ライフサイエンスコーパス: unanticipated

1 ) disulfide link, although the bond angle is unanticipated.

2 those that accrue unexpectedly or are wholly unanticipated.

3 ion in their intermitochondrial transfer was unanticipated.

4 highlight, through a series of examples, the unanticipated ability of the Day/Night Band (DNB) on the

5 w that certain HIV-1 envelope genes have the unanticipated ability to resist specific human defenses

6 Here, we report an unanticipated activity of yeast and human Rad52: inverse

7 No unanticipated adverse events were observed.

8 We also find unanticipated allelic heterogeneity at Tyrp1 and Sox10,

9 These data point to a previously unanticipated and conserved role for TRAPPC11 in LLO bio

10 Our results provide several unanticipated and interconnected findings.

11 hile, initially led to the development of an unanticipated and previously unknown isomer of maoecryst

12 he FeMo-cofactor accompanying CO binding was unanticipated and provides insights into a catalytically

13 Stimulated CNV therefore represents an unanticipated and remarkably controllable pathway facili

14 Our data also reveal an unanticipated anxiogenic role for this particular DOR su

15 ften leads to unprecedented performance, and unanticipated applications.

16 The enzyme adopts an unanticipated architecture in which the C-terminal cyste

17 The eukaryotic core replisome shows an unanticipated architecture, with one polymerase sitting

18 quality control is of critical importance as unanticipated biases, artifacts, or errors can potential

19 Together, our results reveal the unanticipated bifunctional role of VDAC2 to target Bax s

20 elevant environments, and tasks that involve unanticipated biological events.

21 2, and 4-7)-an attributional pattern that is unanticipated by sharers (study 3), that persists days a

22 Unanticipated by this paradigm is the effect progression

23 ndencies on proteostasis networks to uncover unanticipated cancer vulnerabilities.

24 dent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1

25 The findings demonstrate an unanticipated capping-based regulatory mechanism for Fts

26 onditions, and preparation for responding to unanticipated cardiac events in athletic venues.

27 itride nanotubes exhibit unique and hitherto unanticipated catalytic properties, resulting in great s

28 Our studies delineate an unanticipated cell nonautonomous function of MDA-9/synte

29 e that ISG15-deficient patients also display unanticipated cellular, immunological and clinical signs

30 Unanticipated changes in the electronic structure of the

31 apped potential inherent in entirely new and unanticipated chemical subspaces offered by organometall

32 We identified two unanticipated classes of synapses, KC>DAN and DAN>MBON.

33 vivo imaging of regenerating skin and reveal unanticipated collective dynamism in epithelial cell siz

34 reveal that EFA6, BRAG, and cytohesins have unanticipated commonalities associated with divergent re

35 These findings reveal unanticipated communication between stress-induced neura

36 yocardial MCU inhibition leads to previously unanticipated compensatory changes that affect cytoplasm

37 abled the global mapping of TIs and revealed unanticipated complex translational landscapes in metazo

38 At the same time, they reveal unanticipated complexities in the interactions of M with

39 These results reveal unanticipated complexity in the mutual regulation of the

40 thesis of nascent DNA, our results reveal an unanticipated complexity in the regulation of DNA elonga

41 in modifying T-cell function that highlights unanticipated complexity of intercellular communication

42 Unanticipated concerns emerged from countries over accep

43 An unanticipated conformational shift of 4'-phosphopantethe

44 Unanticipated conformations solved for complexes with co

45 Our study reveals an unanticipated connection among dFOXO, stress responses,

46 adverse health effects, with the potentially unanticipated consequence of targeting developing heart

47 An unanticipated consequence of this acidification mitigati

48 As an unanticipated consequence, the extended model also natur

49 aging such an event, as well as a few of the unanticipated consequences associated with the aftermath

50 These results reveal unanticipated consequences of delaying CRY degradation,

51 d microtubule cytoskeleton regulation in the unanticipated context of the single-celled embryo.

52 In the course of this work we observed unanticipated context-dependence between bases which wil

53 We discover unanticipated continuous changes in FRET with applied to

54 the underreported interference of different unanticipated covalent modifications.

