ライフサイエンスコーパス: uncoupler

1 reatment with a liver-targeted mitochondrial uncoupler.

2 (+/-K(+)) is prevented by the presence of an uncoupler.

3 a2+ uptake was blocked with ruthenium red or uncoupler.

4 fect disappears when PMF is eliminated by an uncoupler.

5 R Ca(2+) ATPase (SERCA) and acts on it as an uncoupler.

6 inyl adenosine synthase, as well as being an uncoupler.

7 affinity modulator, and sarcolipin (SLN), an uncoupler.

8 active against Staphylococcus aureus, is an uncoupler.

9 orally active MEK1/2 inhibitor, acted as an uncoupler.

10 at pH 7.5 in the presence of a protonophoric uncoupler.

11 ugh KPF itself is not a direct mitochondrial uncoupler.

12 or prevented by previous depolarization with uncoupler.

13 omethoxy) phenylylhydrazone, a mitochondrial uncoupler.

14 hondria in the presence of 2,4-dinitrophenol uncoupler.

15 o electron transfer chain inhibitors and ion uncouplers.

16 ial respiratory inhibitors and mitochondrial uncouplers.

17 r than controls not exposed to mitochondrial uncouplers.

18 with ICG and perfused with electromechanical uncouplers.

19 ffected by membrane potential or pH gradient uncouplers.

20 tarved cells or in cells treated with energy uncouplers.

21 is compromised by agents such as alcohols or uncouplers.

22 ced interest in the clinical use of chemical uncouplers.

23 as determined by exposing M. tuberculosis to uncouplers.

24 Gap junction uncouplers (1-octanol, carbenoxolone, 18beta-glycyrrheti

25 pressed gap junction genes, and gap junction uncouplers, 18beta-glycyrrhetinic acid (18beta-GA) and o

26 europrotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in animals receiving s

27 The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and w

28 r Alzheimer's disease, and the mitochondrial uncoupler 2,4-dinitrophenol for obesity.

29 A mitochondrial uncoupler, 2,4-dinitrophenol (at 1 mmol/L), blocked the

30 cium ionophore, A23187 and the mitochondrial uncoupler, 2,4-dinitrophenol (DNP) as damaging agents.

31 o or in vivo, against the electron transport uncoupler 3-acetylpyridine (3AP).

32 The application of mitochondrial uncouplers (5 microM CCCP or 5 microM FCCP), eliminated

33 or 2,4-dinitrophenol (DNP, the mitochondrial uncoupler, 50 micromol/L) (15.7+/-2.7% versus 40.8+/-5.5

34 most with known antiinfective activity, for uncoupler activity.

35 have a reduced rate of consumption of ATP on uncoupler addition.

36 Uncouplers also inhibited a background K+ current and in

37 hlorophenyl hydrazone (CCCP; a mitochondrial uncoupler) alter [Ca2+]i and force transients.

38 ribution was inhibited by proton ionophores (uncouplers), alteration of alpha conformation by illumin

39 heart in the absence of an electromechanical uncoupler and (2) to elucidate the mechanism of verapami

40 Treatment of MDCK cells with a mitochondrial uncoupler and a Ca2+ ionophore led to ATP depletion, nec

41 tential titrated by stepwise additions of an uncoupler and expressed as a function of citrate synthas

42 omyocytes, were eliminated by a gap junction uncoupler and reappeared with its removal.

43 Uncouplers and blockers of membrane channels were used t

44 rom the primary site and thus act as symport uncouplers and inhibit transport.

45 t acute administration of DNP (mitochondrial uncoupler) and chronic administration of T(3) decrease e

46 Furthermore, U73122 (Gqalpha-PLC specific uncoupler) and GP2A (Gqalpha specific inhibitor) mirrore

47 Using a combination of inhibitors, uncouplers, and antimycin A, and by following the kineti

48 sitivity of this oxidation to ionophores and uncouplers, and the absence of any delay in the onset of

49 l membrane with visible light results in the uncoupler- and inhibitor-sensitive synthesis of adenosin

50 Mitochondrial uncouplers are potent stimulants of the carotid body.

51 Treatment with chemical inhibitors or an uncoupler, as well as crosses to mutants known to affect

52 Application of the excitation-contraction uncoupler blebbistatin or the mechanosensitive channel b

53 tabolic insults including treatment with the uncoupler carbonyl cyanide 3-chlorophenylhydrazone (CCCP

54 ere larger in the presence of cyanide or the uncoupler carbonyl cyanide 4-trifluoromethoxyphenylhydra

