ライフサイエンスコーパス: unanswered question

1 te such subcellular scaling is a fundamental unanswered question.

2 crease cancer risk has remained an important unanswered question.

3 tein (Cos2/Kif7) binding partners is a major unanswered question.

4 -strand break (DSB) is a central and largely unanswered question.

5 but the mechanism of their recruitment is an unanswered question.

6 ng mammalian CNS is an important but largely unanswered question.

7 ack loop is first triggered is a fundamental unanswered question.

8 ions or vice versa remains a provocative and unanswered question.

9 mportance for cellular physiology is a major unanswered question.

10 enced-based data regarding this longstanding unanswered question.

11 ain access to chromatin remains an important unanswered question.

12 any particular DSB) is a central and largely unanswered question.

13 hese viral proteins are regulated remains an unanswered question.

14 ate signals remains an important and largely unanswered question.

15 osin II within the animal cell CR remains an unanswered question.

16 hich variants lead to CKD remains a critical unanswered question.

17 eurons play an obligatory role remains a key unanswered question.

18 ISA from the vast molecular space remains an unanswered question.

19 tream at the ERC or remains segregated is an unanswered question.

20 occurred during planet formation remains an unanswered question.

21 evolved endothermy remains an important but unanswered question.

22 elerated to relativistic energies remains an unanswered question.

23 how important this constraint is remains an unanswered question.

24 muscles of different sizes is an essentially unanswered question.

25 d in which neurons they function are largely unanswered questions.

26 , including developing new models to address unanswered questions.

27 tastasis in different cancer types have left unanswered questions.

28 This report is concerned with two unanswered questions.

29 tive GTPase domain play in RHD3 function are unanswered questions.

30 rk in this domain by addressing two thus far unanswered questions.

31 the tail and CHD work together are critical unanswered questions.

32 xisting conditions are important and largely unanswered questions.

33 rovide speculative models that address these unanswered questions.

34 tor in mice and humans, still raised several unanswered questions.

35 disease and address molecular mechanisms and unanswered questions.

36 ues to represent a major challenge with many unanswered questions.

37 ects and neonatal lethality remain important unanswered questions.

38 rewardingly active research field with many unanswered questions.

39 ight recent progress, and identify important unanswered questions.

40 ting similarities and raising several as yet unanswered questions.

41 rties of interaction networks have left some unanswered questions.

42 on the emergence of new traits remain major unanswered questions.

43 this into various signals represent critical unanswered questions.

44 bules and move on the mitotic spindle remain unanswered questions.

45 marize the recent advances and highlight key unanswered questions.

46 under different growth conditions raise many unanswered questions.

47 es from distantly related organisms, are key unanswered questions.

48 ves within latent lesions are compelling but unanswered questions.

49 There are several unanswered questions.

50 eds to determine how best to address two key unanswered questions.

51 impacts early development remain important, unanswered questions.

52 and molecular biology tools to explore many unanswered questions.

53 and proliferation of cells remain important unanswered questions.

54 remains unclear, with several long-standing unanswered questions.

55 nization of the chromatin all remain largely unanswered questions.

56 own and knockout murine phenotypes have left unanswered questions.

57 es in tissue expression of HO isoenzymes are unanswered questions?

58 The present study investigates three unanswered questions: 1) Do adipose-resident T cells (AR

59 A fundamental unanswered question about bacterial MCPs is how enzymes

60 One unanswered question about ferrochelatase involves defini

61 One important but largely unanswered question about floristic responses to climate

62 ese repressors can be utilized to explore an unanswered question about LacI function: How many induce

63 A critical unanswered question about mixed lineage leukemia (MLL) i

64 The basic, still unanswered question about visual object representation i

65 This review also discusses some of the major unanswered questions about Ag-NPs, which, when answered,

66 enetics and propose a roadmap for unraveling unanswered questions about BAV through the integrated an

67 poxviral infection, and identify a number of unanswered questions about EV.

