ライフサイエンスコーパス: uncharacterized

1 y of SCVs to resist host defenses is largely uncharacterized.

2 of disruption of this complex remain largely uncharacterized.

3 ving a key step in stress granule regulation uncharacterized.

4 obiome they harbour and transport is largely uncharacterized.

5 dynamics and lipid dependence remain mostly uncharacterized.

6 ancestral populations, leaving other groups uncharacterized.

7 e deformation, but they have been relatively uncharacterized.

8 n HLA DSA and non-HLA autoantibodies remains uncharacterized.

9 red proliferation in response to RSV remains uncharacterized.

10 genomics, much of their biodiversity remains uncharacterized.

11 ng sequence alleles analyzed were previously uncharacterized.

12 ancers/SEs mediating VSMC dysfunction remain uncharacterized.

13 ent glycan structures and their roles remain uncharacterized.

14 s governing membrane organization are mostly uncharacterized.

15 n, the Ab repertoire induced by LATVs remain uncharacterized.

16 pact of metabolic regulation remains largely uncharacterized.

17 ) are largely heterogeneous and functionally uncharacterized.

18 opamine release properties, however, remains uncharacterized.

19 translational regulation remains relatively uncharacterized.

20 g processes that mediate these responses are uncharacterized.

21 EDC activity through this isoform remains uncharacterized.

22 ogical role of mitochondria in ADPKD remains uncharacterized.

23 correlation of the subgroups remains largely uncharacterized.

24 bly might differ among AAV serotypes remains uncharacterized.

25 omplete repertoire of MMP substrates remains uncharacterized.

26 cross the mammalian proteome, remain largely uncharacterized.

27 erse physiological actions remain relatively uncharacterized.

28 ancer arises through mechanisms that are yet uncharacterized.

29 tructure driving the process remains largely uncharacterized.

30 encing the grazing tolerant phenotype remain uncharacterized.

31 ng (AS) regulation in EMT remains relatively uncharacterized.

32 erlying the function of IGPR-1 in ECs remain uncharacterized.

33 mechanisms causing BBB damage in CNS TB are uncharacterized.

34 between them is highly plausible but largely uncharacterized.

35 and human protein O-mannosyltransferases is uncharacterized.

36 r, the majority of missense mutations remain uncharacterized.

37 ite 2-oxindole-3-acetic acid (oxIAA) remains uncharacterized.

38 associated with disease and 39 of which are uncharacterized.

39 aspects of selectivity have remained largely uncharacterized.

40 owever their roles in this process are still uncharacterized.

41 ry of Aboriginal Australians remains largely uncharacterized.

42 neurodevelopmental disorders remains mostly uncharacterized.

43 oxoplasmosis, yet most of their genes remain uncharacterized.

44 g craniocardiac malformations remain largely uncharacterized.

45 regulation of TAZ or YAP expression, remains uncharacterized.

46 e assembled PNKP-XRCC4-LigIV complex remains uncharacterized.

47 ns to be targeted to the mycomembrane remain uncharacterized.

48 acterial disease, has remained biochemically uncharacterized.

49 ries of peoples from this region are largely uncharacterized.

50 rophic stimuli to induce Lin28 have remained uncharacterized.

51 s mixed-species relationship remains largely uncharacterized.

52 s on adaptive trait evolution remain largely uncharacterized.

53 s involved in late biosynthetic steps remain uncharacterized.

54 all conformation of the dysferlin protein is uncharacterized.

55 n; however, the regulatory mechanism remains uncharacterized.

56 ggested previously but many aspects remained uncharacterized.

57 h conformational changes that remain largely uncharacterized.

58 irus (MARV), however, remain almost entirely uncharacterized.

59 in CA between tumors and cultured cells are uncharacterized.

60 ganisms where histone methyltransferases are uncharacterized.

61 defining cell-type identity is still largely uncharacterized.

62 ition of these mixtures has remained largely uncharacterized.

63 additional roles, but other substrates were uncharacterized.

64 Furthermore, we identify a previously uncharacterized, 12-amino acid region within the NRP1 cy

65 freiburgense (CfPutA), which belongs to the uncharacterized 3B class of PutAs.