55 The mitochondrial oxidative phosphorylation uncoupler carbonyl cyanide m-chlorophenyl hydrazone (2 m

56 Although the uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhi

57 The uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP

58 tapsi(m) conditions, hypersensitivity to the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP

59 The electron transport uncoupler carbonyl cyanide m-chlorophenylhydrazone inhib

60 e pH gradient and strongly stimulated by the uncoupler carbonyl cyanide m-chlorophenylhydrazone when

61 phagy after treatment with the mitochondrial uncoupler carbonyl cyanide m-methylhydrazone, because of

62 itochondrial inhibitor NaCN and mitochondria uncoupler carbonyl cyanide p-(trifluoromethoxy) phenyl h

63 r Ca(2+) after addition of the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenyl hy

64 n kinases ERK1 and ERK2 by the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhyd

65 -hydroxy-TEMPO (TEMPOL) or the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhyd

66 disrupted by treating cells with the proton uncoupler carbonyl cyanide p-chlorophenylhydrazone.

67 However, like the mitochondrial uncoupler carbonyl cyanide p-trifluoromethoxyphenyl hydr

68 of the mitochondrial inhibitor NaCN, or the uncoupler carbonyl cyanide p-trifluoromethoxyphenylhydra

69 In the presence of the uncouplers carbonyl cyanide m-chlorophenylhydrazone or v

70 endent stress genes by the respiratory chain uncoupler, carbonyl cyanide m-chlorophenyl hydrazine (CC

71 by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCC

72 cal hypoxia model of mitophagy induced by an uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCC

73 class through the coronary arteries with the uncoupler, carbonyl cyanide p-trifluoromethoxyphenylhydr

74 ane potential was dissipated by the chemical uncoupler carbonylcyanide m-chlorophenyl hydrazone.

75 in the presence of Zn2+ was abrogated by the uncoupler carbonylcyanide m-chlorophenylhydrazone, sugge

76 It was also inhibited by the proton uncoupler carbonylcyanide m-chlorophenylhydrazone, sugge

77 kainic acid, and NMDA, and the mitochondrial uncoupler carbonylcyanide p-(trifluoromethoxy)phenyl hyd

78 The proton uncouplers carbonylcyanide-4-(trifluoromethoxy) phenylhy

79 The proton uncouplers carbonylcyanide-4-(trifluoromethoxy)phenylhyd

80 in purple membrane suspensions by the energy-uncoupler CCCP or by lysis of the cells.

81 s TonB independent and was unaffected by the uncouplers CCCP (carbonyl cyanide m-chlorophenylhydrazon

82 yrphostins A9 and AG126 act as mitochondrial uncouplers, collapsing the mitochondrial membrane potent

83 ng respiration and ATP biosynthesis, and are uncouplers, collapsing the pH gradient and membrane pote

84 of electron transport and DeltapH at various uncoupler concentrations or light intensities was obtain

85 tochondrial respiratory chain inhibitors and uncouplers decreased mitochondrial membrane potential le

86 eficial effects of DNP suggest that chemical uncouplers deserve further investigation for the treatme

87 , application of glutamate together with the uncoupler did not prevent the changes in movement or sha

88 emonstrated that their relative potencies as uncouplers differed from their in vitro kinase-inhibitor

89 l CMRO2 in the presence of the mitochondrial uncoupler dinitrophenol (DNP) were compared using 16.4 T

90 ine of these matched proteins induced by the uncoupler dinitrophenol.

91 Mitochondrial uncouplers dissipate this proton gradient and disrupt nu

92 Chemical uncouplers do not induce obvious changes in Cx43-EGFP ju

93 single or repetitive pulses of substrate- or uncoupler-elicited energetic-redox transitions.

94 We have previously used measurements of uncoupler-enforced reverse activity to demonstrate that

95 the formation of a mixed complex between the uncoupler, ETH-129, and Ca(2+) that readily permeates th

96 We conclude that uncouplers excite the carotid body by inhibiting a backg

97 RN revealed that (1) RN is stimulated by the uncoupler FCCP and high levels of substrates, demonstrat

98 induction of mitophagy by the mitochondrial uncoupler FCCP is independent of the effect of mitochond

99 s were inhibited by hypoxia, cyanide and the uncoupler FCCP, but the greatest sensitivity was seen in

100 On the other hand, mitochondrial metabolic uncoupler FCCP, in the presence of oligomycin (to preven

101 nd mouse HSCs were treated with the chemical uncouplers FCCP and Valinomycin.

102 , however, is to discover safe mitochondrial uncouplers for practical use.

