ライフサイエンスコーパス: unactivated

1 ombin, a closely related serpin, essentially unactivated.

2 er/intramolecular double carboalumination of unactivated 2-substituted 1,5-dienes, which provides eff

3 PO3(2-), 2.5 +/- 0.1; S2O3(2-), 2.9 +/- 0.1; unactivated; 2.4 +/- 0.2.

4 these complexes: (1) transmetalation via an unactivated 6-B-3 intermediate that dominates in the pre

5 to our knowledge, broadly applicable use of unactivated alcohols as latent alkylating reagents, achi

6 r improving the mass spectral sensitivity of unactivated alcohols was developed.

7 ubstituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved

8 fast rates and high selectivities, even with unactivated aliphatic alcohols.

9 nes to both beta-substituted vinylarenes and unactivated aliphatic alpha-olefins.

10 als generated by single-electron transfer to unactivated aliphatic amides; however, little variation

11 the palladium-catalyzed direct arylation of unactivated aliphatic C-H bonds in free primary amines.

12 The selective functionalization of unactivated aliphatic C-H bonds over intrinsically more

13 Many enzymes oxidize unactivated aliphatic C-H bonds selectively to form alco

14 uplings between unsaturated hydrocarbons and unactivated aliphatic C-H bonds via a metal-hydride path

15 atalyzed site-selective functionalization of unactivated aliphatic C-H bonds, providing chemically di

16 n-amidyl radicals remove hydrogen atoms from unactivated aliphatic C-H bonds.

17 for the selective late-stage modification of unactivated aliphatic carbon centers in small molecules

18 the first time, the olefin scope encompasses unactivated aliphatic olefins as well as activated aroma

19 strate scope, in particular noncompliance of unactivated aliphatic olefins, has discouraged the use o

20 The first systematic investigation of unactivated aliphatic sulfur compounds as electrophiles

21 nation of phenylacetic acid derivatives with unactivated, aliphatic alkenes in good to excellent yiel

22 Herein, we report an approach to unactivated, aliphatic C-H bromination using readily ava

23 oride (COPC) can catalytically dehydrogenate unactivated alkanes and alcohols under near-UV irradiati

24 tive C-H insertion of azavinyl carbenes into unactivated alkanes has been developed.

25 The dehydrogenation of unactivated alkanes is an important transformation both

26 we report a desaturation reaction of simple, unactivated alkanes that is mechanistically unique.

27 ative dehydrogenative carboxylation (ODC) of unactivated alkanes with various substituted benzoic aci

28 much faster than the radical addition to an unactivated alkene.

29 olecular hydroacylation of a wide variety of unactivated alkenes and alkynes with beta-S-substituted

30 alyzed intermolecular [2+2] cycloaddition of unactivated alkenes and cross cycloaddition of alkenes a

31 lyzed intramolecular addition of alcohols to unactivated alkenes and subsequent aryl C-H functionaliz

32 The intermolecular hydroaminoalkylation of unactivated alkenes and vinyl arenes with secondary amin

33 ficant aspects of the present method is that unactivated alkenes are suitable substrates for this met

34 rivatives to be coupled with a wide range of unactivated alkenes at catalyst loadings as low as 2 mol

35 for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidativ

36 photoredox catalyzed difluoromethylation of unactivated alkenes coupled with C-C bond formation to a

37 oselective methods enabling cyclization onto unactivated alkenes exist.

38 zed 1,2-dicarbofunctionalization reaction of unactivated alkenes has been developed, wherein a cleava

39 ions of a halogen and phosphoramidic acid to unactivated alkenes have been developed, catalyzed by a

40 synthesis of vinylarenes, but reactions with unactivated alkenes have typically occurred in low yield

41 anti-Markovnikov-selective hydroamination of unactivated alkenes is a significant challenge in organo

42 A copper-catalyzed aminoazidation of unactivated alkenes is achieved for the synthesis of ver

43 general method for the hydropyridylation of unactivated alkenes is described.

44 )-mediated free radical hydrofluorination of unactivated alkenes is disclosed using Selectfluor reage

45 An intermolecular 1,2-carboamination of unactivated alkenes proceeding via a Pd(II)/Pd(IV) catal

46 The intermolecular addition of N-H bonds to unactivated alkenes remains a challenging, but desirable

47 lkenes, and all the examples of additions to unactivated alkenes require large excesses of alkene.