66 e identify the RNA target for the previously uncharacterized 5-methylcytosine (m(5)C) methyltransfera

67 ds, bile acids, sphingosines, and previously uncharacterized adducts, including ammoniated cardiolipi

68 , the enthalpies of adsorption of previously uncharacterized adsorbents were estimated as a function

69 Host sensing of corynebacteria is largely uncharacterized, albeit the recognition of lipoglycans b

70 vel perkinsids, coccidians, colpodellids and uncharacterized alveolates.

71 s leading to kidney tumor development remain uncharacterized and effective therapies are yet to be id

72 These in vivo studies provide a previously uncharacterized and important molecular atlas for explor

73 tological screening, we uncover a previously uncharacterized and polarized component (SpmY) of the Ta

74 ic mRNA content, and the ability to consider uncharacterized and possibly highly variable cell types.

75 h the continuing discovery of AMPs, many are uncharacterized and their exact mechanism remains unknow

76 c effects in patients with psoriasis remains uncharacterized, and a method is needed for the noninvas

77 e, which we designate mcrA, is conserved but uncharacterized, and it encodes a putative transcription

78 whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the select

79 ther than miRNA targets is currently largely uncharacterized, and this limits the application of RNA

80 n diseases; however, its synapse proteome is uncharacterized, and whether the teleost-specific genome

81 processes and identified modes of action for uncharacterized antibiotics.

82 ts and mechanism of action (MoA) for new and uncharacterized anticancer drugs is important for optimi

83 This transcript appears to be an uncharacterized antisense RNA.

84 ORCA3 forms a physical cluster with two uncharacterized AP2/ERFs, ORCA4 and 5.

85 The ESV1 protein and a similar uncharacterized Arabidopsis protein (named Like ESV1 [LE

86 e Candidate Phyla Radiation (CPR) and as yet uncharacterized Archaea.

87 ration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism.

88 hould provide evidence for important but yet-uncharacterized aspects of bacterial physiology and may

89 e report the systematic analysis of one such uncharacterized assembly factor, Pet117, and demonstrate

90 in, Cas13b, along with one of two previously uncharacterized associated proteins, Csx27 and Csx28.

91 s of signaling cascades - to identify so far uncharacterized asthma pathogenesis pathways.

92 A previously uncharacterized auditory pathway was then revealed: it b

93 sis reveal a surprising wealth of previously uncharacterized biochemical reactions that have potentia

94 n on the function of a variety of previously uncharacterized biosynthetic enzymes, including a YcaO d

95 etraterpenoid hydrocarbon lycopadiene via an uncharacterized biosynthetic pathway.

96 ts such as music and language remain largely uncharacterized, but likely constrain cultural transmiss

97 ducing end of beta-1,3-glucan chains, and an uncharacterized C-terminal module classified into CBM fa

98 ErbB family possesses a unique, structurally uncharacterized C-terminal tail that plays an important

99 Here we identified a previously uncharacterized cell death pathway regulated by TAK1, wh

100 Here we describe a previously uncharacterized cellular response induced by heme: the f

101 mutant, six patients carried the previously uncharacterized CFH-411T variant.

102 the most-abundant prokaryote belonged to an uncharacterized clade of Chlorobi classified as Chlorobi

103 involved in the symbiosis form a previously uncharacterized clade of DGK domain proteins.

104 this enzyme suggested that it is a novel and uncharacterized class of AHL lactonase.

105 Plasmid DNA sequencing of previously uncharacterized clinical extended-spectrum beta-lactamas

106 r several microcompartment types, additional uncharacterized components complicate systematic investi

107 esis, respectively, and predicted previously uncharacterized components of known processes.

108 of known virulence mechanisms in addition to uncharacterized components of T3SS2.

