ライフサイエンスコーパス: uncoupling protein

1 rotein 3 (UCP3), a thermogenic mitochondrial uncoupling protein.

2 s superoxide generation through induction of uncoupling proteins.

3 chemical potential, is mediated primarily by uncoupling proteins.

4 ng thermogenesis, related to the activity of uncoupling proteins.

5 nucleotides, which are antagonists of cloned uncoupling proteins.

6 lipid radicals, a species known to activate uncoupling proteins.

7 pecies, recently recognized as activators of uncoupling proteins.

8 of mitochondrial biogenesis or activation of uncoupling proteins.

9 esis requires upregulation of Pgc-1alpha and uncoupling protein 1 (Ucp-1) in brown adipose tissue.

10 In uncoupling protein 1 (UCP-1) knockout mice, the middle a

11 wn AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-l

12 orrelates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncou

13 uch as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long

14 expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription

15 dipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energ

16 (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in BA

17 m promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-

18 Both uncoupling protein 1 (UCP1) and UCP3 are important for m

19 h was accompanied by increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose ti

20 Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is prec

21 Uncoupling protein 1 (UCP1) catalyzes fatty acid-activat

22 s previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3

23 eling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and

24 A 90% reduction in uncoupling protein 1 (UCP1) expression in interscapular

25 ses the endogenous PGC-1alpha protein level, uncoupling protein 1 (UCP1) expression, and oxygen consu

26 nduces mitochondrial dysfunction and reduces uncoupling protein 1 (UCP1) expression.

27 ed to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interactio

28 ent in liver did not alter the expression of uncoupling protein 1 (Ucp1) gene, which regulates thermo

29 lic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.

30 ses expression of the brown adipocyte marker uncoupling protein 1 (UCP1) in both adipose tissue depot

31 VMH BDNF thermogenic effects are mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

32 t production and decreased the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

33 is is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocyte

34 n through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals.

35 LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes,

36 Uncoupling protein 1 (UCP1) is highly expressed in brown

37 Uncoupling protein 1 (UCP1) is nearly absent in brown ad

38 Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshiver

39 Uncoupling protein 1 (UCP1) is the established mediator

40 nts of heat through activation of the unique uncoupling protein 1 (UCP1) located within the inner mit

41 Uncoupling protein 1 (UCP1) mediates nonshivering thermo

42 Uncoupling protein 1 (UCP1) plays a central role in nons

43 We combined an uncoupling protein 1 (UCP1) reporter system and expressi

44 tem regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adren

45 This was associated with recruitment of uncoupling protein 1 (UCP1)(+) beige adipocytes in WAT,

46 al analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brow

47 n browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermoge

48 he expression of PGC1alpha, PDK4, PPARalpha, uncoupling protein 1 (UCP1), and neuron-derived orphan r

49 thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue ha

50 t of glucose homeostasis were independent of uncoupling protein 1 (UCP1), but required expression of

51 protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food

52 ssue (BAT), characterized by the presence of uncoupling protein 1 (UCP1), has been described as metab

53 uce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with

54 high glucose after overexpression of either uncoupling protein 1 (UCP1), superoxide dismutase 2 (SOD

55 Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (UCP1)-based) and skeletal muscle (

56 attributed to its role in fuel oxidation and uncoupling protein 1 (UCP1)-mediated thermogenesis.

57 ession localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Ald

58 sion analyses and found that a population of uncoupling protein 1 (UCP1)-positive human adipocytes po

59 haracterized by the appearance of pockets of uncoupling protein 1 (UCP1)-positive, multilocular adipo

60 fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1).

61 r thermogenic energy expenditure mediated by uncoupling protein 1 (UCP1).

62 on the principal effector of thermogenesis: uncoupling protein 1 (UCP1).

63 of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1).

64 ough thermogenic respiration, which requires uncoupling protein 1 (UCP1).

65 thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1).

66 omys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1).

67 both electron transport chain components and uncoupling protein 1 (UCP1).