68 is noteworthy for calling attention to still unanswered questions about how the historical events of

69 on of research activities, but has left many unanswered questions about how this regulation functions

70 spite decades of study, there are still many unanswered questions about metastasis, the process by wh

71 Some of the important unanswered questions about perioperative nutrition suppo

72 of freedom in ventilator settings leave many unanswered questions about the biophysical determinants

73 There are many unanswered questions about the developmental relationshi

74 tial resemblance to human psoriasis, leaving unanswered questions about the etiology of this disease.

75 There are many unanswered questions about the evolution of the ancient

76 ances are accompanied by a growing number of unanswered questions about the function of the individua

77 Unanswered questions about the IRESs themselves have to

78 However, there remain unanswered questions about the mechanism of channel open

79 ins unknown and adds a new dimension to many unanswered questions about the mechanism of DSB repair.

80 e anatomical features of turtles have raised unanswered questions about the origin of their unique bo

81 There are many important unanswered questions about the pathophysiology, diagnosi

82 e neurotransmitter cycle and indicate basic, unanswered questions about the presynaptic regulation of

83 There are many unanswered questions about the role of imaging in defini

84 the defect in DNA repair, and highlights the unanswered questions about the tumor suppressor paradox

85 the opportunity to address these fundamental unanswered questions about their electronic structure an

86 The review identifies important unanswered questions about these cells regarding their o

87 To resolve unanswered questions about these inhibitors, we develope

88 nts in different species and highlights some unanswered questions about this important developmental

89 f piRNA production and function, and discuss unanswered questions about this intriguing new class of

90 regulation of these functions, and the many unanswered questions about this largely unexplored mecha

91 rable attention to DNA looping by LacI, many unanswered questions about this mechanism, including the

92 This reflects, in part, unanswered questions about whether immunologic recogniti

93 A number of unanswered questions and challenges remain, such as how

94 future directions for inquiry, highlighting unanswered questions and conceptual issues concerning ho

95 ent and function, as well as other currently unanswered questions and controversies in the field are

96 e initiation and progression, there are many unanswered questions and emerging facets of miRNA biolog

97 By identifying key unanswered questions and gaps in clinical data, it will

98 In addition, we point out unanswered questions and identify critical challenges, t

99 atients who die in the ICU often remain with unanswered questions and suffer from lack of closure.

100 eries made during the past decade, highlight unanswered questions and suggest new directions.

101 ese neuropeptides and outlines the important unanswered questions and testable hypotheses.

102 y known about depression in glioma, the main unanswered questions and the types of studies that shoul

103 We highlight controversies, point out key unanswered questions, and briefly outline what we believ

104 w all available lines of evidence, delineate unanswered questions, and develop, if it seemed reasonab

105 ssue of the JCI, identify a number of as yet unanswered questions, and discuss some of the therapeuti

106 Here, we analyze the recent advances, unanswered questions, and potential of BacNa(V)s as temp

107 lance, 5) interventions, and 6) limitations, unanswered questions, and resource and policy needs.

108 Here we highlight some unanswered questions, and some promising areas for resea

109 We discuss advances and the unanswered questions, and ways in which progress might b

110 Two key unanswered questions are (1) whether short-term temperat

111 impses ahead on these subjects and other yet-unanswered questions are discussed.

112 in primary neurons is controversial, leaving unanswered questions as to how and where Parkin-mediated

113 young and aged humans, there are still many unanswered questions as to how the genetic pathways that

114 Unanswered questions as to the regulatory mechanisms and

115 We close (4) with a consideration of unanswered questions as well as existing arguments again

116 Here we detail recent advances and unanswered questions at the intersection between inflamm

117 rd specific B-cell subsets in the embryo are unanswered questions, because the systemic circulation i

118 those in other midline models and highlight unanswered questions both for retinal axon growth and ax

119 This review highlights unanswered questions, challenges, recent advances, unres

120 Major unanswered questions concern the nature of the endogenou

121 A major unanswered question concerning "pain" circuitry is the e

122 An unanswered question concerning prevalence and disease se

123 ression in the brain poses an intriguing yet unanswered question concerning their roles in the nervou

124 ponse to infection; however, there are still unanswered questions concerning SARS-CoV pathogenesis.