48 or the hydrogenation of sterically hindered, unactivated alkenes such as trans-methylstilbene, 1-meth

49 -light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the

50 nt atom transfer radical additions (ATRA) to unactivated alkenes to form chloro, difluoromethylated a

51 amine derivatives and alcohols onto pendant unactivated alkenes to provide a range of valuable satur

52 lecular benzylation and heterobenzylation of unactivated alkenes to provide functionalized allylbenze

53 des in a mild and regioselective manner from unactivated alkenes using cobalt catalysis is described.

54 elective Pd-catalyzed vicinal diamination of unactivated alkenes using N-fluorobenzenesulfonimide as

55 We report the first reductive coupling of unactivated alkenes with N-methoxy pyridazinium, imidazo

56 The intermolecular hydroamination of unactivated alkenes with simple dialkyl amines remains a

57 conjugated polar alkenes, hydrosilylation of unactivated alkenes, and hydrodefluorination of fluoroal

58 For unactivated alkenes, the Heck-type beta-hydride eliminat

59 s proceed under mild thermal conditions with unactivated alkenes, tolerating both amine and ether fun

60 ition reaction between boron alkylidenes and unactivated alkenes.

61 s for highly stereoselective arylboration of unactivated alkenes.

62 alpha,beta-unsaturated carbonyl compounds to unactivated alkenes.

63 ts, an Fe(acac)3-catalyzed cross-coupling of unactivated alkyl aryl thio ethers with aryl Grignard re

64 Pd-mediated one-pot ketone synthesis from an unactivated alkyl bromide and a thioester has been exten

65 se reactions efficiently deliver esters from unactivated alkyl bromides across a diverse range of sub

66 the palladium-catalyzed carbocyclization of unactivated alkyl bromides with alkenes is described.

67 )](2+) (2b) species capable of hydroxylating unactivated alkyl C-H bonds with stereoretention in a ra

68 ntermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowled

69 metal-catalyzed cross-coupling reactions of unactivated alkyl electrophiles are emerging as a powerf

70 methods for the formation of C-C bonds from unactivated alkyl electrophiles have been described in r

71 alytic asymmetric methods for cross-coupling unactivated alkyl electrophiles.

72 via C-N bond activation of an amine with an unactivated alkyl group.

73 A catalytic C-H alkylation using unactivated alkyl halides and a variety of arenes and he

74 Carbonylations of unactivated alkyl halides remain a challenge and current

75 lyzed reductive cyclization/carboxylation of unactivated alkyl halides with CO2 is described.

76 sful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, includin

77 lative C-C coupling of terminal alkynes with unactivated alkyl iodides has been developed, enabling h

78 method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described.

79 alyzed alkyne insertion/Suzuki reaction with unactivated alkyl iodides is described.

80 A palladium-catalyzed Heck-type reaction of unactivated alkyl iodides is described.

81 rmine the rates of spontaneous hydrolysis of unactivated alkyl sulfate monoesters by S-O bond cleavag

82 (ppy)3 can be utilized to form radicals from unactivated alkyl, alkenyl and aryl iodides.

83 e to functionalize a series of activated and unactivated alkynes in an entirely selective and predict

84 A regioselective anti-hydrochlorination of unactivated alkynes is reported.

85 Unactivated alpha-branched primary and secondary aliphat

86 We report the intermolecular amination of unactivated alpha-olefins and bicycloalkenes with arylam

87 ular, metal-catalyzed addition of phenols to unactivated alpha-olefins.

88 ve sulfa-Michael addition of alkyl thiols to unactivated alpha-substituted acrylate esters catalyzed

89 modeled in a system possessing an otherwise unactivated amide positioned between two carboxy groups.

90 rst base metal-catalyzed alpha-alkylation of unactivated amides and esters by alcohols.

91 des direct access to acyl-type radicals from unactivated amides under mild electron transfer conditio

92 alytic intermolecular reductive couplings of unactivated and activated olefin-derived nucleophiles wi

93 n reactivity with factors Xa and IXa in both unactivated and heparin-activated states, indicating tha

94 ithrombin reactivity with these proteases in unactivated and heparin-activated states.

95 ulated T cells remain largely phenotypically unactivated and show a lower death rate than activated T

96 e of a readily available amine source (DPH), unactivated and styrene-type olefins can now be stereosp

97 , with the sorted cells being highly viable, unactivated, and functionally intact.