55 cated, labor-intensive, and often results in unanticipated crosstalk.

56 Thus, our study identifies an unanticipated dependence of liver regeneration on MICU1

57 the HECT domain ligase Smurf2, leads to the unanticipated depletion of E2 approximately Ub and thus

58 of drug refractory symptomatic PAF, with no unanticipated device-related adverse events.

59 lasm-membrane interface and reveal large and unanticipated differences among these residues.

60 domains and contact similar regions of RNAP, unanticipated differences are observed in their domain a

61 ar information obtained by TOF-SIMS revealed unanticipated differences in the type and composition of

62 esearch also coincides with the emergence of unanticipated difficulties in detecting genetic variants

63 -interacting RNAs revealed a fascinating and unanticipated dimension of biology.

64 Our unanticipated discovery highlights the importance of det

65 Target identification led to the unanticipated discovery that inhibition of the enzyme di

66 resilience of individuals or populations to unanticipated disturbances, and we find that resilience

67 Our data reveal unanticipated diversity in recognition sequences for cha

68 Surprisingly, some chain pairs form unanticipated double-helix regions that result from mutu

69 the genome, thereby providing insights into unanticipated drug effects.

70 Our work explains the unanticipated dynamics that eco-evolutionary feedbacks c

71 However, because of the unanticipated early termination of the trial, it is not

72 m laboratories, coupled with the prospect of unanticipated ecological change, demands caution.

73 Reduction in CTLA4 levels had an unanticipated effect in promoting Treg function both in

74 not allow the intended comparison due to an unanticipated effect of the direction of visuomotor adap

75 d also illuminates potentially unintended or unanticipated effects of varying dendrimer surface chemi

76 tion, with altered dosR expression revealing unanticipated effects on bacterial survival during hypox

77 such as chromatin modification enzymes, have unanticipated effects on pre-tRNA end processing.

78 ealed that GNE deficiency is associated with unanticipated effects on the structure of cell-surface g

79 ch may restrict a cell's ability to adapt to unanticipated environmental challenges.

80 er complex in plant cells, our work provides unanticipated evidence for the role of peroxisome dynami

81 mes of yeast, red algae, and malaria reveals unanticipated evolutionary modularity and coevolving com

82 In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections.

83 ting recent investigations reveal a range of unanticipated extrarenal effects of aldosterone, as well

84 These new assemblies uncovered unanticipated features and new potential regulatory mech

85 exist between four of the six ORC subunits, unanticipated features are also evident.

86 ient thiolactone production is driven by two unanticipated features of the system: (i) membrane assoc

87 The model predicted an unanticipated feedback loop, whereby Raf/MEK/ERK signall

88 Cytokine priming was required to elicit the unanticipated finding that Siglec-8 engagement promotes

89 may also help detect clinically significant unanticipated findings in an otherwise healthy populatio

90 ne IL-22 in MCMV infection, we discovered an unanticipated function for neutrophils as potent antivir

91 These findings suggest an unanticipated function for parasite lysosomal degradatio

92 of Blood, Das et al assign a very novel and unanticipated function to plasminogen by showing that it

93 r our model and experimental results suggest unanticipated functional benefits and costs of adaptatio

94 Our results reveal an unanticipated functional interplay between the RAG compl

95 Our findings uncover an unanticipated functional plasticity of the mRNA decappin

96 ation of inter-organ communications that are unanticipated, functionally important, and would have be

97 ovides an updated view of new and previously unanticipated functions of complement and how these affe

98 phenotypes of these pex alleles may reflect unanticipated functions of the peroxisomal ATPase comple

99 Our results demonstrate unanticipated, fundamentally important roles for UNC-43/

100 veloped melanoma-associated retinopathy with unanticipated fundus findings while receiving treatment

101 Host nuclear DNA further indicated unanticipated gene flow through the Andes mountains conn

102 edge of potential key regulators and reveals unanticipated gene network dynamics that drive cell fate

103 Within the germline, we uncovered an unanticipated gradient of telomerase activity that also

104 cepts might help improve outcome and prevent unanticipated harm.

