ライフサイエンスコーパス: unable

1 ing the function of the biological lens, are unable as yet to provide such an implant with the requis

2 A total of 75 patients were unable or refused to participate and were excluded; the

3 nts with HG NMIBC after BCG therapy who were unable or unwilling to undergo radical cystectomy.

4 Moreover, these methods are unable to accommodate complex designs.

5 ential and hyperbolic discounting models are unable to account for the attraction effect, recently pr

6 rations of androgenic compounds were largely unable to account for the in vitro activity.

7 We show that Ift56(hop) cilia are unable to accumulate Gli proteins efficiently, resulting

8 e nonfunctional, and therefore mature HMR is unable to accumulate in either plastids or the nucleus.

9 Strikingly, core IFTB proteins are unable to accumulate normally within Ift56(hop) cilia, i

10 DIACYLGLYCEROL ACYLTRANSFERASE1 (PDAT1) were unable to accumulate TAGs after heat stress, phosphatidy

11 cies, possibly because genotypes 3 and 4 are unable to achieve the same fitness due to repeated host

12 In conclusion, we were unable to acquire the GDM phenotype in any of our experi

13 Despite being unable to activate the cognate ghrelin receptor (GHS-R),

14 TEADs are unable to activate transcription and require the help of

15 dyshomeostasis develops when beta-cells are unable to adapt to peripheral insulin demands.

16 ding site either result in the protein being unable to adopt outward-facing conformations or in a glo

17 21 days; the same number of free islets was unable to affect glucose levels.

18 (1.13, 1.00-1.28; p=0.0562) than were those unable to afford the medicines.

19 The proportion of households unable to afford two blood pressure-lowering medicines w

20 We were unable to ascertain avoidance responses in fathead minno

21 throughout the genome yields an RNA that is unable to assemble efficiently.

22 We were unable to assess possible episodes of remission and rela

23 We were unable to assess the effect of human donor milk as use w

24 Mutation rates were unable to be determined because the branching order in t

25 had neutralizing antibodies to a flavivirus (unable to be identified), and one sample each was confir

26 ar Th, and CTL functionalities, yet they are unable to be infected by SIV.

27 DMACl surface species were unable to be measured after multiple ALD cycles as a res

28 ge to allow unrelated interventions that are unable to be performed because of weight limits (ie, ort

29 lasmacytoma, provided that whole-body MRI is unable to be performed, and to distinguish between smoul

30 ing long-term oral steroids and participants unable to be tested using spirometry were excluded.

31 tructural modification resulted in a protein unable to bind IgE from allergic patients.

32 is phosphorylated at Cyclin B/CDK1sites and unable to bind PNG and PLU.

33 brosis, a 3-amino acid point mutant that was unable to bind pSMAD3 proved ineffective.

34 PRP19 mutants unable to bind RPA or lacking ubiquitin ligase activity

35 However, these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 co

36 mutant associated with only a subset and was unable to bind to E1.

37 AP lacking gp226 is catalytically active but unable to bind to promoter DNA.

38 ounteract interferon (IFN) responses but was unable to block general gene expression in human or cani

39 cause available structural methods have been unable to capture microtubule-bound intermediates of thi

40 Models were also unable to capture observed treatment effects on phenolog

41 Notably, ID-causing TRMT1 variants are unable to catalyze the formation of m2,2G due to defects

42 e oxygen species (ROS) during the day and is unable to clear it during the night.

43 Current approaches are unable to clear the virus despite decades of therapy due

44 in encoded by the gene lpdG Although we were unable to co-crystallize LpdG with an endogenous phenazi

45 We are unable to comment on long-term antibody sensitisation ef

46 who needed urgent medical attention or were unable to communicate clearly were not eligible.

47 l treatment or inpatient admission, who were unable to communicate clearly, and who were intoxicated

48 cancer cell lines to EGFR blockade, they are unable to compensate for inhibition of PI3K signaling in

49 and missing data from participants who were unable to complete all study visits.

50 ular chains, illustrative of cells that were unable to complete division.

51 Laboratory results showed that BPH was unable to complete its life cycle on L. sayanuka, and N.

52 uterine fibroids and/or adenomyosis who were unable to conceive.