98 ith HBpin, pin = pinacolato) of a variety of unactivated, and sometimes very bulky, carbonyl compound

99 -mediated insertion of an aryl group into an unactivated arene.

100 ategy for the direct trifluoromethylation of unactivated arenes and heteroarenes through a radical-me

101 ategy for the direct trifluoromethylation of unactivated arenes and heteroarenes under either ultravi

102 of arynes from acyclic building blocks with unactivated arenes in intra- and intermolecular manners

103 a,alpha-diarylation of aromatic ketones with unactivated arenes in the presence of selenium dioxide a

104 The direct arylation of unactivated arenes is a very practical and highly conven

105 processes for Friedel-Crafts alkylations of unactivated arenes is an important objective of interest

106 a catalytic intermolecular C-H silylation of unactivated arenes that manifests very high regioselecti

107 ich facilitates the C-H functionalization of unactivated arenes to form the biaryl products.

108 vious studies have reported the arylation of unactivated arenes with ArX, base (KO(t)Bu or NaO(t)Bu),

109 increased activity for the C-H borylation of unactivated arenes.

110 s highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles as substrates.

111 earth-metal complexes allows the cleavage of unactivated aromatic C-H bonds.

112 agent for a variety of substrates, including unactivated aryl bromides.

113 om temperature cross-coupling reactions with unactivated aryl chlorides are rare.

114 g aryldiphosphine ligand, to oxidatively add unactivated aryl chlorides at room temperature.

115 our observation of efficient reaction of an unactivated aryl iodide at -40 degrees C especially stri

116 The unactivated aryl-Br bond was utilized further to synthes

117 f a sterically unhindered but electronically unactivated aryl-Br bond.

118 ither the chemical mechanisms by which these unactivated atoms obtain methyl groups nor the actual me

119 Recently, a direct arylation of unactivated benzene has been achieved in the presence of

120 They reduce unactivated benzenes to the corresponding radical anions

121 Notably, isolated methylene groups and unactivated benzylic sites are accessible.

122 at least 1-2 orders of magnitude higher for unactivated biochars and 3-4 orders of magnitude higher

123 Unactivated biochars had limited effectiveness for organ

124 Unactivated biochars were as effective as the steam acti

125 r PCB concentration reductions of 18-80% for unactivated biochars, and >99% for ACs with 5% by weight

126 dy identifies a key aspect of DC biology: an unactivated BMDC is CD37(hi)CD82(lo), resulting in a hig

127 The fluorination of unactivated C(sp(3) )-H bonds remains a desirable and ch

128 nsfer, for the directed functionalization of unactivated C(sp(3) )-H bonds.

129 C(sp(3))-H bond of toluene and a completely unactivated C(sp(3))-H bond of cyclohexane demonstrate t

130 carbenoid chemistry, i.e., insertion into an unactivated C(sp(3))-H bond, has not be realized.

131 ate, examples of intermolecular arylation of unactivated C(sp(3))-H bonds in the absence of a directi

132 is for the selective activation of otherwise unactivated C(sp(3))-H bonds, followed by their trifluor

133 talyzed method for the borylation of remote, unactivated C(sp(3))-H bonds.

134 The HAT at unactivated C(sp(3))-H sites is enabled by the easily in

135 This work constitutes an example of the unactivated C(sp(3))-SCF3 bond formation by C-H activati

136 kable because the reactions must occur at an unactivated C-H bond over functional groups that are mor

137 orm C-C bonds or install functionality at an unactivated C-H bond will be presented, and the potentia

138 These methods highlight the use of unactivated C-H bond, especially the C(sp(3))-H bond of

139 ds to intramolecular carbene insertions into unactivated C-H bonds and intermolecular carbene inserti

140 ions based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the

141 f nitrogen-containing functional groups into unactivated C-H bonds is not catalyzed by known enzymes

142 methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in

143 ected fluorination of benzylic, allylic, and unactivated C-H bonds mediated by iron.

144 io- and stereoselective functionalization of unactivated C-H bonds using molecular dioxygen and two e

145 This method highlights the emerging value of unactivated C-H bonds, particularly the C(sp(3))-H bond

146 Selective functionalization of unactivated C-H bonds, water oxidation, and dioxygen red

147 d participate in the amination of strong and unactivated C-H bonds.

148 mical strategy for the homolytic cleavage of unactivated C-H bonds.