105 This deep phenotyping has revealed unanticipated heterogeneity of clinical features, betwee

106 Here we report unanticipated heterogeneity within the Lgr5+ ISC pool.

107 These data demonstrate a previously unanticipated high skeletal disequilibrium of the clonal

108 observed ciliogenesis defects and provide an unanticipated, highly conserved link between PAM, amidat

109 These studies have thus revealed an unanticipated homeodomain factor/beta-catenin/Satb1-depe

110 under physiological conditions, resulting in unanticipated hybrid recombinations in approximately 10%

111 ned outcome (i.e., death, cardiac arrest, or unanticipated ICU admission) was 0.88 (0.88-0.88).

112 data and safety monitoring board detected an unanticipated imbalance across blinded groups in the num

113 An unanticipated immune priming effect of anti-CD71 Ab trea

114 Our findings evoke the possibility of unanticipated immunologic mechanisms subtending the pote

115 or MDSC-mediated immunosuppression that have unanticipated implications for systemic cancer immunity.

116 Rather, cervicovaginal HA plays an unanticipated important role in epithelial barrier prote

117 rom pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis,

118 DNA binding leads to an unanticipated increase in methyl side-chain flexibility

119 nt effect of NRG3 genotype manifesting as an unanticipated increase in ventrolateral PFC activation i

120 e regulate specific stress responses, adding unanticipated information-processing capacity to the MAP

121 These results provide unanticipated insights into endosomal trafficking, illum

122 Collectively, our data reveal unanticipated insights regarding the serological respons

123 When unanticipated insults breach epithelial barriers, dorman

124 report on the functional consequences of the unanticipated interaction of the RNA binding protein K h

125 Complex and unanticipated interactions between manufacturer-specific

126 Due to the complexity of natural systems, unanticipated interactions may lead to erroneous conclus

127 llectively, our results reveal an important, unanticipated interplay between CTCF and nuclear lamina

128 Thus, our studies unveil an unanticipated interplay between two protein modification

129 anaerobic vitamin B12 assembly and reveal an unanticipated intersection of thiamin and vitamin B12 bi

130 ese observations support the existence of an unanticipated intracellular target that mediates the eff

131 formation predominates (70%) and features an unanticipated intramolecular collapse of Tyr(93) in krin

132 We report here the unanticipated isolation of a Chlamydomonas reinhardtii (

133 These efforts reveal a number of unanticipated issues of reactivity and significant stere

134 plying failed phosphate-steering promotes an unanticipated lagging-strand template-switch mechanism d

135 The unanticipated large kinetic isotope effects reported her

136 Our report shows that previously unanticipated, late, severe relapses of Ebola virus can

137 Our results demonstrate an unanticipated level of control in insect acoustic commun

138 Our observations demonstrate an unanticipated level of interchangeability between the tw

139 was withdrawn from the market because of an unanticipated life threatening adverse effect: progressi

140 Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and t

141 iver endothelial cells, thereby unmasking an unanticipated link between angiogenesis and the resoluti

142 Here, we report an unanticipated link between bone marrow and brain in the

143 Our results reveal an unanticipated link between endocycles and the repression

144 Here we reveal an unanticipated link between R-loops and RNA-interference-

145 Through a genetic screen, we uncovered an unanticipated link between the conserved Rho1 GTPase and

146 These data demonstrate a previously unanticipated link between the rates of homeostatic prol

147 gene expression in endothelial cells and an unanticipated link between WNK1 and Slug that is importa

148 One unanticipated major focus has been investigating the che

149 ecific Ca(2+) channel, CATSPER, in a totally unanticipated manner.

150 glycans can influence binding selectivity in unanticipated manners.

151 unctional nanoparticles can be encumbered by unanticipated material properties and biological events,

152 of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.