109 ur studies provide structures for previously uncharacterized components of the PIC, such as TFIIE and

110 Both CD4 and b12 induce large, previously uncharacterized conformational rearrangements in the gp4

111 leading to the identification of previously uncharacterized conformational states of this duplex whi

112 ll-characterized gene, dicer, and a probable uncharacterized cyclin dependent kinase in honey bees, w

113 Prp represents a new clade of previously uncharacterized cysteine proteases, and the dependence o

114 niquely identify the quantum state shared by uncharacterized devices by simply inspecting the correla

115 or 1,092 genes and candidates in genetically uncharacterized diseases including arrhythmogenic right

116 tammetry (FTacV) we have measured previously uncharacterized disulfide bond redox chemistry in Escher

117 eins, identification of genes and viruses in uncharacterized DNA samples, phylogenetic analysis, larg

118 rases, the heme-binding protein ChaN, and an uncharacterized domain of Pasteurella multocida toxin.

119 nted compositional details of the previously uncharacterized DON pool and outlines the means to furth

120 hodiester bond formation remain structurally uncharacterized due to utilization of natural nucleotide

121 Our analysis revealed previously uncharacterized early and progressive abnormal patternin

122 Our work highlights a hitherto uncharacterized effect of alcohol on BAT function, with

123 oseptoria tritici secretes many functionally uncharacterized effector proteins during infection.

124 Here, we identify two previously uncharacterized effectors required for interbacterial an

125 Our findings on the previously uncharacterized effects of LND may provide potential com

126 The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional underst

127 provides a basis for predicting functions of uncharacterized enzymes.

128 This study reveals an uncharacterized epigenetic complex involved in leaf sene

129 as 679-14-D04, which recognizes a previously uncharacterized epitope, prevented oxidative inactivatio

130 Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participat

131 ocyte homoeostasis, pointing to a previously uncharacterized ER stress mechanism that contributes to

132 a single V. fischeri protein, the previously uncharacterized EroS, fully recapitulates the aphrodisia

133 cts and colocalizes with TAC65, a previously uncharacterized essential component of the tripartite at

134 omparative genomic analyses of 94 previously uncharacterized ETEC isolates demonstrated remarkable ge

135 ther, this study demonstrates two previously uncharacterized factors AK023948 and DHX9 as important p

136 We identified many uncharacterized family members, including a universally

137 scription factor and belongs to a previously uncharacterized family that is conserved in heterokont a

138 -mediated cleavage and illuminate previously uncharacterized features of Cas9-gRNA complex formation.

139 nalysis defines approximately 200 previously uncharacterized, fitness-conferring genes unique to the

140 ) to 10(6) biosynthetic gene clusters as yet uncharacterized for potential new therapeutic agents.

141 rt delay periods (1-4 s), but remain largely uncharacterized for tasks with longer delay periods.

142 This previously uncharacterized function of NuMA in rDNA transcription a

143 ained mRNAs in the cytoplasm have previously uncharacterized functions and/or escape surveillance.

144 LK, and ETV6-NTRK3, as well as 20 previously uncharacterized fusion genes identified in The Cancer Ge

145 el B cell-associated cytokine, encoded by an uncharacterized gene (C17orf99; chromosome 17 open readi

146 Our data demonstrate that a previously uncharacterized gene CG7837, which we termed R and B (Rn

147 Both screens also identify a role for the uncharacterized gene TXNDC11, which we show encodes an E

148 at a highly conserved serine residue in the uncharacterized gene VSIG10L that segregated in affected

149 Here, we identify an uncharacterized gene, LOTR1, essential for Casparian str

150 Furthermore, several uncharacterized genes and regulatory sequences demonstra

151 ing transition and predicts the functions of uncharacterized genes in seedling establishment.

152 ght harbor mutations in poorly understood or uncharacterized genes, and their diagnosis relies upon c

153 ms and assigned putative biological roles to uncharacterized genes.

154 eened a cohort of 136 European probands with uncharacterized genetic cause of Charcot-Marie-Tooth dis

155 es for the accurate functional annotation of uncharacterized genomic sequences.

156 An uncharacterized group of HRPKSs was found to contain a C

157 The structure reveals a previously uncharacterized helical membrane domain and a periplasmi

158 % of targeted CEPs, revealed many previously uncharacterized heteromeric complexes.

