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1 ely 65% was conjugated and approximately 35% unconjugated.
4 -IT, DSG, and MP treatment, but not when the unconjugated a-CD3 monoclonal antibody was substituted f
5 LaR); YSFKPMPLaR and YKQGGFLGL together, but unconjugated; a C5a-active, MUC1 epitope construct (YKQG
6 the simple addition of an anti-fluorochrome unconjugated Ab during staining resulted in considerably
7 dge, we show for the first time that whereas unconjugated Ab plus siRNAs reduce arthritis by 19%, our
12 can also reduce nitriles in the presence of unconjugated alkenes and alkynes such as the reduction o
14 ts, all-trans-retinal dimer-ethanolamine and unconjugated all-trans-retinal dimer, in human and mouse
19 associated with markedly elevated levels of unconjugated and glycine-conjugated bile acids in gallbl
20 estinal tract of ethanol-treated rats, while unconjugated and glycine-conjugated species increased.
22 used to examine quantitatively the extracted unconjugated and sulfated steroids, where the recovery e
23 r measuring the absolute quantities of free (unconjugated) and total (conjugated + unconjugated) endo
25 , the majority of gallbladder bile acids was unconjugated, and only a small percentage was conjugated
28 incubated with immunotoxin FN18-CRM9 or the unconjugated anti-CD3 monoclonal antibodies and then exa
34 ituximab into clinical practice as the first unconjugated antibody for cancer treatment, underscoring
37 iation and having therapeutic activity as an unconjugated antibody, protected mice for only 30 days;
39 ained after the administration of either the unconjugated antiluciferase PNA or a PNA conjugate that
40 Both uptake and correction were inhibited by unconjugated aptamer, confirming the role of the aptamer
44 ol/L to 3.59 +/- 3.70 mumol/L (P = 0.01) and unconjugated BA levels increased from 0.18 +/- 0.24 mumo
46 tion and biliary excretion of conjugated and unconjugated BAs were essentially the same in Oatp1b2-nu
47 s markers and total plasma BAs, particularly unconjugated BAs, had markedly risen; this effect could
51 MCAO) were treated intravenously with either unconjugated BDNF, unconjugated MAb, or the BDNF-OX26 co
52 the initial nitroaldols dehydrated to afford unconjugated beta,gamma-unsaturated alpha-nitrosulfones
54 , collectively our findings demonstrate that unconjugated bile acids activate hepatocyte receptor tyr
56 98.3%), duodenum (97.8%), and ileum (89.7%), unconjugated bile acids comprised the largest proportion
57 ice accumulated high levels of predominantly unconjugated bile acids in plasma because of altered exp
67 uction was observed with both conjugated and unconjugated bile salts and was in a dose- and time-depe
68 ux pump by decanoate and the more lipophilic unconjugated bile salts is mediated by Rob, and that the
69 rvations that equilibration of fully ionized unconjugated bile salts occurs at a negligible rate in s
70 icient mice indicated that hepatic uptake of unconjugated bile salts was strongly impaired whereas up
71 ciency interferes with basolateral uptake of unconjugated bile salts, a process mediated by organic a
74 0.96 to 5.73, p = 0.06), lower pre-operative unconjugated bilirubin (HR: 0.84 mumol/l, 95% CI: 0.72 t
76 atabolism, indirectly reflecting in elevated unconjugated bilirubin (UCB; main phenotypic feature of
78 r investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in
79 arly UDCA, increased cecal bile salt levels, unconjugated bilirubin and urobilinogen concentrations,
80 e findings indicate that elevations in serum-unconjugated bilirubin associated with indinavir treatme
81 ositive or HCV-negative specimens except for unconjugated bilirubin at concentrations of >or=20 mg/dl
83 with that in model vesicles, suggesting that unconjugated bilirubin crosses cellular membranes by pas
84 ethod is ideally suited to measuring unbound unconjugated bilirubin in jaundiced human newborns or an
87 orn Ugt1(-/-) mice developed serum levels of unconjugated bilirubin that were 40-60 times higher than
89 increased levels of bilirubin conjugates and unconjugated bilirubin, and in 60%, granules of amorphou
90 bilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common clinic
91 ponsible for the clearance and metabolism of unconjugated bilirubin, the hydrophobic end-product of h
92 , FLVCR has a narrow substrate range because unconjugated bilirubin, the primary breakdown product of
94 lirubin conjugation could increase levels of unconjugated bilirubin; the effects can be benign and fr
98 term, which resulted in 0.68 +/- 0.312 ng of unconjugated BPA per mL of maternal serum, a level compa
101 yer movement differed between conjugated and unconjugated BSs as determined with Laurdan-labeled lipo
107 deoxycholic, cholic, and deoxycholic acid in unconjugated (CDCA, CA, and DCA) and tauro-conjugated (t
108 lete Freund's adjuvant more effectively than unconjugated CGRP8-37 Our results show that CLR signals
113 and bile at baseline revealed predominantly unconjugated cholic acid and absence of the usual glycin
118 gher anti-LPS IgG levels than mice receiving unconjugated COPS and exhibited high antiflagellin IgG;
119 been quantified after being converted to its unconjugated counterpart by sulfatase/glucuronidase.
