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1 of the carrier to adrenergic activation and uncoupling.
2 fatty acid and glucose oxidation, as well as uncoupling.
3 NAFLD is via salicylate-driven mitochondrial uncoupling.
4 is by dissipating energy through thermogenic uncoupling.
5 brain show a high level of palmitate-induced uncoupling.
6 ions for Asn in DIII-S6 showed somewhat less uncoupling.
7 educed antioxidant capacity of cells and NOS uncoupling.
8 e), that produces mild hepatic mitochondrial uncoupling.
9 ding with matrix alkalinization, followed by uncoupling.
10 susceptibility on pharmacological electrical uncoupling.
11 ring, which could lead to significant future uncoupling.
12 blasts during pharmacological gap junctional uncoupling.
13 l membrane potential following mitochondrial uncoupling.
14 ncoupling protein 3 (UCP3) and mitochondrial uncoupling.
15 ance to halothane- and acidification-induced uncoupling, absence of voltage-dependent fast inactivati
17 ss the mitochondrial inner membrane, thereby uncoupling adenosine diphosphate phosphorylation from nu
19 tes, as well as in those treated with TNF or uncoupling agent carbonyl cyanide m-chlorophenyl hydrazo
21 development of liver-targeted mitochondrial uncoupling agents as a potential novel therapy for lipod
22 mapping in the absence of electromechanical uncoupling agents, the method relieves a long-standing l
25 ligomycin resistant, suggesting ATP synthase uncoupling and bypass of the normal Fo-A6-subunit requir
27 Endothelial nitric-oxide synthase (eNOS) uncoupling and increased inducible NOS (iNOS) activity a
28 o limit the reduction in stroke volume, with uncoupling and increased wall stress as a consequence.
29 specifically with regard to the substantial uncoupling and limited stabilization of the C4a-hydroper
30 s deregulation can explain the mitochondrial uncoupling and lower ATP levels in VCP mutation-bearing
37 and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are key contributors to heart
38 metabolic substrate usage and mitochondrial uncoupling, and protects against ischaemia/reperfusion.
39 dothelial caveolae, which contributes to NOS uncoupling, and, hence, reduced NO-mediated coronary vas
41 ative stress and nitric oxide synthase (NOS) uncoupling are thought to contribute to Fabry cardiovasc
45 leration of basal respiration by genetically uncoupling ATP synthesis from electron transport resulte
48 ained 40% of the ATPase activity, suggesting uncoupling between ATP hydrolysis and activation of the
49 ine-bound closed conformation, revealing the uncoupling between ATP-PRT open and closed conformations
51 an imbalance in glucose carbon allocation by uncoupling biosynthetic pathway activity, which could di
53 Dysregulation of TGF-beta alters MSC fate, uncoupling bone remodeling and causing skeletal disorder
56 examine the mechanism behind lipid-dependent uncoupling by comparing the propensities of two prokaryo
57 V or caCaMKIV, respectively, suggesting that uncoupling CaMKIV activation from activity generates an
59 t produces mild liver-targeted mitochondrial uncoupling could decrease hypertriglyceridemia and rever
60 are differentially regulated in response to uncoupling Crkl from its signaling pathways in the devel
61 at S384 by the PP2A-B56 phosphatase, thereby uncoupling cyclin E degradation from cyclin E-CDK2 activ
64 on levels increased in the tumor cell lines (uncoupling effect), resulting in a DeltaPsi(m) decrease
65 oA oxidation and its concentration-dependent uncoupling effect, together with a partial lipid-depende
67 e fuel role of lipids is influenced by their uncoupling effects, and how this affects mitochondrial e
69 t a statistically significant reversal after uncoupling electron transport from ATP synthesis, consis
70 ediated arginase activation, endothelial NOS uncoupling, endothelial dysfunction, and atherogenesis.
71 adation, but increases chromosomal breakage, uncoupling fork protection, and chromosome stability.