159 NMR spectroscopy to open the "black box" of uncharacterized high-MW DON.

160 roach reveals that MobM follows a previously uncharacterized histidine/metal-dependent DNA processing

161 e data suggest the existence of a previously uncharacterized historical plague focus that persisted f

162 complex subunit 7 (BORCS7) and a previously uncharacterized, human-specific arsenite methyltransfera

163 encing have led to the rapid accumulation of uncharacterized 'hypothetical proteins' in the public da

164 together, these data identify the previously uncharacterized IGF1-RIT1-Akt-Sox2 signaling pathway as

165 These studies demonstrate that a previously uncharacterized ILC population regulates the activity an

166 ysiological properties of OLs remain largely uncharacterized in different brain regions.

167 eostasis and highlights a pathway previously uncharacterized in retinal dystrophy.

168 ent, the known genetic risk loci are largely uncharacterized in terms of the variant or gene responsi

169 imethylguanosine synthase (TGS1), previously uncharacterized in the plant kingdom.

170 s (ORFs) previously designated "predicted," "uncharacterized," "inferred," or "hypothetical" polypept

171 ction, which may create an interface for yet uncharacterized interacting proteins.

172 C (a.k.a., Harmonin), revealing a previously uncharacterized interaction mode both for MyTH4-FERM tan

173 eractomes and to focus on well-conserved yet uncharacterized interactors for further study.

174 ructure reveals not only that the previously uncharacterized internal domain is a member of the polyc

175 loop of ENaC-alpha, as well as to a hitherto uncharacterized internal site.

176 ent, and we map the expression of previously uncharacterized ionotropic GABA receptors.

177 This identified 116 previously uncharacterized KIR alleles, which were all demonstrated

178 membranes, including a subset of previously uncharacterized Legionella effectors that appear to be a

179 indicate the existence of a novel, presently uncharacterized ligand for the activating NK cell recept

180 e habitats and include members of previously uncharacterized lineages.

181 tRNA halves as well, suggesting a previously uncharacterized link between 5'-tRNA halves and td-piRNA

182 Our study reveals a previously uncharacterized link between cell density and piRNA biog

183 hia effectors and point to potential, as yet uncharacterized, links between known phenotypes induced

184 se, and rather support the involvement of an uncharacterized lipase and/or of multiple hydrolases.

185 ctivation in the heart requires a previously uncharacterized lncRNA-dependent epigenetic checkpoint.

186 that the biological function of thousands of uncharacterized lncRNAs of this class may be inferred fr

187 ellulare uncovered mutations in a previously uncharacterized locus, mmpT5 Preliminary analysis sugges

188 A previously uncharacterized long noncoding RNA (lncRNA), SMN-antisen

189 iated with the up-regulation of a previously uncharacterized long noncoding RNA (lncRNA), termed AK14

190 MYLIP, rs6924995 lies within RP1-13D10.2, an uncharacterized long noncoding RNA.

191 AP kinase cascade that includes a previously uncharacterized MAP kinase kinase, CrMAPKK1.

192 tilizes a magnesium sensing PhoP-PhoQ and an uncharacterized MarR-like transcriptional regulator (San

193 These findings describe a previously uncharacterized mechanism by which TbetaRII is tightly c

194 ts natural sheep host to reveal a previously uncharacterized mechanism used by an arbovirus to manipu

195 marine heterotrophic bacteria using largely uncharacterized mechanisms.

196 present investigation of AlmG, the hitherto uncharacterized member of the AlmEFG pathway.

197 ParS, a largely uncharacterized membrane sensor of a two-component syste

198 We show herein that a previously uncharacterized membrane-associated M. tuberculosis prot

199 ectively, this study has revealed previously uncharacterized metabolic reprogramming involving an ALO

200 These results underscore the extent of uncharacterized microbial diversity and provide fruitful

201 ur proteins proposed to form the shell of an uncharacterized microcompartment designated the Rhodococ

202 We identified a so far uncharacterized mitochondrial protein (open reading fram

203 we have focused our attention on RPUSD4, an uncharacterized mitochondrial putative pseudouridine syn

204 reveal differential splicing as a previously uncharacterized mode of translational control under hypo

205 best-characterized nanodomain markers via an uncharacterized moiety called REMORIN C-terminal Anchor.