120 lying the efficacy of the conjugate over its unconjugated counterpart have been largely uninvestigate
121 excretion dynamics of polymer-conjugated and unconjugated CPT appear similar between animals and huma
124 protein conjugate vaccine was compared with unconjugated CRM197 and diphtheria toxin, its parent mol
128 ying enzymes, which leads to accumulation of unconjugated cytotoxins and carcinogens in the bladder.
131 tion was also evidenced by the fact that the unconjugated drug (desacetylvinblastine monohydrazide) w
132 ering the drug at a much lower dose than the unconjugated drug injected systemically to effectively i
134 d growth-inhibitory activity compared to the unconjugated drugs; sites of alkylation at tracts of mul
137 quitin complex and subsequent release of the unconjugated E2 protein upon ubiquitin transfer to a sub
141 free (unconjugated) and total (conjugated + unconjugated) endogenous estrogens and estrogen metaboli
142 (4-OT), a homohexameric enzyme, converts the unconjugated enone, 2-oxo-4-hexenedioate (1), to the con
144 percent for alpha-fetoprotein, 4 percent for unconjugated estriol, 29 percent for hCG, 25 percent for
145 protein, total human chorionic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 wee
147 assayed plasma concentrations of estradiol, unconjugated estriol, testosterone, progesterone, prolac
148 (DI-SPME- HPLC-ESI -MS) for determination of unconjugated fatty acids (FA) in fish and human plasma.
149 In the rat, dinorCDCA was secreted mostly in unconjugated form (the majority as dinor-alpha-muricholi
150 tula rats, sulindac was recovered in bile in unconjugated form and induced hypercholeresis of canalic
151 of target proteins, ISG15 can be found in an unconjugated form both inside of the cell and released f
154 ge 1.8-3.0), consisting predominantly of the unconjugated form; that of the control patients was 0.76
155 resis when secreted into canalicular bile in unconjugated form; the mechanism is cholehepatic shuntin
156 - 248 mumol/L) and predominantly excreted in unconjugated forms (79.4% +/- 3.9%) and as sulfates and
157 n their conjugated (glycine and taurine) and unconjugated forms was monitored by isothermal titration
158 (ng/mL) and 0.005 to 0.017 ng/mL for "free" (unconjugated forms) and "total" (unconjugated plus conju
159 amster, glucuronidation was greater, and the unconjugated fraction contained equal parts of dinorCDCA
160 A method is described for measuring the unconjugated fraction of the unbound bilirubin concentra
167 We conducted safety studies of purified unconjugated genistein, daidzein, and glycitein, and def
168 ating concentrations of biologically active (unconjugated) genistein in certain strains of mice cast
171 gosaccharides (HMOs) are a family of diverse unconjugated glycans that exist in human milk as one of
173 We evaluated sera from women immunized with unconjugated group B streptococcal (GBS) type III (GBS I
175 were readily removed, and the two remaining unconjugated HPODEs could then be easily isolated regioi
177 e oligomerization and albumin-binding of the unconjugated hybrid peptide as well as its lipidated var
180 are genetic disorders associated with severe unconjugated hyperbilirubinemia and a life-long risk of
181 y inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a deficiency o
184 by the donor liver and present with isolated unconjugated hyperbilirubinemia in liver transplant reci
185 ansplant Clinic, five patients with isolated unconjugated hyperbilirubinemia in the absence of hemoly
187 r-Najjar syndrome type I is characterized by unconjugated hyperbilirubinemia resulting from an autoso
188 ally lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from deficienc
189 ndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver
190 disorders, jaundice resulting from isolated unconjugated hyperbilirubinemia, and rash or photosensit
195 % tumor growth inhibition compared to 60% by unconjugated Ida alone and led to significant enhancemen
196 vitro cytotoxicity of DDCs was comparable to unconjugated Ida in several sensitive and resistant canc
198 The initial charge heterogeneity of the unconjugated IgG-2 monoclonal antibody (mAb) was assesse
201 conjugation inhibits many viruses, and free (unconjugated) ISG15 can also act as an antiviral protein
202 fety and pharmacokinetic studies of purified unconjugated isoflavone preparations containing genistei