53 However, the study was unable to conclude that the success rate with donor corn

54 TR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior.

55 We were unable to confirm whether the increase in rates of treat

56 dental pulp cells; however, these cells are unable to contribute to the formation of pulp cells or o

57 ers (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genet

58 rials are increasingly important, yet we are unable to control how they stretch with much more sophis

59 lture model, CLDN4-deficient astrocytes were unable to control lymphocyte segregation.

60 cquired an ILC1-like gene signature and were unable to control tumor metastasis or viral infection.

61 nal assembly of the outer kinetochore but is unable to correct errors in kinetochore-microtubule atta

62 th an impaired telomerase holoenzyme that is unable to correctly assemble with its nucleic acid subst

63 and authentic samples but the assessors were unable to correctly identify the counterfeited product i

64 contrast to complex plant meristems, we were unable to correlate the plant morphogen auxin with bud p

65 ficient in steady-state conditions but it is unable to cover further needs.

66 s during the beam-walking challenge and were unable to cross the beam.

67 er antibiotics that ancestral TEM-1 had been unable to deactivate.

68 ever, plaque progression renders macrophages unable to degrade exogenous atherogenic material and end

69 Mammalian macrophages that are unable to degrade internalized bacteria also exhibit com

70 anced gate-to-channel capacitive coupling is unable to deliver high-performance device behavior.

71 If bystanders are unwilling or unable to deliver rescue breaths, we recommend that resc

72 However, we have been unable to demonstrate this dissociation when we added ch

73 ys in global analysis means the technique is unable to describe dynamic motion, a process which is re

74 We were unable to detect any impact of the UAV on breeding succe

75 We were unable to detect EBV-2 in T-cell samples from mothers bu

76 these clusters are either limited in scope, unable to detect relationships beyond motif similarity,

77 nd fluorescent microscopy methods were found unable to detect the cell differentiation at the same ti

78 hy and steatohepatitis, and adjudication was unable to determine the cause of death.

79 Therefore, the USPSTF was unable to determine the magnitude of the benefits or har

80 il of the chemokine receptor CXCR4, but were unable to determine which specific residues were phospho

81 spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to by

82 oprotein, which are limited in that they are unable to differentiate by species and require an additi

83 t pathogenicity of nsSNVs; however, they are unable to differentiate heterozygous, dominant disease-c

84 orescent protein tags, researchers have been unable to directly assess VF dynamics from virus-produce

85 Although unable to discriminate between anaphylaxis and cardiovas

86 uitiveness, the traditional sequence logo is unable to display the intra-motif dependencies and there

87 This coincides with M.tb DK9897 being unable to disrupt the phagosome membrane and make contac

88 Currently available tests are unable to distinguish between asymptomatic sensitization

89 ults show that newly sighted individuals are unable to distinguish between faces and nonfaces immedia

90 omplicated by cross reactivity and therefore unable to distinguish Zika from Dengue infection in the

91 ork to coordinate cognitive activity, but is unable to do so at tonically elevated noradrenergic leve

92 noid directly from membranes, while HCPs are unable to do so.

93 pecific epitopes, whereas a post-fusion F is unable to do so.

94 donation, many who wish to donate are still unable to do so.

95 sphate (ATP)-degrading ecto-enzyme CD39 were unable to do so.

96 We were unable to draw any conclusions on the cost-effectiveness

97 f magnitude; the beating flagellum is simply unable to draw enough water through the fine filter.

98 vious research has shown that residents were unable to effectively challenge a superior's wrong decis

99 phenotypes, but approaches to date have been unable to efficiently link the effects of mutations in c

100 Finally, Glc-bleached SSB01 cells appeared unable to efficiently populate anemone larvae.

101 2 vaccine strain, which has been shown to be unable to enter into neurons and establish latency in mi

102 not expressed at the plasma membrane and is unable to entrap virions, activated NF-kappaB in concert

103 -amino terminal splice variant of PTEN, were unable to eradicate Pseudomonas aeruginosa from the airw

104 rain, USA300 also seems to have been largely unable to establish itself as an endemic infection in ot

