ライフサイエンスコーパス: unchecked

1 eration of cancer cells proceeds essentially unchecked.

2 ury, although it may also cause harm if left unchecked.

3 ic plasticity or contribute to epilepsy when unchecked.

4 significant morbidity and mortality if left unchecked.

5 allows the inflammatory response to continue unchecked.

6 le leaving piriform-mediated odor clustering unchecked.

7 llow them to evade apoptosis and proliferate unchecked.

8 can cause tissue damage and organ failure if unchecked.

9 es, either alone or collaboratively, if left unchecked.

10 reated patients, and Th17 responses remained unchecked.

11 cur, and intracellular bacterial growth goes unchecked.

12 e resistant strain to persist or to multiply unchecked.

13 excitation or depression of circuits if left unchecked.

14 n host macrophages and can be lethal if left unchecked.

15 he damage that would result if mistakes went unchecked.

16 it can have detrimental consequences if left unchecked.

17 entral tolerance, and can cause T1DM if left unchecked.

18 If unchecked, a runaway inflammatory response can cause sig

19 REAM-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin.

20 Unifying characteristics include unchecked abilities of tumor cells to proliferate and sp

21 Unchecked accumulation of reactive oxygen species (ROS)

22 and neurological symptoms of FXS result from unchecked activation of mGluR5, a metabotropic glutamate

23 t these defects are due in large part to the unchecked activity of dE2F2, since they can be suppresse

24 e2f1 mutant cells is severely reduced due to unchecked activity of the repressor dE2F2 in these cells

25 When left unchecked, algae can cause declines in seagrass producti

26 Unchecked amino acid accumulation in living cells has th

27 r expression is tightly regulated to prevent unchecked amplification.

28 e process, coagulation is allowed to proceed unchecked and contributes to the pathogenesis of cerebra

29 ccurred in IFN-gamma gko mice, the virus was unchecked, and the infection led to death.

30 ogen response, whose deregulation may foster unchecked AR activity in PCa.

31 Through this pathway, RB depletion induced unchecked AR activity that underpinned therapeutic bypas

32 associated with severe pathologies, whereas unchecked autophagy activity causes cell death.

33 eral tolerance and its absence can result in unchecked autoreactive responses, leading to diseases li

34 ea are significantly decreased, resulting in unchecked bacterial growth and perforation.

35 The elevation of the SL1 binding mode, unchecked by a proportionate population of binding modes

36 despread economic burden and remains largely unchecked by existing control strategies.

37 eventually die, as p53 expression continues unchecked by remethylation.

38 o robust inflammatory responses that if left unchecked can lead to autoimmune disease and other seque

39 ), can elicit hypoxia-like responses that if unchecked can lead to unusual peri-implant pathologies,

40 es a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction.

41 in tumor suppressor gene function, allowing unchecked cell cycle progression and, by genomic instabi

42 Because unchecked cell cycle progression leads to hyperprolifera

43 ading to increasing possibilities to control unchecked cell growth and metastasis.

44 Unchecked cell growth is a hallmark of cancer.

45 ar signal transduction pathways that lead to unchecked cell growth.

46 in TG mice, together with ZD, might lead to unchecked cell proliferation and accelerated NMBA-induce

47 and c-IAP1, may help to explain unwanted and unchecked cell proliferation in this disease.

48 of increased mitotic signaling coupled with unchecked cellular growth.

49 ression and/or activation is associated with unchecked cellular proliferation, resistance to apoptoti

50 the other E. coli polymerases, which if left unchecked could hinder its ability to synthesize DNA in

51 sms, thus allowing bacterial toxins to cause unchecked, devastating physiological derangements in the

52 s who are at risk for severe consequences of unchecked disease persistence or progression." This year

53 its cell defenses that would be triggered by unchecked EBNA2 prooncogenic activity.

54 splicing may prevent the adverse effects of unchecked elongation or diminution of coding ends during

55 With unchecked emissions, the central warming can reach the d

56 H ratio in chronic SIV infection may lead to unchecked expansion of both TFH and GC B cells.

57 2/Id3 double-knockout mice that is caused by unchecked expansion of invariant NKT (iNKT) cells or a u

58 tion and suggest possible mechanisms for the unchecked expansion of TFH cells in HIV/SIV infection.

59 and functions as a vital barrier against the unchecked expansion of tumor stem cell pools; however, l

60 " These are hypothesized to be formed by the unchecked extension of identical but much shorter struct

61 -estradiol-driven p27 degradation to proceed unchecked for cell cycle progression.

62 However, unchecked free radical generation is also responsible fo

63 Unchecked glucose-mediated oxidative stress and advanced

64 In humans and pigs lacking CFTR, unchecked H(+) secretion by the nongastric H(+)/K(+) ade

65 These observations suggest that unchecked HIV-1 replication may lead to depletion or dys

66 thogenesis by promoting inflammation through unchecked IL-17 production and facilitating the developm

67 lly maintained by tonic signals that prevent unchecked immune responses to nucleic acids released dur

68 event excessive tissue destruction caused by unchecked immune responses.

69 lower at baseline, the production of cGMP is unchecked in eNOS-/- and nNOS-/-, eNOS-/- mice upon neur

70 Although differentiation proceeds unchecked in the absence of patS and hetN expression, di

71 to determine why an immunogenic tumor grows unchecked in the anterior chamber (a.c.) of the eye.