204 A single-dose administration of purified unconjugated isoflavones at amounts that exceed normal d
208 Total (conjugated plus unconjugated) and unconjugated levels of these steroid hormones were measu
210 rCTB-conjugated group than in mice given the unconjugated liposome preparations, although the latter
211 to those in mice given one of the following unconjugated liposome preparations: (i) empty liposomes,
212 lar linear probe) after injection of saline, unconjugated liposomes and antibody conjugated liposomes
214 intravenously with either unconjugated BDNF, unconjugated MAb, or the BDNF-OX26 conjugate at a dose o
219 achieve higher clinical response rates than unconjugated mAbs targeting the same cell surface antige
223 h carrier RC-121, but after the injection of unconjugated mixture of AN-201 and RC-121 at doses of 30
226 ee distinct fields of research have emerged: unconjugated MoAbs, immunotoxin-conjugated MoAbs (ITs),
230 range of monomers, including conjugated and unconjugated monomers, using ultralow concentrations of
231 many additional contributions on the use of unconjugated "naked" antibodies for the treatment of can
236 onjugated oligonucleotides is different from unconjugated oligonucleotides, appropriate analytical me
238 eductions in uptake could increase levels of unconjugated or conjugated bilirubin (Rotor syndrome).
240 n was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to ex
243 ential for net uptake because neither of the unconjugated parent compounds are accumulated under ener
244 incubation of the immune serum with soluble, unconjugated peptide, indicating the specificity of the
245 decreased integrin binding affinity than the unconjugated peptide, it indicated integrin specific acc
247 emagglutinin (HA) and show that although the unconjugated peptides are inactive, the cholesterol-conj
248 small but significant role in the uptake of unconjugated phosphorothioate ASOs into hepatocytes.
249 also appears to play a role in the uptake of unconjugated phosphorothioate modified ASOs in the liver
251 tion in vitro relative to free ovalbumin, an unconjugated physical mixture of ovalbumin and polymer,
252 for "free" (unconjugated forms) and "total" (unconjugated plus conjugated forms) measurements, respec
258 ee of flexibility - at least as great as the unconjugated polysaccharides, and very different from th
259 e stimulation, ubp3 Delta mutants accumulate unconjugated polyubiquitin chains as well as polyubiquit
260 to improve staining using anti-fluorochrome unconjugated primary Abs followed by secondary staining
261 es can result in a mixture of conjugated and unconjugated products, which are often difficult to sepa
263 Using these, the g-factor spectra of other unconjugated proteins, measured in solution or as films,
266 chronic lymphocytic leukemia, and additional unconjugated, radiolabeled, and drug-conjugated monoclon
269 renal medullary secretion, we injected DSAP, unconjugated saporin (SAP), or saline bilaterally into t
270 jugated to the mu-opioid agonist dermorphin; unconjugated saporin and dermorphin were used as control
271 before the start of conditioning therapy for unconjugated serum bilirubin concentrations of at least
272 n was shown to reach up to 22 hours, whereas unconjugated single-stranded DNA was degraded within min
275 take and was markedly more effective than an unconjugated SSO or the monovalent conjugate in modifyin
277 90:10, v/v) in the first step to extract the unconjugated steroids and chloroform/2-butanol (50:50, v
279 on naturally occurring steroid sulfates and unconjugated steroids derivatized to their sulfate ester
287 ), displayed superior activity compared with unconjugated trastuzumab or trastuzumab linked to other
288 CPS-tetanus toxoid conjugate vaccine and the unconjugated two-repeat alpha C protein, which protected
289 rotein and cytosolic fractions and decreased unconjugated ubiquitin in the cytosol, without changes i
293 This screen revealed a series of physiologic unconjugated urinary catechols that were able to functio
297 GF (100 mug/kg), a matching concentration of unconjugated VEGF (18.65 mug/kg), ELP alone (100 mug/kg)
300 of organic anions, including conjugated and unconjugated xenobiotics and bile acids, from the liver.
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