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1 entially has a dynamic complexity heretofore unappreciated.
2 th glucose intolerance, which was heretofore unappreciated.
3 utions of this American family should not go unappreciated.
4 known genes whose importance was previously unappreciated.
5 s identifies the previously undetectable and unappreciated 5hmC/5mCpGs as one of the major states for
11 y of a particular phosphatase was previously unappreciated and exemplifies how a phospho-network is p
14 These transthalamic circuits represent an unappreciated aspect of cortical functioning, which I di
17 thereby revealing a selective and previously unappreciated ATP requirement for actin cable disassembl
19 formation." Here we demonstrate a previously unappreciated benefit of memory transformation, namely,
22 ology and disease has uncovered a previously unappreciated breadth of mechanisms by which females and
25 d RNA (ssRNA) leviviruses, have a previously unappreciated capacity for evolving novel inhibitors of
27 an T cell phenotypes and observed previously unappreciated cellular populations within an orchestrate
28 variability in RGN off-target activities and unappreciated characteristics of off-target sequences.
29 in input populations can identify previously unappreciated circuit elements that critically support b
30 e network output and (2) reveal a previously unappreciated circuit mechanism that increases RGC sensi
31 The differences reported herein may reflect unappreciated clinical differences in patients infected
32 ing approach is to understand the relatively unappreciated communication that exists between the brai
33 axia type 1 (SCA1), we identify a previously unappreciated compensatory role for neuronal shrinkage.
34 e cells, we were able to identify previously unappreciated complexities in the biology of APP cleavag
38 ogical analysis has uncovered the previously unappreciated complexity of the bacterial microbiome at
39 Together, these data reveal a previously unappreciated complexity of the Plasmodium sporozoite su
40 iological techniques have shown a previously unappreciated complexity to the bacterial microbiome of
41 The 2La inversion is a major and previously unappreciated component of the natural malaria transmiss
46 ntiviral response to two DNA viruses, and an unappreciated contribution to the innate control of an R
47 idases and secreted enzymes, in general, are unappreciated controls on the cycling of metals and reac
50 Collectively, our data reveal a previously unappreciated critical cell-autonomous role of TNF on mo
51 y important new studies showing a previously unappreciated deep remodeling of lipid homeostasis, incl
52 teractions in the membrane and is frequently unappreciated, despite the fact that its magnitude can b
53 follow these movements, revealing previously unappreciated details of strikingly complex and dynamic
54 1 and LPA generation and identify previously unappreciated determinants of ANXA1 and ALX/FPR2 signali
55 c suppression analysis uncovers a previously unappreciated, DNA repair-independent function of BRCA1
57 ata indicating that efferocytosis is a major unappreciated driver of lesion expansion but also a reve
58 d diabetes, metformin activates a previously unappreciated duodenal Ampk-dependent pathway to lower H
59 ion of DVL2 and DVL3, revealing a previously unappreciated DVL isoform selectivity by different WNT-F
61 get gene expression, suggesting a previously unappreciated effect of DAC on transcriptional regulatio
62 the nature and magnitude of these previously unappreciated effects, using available estimates of pale
63 a reveal PrPC downregulation as a previously unappreciated element of disease pathogenesis that defin
65 ese results provide insights into previously unappreciated events in intracellular invasion by T. cru
66 y coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a
68 , our data suggest that TFEB is a previously unappreciated, evolutionarily ancient transcription fact
69 lial cell proliferation may be indicative of unappreciated evolutionary functional redundancy to faci
70 ther, these results demonstrate a previously unappreciated facet of Treg function and suggest that ch
76 anics, we show the existence of a previously unappreciated flow-induced shear stress threshold that t
77 on along a broad axon backbone represents an unappreciated form of plasticity underlying developmenta
83 ting that p-T153/Y155 regulates a previously unappreciated function of TDP-43 in the processing of nu
84 Moreover, our results highlight a previously unappreciated function of the immune system in controlli
88 r mammalian genomes, and suggests a hitherto unappreciated fundamental genetic difference in the way
93 metric fluorescence microscopy and report an unappreciated heterogeneity: peripheral lysosomes are le
94 ious genotypes uncovered multiple previously unappreciated host factors, including E-cadherin, that m
95 Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread
96 a demonstrate the generation of a previously unappreciated IL-10 producing ILC2 effector cell populat
98 itors and highlights the broader, previously unappreciated impact blocking HCV cell-to-cell spread ca
99 ith auxiliary proteins, our data identify an unappreciated impact of polyamine permeation in shaping
100 ice as many other deep-branching lineages of unappreciated importance in plankton ecology studies.
101 lphabetaTCR expression, directs a previously unappreciated initial phase of repertoire selection.
