modeling plant fo

207 Such characterizations may ultimately provide insight and differences between long-

208 constants (KM) for different substrates and ultimately provides a means to quantify the linkage (i.e

209 Forest wood products that ultimately reach landfill, and some portion of which pro

210 the release of organic wastes, some of which ultimately reaches the underlying sediments.

211 its odds of a chance collision with prey and ultimately reducing BV's search space for prey.

212 repressed LEF1 protein and mRNA expression, ultimately reducing LEF1 transcriptional activity, as ju

213 These findings suggest that inner speech may ultimately reflect a special type of overt speech.

214 the receptor in different nuclear reservoirs ultimately regulates the concentration of receptor avail

215 llograft models were sensitive to HDM201 but ultimately relapsed under treatment.

216 es that sequester misfolded proteins and are ultimately removed by autophagy.

217 of viral genomic material, so the virus can ultimately reproduce and spread.

218 the prospects for HSC rejuvenation therefore ultimately requires approaching those HSCs that are func

219 omonas leads to progressive lung destruction ultimately requiring lung transplantation (LT).

220 inflammatory mediators from microglia cells, ultimately rescuing neurons from death.

221 lung compliance, disrupted gas exchange, and ultimately respiratory failure and death.

222 g is prerequisite for developmental programs ultimately responsible for the appropriate long-range AM

223 utations and alteration of stress responses, ultimately restoring normal ATP production, macromolecul

224 evate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males a

225 and macroscale (through colloidal assembly), ultimately resulting in a controllable photonic lattice

226 ycolytic flux, Nrf-2 and glutathione levels, ultimately resulting in caspase-3 activation and apoptos

227 events between host and microbe are complex, ultimately resulting in clearance of the microbe, stable

228 ndothelial selectins and adhesion molecules, ultimately resulting in increased monocyte recruitment t

229 y glycogen synthase kinase 3beta (GSK3beta), ultimately resulting in increases in USP48 DUB activity.

230 ventricular filling and pulmonary perfusion, ultimately resulting in right ventricular failure and di

231 tropic and metabotropic glutamate receptors, ultimately resulting in synaptic dysfunction and loss.

232 itment of DNA methyltransferase 3a (DNMT3a), ultimately resulting in the transcriptional and epigenet

233 anomalous state of condensed chromatin that ultimately results in apoptosis.

234 gamma signaling to mediate protection, which ultimately results in recruitment of neutrophils to furt

235 Ultimately, results suggest favorable scaling of emissio

236 ts in whom a diagnosis of current asthma was ultimately ruled out were followed up clinically with re

237 e efficient drug design and development, and ultimately safer and more effective therapies for tuberc

238 aches are tackling these challenges and will ultimately serve as an engine for biological discovery a

239 basic neuroscience to better health and will ultimately serve both basic and applied goals.

240 We report the creation of an ultimately-shallow junction at the surface of n-type sil

241 nsitivity and average competitive ability-to ultimately shape biomass production, respiration, and ca

242 , influences learning opportunities [5], and ultimately shapes one's developmental path.

243 oxical findings can be reconciled and how GR ultimately shifts the balance to a net anti-inflammatory

244 nforcing loop, to provide the structure that ultimately specifies the translation of each ORF.

245 ment accuracy, automated data filtering, and ultimately statistical power for detection of metabolite

246 e to and where in the Earth hydrocarbons are ultimately stored.

247 rm, where all embryo-nourishing reserves are ultimately stored.

248 rol ubiquitin ligase assembly, function, and ultimately substrate degradation.

249 d so that these KPD innovations programs are ultimately successful.

250 es that underpin ideologies and actions that ultimately sustain group-based hierarchy.

251 Ultimately, symbiosis can lead to symbiogenesis, or spec

252 te metabolism in neurons and astrocytes, and ultimately synaptic plasticity loss evident by a decreas

253 artment to increase ERK1/2 activation, which ultimately targets Myrf, as well as converges with the P

254 ondary infections, symbiont interactions and ultimately the magnitude of parasite epidemics.

255 Ultimately the model provides a platform for future deve

256 macroscopic failures of tissues, organs and ultimately the organism.

257 Animal behavior is ultimately the product of gene regulatory networks (GRNs

258 the nature of the cancer-initiating cell and ultimately the resulting tumour phenotype.

259 ts in asymmetrical membrane protrusions and, ultimately, the closure of the aperture.

260 Ultimately, the compatibility of this implementation wit

261 Ultimately, the developed strategy allows the rapid gene

262 icking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis.

263 Ultimately, the limits of detection were reduced to leve

264 Ultimately, the nanoscale droplets flatten out to form l

265 nse affects downstream immune functions and, ultimately, the outcome of infectious or malignant disea

266 or image acquisition and interpretation, and ultimately their professional satisfaction.

267 d regulate the output to motor neurons (MN); ultimately these drive contraction of the tail and limb

268 Ultimately, these classification systems should be unifi

269 Ultimately, these comparisons will help to identify the

270 Ultimately, these results highlight the variability of e

271 Ultimately, this approach to in vivo Treg induction coul

272 munity structure and adaptive evolution, and ultimately through large-scale alterations of the ocean'

273 the BNC or toward a proton loading site (and ultimately through the membrane) must be highly regulate

274 tropical peat swamps, although this can lead ultimately to a shift to ombrotrophy and a subsequent re

275 anslatable to in vivo studies on animals and ultimately to clinical applications.

276 nd pave the way to clinical approaches aimed ultimately to halt metastasis.

277 ion from CHB to HBV-associated cirrhosis and ultimately to HBV-associated HCC.

278 w will be paramount if Precision Oncology is ultimately to lead to clinical benefits.

279 ter cell formation and drug resistance leads ultimately to mycobacterial cell death.

280 ve terminals leads to synaptic pathology and ultimately to neurodegeneration.

281 esponse and the amino acid response, leading ultimately to nutrient starvation and GIC cell death.

282 veness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients.

283 pression of interferon stimulated genes, and ultimately to the anti-viral and anti-proliferative prop

284 These results lead ultimately to the design of a new protocol in which an a

285 es and single cells at the micro scale, and, ultimately, to characterizing samples with subdiffractio

286 Hmgb1-associated histone modifications and, ultimately, transactivation of inflammatory genes in mou

287 iciently controlled, enaminochromanones were ultimately transformed into a more complex family of pol

288 hat in both settings inorganic Hg, which was ultimately transformed to monomethylmercury (MeHg) and b

289 ertrophy, a thick-walled left ventricle (LV) ultimately transitions to a dilated cardiomyopathy.

290 It is ultimately unclear whether plants produce fine roots of

291 robe will become important for analyzing and ultimately understanding lipid signaling events in a com

292 Ultimately, understanding how various ubiquitin interact

293 disease-resistant cell populations, that may ultimately unveil novel therapeutic approaches.

294 Ultimately, use of humanized mice may lead to the implem

295 affect UV-induced DNA damage and repair and ultimately UV carcinogenesis.

296 If ultimately validated as a prognostic biomarker, urinary

297 He ultimately was extubated and discharged home.

298 Ultimately, we believe that, although methods need to im

299 Ultimately, we encourage the careful application of SAOM

300 water homeostasis, pathogen resistance, and ultimately yield.