74 yofilament Ca(2+) sensitivity and, moreover, uncoupling from the impact of phosphorylation of cTnI me
75 minal residues (2)ERSTQ leads to loss of the uncoupling function even though the truncated peptide ca
77 acterize a unique pharmacological target for uncoupling GIV-dependent signaling downstream of multipl
78 l looping combustion with and without oxygen uncoupling have received considerable attention of resea
79 K activator, had no effect on proliferation, uncoupling high AMPK activity from inhibition of prolife
80 EPO prevented IL-2-induced proliferation by uncoupling IL-2 receptor signaling, inhibiting phosphory
84 , and nitro-oxidative stress as well as eNOS uncoupling in the vessel wall, which can be prevented by
86 stimulate its ubiquitination function, thus uncoupling increases in p53 binding from its E3 ubiquiti
88 epidermis, we show that forced mitochondrial uncoupling inhibits skin carcinogenesis by blocking Akt
90 hese findings demonstrate that mitochondrial uncoupling is an effective strategy to limit proliferati
91 oterenol, evidence of excitation-contraction uncoupling is indicated by an elevation in diastolic cal
93 C-1 activity slows reproductive development, uncoupling it from its typical progression relative to t
94 ing the remodelling and turnover of K16, and uncoupling it from K6, iRHOM2 regulates the epithelial r
95 -p38 MAPK-CMA pathway in the mouse brain and uncoupling it results in a greater loss of SNc dopaminer
97 adipogenic, insulin sensitivity, and energy uncoupling machinery, while limiting inflammation in WAT
98 f of concept that mild hepatic mitochondrial uncoupling may be a safe and effective therapy for the r
99 hetic anion transporters and potentially the uncoupling mechanism of naturally occurring membrane pro
101 Blocking ROS production with rotenone by uncoupling mitochondria or by expressing the alternative
104 wever, regulated their mRNA concentration by uncoupling mRNA stability from the transcription rate.
107 hondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP generation.
109 therapeutic efficacy through pharmacological uncoupling of a convergence point of NF-kappaB-mediated
110 ent in IBA and 4OGlcI3F, and allele-specific uncoupling of a subset of PEN3 functions suggest that PE
114 CA throughout its kinetic cycle and promotes uncoupling of Ca(2+) transport from ATP hydrolysis.
115 halamic inflammatory pathways results in the uncoupling of caloric intake and energy expenditure, fos
119 has no effect on work output, indicating an uncoupling of disassembly speed from protofilament strai
120 ventricular dysfunction was associated with uncoupling of endothelial nitric oxide synthase (NOS) ac
123 HFS throughout the light-dark cycle suggests uncoupling of hypothalamic responses involving appetite-
125 3K27me3 at the Zbtb16/PLZF promoter leads to uncoupling of iNKT cell development from TCR specificity
126 act epithelia; the other prerequisite is the uncoupling of intercellular contacts, which induces Rho-
127 dent impaired autophagic flux after chemical uncoupling of mitochondria, increased mitochondrial-prot
129 propose that ethanol-induced inhibition and uncoupling of mRNA and protein synthesis through direct
134 Inadequate availability of BH4 leads to uncoupling of nitric oxide synthases and production of h
136 mbrane transfer of protons, resulting in the uncoupling of oxidative phosphorylation from ATP product
137 a highly phase-specific pattern, suggesting uncoupling of phenotypic evolution across life-history p
138 ate testable predictions for coupling versus uncoupling of phenotypic evolution of tadpole and adult
143 ute PI3K activation and provide evidence for uncoupling of Ser(473) and Thr(308) phosphorylation, as
144 e the structural regions of SLN that mediate uncoupling of SERCA, we employed mutagenesis and generat
147 tion of GC responses was, in part, caused by uncoupling of Tfh-B cell interactions, as evidenced by r
151 n, pharmacologically induced neuromechanical uncoupling of the diaphragm should facilitate lung-prote
152 hat has little constitutive activity reveals uncoupling of the ligand-binding domain from conserved c
153 ia TSC1 gene deletion in chondrocytes causes uncoupling of the normal proliferation and differentiati
154 substitutions for Asn in both S6s result in uncoupling of the pore domains from their voltage-sensor
156 in avian DT40 cells, indicative of extensive uncoupling of the replicative helicase and polymerase.
157 ural features within the S4-S5 linker permit uncoupling of the voltage sensor from the pore in the ab
158 sor-competent and -incompetent molecules and uncoupling of the VSR and particle assembly capacities.
159 ation of aperiodic decidual gene expression; uncoupling of these events may cause recurrent pregnancy
161 enigmatic outcomes are due to a biochemical uncoupling of tolerogenic signaling, or simply a quantit
166 e and inhibited by IL-4R-signaling in vitro, uncoupling parasite killing from expulsion mechanisms.
168 ansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitocho
170 pathetic stimulation, activate mitochondrial uncoupling protein (UCP)-1 and oxidize fatty acids to ge
171 expression of the brown fat signature genes uncoupling protein (UCP)-1 and peroxisome proliferator-a
175 wn AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-l
176 dipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energ
177 (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in BA
178 m promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-
180 h was accompanied by increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose ti
182 s previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3
183 eling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and
185 ed to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interactio
186 ses expression of the brown adipocyte marker uncoupling protein 1 (UCP1) in both adipose tissue depot
187 t production and decreased the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT
188 is is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocyte
189 LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes,
193 nts of heat through activation of the unique uncoupling protein 1 (UCP1) located within the inner mit
198 al analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brow
199 n browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermoge
200 t of glucose homeostasis were independent of uncoupling protein 1 (UCP1), but required expression of
201 protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food
202 ssue (BAT), characterized by the presence of uncoupling protein 1 (UCP1), has been described as metab
203 uce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with
205 attributed to its role in fuel oxidation and uncoupling protein 1 (UCP1)-mediated thermogenesis.