103 hlorophenylhydrazone (CCCP), a mitochondrial uncoupler, found that more than half of the mitochondria

104 The therapeutic potential of mitochondrial uncouplers has been investigated for the treatment of me

105 The gap-junction uncoupler heptanol had no effect.

106 Treatment with the gap junction uncoupler heptanol significantly reduced the movement of

107 Ca(2+)-free dextran and by the gap junction uncoupler, heptanol, indicated that it was generated by

108 ntally by local perfusion of a mitochondrial uncoupler in a monolayer of cardiac myocytes.

109 characterized as a functional mitochondrial uncoupler in Drosophila.

110 Oleate does not substitute for the uncoupler in either regard.

111 tured hippocampal neurons to a mitochondrial uncoupler in glucose-free medium promotes the formation

112 ed of ATP by incubation with a mitochondrial uncoupler in glucose-free medium.

113 have led to suggestions that they may act as uncouplers in cells.

114 y Cx40-specific and nonspecific gap junction uncouplers in the lungs of wild-type mice and in lungs f

115 Both uncouplers increased the expression of mitochondrial gen

116 Uncouplers increased trap closure delay and significantl

117 espiration is also inhibited by nigericin or uncoupler, indicating that an acidic matrix pH antagoniz

118 in the presence of a mitochondrial membrane uncoupler, indicating that mitochondria are the main sit

119 inhibited by low concentrations of a proton uncoupler, indicating that PLUTO functions as a proton-s

120 In 60-hour-old biofilms, the extent of uncoupler-induced cell loss was strongly attenuated, ind

121 The capacity for MgATP-dependent, uncoupler-insensitive conjugate transport in vitro stric

122 olated from these cells for MgATP-dependent, uncoupler-insensitive DNP-GS transport.

123 more than 90% impaired for MgATP-dependent, uncoupler-insensitive DNP-GS transport.

124 yl)glutathione (DNP-GS), an MgATP-dependent, uncoupler-insensitive pathway and an electrically driven

125 ae is inferred to encode an MgATP-energized, uncoupler-insensitive vacuolar glutathione S-conjugate t

126 thways identified, only the MgATP-dependent, uncoupler-insensive pathway is subject to inhibition by

127 that Endosidin9 (ES9), a novel mitochondrial uncoupler, is a potent inhibitor of clathrin-mediated en

128 enuated by the presence of the mitochondrial uncoupler M3778 but potentiated by the presence of cobal

129 studies have suggested that a mitochondrial uncoupler might work in a similar manner.

130 I inhibitor), dinitrophenol (a mitochondrial uncoupler), muscle contraction, and sorbitol (producing

131 t blocked mitochondrial Ca(2+) accumulation (uncouplers, nocodazole) eliminated the observed inhibiti

132 in the presence of 0.1 mM dinitrophenol, an uncoupler of ATP synthesis.

133 occurring sVegfr-2 thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of

134 neurons pretreated with pertussis toxin, an uncoupler of G proteins and MOR.

135 nsmembrane receptors, or pertussis toxin, an uncoupler of G(i) from adenylate cyclase.

136 y increased Ptran (to 0.22) and heptanol, an uncoupler of gap junction channels, significantly decrea

137 The effects of pertussis toxin, an uncoupler of Gi protein from adenylate cyclase, and luzi

138 th application of 2,4-dinitrophenol (DNP, an uncoupler of mitochondrial ATP production) induced an in

139 ort complex II (thenoyltrifluoroacetone), an uncoupler of oxidative phosphorylation (carbonyl cyanide

140 morphology precludes UCP4 from acting as an uncoupler of oxidative phosphorylation but is consistent

141 f electron transport chain complex II, by an uncoupler of oxidative phosphorylation, by uncoupling pr

142 In this study, we found that the classic uncoupler of oxidative phosphorylation, carbonyl cyanide

143 l cyanide m-chlorophenylhydrazone (CCCP), an uncoupler of oxidative phosphorylation, completely preve

144 It is thought to be an uncoupler of oxidative phosphorylation.

145 Benzene, an effective uncoupler of oxygen consumption in purified naphthalene

146 us, azide does not appear to act as a simple uncoupler of proton transport and ATP hydrolysis.

147 We recently showed that sarcolipin (SLN), an uncoupler of the sarco(endo)plasmic reticulum Ca(2+) ATP

148 reversed by V-type ATPase inhibitors and by uncouplers of endosomal intralumenal pH, and was correla

149 phosphorylation events were not affected by uncouplers of oxidative respiration, inhibitors of elect

150 tment of cells with metabolic inhibitors and uncouplers of photosynthetic electron transport showed t

151 S) production through use of pharmacological uncouplers of the mitochondrial electron transport chain

152 bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration.