149 ivation, discrimination between two similar, unactivated C-H positions is beyond the scope of current

150 selectivity for the hydroxylation of remote, unactivated C-H sites in a complex scaffold.

151 A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or be

152 zes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octan

153 le assembly involves functionalization of an unactivated carbon center.

154 ine (rSAM) methyltransferases that methylate unactivated carbon centers.

155 step involves the electrophilic attack of an unactivated carbon dioxide unit on a metal-sigma-acetyli

156 dical SAM (RS) enzymes is the methylation of unactivated carbon or phosphorous atoms found in numerou

157 e highly enantioselective transformations of unactivated carbon-carbon multiple bonds.

158 Functionalization of unactivated carbon-hydrogen (C-H) single bonds is an eff

159 insertion of one atom of oxygen from O2 into unactivated carbon-hydrogen and carbon-carbon bonds, wit

160 ion involving a covalent linkage between two unactivated carbons within the side chains of lysine and

161 membered lactones, the first class of simple unactivated carboxylic acid derivatives that had long be

162 ts (E degrees = -2.8 V) for the reduction of unactivated carboxylic acid derivatives to primary alcoh

163 hondrial fatty acid oxidation (FAO) in human unactivated CD4 T(mem) cells was significantly enhanced

164 s observed being conserved, in comparison to unactivated complex, after trapping.

165 gly more electron-deficient arene before the unactivated "control" ring undergoes monobromination.

166 normally unreactive azadienophiles including unactivated cyano groups and heterosubstituted imine der

167 abilizations of the transition state for the unactivated decarboxylation of 2.9 kcal/mol.

168 ed by iridium-catalysed C-H silylation of an unactivated delta-C(sp(3))-H bond to produce a silolane

169 al electron-demand [4 + 2] cycloadditions of unactivated dialkylhydrazones are unprecedented.

170 ighly enantioselective Nazarov reactions of "unactivated" dienones, producing hydrindenone products h

171 for the cis-bis(silyl)ation of alkynes using unactivated disilanes is reported.

172 tivity of metal fragments in the reaction of unactivated E-H bonds (E = H, R3Si, NH2, R2P).

173 re able to overcome the reactivity issues of unactivated enamides, known as the least reactive carbox

174 r that binds the intracellular domain of the unactivated epidermal growth factor receptor (EGFR).

175 especially challenging alkylation is that of unactivated esters and amides.

176 protocol for the base-mediated amidation of unactivated esters with amino alcohol derivatives is rep

177 zed beta-ketophosphonates in the presence of unactivated esters with high yields.

178 converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a one-pot ma

179 echanistic investigation of the reduction of unactivated esters, carboxylic acids, and amides using S

180 is distinguished by a wide scope, including unactivated fluoroarenes, without compromising its effic

181 Both activated and unactivated free amines were oxygenated efficiently to p

182 ctive mono-alkylation of aliphatic amines by unactivated, hindered halides persists as a largely unso

183 Treatment of unactivated human lymphocytes with lysosomal inhibitors

184 nd stereocontrol in the functionalization of unactivated hydrocarbon chains will greatly facilitate t

185 a 5'-deoxyadenosyl radical that can abstract unactivated hydrogen atoms from a variety of organic sub

186 dition of an aryl pinacolboronic ester to an unactivated imine.

187 While unactivated imines were not reactive to alpha-diazo carb

188 ctive and E/Z-selective allylic oxidation of unactivated internal alkenes via a catalytic hetero-ene

189 enabling the catalytic hydrophosphination of unactivated internal alkynes.

190 zed hydroamination that effectively converts unactivated internal olefins-an important yet unexploite

191 groups chemoselectively to a wide variety of unactivated ketone compounds via their enone counterpart

192 ic nitro-Mannich reaction of nitromethane to unactivated ketone-derived imines allows the enantiosele

193 Enzyme catalysed PSRs with unactivated ketones are unprecedented, and, furthermore,

194 Direct alpha-alkylation of unactivated ketones using benzylic alcohols as electroph

195 etric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles

196 S) can catalyse the PSR between dopamine and unactivated ketones, thus facilitating the facile biocat

197 lective, tandem geminal dihalogenation of an unactivated methyl group, a reductive fragmentation/trap

198 he catalytic alkylation of unconstrained and unactivated methylene C-H bonds with high synthetic rele

199 engineering, and applied to the oxidation of unactivated methylene C-H bonds.

200 the C-H bonds of beta-methyl groups over the unactivated methylene C-H bonds.