105 However, data are limited, and we were unable to estimate NDI after GBS sepsis.

106 Many AF cohort studies did not or were unable to examine racial differences.

107 e limitation of our analyses is that we were unable to examine the characteristics of cases that were

108 We are unable to exclude confounding due to other events occurr

109 nt model of radical-pair magnetoreception is unable to explain the findings of the reported behaviora

110 f extreme droughts in South America, but are unable to explain the severity of the 2016 observed rain

111 Although unable to express CD80 and CD86 in response to stimulati

112 iple behavioral analysis approaches, we were unable to extend these findings to normal mice observing

113 ole fungicides may put bees at risk of being unable to extract sufficient energy from their natural f

114 me c pathway in both strains, the mutant was unable to fine-tune the expression and activity of oxida

115 d on distant cytotoxic log-kill effects were unable to fit the data.

116 ble sitA mntH mutant of R. leguminosarum was unable to fix nitrogen (Fix(-) ) with legumes belonging

117 blished human CPVT mutant RyR2(R4497C), were unable to follow 3.7 Hz pacing, with progressive defects

118 hose enrolled within the previous fortnight, unable to follow-up, or having psychiatric illness, neut

119 with the shRNA targeting IGF-1 receptor were unable to form an axon and, therefore, neuron polarity w

120 t evidence that neurons exposed to Abeta are unable to form new synapses, resulting in learning defic

121 ssess unusual blunt-ended telomeres that are unable to form t-loops or complex with single-strand DNA

122 In this location, the alphaC fragment is unable to form the conserved catalytic interface that wa

123 , overexpression of the wild-type PRKACA was unable to fully recapitulate the oncogenic activity of D

124 We found that a slicing-defective AGO4 was unable to fully recover AGO4-dependent het-siRNA accumul

125 lly distinct classes of E3s, the E2 UBCH7 is unable to function with really interesting new gene (RIN

126 ously in L. major, but unexpectedly, we were unable to generate fkp40(-)/afkp80(-) double mutants, un

127 nic HDC-deficient L. reuteri mutant that was unable to generate histamine did not suppress carcinogen

128 simply need less sleep, or rather, are they unable to generate the sleep that they still need?

129 nding was measurably weaker when motors were unable to generate torque.

130 ta-lacking cancer cells, which are otherwise unable to generate tumors after independently seeding th

131 of patients, the physicians were unsure and unable to give advice before 70-GS testing.

132 In contrast, hippocampal patients were unable to grasp the higher-order structure of the task w

133 cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted

134 ts in hem1Delta abc3Delta mutant cells being unable to grow in the presence of hemin as the sole iron

135 agos tortoises on Santa Cruz Island would be unable to grow to their enormous sizes without access to

136 ow that cells lacking both SCAR and WASP are unable to grow, make pseudopods or, unexpectedly, migrat

137 ear because conventional imaging methods are unable to guide management of therapies in specific hipp

138 nophosphate-hydrolyzing lactonase SsoPox are unable to hydrolyze bulkyorganophosphates with challengi

139 this discovery remained unclear, as we were unable to identify a functional adenylate cyclase in S.

140 However, we were unable to identify evidence for an association between A

141 ma (MCL) remains incurable, and we are still unable to identify patients who will not benefit from th

142 Although we are still unable to identify the cause of CHD for most patients, r

143 Previous studies have been unable to identify the full spectrum of driver genes and

144 ciated virus (AAV) into FKRP mutant mice was unable to improve dystrophic phenotypes, both histologic

145 However, prednisolone treatment was unable to improve the myogenesis of stem cells and reduc

146 using a COX2-knock-out mouse where pFUS was unable to increase MSC tropism.

147 phane (SFN) and dimethyl fumarate (DMF), are unable to induce a similar response.

148 lpha-syn, at levels that, by themselves, are unable to induce acute dopamine (DA) neurodegeneration.

149 Finally, activated cofilin is unable to induce apoptosis in cells genetically lacking

150 tal and adult hUGT1/Car(-/-) mice, PEITC was unable to induce CYP2B10.