153 These findings suggest an unanticipated mechanism by which GNE activity might affe

154 The structure reveals a new, unanticipated mechanism by which proteins can recognize

155 flagellar export and assembly, and a new and unanticipated mechanism for constant rate flagellum grow

156 ar occupancy of the cell, thus suggesting an unanticipated mechanism for cytosol homeostasis during c

157 Our data suggest an unanticipated mechanism of developmental compensation wh

158 These results identify an unanticipated mechanism regulating amino acid metabolism

159 hifted invertebrate assemblage structure via unanticipated mechanisms, while still conforming to comm

160 Together these observations reveal unanticipated mechanistic ties between two distinct form

161 d from skeletal muscle activity, a number of unanticipated metabolites were also determined to be sig

162 tella bryantii B14 Xyn10C (1.68 A) reveal an unanticipated mode for ligand binding.

163 ng core structures have revealed a number of unanticipated modes of reactivity inherent to these comp

164 against a predefined glycan library owing to unanticipated modifications.

165 geneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a s

166 east ISW1 chromatin remodeling complex as an unanticipated mRNP nuclear export surveillance factor th

167 ys provide many candidate genes, but finding unanticipated mutated genes will offer new insights into

168 s that continued climate warming can lead to unanticipated, negative effects on temperate fish popula

169 This unanticipated nucleosome assembly activity of AM-PARP-1,

170 r pathogenesis, uncovering alterations in an unanticipated number of genes and regulatory elements.

171 An unanticipated observation from these studies is proregen

172 These unanticipated observations indicate that, during cold re

173 More medications on the US market may have unanticipated off-target inhibition of CYP27A1, and we p

174 orms have proven functional, all can produce unanticipated off-target lesions and have difficulty dis

175 These results establish and elucidate the unanticipated oncogenic function of RUNX1 in AML.

176 y for restoring RNAi to zebrafish and reveal unanticipated opposing effects of a seed mismatch with i

177 There were no unanticipated or serious ocular adverse events (AEs).

178 AMBRA intervention may have operated through unanticipated or unmeasured pathways not included among

179 nuclear body formation-G1 arrest axis as an unanticipated outcome of homologous recombination defici

180 rphous and amyloid protein aggregation is an unanticipated outcome of such stress.

181 ractions among these pathogens could mediate unanticipated outcomes of clinical interventions, includ

182 One of these pathways involves an unanticipated oxygen-nitrogen exchange of the sulfonamid

183 elective chromosome condensation provides an unanticipated paradigm for antimicrobial action that may

184 This study provides insight into an unanticipated paradoxical role of Rosi in mediating hype

185 s for substrate recognition and cleavage, an unanticipated parallel in their mode of action.

186 Here, we report several unanticipated passive and active properties of the cereb

187 onic development, induces a highly specific, unanticipated pathological state.

188 ls can identify new immunotherapy targets in unanticipated pathways.

189 Unanticipated patterns of ecological succession were obs

190 Such treatments may however cause additional unanticipated phenomena which may affect wheat bran tech

191 The unanticipated phenotypic outcomes elicited by neomorphic

192 d through conformational analysis to explain unanticipated photoinduced pinacolization, as well as th

193 ary innate immunity, these studies elucidate unanticipated physiological functions for Piwi proteins

194 This study reveals an unanticipated plasticity of the adult skin epithelium wh

195 These findings demonstrate unanticipated plasticity of type I cells and a bidirecti

196 otomy, patients were deemed ineligible if an unanticipated pneumonectomy was indicated, or if air lea

197 otomy, patients were deemed ineligible if an unanticipated pneumonectomy was indicated, or if air lea

198 canonical SH2 pY site while pS1493 binds an unanticipated pocket 70 A distant.

199 This was a natural experiment using the unanticipated pollution event by comparing the prevalenc

200 The chimeric circuit therefore reveals unanticipated principles of circuit-level operation unde

201 and phosphatases as well as many previously unanticipated proteins and pathways.