68 ng thermogenesis involved the stimulation of uncoupling protein 1 (UCP1; P<0.01), peroxisome prolifer

69 MTII treatment also stimulated uncoupling protein 1 activity in the brown adipose tissu

70 ivated receptor gamma coactivator 1alpha and uncoupling protein 1 and 3, and these changes can be rev

71 temperature as a result of higher levels of uncoupling protein 1 and a low abundance of the proinfla

72 validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the a

73 press markers of brown and beige fat such as uncoupling protein 1 and transmembrane protein 26.

74 Moreover, the abundance of uncoupling protein 1 competent brite cells in white adip

75 loss was significantly associated with less uncoupling protein 1 expression (P = 0.006, R(2) = 0.09)

76 Cytochrome c oxidase activity, uncoupling protein 1 expression and maximal norepinephri

77 rd white adipocytes while directly elevating uncoupling protein 1 expression and pre-adipocyte differ

78 Pep19 induced uncoupling protein 1 expression in both white adipose ti

79 Uncoupling protein 1 expression induced by Pep19 in 3T3-

80 acids, glycolysis, fatty acid synthesis, and uncoupling protein 1 expression.

81 ific defect in proton leak due to attenuated uncoupling protein 1 expression.

82 POMC gene delivery enhanced uncoupling protein 1 in brown adipose tissue (BAT) by mo

83 nterscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positiv

84 Moreover, CNTF(Ax15) increased uncoupling protein 1 mRNA expression in BAT and energy e

85 membrane potential, or by overexpression of uncoupling protein 1 or superoxide dismutase.

86 Uncoupling protein 1(+) beige adipocytes are dynamically

87 neither presence nor thermogenic function of uncoupling protein 1(+) beige adipocytes contributed to

88 ose tissue but expresses neither brown (e.g. uncoupling protein 1) nor white adipocyte markers.

89 om these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissip

90 ets, including PPARgamma coactivator 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase

91 ubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regul

92 h number of mitochondria and the presence of uncoupling protein 1, brown fat adipocytes can be termed

93 lt, lipolysis, as well as the mRNA levels of uncoupling protein 1, guanosine monophosphate reductase,

94 ic markers PPARgamma coactivator 1 alpha and uncoupling protein 1, mirrored the differentiation patte

95 ined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of t

96 ramembraneous segments and the mitochondrial uncoupling protein 1, which is a transmembrane protein e

97 uced a smaller increase in BAT blood flow in uncoupling protein 1-deficient mice than in wild-type mi

98 increase BAT blood flow, CU was performed in uncoupling protein 1-deficient mice with impaired BAT ac

99 ipose tissue (BAT)-deficient obese UCP1-DTA (uncoupling protein 1-diphtheria toxin A) mice.

100 d body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white

101 of heat through the actions of mitochondrial uncoupling protein 1.

102 genes characteristic of brown fat, including uncoupling protein 1.

103 wn adipose tissue respiration independent of uncoupling protein 1.

104 tissue-derived AAMs expressed high levels of uncoupling protein 1.

105 Based on cell-specific markers and on uncoupling protein-1 (characteristic of both BAT and bei

106 n were prevented by overexpression of either uncoupling protein-1 (UCP-1) or manganese superoxide dis

107 ), leptin, C/EBPalpha, and PPARgamma but not uncoupling protein-1 (UCP-1), the CD45 hematopoietic lin

108 issipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates

109 ous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tis

110 ice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in the artery wall.

111 Uncoupling protein-1 (UCP1) is abundantly expressed in t

112 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in w

113 BAT activation, namely increased lipolysis, uncoupling protein-1 (UCP1) mRNA, and glucose uptake, ar

114 known, as they lack brown adipose tissue and uncoupling protein-1 (UCP1), which mediate adaptive non-

115 vated receptor-gamma-coactivator-1alpha, and uncoupling protein-1 and -2 were increased in WAT.