125 One of the most fundamental unanswered questions concerning the bacterial chemotaxis

126 There are also many unanswered questions concerning the mechanism of action

127 ess could be adaptive in vivo, are two major unanswered questions concerning this process.

128 handful of plant ARF-GEFs, a fundamental yet unanswered question concerns the extent to which their f

129 A major unanswered question concerns the mechanism by which the

130 ermanent microbial habitat; thus, an age-old unanswered question concerns the origin of fruit and fer

131 A foundational unanswered question concerns whether different domains o

132 We addressed the critical but unanswered question, does network structure explain demo

133 emokine recognition has been a long-standing unanswered question due to the challenges of structure d

134 A very important unanswered question, especially in the very elderly, is

135 on these factors, and to highlight important unanswered questions for the field.

136 ources and scaffold-cell interactions remain unanswered questions for tissue engineering of heart val

137 Since their discovery in 1958, a fundamental unanswered question has been how electrons can be accele

138 An important unanswered question has been whether melanocortin agonis

139 st research effort, guided by a focus on key unanswered questions, has the potential to yield high-im

140 ble of tumor initiation raised two important unanswered questions: how do PGCCs acquire such stemness

141 An unanswered question, however, is how the activity of a p

142 An important unanswered question, however, is whether aPFC is a homog

143 One important unanswered question, however, is whether these strategie

144 A major unanswered question, however, relates to how positive al

145 ebral cortex has for a long time remained an unanswered question in auditory neuroscience.

146 A major unanswered question in biology and medicine is the mecha

147 cle traffic is achieved remains an important unanswered question in cell biology.

148 An unanswered question in developmental physiology is to wh

149 echanisms regulates this enzyme, and a major unanswered question in glucokinase biology is how post-t

150 A major unanswered question in neuroscience is whether there exi

151 represented within the brain is an important unanswered question in neuroscience.

152 A key unanswered question in plant biology is how a plant regu

153 A key unanswered question in SCA3 and other polyglutamine dise

154 A central unanswered question in stem cell biology, both in plants

155 One fundamental unanswered question in the field of polyglutamine diseas

156 This has become a long-standing unanswered question in the fragile X field, which is als

157 ifying a suitable mechanism has become a key unanswered question in the origin of life.

158 An unanswered question in the SMR field is how the dimeriza

159 troducing negative side effects is the major unanswered question in this field.

160 to regulate blood flow, however, is a major unanswered question in vascular biology.

161 Why we sleep remains one of the enduring unanswered questions in biology.

162 to begin to address some of the fundamental unanswered questions in epilepsy, to dissect epileptic n

163 One of the major unanswered questions in evolutionary biology is when and

164 One of the critical unanswered questions in genome biophysics is how the pri

165 d by newly developed technologies to address unanswered questions in high-altitude adaptation at a ge

166 One of the unanswered questions in mammalian development is how the

167 kling and we conclude by listing a series of unanswered questions in microbial symbiosis that can pot

168 One of the central unanswered questions in prostate cancer research is the

169 One of the major unanswered questions in quantitative proteomics is that

170 We will conclude with a discussion of unanswered questions in redox signalling in skeletal mus

171 deration some hypotheses regarding important unanswered questions in the field and suggest a model fo

172 We also discuss some of the key unanswered questions in the field of DNA methylation and

173 e development of AD, and highlight important unanswered questions in the field.

174 ow it influences cellular function are major unanswered questions in the field.

175 rmalities characterizing ASRD and highlights unanswered questions in the literature and potential fut

176 Two unanswered questions in the proposed mechanistic pathway

177 There remain many unanswered questions in the treatment of pediatric uveit

178 tion, we highlight current controversies and unanswered questions in these areas.

179 nsights and provides a perspective on future unanswered questions in this exciting field.

180 genome for damage is one of the fundamental unanswered questions in this field.

181 l of providing insights into some of the key unanswered questions in this field.