102 to T-cell development and function, identify unappreciated instances of alternative splicing in the h
103 uscle microtissues that reveals a previously unappreciated interaction between active cell mechanics
106 Together, this study identifies a previously unappreciated intrinsic mechanism of FRCs shared between
108 mutations, however, demonstrate a previously unappreciated key role for BPAG1-e in regulating keratin
110 ific regions of the ventricle, suggesting an unappreciated level of plasticity during chamber formati
113 ronal subtypes, we also uncovered previously unappreciated limitations by showing that newborn neuron
114 cell fate and establish a direct, previously unappreciated link between alternative polyadenylation a
115 TF6 serves an important role as a previously unappreciated link between the ER stress and oxidative s
117 microRNA, miR-204, and uncover a previously unappreciated link between TXNIP and incretin action.
119 ta demonstrate that CHMI leads to previously unappreciated long-lasting alterations in the human inna
121 Ohle et al. (2016) demonstrate a previously unappreciated mechanism by which transcription and RNA c
122 ion of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac
123 lose phosphorylation and reveal a previously unappreciated mechanism for regulation of proteoglycan b
124 gether, our results highlight amitosis as an unappreciated mechanism for restoring stem cell homeosta
128 l virulence pathways and reveal a previously unappreciated mechanism of action for anti-infective med
132 eir original targets and reveal a previously unappreciated mechanism that conveys synaptic target sel
133 that this pattern results from a previously unappreciated mechanism that may apply to many species w
137 unifying framework and introduce a hitherto unappreciated mechanism, the radial intercalation of new
138 ing, and analytical tools, shedding light on unappreciated mechanisms of neuro-immune regulation.
139 5-RHOGEF offers an intriguing and previously unappreciated mechanistic link of FZD4 signaling to cyto
140 ron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic
141 rate that cells are equipped with a somewhat unappreciated metabolic flexibility with important impli
143 that E6-expressing cells exhibit previously unappreciated mitotic defects that likely contribute to
144 regulation and perhaps identify a previously unappreciated model that helps to explain the clinical s
147 uncover novel genomic targets and previously unappreciated molecular roles of SOX10 in melanocytes.
148 own p53 targets, we identify many previously unappreciated mRNAs and long noncoding RNAs that are reg
149 s identify MSI2 as a central component in an unappreciated oncogenic pathway promoting intestinal tra
150 ization on vascular function is a previously unappreciated pathophysiological mechanism to sustain hy
152 cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immuni
154 eract the dissipative effect of a previously unappreciated pathway whereby GTP-Cdc42 escapes from the
157 These EPEC isolates exhibited previously unappreciated phylogenomic diversity and combinations of
159 Our study identifies Hrd1 as a previously unappreciated positive regulator of T cells and implies
160 d generalizable approach to solve this often unappreciated problem by modifying the nucleotide sequen
163 we found that the developing cerebellum has unappreciated progenitor plasticity, since it undergoes
164 ells of the antral stomach have a previously unappreciated propensity for conversion into functional
167 lts identify Notch signaling as a previously unappreciated regulator of Th1 and Th2 immunity and an i
168 nd bioactives to identify several previously unappreciated regulators of axon degeneration, including
169 nthesis of OXPHOS complexes, representing an unappreciated regulatory layer shaping the mitochondrial
172 We propose that Cbz-B3A reveals a previously unappreciated regulatory pathway coordinating cytosolic
173 ken together, our findings expose previously unappreciated regulatory plasticity in bacteria and prov
174 chanism is likely a prevalent but previously unappreciated regulatory switch used by the widely distr
178 systems-level analyses can reveal previously unappreciated relationships between neurodevelopmental d
179 solution microscopy, we visualize previously unappreciated reorganization of pre-existing actin filam
180 in response to T. gondii and demonstrate an unappreciated requirement for phagocytosis of live paras
182 n addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level
183 omatin-modifying complexes have a previously unappreciated role during the initiation phase of Hox ge
186 -2R, indicating an autonomous and previously unappreciated role for CD25 in regulating cell functions
188 Our results identify a novel and previously unappreciated role for CK1 as a brake on REST stability
192 vo requires E2F-2, and we also identified an unappreciated role for E2F-2 in erythroblast enucleation
196 Collectively our results suggest a novel and unappreciated role for GABABR activity in determining ex
199 tic replication and demonstrate a previously unappreciated role for Hsc70 in regulating viral replica
207 Collectively, our data reveal a previously unappreciated role for miR-223 in regulating the innate
208 s to execute learned skills and a previously unappreciated role for motor cortex in "tutoring" these
209 ogether, these data demonstrate a previously unappreciated role for Nlrp12 in exacerbating the pathog
214 vector transmissions identify a potentially unappreciated role for skin at infectious bite sites in