206 Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connection between cranial

207 Rather, AutoN cooperated with a hitherto uncharacterized motif, termed AcidicN, to confer H4-tail

208 We identified previously uncharacterized mutations present only in the cultured t

209 nidin biosynthetic enzymes and several novel uncharacterized MYB transcriptional repressors.

210 gene should be considered for patients with uncharacterized myopathies and cardiomyopathies.

211 We identify previously uncharacterized myosin-binding proteins, putative myosin

212 containing Sin3b by binding to a previously uncharacterized N-terminal domain.

213 e (Tm-1L) protein is predicted to contain an uncharacterized N-terminal UPF0261 domain and a C-termin

214 Here, we identify Ccp1, an uncharacterized NAP family protein in fission yeast that

215 by laser ablation, as well as one previously uncharacterized neuron, PDB.

216 e-control contrasts, rs1709393 located in an uncharacterized non-coding RNA locus on chromosomal band

217 om human cancer samples reveled thousands of uncharacterized non-coding RNAs including long non-codin

218 e types of sequence variants in a previously uncharacterized non-mAb protein therapeutic expressed in

219 Here we introduce three previously uncharacterized, nondirection-selective ON-OFF RGC types

220 ll-studied OSM-9 TRPV subunit and relatively uncharacterized OCR-4 TRPV subunit as well as the orthol

221 l role in cancer cell growth, studies remain uncharacterized on the role of inflammasomes in prostate

222 re accessions in which plant regeneration is uncharacterized or difficult to obtain.

223 ting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit

224 ellum culture, indicating the presence of an uncharacterized pathway capable of converting CO2 to for

225 ere, we show that FAN1 contains a previously-uncharacterized PCNA interacting peptide (PIP) motif tha

226 omes, and we identify Hec1 S69, a previously uncharacterized phosphorylation target site in the Hec1

227 small subunit, NtRbcS-T, which belongs to an uncharacterized phylogenetic cluster (T).

228 genomes from two deep-branching, previously uncharacterized phylum-level lineages (here named "Candi

229 nd they play seemingly important, yet mostly uncharacterized, physiological functions.

230 been identified in patients with previously uncharacterized PIDs has opened up the potential for tar

231 single amino acid substitution (R644W) in an uncharacterized polyketide synthase (MuPKS).

232 This previously uncharacterized population generates exclusively myeloid

233 farming is found, and identify a previously uncharacterized population that is neither ancestral to

234 uding promoting its acetylation-a previously uncharacterized post-translational modification of this

235 te and used the resultant data to screen for uncharacterized potential targets.

236 While studying patients with genetically uncharacterized primary immunodeficiencies, we detected

237 uncultivated and its metabolic capabilities uncharacterized, prokaryotes and fungi have the potentia

238 We identified an uncharacterized protein (C11orf84), which we renamed SPI

239 In summary, we report on a previously uncharacterized protein CEFIP that modulates calcineurin

240 Here we identify the uncharacterized protein CMTM6 as a critical regulator of

241 thus describe the key role of the previously uncharacterized protein Eros in host defense.

242 eted proteins, define the role of previously uncharacterized protein export systems, and observe cros

243 Here, we uncovered a previously uncharacterized protein family consisting of three proli

244 acterization, whether it is for a previously uncharacterized protein in basic research or a recombina

245 ucose through the activity of the previously uncharacterized protein kinase Vhs1 and its substrate Si

246 This screen yielded a previously uncharacterized protein named cardiac-enriched FHL2-inte

247 e identify and determine that the previously uncharacterized protein Rv3723/LucA, functions to integr

248 demonstrate that Cordon-Bleu (Cobl)-like, an uncharacterized protein suggested to represent a very di

249 ibe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocyanin meth

250 This uncharacterized protein was predicted as a bacterial cel

251 bule-Associated Stress Protein 1 (MASP1), an uncharacterized protein, increased in abundance during s

252 Here we identify an uncharacterized protein, Tudor interacting repair regula

253 We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling

254 our knowledge, appears unique, a previously uncharacterized protein-to-protein carotenoid transfer m

255 cteria and Archaea with large inventories of uncharacterized proteins are a striking feature of the T

256 to identify the function and ligands of yet uncharacterized proteins having impact on different dise

257 We applied the method on nearly 55.3 million uncharacterized proteins in UniProtKB/TrEMBL resulted in

258 s of enzymes, and the molecular functions of uncharacterized proteins.