151 demonstrated that the resulting proteins are unable to induce IFN-beta, are intrinsically less stable

152 Wnt proteins are unable to induce Lgr5(+) ISC self-renewal, but instead c

153 n exporting a specific class of effectors is unable to induce lipid droplet accumulation, we demonstr

154 M. tuberculosis-infected IL-21R KO mice were unable to induce optimal macrophage responses to M. tube

155 In contrast to TCDD, CA is unable to induce the CYP1A1 gene, thus revealing an AhR

156 at mediates inflammatory responses, and were unable to induce the expression of inflammatory genes in

157 ltured embryonic dental mesenchyme cells are unable to induce tooth formation, they can contribute to

158 bryonic tooth mesenchymal cells renders them unable to induce tooth formation, they do not lose their

159 The nitrated chemokine was unable to induce transendothelial monocyte migration in

160 These mutant Gbetagamma subunits were unable to inhibit VGCC currents.

161 or an N-terminally truncated XLalphas mutant unable to interact with SNX9 or dynamin.

162 ss, lacked very long lipopolysaccharide, was unable to invade enterocytes, and demonstrated decreased

163 hages in the lung, but these macrophages are unable to kill intracellular bacteria.

164 ckpoint (SAC) signaling, such that cells are unable to maintain a prolonged mitotic arrest in the pre

165 The MPA network studied would be unable to maintain connectivity of these small benthic f

166 Peripheral talin-deficient Treg cells were unable to maintain high expression of IL-2Ralpha, result

167 regulatory element-binding protein-2 yet are unable to maintain normal cholesterol levels, suggesting

168 Isolated short peptides usually are unable to maintain their original secondary structures d

169 ithout ADAM10 and Notch1 signaling, DCs were unable to make cytokines that stimulate TH 2 cells and c

170 cecraft and telescope observations have been unable to map the emission from the entire patera floor

171 coding exons), current web applications are unable to map titin variants to domain structures.

172 As organ donation rates remain unable to meet the needs of individuals waiting for tran

173 ich mobile conventional dendritic cells were unable to migrate toward follicular dendritic cells.

174 that transmit signals from a substrate, are unable to mitigate retroactivity effects, even when casc

175 ion by Tregs, whereas in cancer, T cells are unable to mount antitumor responses due to the Treg-enri

176 , we should not penalize researchers who are unable to move abroad for long periods.

177 passively moved through an environment, but unable to move through it themselves, fail to develop ac

178 ages produce reduced levels of IL-18 and are unable to optimally stimulate IFN-gamma production by NK

179 The patients were unable to orchestrate an inflammatory response against L

180 directing groups rather than one is clearly unable to overwhelm it.

181 hysical and mental component subscales, days unable to participate in social life, days on sick leave

182 d of time, even if the displaced persons are unable to pay (water and sanitation as human rights).

183 al behavior and fitness, suggesting they are unable to perceive pheromones.

184 Results showed participants were unable to perform the motion or form task reliably when

185 Most cells would be unable to perform this function because they use their M

186 Orco(S289A) mutants, unable to phosphorylate this position, have low intrinsi

187 Despite this, GWASs alone are unable to pinpoint disease-causing single nucleotide pol

188 h syndrome protein-deficient neutrophils are unable to polymerize actin and exhibit a block in both d

189 eglutathionylation of actin and tubulin, are unable to polymerize either cytoskeletal network and fai

190 restricted to the blood vessels in the lung, unable to populate either the lung parenchymal tissue or

191 and posttreatment depression score, and were unable to predict posttreatment depression severity usin

192 tory for this antigen archival, yet LECs are unable to present their archived antigens to CD8(+) T ce

193 transmission electron microscopy studies are unable to preserve the native state of chemically reacti

194 individual site is, accordingly, potentially unable to prevent aggregation in vivo.

195 In contrast, AUT1 was unable to prevent amphetamine-induced hyperactivity in m

196 ice, we show that the neonatal microbiota is unable to prevent colonization by two bacterial pathogen

197 As a result, valves were unable to prevent fluid backflow and the vessels were in

198 Here we show that human RNase H2 is unable to process an abasic rNMP (rAP site) or a ribose

199 aring stage of development and, as such, are unable to process sound information.

200 L/6 mice deficient for NLRP3 expression were unable to produce IL-1beta in the airways during acute i

201 Bloodstream forms unable to produce inositol pyrophosphates, due to downre

202 is defective in small capsid protein and is unable to produce mature virions.