182 Unanswered questions include the number and effect sizes

183 Important unanswered questions include the optimal means for selec

184 Unanswered questions include those relating to the diver

185 amin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a p

186 This mutant enables new research into unanswered questions, including the existence of potenti

187 f such transitions in gene activity, a major unanswered question is how cells regulate the timing of

188 A key unanswered question is how cellular EADs partially synch

189 A major unanswered question is how division plane orientation is

190 One unanswered question is how infection is controlled and c

191 A key unanswered question is how lymphatic reprogramming by th

192 An unanswered question is how plants might overcome pathoge

193 An unanswered question is how polar septation activates a t

194 An unanswered question is how RssB-mediated degradation of

195 Yet an unanswered question is how the transfer of information b

196 A fundamentally important, presently unanswered question is if nucleation begins as classical

197 important for membrane-interface binding, an unanswered question is its importance relative to simple

198 A major unanswered question is the mechanism of MDV-induced tumo

199 y the identity of the NR2 subunit, a crucial unanswered question is the role of subunit composition i

200 An unanswered question is therefore: Are universally prefer

201 A major unanswered question is what distinguishes the majority o

202 le reduction of pain is important, a largely unanswered question is what other benefits NGF blockade

203 An unanswered question is whether an altered repertoire of

204 However, a fundamental unanswered question is whether cell sorting is dictated

205 An important unanswered question is whether ICAM-1-activated signalin

206 A key unanswered question is whether IgG4, a relatively weak a

207 A longstanding, unanswered question is whether nuclear organization is s

208 A major unanswered question is whether pharmacological inhibitio

209 A major unanswered question is whether plasma exchange is effect

210 One unanswered question is whether risk-taking preference is

211 A key unanswered question is whether systemic GM-CSF (sargramo

212 A critical unanswered question is whether task set shifts in these

213 A central still unanswered question is whether telomerase dysfunction an

214 A key unanswered question is whether the circadian oscillation

215 A more basic, yet unanswered question is whether the Met(20) loop adopts a

216 However, a crucial, but previously unanswered question is whether the nucleation and growth

217 One important unanswered question is whether the role of this modifica

218 An unanswered question is whether the sgmRNAs, which appear

219 An unanswered question is whether the use of branch-site ad

220 However, a critical and largely unanswered question is whether these models generalize f

221 Therefore, an unanswered question is why a current/former smoker of ab

222 s context, one of the most important and yet unanswered questions is whether and how HNO is produced

223 assessment and identified several important unanswered questions meriting future research.

224 gh more recent reports have begun to examine unanswered questions, much work remains to be done.

225 Nevertheless, unanswered questions need to be addressed in clinical tr

226 dian homeostasis in other tissues remains an unanswered question of conceptual and biomedical importa

227 icide clusters are seriously hampered by the unanswered question of why such outbreaks occur.

228 d randomized trials, and then summarizes yet-unanswered questions of hormone therapy and cardiovascul

229 I further consider the as-yet unanswered questions of how much of the mind and brain a

230 recent findings as well as to highlight key unanswered questions of the field.

231 Despite this many unanswered questions on its cause, management and outcom

232 We suggest that identifying key unanswered questions on the relationship between science

233 The current dilemmas, unanswered questions, operational issues, challenges, an

234 This unanswered question originated with the idea of ecologic

235 egulation in the heart, there are still many unanswered questions, particularly concerning mitochondr

236 Whilst there are still many unanswered questions, recent developments in these areas

237 One key unanswered question regarding oleamide and all other pri

238 throughout the world, and yet there are many unanswered questions regarding both the mechanisms of th

239 bal proteomics have the potential to address unanswered questions regarding microRNA-mRNA interaction

240 er-forming and membrane protein pilins leave unanswered questions regarding pilin structures, assembl

241 Unanswered questions regarding RSV epidemiology need to

242 e of Cx-based channels, there are still many unanswered questions regarding structure-function relati