72 oliferation and tumorigenesis accompanied by unchecked inactivation of the retinoblastoma tumor suppr

73 e during the peak of infection, but not with unchecked inflammation or with increased cellular respon

74 Unchecked inflammation, impaired keratinocyte differenti

75 (ARDS) provokes three pathologic processes: unchecked inflammation, interstitial/alveolar protein ac

76 However, when allowed to continue unchecked, inflammation may result in autoimmune or auto

77 Although the precise origin of the unchecked inflammatory response in obesity is unclear, i

78 disease and diabetes, may develop because of unchecked inflammatory responses that have maladapted ov

79 merged during the 20th century and continues unchecked into the 21st century.

80 homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.

81 ulation of protein aggregates; however, when unchecked, it can be detrimental and cause autophagic ce

82 in response to various stimuli, but if left unchecked, it can inflict oxidative damage on all types

83 er than 10% in some regions of the world (if unchecked), lack of data and the observed heterogeneity

84 es coordinate antimicrobial immunity and, if unchecked, lead to autoimmune disease.

85 erosis, these repair processes appear to run unchecked, leading to aberrant remodeling and fibrosis o

86 ositive regulation of IL-12 by IFN-gamma, if unchecked, leads to excessive cytokine production and to

87 ike differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmuni

88 that EBV-infected B cells proliferate in an unchecked manner due to suppression of cytotoxic T cells

89 collective U-turn, divergent migration, and unchecked migration against an obstacle.

90 containing the transcription factor YY1, and unchecked miR-134 expression following SIRT1 deficiency

91 ways through the basal ganglia, resulting in unchecked movements via thalamic disinhibition.

92 rculatory system or vascular endothelium and unchecked neutrophil transmigration.

93 Unchecked NF-kappaB signalling can engender autoimmune p

94 ceptor may protect against excitotoxicity of unchecked NMDA receptor recruitment during induction and

95 aintenance of neuronal homeostasis; however, unchecked or dysregulated autophagy can lead to cell dea

96 ICSBP-deficient mice exhibited unchecked parasite replication in vivo and rapidly succu

97 ls to progress towards the endocrine lineage unchecked, particularly as part of the secondary transit

98 bit immunosurveillance and thereby allow the unchecked persistence and proliferation of premalignant

99 hy mitochondrial domains from elimination by unchecked PINK1-Parkin activity.

100 ui society collapsed because of centuries of unchecked population growth within a fragile environment

101 ulations could be driven to extinction by an unchecked proliferation of TEs.

102 ed MCMV susceptibility mutation that permits unchecked proliferation of the virus, causing death.

103 upts epithelial organization and also causes unchecked proliferation.

104 If unchecked, recurrent episodes of acute pancreatitis may

105 damage checkpoint and, when mutated, permit unchecked replication of damaged DNA in S-phase.

106 Additionally, proliferation continues unchecked, resulting in two types of tumors also found i

107 If unchecked, ROS production and oxidative stress mediate t

108 evated plasma TPO levels, which serves as an unchecked stimulus to drive the observed excessive megak

109 Unchecked, sustained mTOR activity results in defects in

110 monstrated that mortality is associated with unchecked tachyzoite replication.

111 zeta; PTN inactivates RPTPbeta/zeta, leaving unchecked the continued endogenous activity of tyrosine

112 If unchecked, the expression of the GRFs in the stem cell n

113 If past obesity trends continue unchecked, the negative effects on the health of the U.S

114 If unchecked, the temperature-driven increases in resting C

115 If anthropogenic emissions continue unchecked, the warming increase may reach 8-10 degrees C

116 lated; however, when matrix replacement goes unchecked, there is unwanted and irreversible tissue sca

117 may leave the oncogenic activities of Runx2 unchecked, thereby driving promiscuous expression of Run

118 If unchecked, these trends will lead to a steep decline in

119 If left unchecked, this bias is likely to skew data interpretati

120 Left unchecked, this causes titration of RNA polymerase and a

121 Unchecked, this cooling would lead to massive accumulati

122 Unchecked, this side reaction will also prevent applicat

123 Myeloid cell proliferation proceeds unchecked throughout the course of mycobacterial infecti

124 ation, compromised PI(3)K activity allows an unchecked TLR-induced inflammatory responses and constit

125 Unchecked TLR4 activation might result in autoimmune dis

126 ck of IL-4 in the deficient mice resulted in unchecked TNF-alpha production, which appeared to cause

127 s impeding incisor abrasion and resulting in unchecked tooth elongation.

128 lta mutant, plasmid instability results from unchecked transcription elongation, which can be suppres

129 This syndrome is due to unchecked transfer of iron into the bloodstream in the a

130 ends upon adaptive control mechanisms, since unchecked transposon activity can impact long-term fitne

131 from endogenous retroelements that, if left unchecked, trigger elevated production of type I interfe

132 lay of innate immune responses, allowing for unchecked viral growth and ultimately severe immunopatho

133 nate and adaptive immune system that if left unchecked will lead to the rejection of transplanted cel

134 e limits suggests that biodiversity loss, if unchecked, will undermine efforts toward long-term susta

135 By 2050 these dietary trends, if unchecked, would be a major contributor to an estimated

136 from reactive chemical species that, if left unchecked, would cause mutagenic DNA damage.