202 xamples of unexpected acid-base behavior and unanticipated proximity-induced reactivity accounted for

203 lic bromides, and we provide evidence for an unanticipated radical chain pathway wherein oxidative ad

204 However, unanticipated reductions in the abundance of numerous tr

205 Our results uncover an unanticipated regulatory circuit involving broad epigene

206 These results support an unanticipated regulatory mechanism that integrates ubiqu

207 This cross-species approach identified unanticipated regulatory networks in mesodermal cells wi

208 We conclude that nucleoporins play an unanticipated regulatory role in NEBD, by recruiting PLK

209 Our data reveal an unanticipated requirement for the NSD pathway during oxi

210 Finally, our analysis reveals an unanticipated requirement specifically for FMNL1 and FMN

211 thal interactions and the swift emergence of unanticipated resistance mechanisms to otherwise effecti

212 e is marked loss of iron from the spleen, an unanticipated result, given the iron sequestration repor

213 Unanticipated results demonstrated that although recombi

214 Given unanticipated results regarding the role of BPD and stud

215 To account for these unanticipated results, a new mechanism that involves act

216 y 5'-CGCG-3' binder, favors 5'-GCGC-3' in an unanticipated reverse binding orientation.

217 e for C7H11(+), which is produced through an unanticipated ring-opening rearrangement path.

218 d near criticality and our model revealed an unanticipated role for activity-dependent depression in

219 Our studies reveal an unanticipated role for an F-box protein that inhibits pr

220 These findings establish an unanticipated role for ATM in the signaling of DNA SSBs

221 this issue of JEM, Swanson et al. report an unanticipated role for cGAMP in priming and activation o

222 Our results demonstrate an unanticipated role for FSH in establishing the signaling

223 Thus, we have uncovered an unanticipated role for hCDC14A in cell migration and adh

224 otency genes in reprogramming and unveils an unanticipated role for KLF4 in transcriptional pause rel

225 These findings demonstrate an unanticipated role for lipin-1 as a mediator of macropha

226 Collectively, our results reveal an unanticipated role for mRNA 3' end formation factors in

227 Our results therefore highlight an unanticipated role for p53 family proteins in a regulato

228 r signalling pathway, unveiling a previously unanticipated role for phagocytosis in transfer of patho

229 A new study reveals an unanticipated role for social context in driving group b

230 This is an unanticipated role for Sst interneurons, which have been

231 ween caloric load and reward and describe an unanticipated role for sweet taste in regulating carbohy

232 Here, we report an unanticipated role for the inactive EGFR in autophagy in

233 This study identifies an unanticipated role for the X-linked inhibitor of apoptos

234 finding is important because it uncovers an unanticipated role for TRPV4 in itch, thereby identifyin

235 and DNA repair, it may play an important and unanticipated role in coordinating the balance between r

236 set of cortical neurons and Sox4 playing an unanticipated role in designating secondary progenitors.

237 TEN, G-protein-coupled receptors may have an unanticipated role in driving tumour growth and invasion

238 Interestingly, we found that Mot1 has an unanticipated role in establishing or maintaining the oc

239 f N-terminal acetylation, and its previously unanticipated role in protein biogenesis, globally rescu

240 p358 (also known as Ranbp2) has a previously unanticipated role in Y-complex oligomerization.

241 Our results reveal an unanticipated role of Cav-1 in regulating lipolysis in n

242 Our findings reveal an unanticipated role of Cln1 in regulating lysosomal targe

243 These results support an unanticipated role of cystatin D in the cell nucleus, co

244 These results reveal an unanticipated role of IN for polyprotein proteolytic pro

245 Together, these data demonstrate an unanticipated role of parenchymal cells, as shown here f

246 ve virulence chemistry of Cif and suggest an unanticipated role of physiological epoxides in intracel

247 This study also uncovers a previously unanticipated role of PLK1 as a potent activator of MAPK

248 This work reveals an unanticipated role of RecA bundles in channelling the mo

249 bone and postnatal lethality, indicating an unanticipated role of Tbx1 in neural crest development.

