ライフサイエンスコーパス: umpolung

1 e pivotal intermediates in carbene-catalyzed umpolung.

2 developed using a phosphine-catalyzed tandem umpolung addition and intramolecular cyclization of amid

3 chiral N-heterocyclic carbene catalyzes the umpolung addition of aldehydes to racemic alpha-keto est

4 eocyclic carbene catalyzes the a(3) --> d(3)-umpolung addition of alpha,beta-enals to racemic alpha-k

5 ntermediate provides evidence for an unusual umpolung addition of glyoxylates to nitrosobenzenes with

6 The coupling occurs through umpolung addition of organometallic reagents to the nitr

7 The first umpolung addition/intramolecular Wittig reaction, cataly

8 riazolyl N-heterocyclic carbene catalysts in umpolung aldehyde chemistry requires a straightforward r

9 he mechanism of the former is a tandem gamma-umpolung/aldol/Wittig/dehydration process, as establishe

10 a hindered, quaternary stereocenter using an umpolung allylation are also highlights from a strategy

11 nitromethane to aldehydes and finishing with Umpolung Amide Synthesis (UmAS).

12 amides in peptides by simply performing the umpolung amide synthesis reaction under an atmosphere of

13 The mechanism of umpolung amide synthesis was probed by interrogating pot

14 ering a didactic overview of organocatalytic umpolung and should serve as an inspiration for further

15 ssistance of C-C bond formation (i.e., "LUMO umpolung") and crossover from a diradical to a zwitterio

16 The cooperative umpolung annulation eliminates mutual deactivation and l

17 This umpolung approach allows for the construction of optical

18 s via in situ-derived azoalkenes provides an umpolung approach to ketone alpha-alkylation that has co

19 In this study, we outline an umpolung approach, which is triggered by oxidative initi

20 ex molecules primarily by polarity reversal (umpolung) approaches.

21 utility, under mild conditions; indeed, the umpolung borylation of a tertiary alkyl bromide can be a

22 These methods provide the first umpolung C-H functionalization of azapentadienyl palladi

23 N-Heterocyclic carbenes (NHCs) catalyze Umpolung condensation reactions of carbonyl compounds, i

24 carbene capable of promoting intermolecular Umpolung condensation through proton transfer and procee

25 )-mediated reduction of amides and reductive umpolung cyclizations via aminoketyl radicals as a key s

26 s of the two reactants are reversed (German, umpolung) during carbon-nitrogen bond formation relative

27 Organolithiums add in an umpolung fashion to the beta-carbon of N-carbamoyl enami

28 allyl, alkynyl, and heteroaryl groups in an umpolung fashion.

29 show that this central linkage undergoes an umpolung from Te-->Pt in [1](+) to Te<--Pt in 2.

30 Leveraging a unique "Umpolung"-mediated beta-protonation, this process has ev

31 ypically employed in the generation of these Umpolung nucleophiles.

32 clic guanidines through iodine(III)-mediated umpolung of halide salts is described.

33 e beta-C-H halogenation of cyclic enones via umpolung of the beta-carbon.

34 ansfer upon photoexcitation, but results in "umpolung" or a reversal of the predicted charge-separati

35 Umpolung (polarity reversal) strategies of aldehydes and

36 This umpolung reaction allows for an unconventional preparati

37 ective and enantioselective C-C bond-forming umpolung reaction of imines and enones under the catalys

38 Enabled by this unprecedented umpolung reaction of imines, conceptually new and concis

39 the gas phase acidity and selectivity in two Umpolung reactions catalyzed by these species; such corr

40 The development of asymmetric umpolung reactions of imines (in which the imines act as

41 that promote the highly efficient asymmetric umpolung reactions of imines with the carbon electrophil

42 These umpolung reactions provide a conceptually new and practi

43 cycloisomerizations, formal cycloadditions, umpolung reactions, rearrangements and ring-opening lact

44 This umpolung signals an increase in the electron releasing a

45 We find that the first Umpolung step, the addition of the NHC catalyst to a car

46 The umpolung strategy encompasses all the methods that make

47 Herein we report an umpolung strategy for the bioconjugation of selenocystei

48 ion of the alkyl group, in contrast with the umpolung strategy for this bond construction (cross-coup

49 iphosphate formation be carried out using an umpolung strategy in which pyrophosphate was activated t

50 Here we describe how an umpolung strategy that involves the addition of Grignard

51 The current strategy represents an umpolung strategy when compared to the literature approa

52 The use of this umpolung synthon has enabled, in enantiomerically enrich

53 ide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Bo

54 ide (MAC) reagents are shown to be effective umpolung synthons for enantioselective Michael addition

55 Aryl acetonitrile derivatives are thus umpolung-type synthons of the corresponding aryl carbony

56 se transformations employ typical as well as Umpolung types of bond disconnections and have served as

57 amide carbonyl functionality and subsequent umpolung via N-oxide addition generates an electrophilic

58 Through polarity reversal, or "umpolung", we show here that typical nucleophiles, such

59 se dimerization events represent an affinity umpolung, wherein the inversion in electronic affinity r