203 neurons, we show that they are both mute and unable to produce the expiratory drive required for voca

204 sion profile of mesendodermal cells and were unable to progress to fully reprogrammed phenotype.

205 nt 7 mRNA with NXF1, mutant NS1 polypeptides unable to promote mRNA export did neither.

206 TP with 2-deoxyglucose and sodium azide were unable to properly regulate pH.

207 Those unable to provide consent and unable to read English wer

208 s suffer from multiple limitations: they are unable to provide fully natural visual cues and comforta

209 ions in the heterozygous state but have been unable to purge the mutation burden; such purging should

210 Most small molecules are unable to rapidly traverse the outer membrane of Gram-ne

211 appressoria from hyphal tips, but these are unable to re-polarize, and rice infection is impaired.

212 To date, these discussions have been unable to reach a consensus regarding how these outcomes

213 The task force was unable to reach agreement on a single test that can reli

214 Those unable to provide consent and unable to read English were excluded.

215 PDK1-deficient HSCs were also unable to reconstitute the hematopoietic system.

216 lacks a functional C-terminal domain and is unable to recruit the E3 ubiquitin ligase TRIM62.

217 We were unable to recruit the planned 3,000 participants and the

218 Because of this, ZmTrxh is unable to reduce disulfide bridges but possesses a stron

219 in HIV-1(+) elite neutralizers typically are unable to reduce viremia in the same individuals from wh

220 The adult human heart is unable to regenerate after various forms of injury, sugg

221 centrosome disassembly, rendering the heart unable to regenerate.

222 Mutant flies unable to regulate Orco function through phosphorylation

223 By contrast, SurA is unable to release tOmpA from Skp, providing direct evide

224 thylation, although we highlight that we are unable to reliably separate causality from horizontal pl

225 Antibiotics are unable to remove biofilms from surgical implants.

226 nts had more to gain from treatment, we were unable to replicate any genotype-treatment interactions

227 As anticipated, vDeltaI2 was unable to replicate in cells that did not express I2.

228 tant viruses lacking hydrolase activity were unable to replicate in mammalian BHK-21 cells or mosquit

229 nipulation to match a reported error, we are unable to replicate post-FISP production gains.

230 nt associations at P </= 5 x 10(-5) but were unable to replicate these.

231 on regulatory protein 2 (IRP2), rendering it unable to repress ferritin mRNA translation.

232 dCpf1 fusions were unable to repress gene expression.

233 Fire models were unable to reproduce the pattern and magnitude of observe

234 We are, however, unable to reproduce the spatial offset between these cel

235 localized to the stereocilial tips, but were unable to rescue FM4-64 labeling.

236 it decreased competitiveness in vivo and are unable to rescue hematopoiesis in the setting of myelosu

237 tion of Ren1d(-/-) mice with human renin was unable to rescue the abnormality seen in macula densa st

238 contrast, and fluorescence microscopies, are unable to resolve 3D structures deep inside (>50 mum) tu

239 gs into metagenome-assembled genomes but are unable to resolve strain-level variation.

240 Crystallography studies on Naa60 were unable to resolve the C-terminal tail of Naa60, which is

241 exhibited defective ruffled borders and were unable to resorb bone in vitro.

242 c plaques are phenotypically defective being unable to resorb calcification.

243 bear the cognate IL-6 receptor and are thus unable to respond to classic IL-6 receptor signaling.

244 ells was impaired, and aged bumble mice were unable to respond to NP-Ficoll immunization.

245 l, it is expressed at very low levels and is unable to reverse methionine and adenine auxotrophy of P

246 ly therapeutic settings by about 50% but was unable to reverse the established fibrosis.

247 progressed to the antral stage but many were unable to rupture.

248 abour intensive, subjective in analysis, and unable to screen a large numbers of gene fusions.

249 ge of oral cholera vaccine, authorities were unable to secure sufficient doses to vaccinate the entir

250 goal-directed responding-that is, mice were unable to select actions based on the likelihood that th

251 We show that the plant is unable to select against the non-fixing strain at the po

252 k, faces challenges as many participants are unable to self-regulate.