243 Currently, however, there are many unanswered questions regarding the biological mechanism,

244 One of the primary unanswered questions regarding the dispersal of Romani p

245 Despite its importance, there are still many unanswered questions regarding the formation and evoluti

246 ells is still under investigation, with many unanswered questions regarding the interaction of virus-

247 s of YD-boundary nanodiamonds have left many unanswered questions regarding the nature and occurrence

248 There are many unanswered questions regarding the physiology of glucose

249 There are still many unanswered questions regarding the precise physiological

250 We also discuss major unanswered questions regarding the role that defects in

251 However, there are several unanswered questions regarding the sources of Earth's vo

252 One of the most challenging unanswered questions regarding the structural biology of

253 There are several unanswered questions regarding this approach, and until

254 ation systems, and suggest the most pressing unanswered questions related to understanding these impo

255 Unanswered questions remain about how common chronic rar

256 Many unanswered questions remain about how to design duty-hou

257 Unanswered questions remain about the interactions betwe

258 development and myelination, many important unanswered questions remain about the mechanisms that co

259 Many unanswered questions remain and additional work is requi

260 Many unanswered questions remain including long-term success

261 Unanswered questions remain including the relationship o

262 and experimental structure-function studies, unanswered questions remain regarding the transport mech

263 Although an evidence base exists, unanswered questions remain regarding the use of thrombo

264 However, important unanswered questions remain--for example, we do not know

265 ed trials exist in this area of medicine and unanswered questions remain.

266 ried protocols for administration; thus many unanswered questions remain.

267 trials are currently underway and important unanswered questions remain.

268 erald a new era for iron chelation, but many unanswered questions remain.

269 nterconnected pathways, and identify the key unanswered questions remaining in this field.

270 There are a number of unanswered questions remaining, however, which will need

271 re effective; however, there are many as yet unanswered questions such as why some patients with vest

272 dard and novel therapies are promising, many unanswered questions, such as duration of therapy and op

273 ity of the response to asbestos and the many unanswered questions suggested the need for a systems bi

274 tically ill patients, presents the facts and unanswered questions surrounding gut-derived sepsis, and

275 However, there are still unanswered questions surrounding PARP inhibitors, namely

276 There remain unanswered questions surrounding surgical checklists as

277 have the opportunity to address some of the unanswered questions surrounding the evolution of these

278 explore the history, recent discoveries, and unanswered questions surrounding the relationship betwee

279 ns from a structural prospective and discuss unanswered questions surrounding this fascinating class

280 controls these logical processes remains an unanswered question that has been merely superficially a

281 ese activities and loop formation is another unanswered question that should keep investigators occup

282 y and immunodeficiency, and pose a series of unanswered questions that are expected to be central in

283 ith heart failure and highlight the critical unanswered questions that are ripe for future investigat

284 re are ongoing controversies and many as yet unanswered questions that are the subject of ongoing and

285 There are still many unanswered questions that challenge our understanding of

286 We conclude by discussing the critical unanswered questions that face this field in the coming

287 timing of ERK activation remain fundamental unanswered questions that limit understanding of how arr

288 of this signaling module as well as several unanswered questions that may guide future investigation

289 of JAK2-targeted therapy, and the important unanswered questions that need to be addressed to improv

290 areas of analysis to explore the expanse of unanswered questions that remain regarding the phenomena

291 en conquered, there are critically important unanswered questions that remain.

292 From a mechanistic perspective, two key unanswered questions that require further investigation

293 This paper presents nine unanswered questions that researchers and educators migh

294 making it possible to begin to address major unanswered questions: the extent of natural methylation

295 aw attention to new findings and some of the unanswered questions, unresolved issues, and controversi

296 acity electrodes with anionic redox, a still unanswered question was remaining regarding the importan

297 a patient case that illustrates two of many unanswered questions: which sarcoma patients are most li

298 mitochondrial dynamics emerged and consider unanswered questions whose dissection might lead to mito

299 tists are hopeful that many of the currently unanswered questions will be addressed.

300 However, there are still many unanswered questions with regard to the factors that pro