201 The room-temperature hydrophosphinylation of unactivated monosubstituted alkenes using phosphinates (

202 h enantioselectivities to both activated and unactivated nitroalkenes.

203 nd abundantly available alcohols (C-OH) with unactivated nucleophilic coupling partners (C-H), leadin

204 tion, and alpha-alkylation/alkenylation with unactivated olefins and alkynes.

205 ity in the room-temperature hydrogenation of unactivated olefins and were found to be significantly m

206 y catalyze the hydrogenation of a variety of unactivated olefins at 100 degrees C.

207 talyzed intermolecular hydroaryloxylation of unactivated olefins by iridium "pincer" complexes.

208 Thus, unactivated olefins can be joined directly to electron-d

209 sulfonates as alkylating agents, the use of unactivated olefins for alkylations has become attractiv

210 alyst-free, and metal-free bromoamidation of unactivated olefins has been developed.

211 We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-bas

212 -catalyzed oxidative coupling of furans with unactivated olefins to generate branched vinylfuran prod

213 tem for the intramolecular hydroamidation of unactivated olefins using simple N-aryl amide derivative

214 nthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of

215 New advances in the functionalization of unactivated olefins with carbon nucleophiles have provid

216 We report a series of hydroarylations of unactivated olefins with trifluoromethyl-substituted are

217 Unactivated olefins, featuring a wide range of functiona

218 ramolecular ketone alkylation reactions with unactivated olefins, resulting in Conia-ene-type reactio

219 I) hydride (CuH)-catalyzed hydroamination of unactivated olefins, the substantially enhanced reactivi

220 highly electron-rich heteroaryl bromides and unactivated olefins.

221 lar hydroamination reactions of indoles with unactivated olefins.

222 oward catalytic ketone alpha-alkylation with unactivated olefins.

223 - and diastereoselective cyclopropanation of unactivated olefins.

224 e of subunits between holoenzymes, including unactivated ones, enabling the calcium-independent phosp

225 d CaMKII holoenzymes to exchange dimers with unactivated ones.

226 lboronic acids, potassium metabisulfite, and unactivated or activated alkylhalides is described.

227 or human monocytes to complete diapedesis on unactivated or inflamed human endothelium, under both st

228 ul method for selective functionalization of unactivated or intrinsically less reactive C-H bonds.

229 of carbon-based nucleophiles to unprotected/unactivated (or N-H) ketimines.

230 ntramolecular direct C(sp(3))-H amination of unactivated organic azides to generate a range of satura

231 pathway is responsible for the metabolism of unactivated organophosphonates under conditions of phosp

232 Constitutive internalization of unactivated PAR1 is mediated by the clathrin adaptor pro

233 Constitutive internalization of unactivated PAR1 is mediated by the clathrin adaptor pro

234 not constitutively associated with talin in unactivated platelets, but becomes bound to talin in res

235 rders-of-magnitude greater than those of the unactivated polymers.

236 A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with C

237 ming process is successful with a variety of unactivated primary and secondary alkyl halides, includi

238 2-type stereoinvertive oxidative addition of unactivated primary and secondary alkyl tosylates.

239 ategy developed for the functionalization of unactivated primary beta C-H bonds of aliphatic amines.

240 is associated with selective oxygenation of unactivated primary C-H bonds.

241 A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlor

242 -catalyzed process for the cross coupling of unactivated primary, secondary, and tertiary alkylcarbas

243 ch allows for the borylation of activated or unactivated primary, secondary, and tertiary bromides.

244 to catalyze the intramolecular amination of unactivated primary, secondary, or tertiary aliphatic C-

245 ntioselective intramolecular, silylations of unactivated, primary C(sp(3))-H bonds.

246 patterns over all trapping times studied for unactivated protein complexes, suggesting that any confo

247 EK first delivered unactivated PS throughout the silt.

248 An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp(3)/sp(2))-H func

249 a lactam and a 2-oxazolidinone) couple with unactivated secondary (and hindered primary) alkyl bromi

250 e and pyrrole derivatives are alkylated with unactivated secondary aliphatic alcohols by a Bronsted a

251 upling of a range of primary carbamates with unactivated secondary alkyl bromides at room temperature

252 rmation, specifically, that the cyanation of unactivated secondary alkyl chlorides can be achieved at

253 of coupling a carbamate nucleophile with an unactivated secondary alkyl electrophile to generate a s