215 ain-of-function model, unveiled a previously unappreciated role for Socs1 in directly modulating p53
217 n together, our findings reveal a previously unappreciated role for the cell surface accumulation of
218 the immune response, revealing a previously unappreciated role for the extracellular matrix in regul
220 ectively, these results suggest a previously unappreciated role for the innate immune receptor Nod1 i
224 f Rkr1 substrates and highlight a previously unappreciated role for this ubiquitin ligase at the ER m
227 ulator of PDGFRbeta, and reveal a previously unappreciated role for VMCs in systems-level vascular pa
228 suggest that CaMKIIalpha plays a previously unappreciated role in ASD-related synaptic and behaviora
229 im15/Gwl regulation of PP2A plays a hitherto unappreciated role in cell size homeostasis during metab
230 ur results demonstrate that HSP90beta has an unappreciated role in controlling hepatic progenitor cel
233 propose that local astrocyte support has an unappreciated role in maintaining glutamate release sync
234 tic thermal convection may play a previously unappreciated role in mediating surface-catalyzed synthe
235 ts demonstrate that ICP27 plays a heretofore-unappreciated role in modulating the efficiency of proge
236 A methylation in enhancers play a previously unappreciated role in regulating the transcriptional res
237 mer-binding transcription factor 4) plays an unappreciated role in the ES cell cycle by forming a com
238 ty of CAFs may play a crucial and previously unappreciated role in the formation of tumor-associated
239 tention in the bone marrow play a previously unappreciated role in viral control and contrast the pot
240 together, our results establish a previously unappreciated role of BAP1 in modulating the cellular ad
241 in vitro and in vivo, we reveal a previously unappreciated role of cAMP response element binding prot
243 pendent RTT phenotypes, reveals a previously unappreciated role of CREB signaling in RTT pathogenesis
245 ze public data sets and uncover a previously unappreciated role of epigenome deregulation in the gene
247 d mice, the latter highlighting a heretofore unappreciated role of GABAergic MnPO neurons in thirst r
248 er, these observations point to a previously unappreciated role of GS protein-coupled A2aR in regulat
250 findings reveal an important and previously unappreciated role of IRBP in protecting the photorecept
253 gether, these findings unveiled a previously unappreciated role of p62 in the regulation of BCSCs, as
255 ken together, our study reveals a previously unappreciated role of reduced BLK expression on extraper
256 the data in this study revealed a previously unappreciated role of sepsis in shaping the quantity and
257 ancer cell survival and uncover a previously unappreciated role of SLC7A11 to promote cancer cell dep
259 en together, these data highlight a critical unappreciated role of the host innate immune system in e
263 iastolic heart disease and define previously unappreciated roles for Micu2 in regulating angiotensin
264 erochromatic repression uncovered previously unappreciated roles for Sir1, a silencing establishment
265 ent of planarian GPCRs and reveal previously unappreciated roles for these receptors in systemic and
267 te the identification of TFs with previously unappreciated roles in CD8(+) T cell differentiation.
269 at human Mdm1 homologues may play previously unappreciated roles in interorganelle communication and
272 ome is essential for male viability, and has unappreciated roles in Turner's syndrome and in phenotyp
273 ymatic functions could be critical, as these unappreciated roles may hold clues to the ineffectivenes
275 ve identified macroautophagy as a previously unappreciated route for delivering membrane lipids to ly
276 this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy numb
277 results indicate that including a previously unappreciated score that quantifies tissue-specific nucl
278 vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on thei
279 of early thymocytes, including a previously unappreciated ShcA-c-Abl axis that regulates thymocyte p
280 is study provides evidence of the previously unappreciated signaling crosstalk between Kras and RhoA
282 erence with mitochondrial dynamics may be an unappreciated strategy that pathogens use to block host
283 ar populations occurring within a previously unappreciated structurally stereotypic organ architectur
284 n and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are
286 TISs in the human genome can be a previously unappreciated substrate of translational control mediate
288 esults suggest that OTR antagonists may have unappreciated therapeutic potential for stress-induced p
290 our tracing studies, including a previously unappreciated top-down reinforcing circuit from anterior
291 n this study, we have described the formerly unappreciated trans-proteolytic activity of the enzyme a
293 les of m(6)A, but also uncovers a previously unappreciated translational control mechanism in heat sh
295 llectively, these data identify a previously unappreciated Trim24-dependent requirement for IL-1R exp
297 ination of epsin, and uncovered a previously unappreciated ubiquitin-binding surface within VEGFR2.
299 fourth edge of the antibiotic sword remained unappreciated until recently, i.e., the cost that an ant
300 ive field surveys have revealed a previously unappreciated wild lifestyle of S. cerevisiae outside th
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