250 Our findings reveal a new and unanticipated role of the 5-HT2B receptor N terminus as

251 nase and CAK activities of Mcs6, revealed an unanticipated role of the CAK branch in the transcriptio

252 Here, we report an unanticipated role of Vps34 in the activation of p62 for

253 ve family of RNA binding proteins and reveal unanticipated roles for a lncRNA and PUMILIO proteins in

254 ies enabled by this mouse suggest previously unanticipated roles for ATP and P2X4 receptors in the ne

255 r data therefore reveal novel and previously unanticipated roles for CXCR2 in the orchestration of th

256 BK1 as a direct mTORC1 activator and suggest unanticipated roles for mTORC1 downstream of TBK1 in con

257 Our findings reveal unanticipated roles for pseudouridylation and provide a

258 n of 170kDa) and Sil1, both of which perform unanticipated roles in various biological functions and

259 This work therefore reveals an unanticipated route by which the environment can modulat

260 and virus host cell interaction, and suggest unanticipated routes of subcellular cargo delivery.

261 patients with diabetic retinopathy, with no unanticipated safety events.

262 These findings reveal an unanticipated scope of the alternative splicing program

263 Intriguingly, we reveal an unanticipated sensitivity determinant within the C-termi

264 s of the insertions were precise, and had no unanticipated sequence modifications.

265 An unanticipated severe neurologic disorder occurred after

266 interspecific interactions and produce rapid unanticipated shifts in the demographics of pest complex

267 These results reveal an unanticipated side effect on stem cells that may contrib

268 approved for one or a few indications, their unanticipated side effects and off-label use have contri

269 effects of miRNAs create additional risks of unanticipated side effects.

270 r, A-NHEJ provides a mechanism of previously unanticipated significance in telomere dysfunction-induc

271 roteins, such as PH3 and TTG2, and reveal an unanticipated similarity in the regulatory circuitry tha

272 Moreover, there were some unanticipated ("sleeper") effects as both self-esteem an

273 indings reveal adult hippocampal NSPCs as an unanticipated source of an essential growth factor and i

274 We also report an unanticipated source of current fluctuations that reflec

275 citrate lyase of the glyoxylate shunt and an unanticipated source, aspartate oxidase, the enzyme cata

276 nt kinase inhibitor p18(INK4c), revealing an unanticipated specificity between a GHV cyclin and a sin

277 These data demonstrate unanticipated specificity of anti-AsGM1 Ab depletion on

278 dilauroylphosphatidylcholine binding drives unanticipated structural fluctuations outside of the can

279 We discover the unanticipated structural requirement that TFP motors nee

280 Our results reveal a previously unanticipated structural role for natively unfolded GLFG

281 al process that leads to the formation of an unanticipated structure comprised of an intimate mixture

282 Indeed, such unanticipated structures may prove to be convenient stra

283 osomal, telomere fusions and evidence for an unanticipated sufficiency of DNA ligase 1 for these intr

284 rld's cases occurred in Nigeria following an unanticipated surge in incidence.

285 o discover agonist antibodies that engage an unanticipated target and regulate macrophage polarizatio

286 ne activity affected learning rate following unanticipated task changes, in a way that depended on pa

287 When these crossovers are unanticipated, they appear to be the result of serendipi

288 excited state as one might expect, but from unanticipated through-space aromatic-dimer states.

289 sis reveals that cells have a remarkable and unanticipated tolerance for forced protein associations,

290 cases - before being recalled by the FDA for unanticipated toxicity in humans.

291 llectively, our results reveal an important, unanticipated transcriptional role of interphase condens

292 This study thus reveals an unanticipated transcriptional role of the DKC1 complex i

293 namics of DNA gyrase using AuRBT revealed an unanticipated transient intermediate.

294 o previous studies, our findings indicate an unanticipated tumor-suppressive role for HIF2alpha in ne

295 Our findings reveal an unanticipated type of VTA neuron that cotransmits glutam

296 eroids over the past decade have revealed an unanticipated underlying structure that points to a dram

297 Our findings demonstrate a previously unanticipated, unique role of gamma-CYA in regulating ep

298 bs used in human clinical trials resulted in unanticipated vascular complications, leading to heighte

299 s-synaptic Nrxn.Nlgn complexes, revealing an unanticipated way to contribute to the identity of synap

300 stry of glacial and proglacial ecosystems in unanticipated ways.