254 amily of stereoconvergent cross-couplings of unactivated secondary alkyl electrophiles has been devel

255 atic amines can be cleanly mono-alkylated by unactivated secondary alkyl iodides in the presence of v

256 ess for the stereospecific cross-coupling of unactivated secondary alkylboron nucleophiles and aryl c

257 de THF, while the alkylation works well with unactivated secondary bromides and iodides in 2-methylte

258 It can cleave benzylic and unactivated secondary C-H bonds, but exhibits unique sel

259 ME at -60 degrees C enables deprotonation of unactivated secondary dialkyl TIB esters, but not the ca

260 acemic alpha-zincated N-Boc-pyrrolidine with unactivated secondary halides, thus providing a one-pot,

261 eports of metal-catalyzed cross-couplings of unactivated secondary or tertiary alkyl halides with sil

262 Additionally, sp(3) C-H bonds of unactivated secondary sp(3) C-H bonds could be functiona

263 The Cdelta -H amination of unactivated, secondary C-H bonds to form a broad range o

264 ced by a 9-12-membered ring, were made by an unactivated Smiles rearrangement of five- to eight-membe

265 e C-methylation of thiazole, occurring at an unactivated sp(2) carbon.

266 ide-directed selective C-C bond formation at unactivated sp(3) C-H bonds in molecules that contain ma

267 The direct functionalization of unactivated sp(3) C-H bonds is still one of the most cha

268 The direct alkylation of unactivated sp(3) C-H bonds of aliphatic amides was achi

269 e direct carbonylation of aromatic sp(2) and unactivated sp(3) C-H bonds of amides was achieved via n

270 , a palladium-catalyzed functionalization of unactivated sp(3) C-H bonds with internal alcohol nucleo

271 oxometalate-catalyzed aerobic olefination of unactivated sp(3) C-H bonds.

272 endent radical SAM enzyme that methylates an unactivated sp(3) carbon during the biosynthesis of gent

273 Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed.

274 intermolecular dehydrogenative amination of unactivated sp(3) carbons is also realized.

275 via a C-H bond functionalization process on unactivated sp(3) carbons with the assistance of a biden

276 of alkyl ethers by the functionalization of unactivated sp(3)- and sp(2)-hybridized C-H bonds.

277 groups that can be introduced, especially at unactivated sp(3)-hybridized positions.

278 s in regioselective Diels-Alder reactions of unactivated substrates and identify [Co(I)(dppe)](+) as

279 nd substrates, except for the combination of unactivated substrates and poor nucleophiles, as seen fo

280 s in regioselective Diels-Alder reactions of unactivated substrates such as 1,3-dienes and alkynes.

281 egy for sulfur incorporation into completely unactivated substrates.

282 The palladium-catalyzed alpha-arylation of unactivated sulfoxides has been developed.

283 es supplying energy for diverse functions of unactivated T(mem) cells differ from that required for f

284 Apoptosis of unactivated T(mem) cells induced by IL-2 deprivation or

285 control homeostatic lymphoid trafficking of unactivated T(mem) cells, altered FAO and glycolysis onl

286 r maintenance and surveillance activities of unactivated T(mem) cells.

287 at promote the unique [2+2] cycloaddition of unactivated terminal alkenes.

288 ve Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes.

289 f alpha-functionalized ketones containing an unactivated terminal alkyne and produces an exo-methylen

290 directed, regiocontrolled hydroamination of unactivated terminal and internal alkenes is reported.

291 The enantioselective allylic amination of unactivated terminal olefins represents a direct and att

292 e of the reaction is quite broad in terms of unactivated terminal olefins, proceeds at room temperatu

293 The first Suzuki cross-couplings of unactivated tertiary alkyl electrophiles are described.

294 our first examples of coupling reactions of unactivated tertiary alkyl electrophiles, as well as our

295 pecially noteworthy is our ability to employ unactivated tertiary alkyl halides as electrophilic coup

296 ples, as well as one example of an otherwise unactivated tertiary C-H bond.

297 e use of a group 10 catalyst to cross-couple unactivated tertiary electrophiles to form C-C bonds.

298 yst accomplishes Miyaura-type borylations of unactivated tertiary, secondary, and primary alkyl halid

299 Crabtree's catalyst in the hydrogenation of unactivated trisubstituted olefins and superior activity

300 ic dichotomy between Negishi reactions of an unactivated versus an activated secondary alkyl bromide.