153 pite a widely accepted role of arrestins as "uncouplers" of G protein-coupled receptor (GPCR) signali

154 re control, use of an excitation-contraction uncoupler, optimal vibratome settings and correct handli

155 rial Ca(2+) uptake by either a mitochondrial uncoupler or a Ca(2+) uniporter inhibitor.

156 Treatment of cultures with an uncoupler or blocking ATP synthesis with oligomycin also

157 ed with GSK inhibitors and were treated with uncoupler or cyanide or were made anoxic.

158 nses recorded in the absence and presence of uncoupler or from [Ca2+]c elevations evoked by uncoupler

159 s, inhibiting mitochondrial function with an uncoupler or interrupting the electron transport chain w

160 coupler or from [Ca2+]c elevations evoked by uncoupler or ionophore applied after complete Ca2+ mobil

161 be enhanced by treatment with mitochondrial uncouplers or dissipated by drug-induced disaggregation

162 Remarkably, mitochondrial uncouplers or Na+ depletion prevent the ability of T cel

163 on mechanism distinct from that triggered by uncouplers or the apoptosis inducer staurosporine.

164 Ca(2+) and is not affected by ruthenium red, uncouplers, or ionophores that perturb transmembrane gra

165 ce of CN(-) or rotenone or the mitochondrial uncoupler p-trifluoromethoxyphenyl hydrazone (FCCP).

166 ted by the CB1R antagonist rimonabant and Gi uncoupler pertussis toxin, and absent in Cnr1(-/-) RGCs.

167 , cells were pretreated with a mitochondrial uncoupler prior to EGF stimulation.

168 revealed by preincubation with mitochondrial uncouplers prior to ATP treatment.

169 as substantially lower in the presence of an uncoupler (Q(10) = 1.61) than its absence (Q(10) = 2.08)

170 mparison, the neuronal-specific gap junction uncouplers quinine (250 microM) and mefloquine (500 nM)

171 DNP)-treated (protonophore and mitochondrial uncoupler) rats.

172 Uncouplers reduced pHi by 0.1 unit.

173 The effect of uncoupler reflects the collapse of an opposing potential

174 will review the small molecule mitochondrial uncouplers reported to date and explore their potential

175 s that target the proton motive force (PMF), uncouplers, represent one possible class of compounds th

176 ucers and blockers can be distinguished from uncouplers, respiratory inhibitors, and blockers of Ca(2

177 ATP depletion induced by a mitochondrial uncoupler resulted in similar alterations even in the pr

178 The uncouplers S13 and dinitrophenol showed that NarK2 was n

179 s indicate that the relative contribution of uncoupler-sensitive mitochondrial hydrogen peroxide prod

180 mitochondrial polarization, as indicated by uncoupler-sensitive quenching of the red TMRM fluorescen

181 Secondly, it was uncoupler-sensitive, and thus triggered by the DeltapH a

182 reas the maximal rate of electron transport (uncoupler-stimulated respiration) was inhibited by appro

183 GFP channels exhibit slow gating by chemical uncouplers such as CO(2) and alkanols.

184 olated rod photoreceptors with the G protein uncoupler suramin or pertussis toxin, which inactivates

185 e, we show that SR4 is a novel mitochondrial uncoupler that causes dose-dependent increase in mitocho

186 onyl cyanide m-chlorophenyl), a protonophore uncoupler that decreases mitochondrial Ca2+ uptake, decr

187 We also show the use of respiratory uncouplers to simulate ischemia in the single myocyte an

188 ve relied on high concentrations of chemical uncouplers to trigger mitochondrial depolarization, a st

189 zone (FCCP), a mitochondrial proton gradient uncoupler, to release mitochondrial free calcium ([Ca2+]

190 Small molecule mitochondrial uncouplers transport protons from the mitochondrial inne

191 Possible cytotoxicity by uncoupler treatment was evaluated by caspase 3/7 activit

192 rkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespread mitophagy and

193 (JC-1) in the presence of substrates/ADP or uncouplers (valinomycin/carbonyl cyanide p-(trifluoromet

194 d mitochondria, no stimulation of the MPT by uncoupler was observed in the presence or absence of thi

195 alternative explanations for the effects of uncouplers were evaluated: (a) the 'back-pressure' of th

196 Thus, a new class of V-ATPase inhibitors (uncouplers), which are not simply ionophores, provided n

197 Mitochondrial uncouplers, which reduce the proton gradient across the

198 In the latter case, the uncouplers would decrease the RC time constant for membr