259 rgence allowed for the emergence of a so-far-uncharacterized RbcS cluster.

260 These studies reveal a previously uncharacterized reaction for this family; OxsA catalyzes

261 their precise germline roles remain largely uncharacterized, recent discoveries suggest that they fu

262 hypothesis that PMAT1 might be a previously uncharacterized regulator of NAE metabolism in plants.

263 Our findings of transcribed uncharacterized regulatory regions that contain CRSs sup

264 ding regions in two newly discovered, though uncharacterized, regulatory RNAs.

265 We highlight poorly-understood or previously-uncharacterized repair systems and components, e.g. pote

266 ogether, our study uncovered many previously uncharacterized repressors of ERVs, and defined an essen

267 iodic fever, and developmental delay with an uncharacterized retinal dystrophy is caused by TRNT1.

268 Here we describe a previously uncharacterized rhodopsin, Rh7, which contributes to cir

269 Here, we present the genome of a previously uncharacterized Rickettsia endosymbiont from Culicoides

270 We show a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly

271 genes, including noncoding RNA LINC01124 and uncharacterized RNA AK127400 in the module related to th

272 al RBP features, but 99 exhibited previously uncharacterized RNA-binding activity.

273 These findings highlight a previously uncharacterized role for flow-induced metabolic reprogra

274 gether, these findings identify a previously uncharacterized role of folate/DHFR/AMPKalpha axis in re

275 Thus, our study reveals a previously uncharacterized role of RAD51 in initiating immune signa

276 t, we show that a large degree of previously uncharacterized site-to-site variability exists in footp

277 parent autosomal recessive inheritance of an uncharacterized skeletal dysplasia.

278 applicable for newly identified, previously uncharacterized small molecules.

279 termined spermine (SPM) sensitivity of these uncharacterized SNPs and found that Q212R-containing cha

280 lliculus formation by depleting a previously uncharacterized stem cell zone.

281 The three genes form an uncharacterized subclade of the SMXL gene family that me

282 xpressed in the pineal gland in a previously uncharacterized subgroup of cells.

283 Many M. tuberculosis P450s remain uncharacterized, suggesting that their further analysis

284 epresses several known as well as previously uncharacterized targets that play critical roles in cont

285 However, because most lncRNAs are currently uncharacterized, the identification of novel oncogenic l

286 were identified and recognition motifs for 6 uncharacterized Thermus-family enzymes were predicted.

287 ransfer cellular functions to a functionally uncharacterized tissue.

288 ablished, but the extent to which previously uncharacterized toxins utilize these mechanisms is unkno

289 B. pertussis encodes many uncharacterized transcription factors, and very little i

290 owerful technologies in well-established and uncharacterized translation-dependent processes holds th

291 proteins, we found that OIG-8, a previously uncharacterized transmembrane protein with a single immu

292 broad substrate tolerance for the otherwise uncharacterized TruF family.

293 This approach unearthed a previously uncharacterized two-component system, named UzcRS, which

294 ched gene of the screen encodes a previously uncharacterized type I transmembrane protein, KIAA0319L

295 sampling/sample processing and the number of uncharacterized/unverifiable porcine proteins may have c

296 PWWP2A is a functionally uncharacterized, vertebrate-specific protein that binds

297 ause many aspects of this key process remain uncharacterized, we developed a facile method for the in

298 enesis; however, their transcriptome remains uncharacterized, which limits functional understanding o

299 natures cluster more than half of the so far uncharacterized yeast genes and provide functional annot

300 Here we identify the uncharacterized zinc finger protein Tmc1 as a dynamicall