206 sion analyses and found that a population of uncoupling protein 1 (UCP1)-positive human adipocytes po
212 temperature as a result of higher levels of uncoupling protein 1 and a low abundance of the proinfla
215 loss was significantly associated with less uncoupling protein 1 expression (P = 0.006, R(2) = 0.09)
219 nterscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positiv
221 neither presence nor thermogenic function of uncoupling protein 1(+) beige adipocytes contributed to
222 ined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of t
223 ramembraneous segments and the mitochondrial uncoupling protein 1, which is a transmembrane protein e
224 d body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white
227 Additionally, intracellular glutathione and uncoupling protein 2 (UCP2) gene expressions were quanti
229 atty acids (FFAs) and elevated expression of uncoupling protein 2 (UCP2) without concomitant increase
232 is increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, th
234 ers have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery
236 ion, fatty acid oxidation, and mitochondrial uncoupling protein 3 (UCP3) levels, while increasing gly
237 lex IV subunit 1 (COX1) was tightly bound to uncoupling protein 3 (UCP3), but this complex was disrup
240 me proliferator-activated receptor alpha and uncoupling protein 3, increases in mitochondrial protein
243 y mouse neurons and test the hypothesis that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are sp
244 lity of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for sta
245 the well-known betaAR-dependent increase of uncoupling protein UCP1 expression and expansion of beig
249 issipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates
250 ous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tis
251 enic fat cell that express the mitochondrial uncoupling protein-1 and thus represent a powerful targe
252 dipose tissue (WAT) were stained for CB1 and uncoupling protein-1 by immunofluorescent staining.
254 t is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration
256 nscription factor-3 (Atf3) and mitochondrial uncoupling protein-2 (Ucp2) are highly induced in Tsc2-d
257 our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with B
258 Here, we demonstrated that the mitochondrial uncoupling protein-2 (UCP2) regulates NLRP3-mediated cas
259 ation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G pr
262 s superoxide generation through induction of uncoupling proteins (UCPs), and transgenic overexpressio
263 he aim of this study was to evaluate whether uncoupling proteins (UCPs), located in the inner membran
265 the transcriptional and protein abundance of uncoupling proteins that mediates thermogenesis, and it
267 endent of adenine nucleotide translocase and uncoupling proteins, decreased mitochondrial membrane po
269 neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metab
270 controls to evaluate: (i) ADMA-mediated NOS uncoupling reduces epithelial production of NO and incre
271 ed to play a role in apoptotic cell death by uncoupling regions important for IP3 binding from the ch
274 ssary for the initiation of sexual behavior, uncoupling sexual behavior from reproductive status.
276 , Pten is not effectively repressed, thereby uncoupling STAT5 phosphorylation and phosphoinositide-3-
279 e); end-systolic peak (peak ); and diastolic uncoupling (systolic -diastolic at same volume) during e
280 heterodimer, with beta2AR activation rapidly uncoupling TAS2R14 function ( approximately 65% desensit
281 e without affecting stress behavior, thereby uncoupling the contribution of a specific OXT cluster to
282 the perceived intention of others which, by uncoupling the dynamics of sensorimotor facilitation, co
283 t binds directly to the dynein motor domain, uncoupling the enzymatic and mechanical cycles of the mo
284 FC from its cognitive functions by partially uncoupling the mPFC from experience-induced inputs.
285 and androgen receptor signaling, effectively uncoupling the normal negative feedback between these tw
288 godendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlight
291 brown adipocytes (BA) induces mitochondrial uncoupling, thereby increasing energy expenditure by shi
292 m fibrils, thus providing powerful tools for uncoupling these processes and investigating the role of
294 The present work offers two strategies for uncoupling these two processes and converting concerted
295 diated mechanism that activates mitochondria uncoupling to reduce ROS production, which precedes the
296 esses the underlying basis for mitochondrial uncoupling using VCP knockdown neuroblastoma cell lines,
297 s to ventricular dysfunction by electrically uncoupling viable cardiomyocytes in the infarct region.
300 balance leads to nitric oxide synthase (NOS) uncoupling with reduced nitric oxide (NO) formation and
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