253 We were unable to show that empiric treatment with OAD was assoc

254 eased MCC association with the APC/C and are unable to silence the checkpoint efficiently.

255 PKR function is highly specific, as LCMV is unable to similarly inhibit eIF2alpha phosphorylation.

256 Current biosensors designs are, in general, unable to simultaneously meet all these criteria.

257 Unable to smoothly unwind, this conflict bends the helic

258 Strikingly, hH3R365 was completely unable to stimulate GSK3beta phosphorylation, an endpoin

259 nd the structure finally explains why Mpa is unable to stimulate robust protein degradation in vitro

260 Importantly, fatty acids were unable to substitute for the 25 mm glucose pulse during

261 on strategies, in the studies reviewed, were unable to successfully remove carcinogenic PAHs from con

262 formation of a cofilin-binding mode that is unable to sufficiently alter filament mechanical propert

263 larization was impaired and macrophages were unable to sufficiently induce T regulatory cells (Tregs)

264 ure far enough to be fertilized in vitro are unable to support embryonic development beyond the two-c

265 Thus, current technology will be unable to support future broadband demands.

266 IFN)-incompetent cells and that the virus is unable to suppress IFN induced in response to viral repl

267 A sigG mutant was unable to survive envelope damage caused by heat or EDTA

268 apses, depress synaptic transmission and are unable to sustain long-term potentiation (LTP).

269 In contrast, low-dosage bFGF was unable to sustain those markers and, combined with SB, a

270 l S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BChl e but accumulate BChl c; howev

271 igh fidelity replicative DNA polymerases are unable to synthesize past DNA adducts that result from d

272 Moreover, they are unable to tell new from old at better than chance levels

273 stant to chemotherapy and to unfit patients, unable to tolerate intensive chemotherapy.

274 likely because translated viral proteins are unable to transfer from the ER to LDs.

275 This study describes new mutants unable to transform like the wild type that point to nov

276 an elongated beta1-beta2 linker, MazF-mt6 is unable to transition between open and closed states, sug

277 most 100% of insects infected with 6 spores unable to transmit malaria within 5 days post-infection,

278 Although unable to trigger G protein activation, both ligands act

279 ntrinsic ability to ubiquitinate HIFalpha is unable to ubiquitinate AURKA.

280 lly, the degradation of a Psd1(ts) precursor unable to undergo autocatalysis requires the unprecedent

281 management, particularly in patients who are unable to undergo contrast-based radiological studies.

282 However, Set1A(DeltaSET) ESCs are unable to undergo normal differentiation, indicating the

283 of N-methylated amino derivatives, which are unable to undergo such tautomerism, were equal in potenc

284 le to determine the onset of the process but unable to unveil the following dynamics.

285 expression of RDH10 and transgenic rods were unable to use cis-retinol for pigment regeneration.

286 These species (and one unable to use HCO3(-)) increased in abundance with eleva

287 less responsive to the male sex pheromone or unable to use it as a cue at all.

288 ported pseudocobalamin into the cell but was unable to use pseudocobalamin in its homolog of MetH.

289 ient to sustain the growth of cells that are unable to use serine, which is the predominant source of

290 crease in ADP and ATP binding but were still unable to use these as substrates, and enzymatic activit

291 ental environments are force-free, therefore unable to visualize mechanical signals in real time.

292 ions where conventional Raman microscopy was unable to visualize the sublayer.

293 One-third of all stroke survivors are unable to walk, even after intensive physiotherapy.

294 low PCO2 levels, existing climate models are unable to warm Hesperian Mars anywhere near the freezing

295 core AMD 0.62 [-0.62 to 1.87]; p=0.32), days unable to work (no days unable to work adjusted odds rat

296 1.87]; p=0.32), days unable to work (no days unable to work adjusted odds ratio 1.02 [0.61-1.69]; p=0

297 Secondary outcomes were disability, days unable to work, behavioural activation, suicidal thought

298 -3.33, 0.17; p = 0.08); other outcomes (days unable to work, intimate partner violence toward females

299 sability Assessment Schedule 2.0 score, days unable to work, or perpetration of intimate partner viol

300 e effect of drinking, disability score, days unable to work, suicide attempts, intimate partner viole