116 ed high body temperature via upregulation of uncoupling protein-1 and mitochondrial oxygen consumptio

117 enic fat cell that express the mitochondrial uncoupling protein-1 and thus represent a powerful targe

118 dipose tissue (WAT) were stained for CB1 and uncoupling protein-1 by immunofluorescent staining.

119 This increased uncoupling protein-1 content in brown adipose tissue, bu

120 Energy expenditure and uncoupling protein-1 expression in BAT were slightly but

121 si stimulated significantly higher levels of uncoupling protein-1 expression in BAT, and completely r

122 PYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue

123 /-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the br

124 We found that CB1 was colocalized with uncoupling protein-1 in BAT, but neither protein was fou

125 However, uncoupling protein-1 levels were not increased in silden

126 short versions of the adipocyte protein 2 or uncoupling protein-1 promoters or micro-RNA target seque

127 lood vessels after exposure to cold, whereas uncoupling protein-1 was expressed in the cytoplasm unde

128 Expression levels of the tissue-specific uncoupling protein-1 were 180 times higher in BAT than i

129 The localization of uncoupling protein-1, glucose transporter-1, and norepin

130 ase 1), catalase, glutathione S-transferase, uncoupling protein-1, or transcription factor liver X re

131 t is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration

132 ction and brown adipose tissue expression of uncoupling protein-1, which is regulated by sympathetic

133 restriction caused by ectopic expression of uncoupling protein-1.

134 ch encodes the key thermogenic mitochondrial uncoupling protein-1.

135 trated that global deletion of mitochondrial uncoupling protein 2 (UCP2(-/-)) in mice impaired glucag

136 Additionally, intracellular glutathione and uncoupling protein 2 (UCP2) gene expressions were quanti

137 Uncoupling protein 2 (UCP2) has been shown to conduct ca

138 Uncoupling protein 2 (UCP2) is a mitochondrial protein t

139 Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane prot

140 Uncoupling protein 2 (UCP2) is involved in various physi

141 Here we show that voluntary exercise induces uncoupling protein 2 (UCP2) mRNA expression and mitochon

142 Uncoupling protein 2 (UCP2) plays a regulating role in h

143 atty acids (FFAs) and elevated expression of uncoupling protein 2 (UCP2) without concomitant increase

144 of glucose sensing in POMC neurons involves uncoupling protein 2 (UCP2), a mitochondrial protein tha

145 factor, CARP, and beta-myosin heavy chain), uncoupling protein 2 (UCP2), a protein involved in the c

146 ICU1), mitochondrial Ca(2+) uniporter (MCU), uncoupling protein 2 (UCP2), and leucine zipper EF-hand-

147 Uncoupling protein 2 (UCP2), by virtue of its mitochondr

148 pendent on the mitochondrial redox state via uncoupling protein 2 (UCP2)-dependent alterations in mit

149 n evoke strong upregulation of mitochondrial uncoupling protein 2 (UCP2).

150 PPARalpha target gene encoding mitochondrial uncoupling protein 2 (UCP2).

151 d was accompanied by increased expression of uncoupling protein 2 (UCP2).

152 al respiration in mice that are dependent on uncoupling protein 2 (UCP2).

153 ty from inflammation via upregulation of the uncoupling protein 2 (UCP2).

154 elated peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).

155 is increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, th

156 ochondria, ATP-hydrolyzing mitochondria, and uncoupling protein 2 are not significant contributors to

157 ransgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) h

158 agouti-related peptide, neuropeptide Y, and uncoupling protein 2 in the hypothalamus, but no increas

159 Adenosine triphosphate decreased and uncoupling protein 2 increased in fa/fa rats treated wit

160 anoxia and reoxygenation tolerance following uncoupling protein 2 or 3 and combined 2 and 3 RNAi show

161 ion through the AMP-activated protein kinase-uncoupling protein 2 pathway.

162 ation of neuropeptide expression, as well as uncoupling protein 2, and abnormal responses to a metabo

163 to chemotherapy, increase the expression of uncoupling protein 2, and decrease the entry of pyruvate

164 nzymes involved in ROS scavenging, including uncoupling protein 2, catalase, and copper zinc superoxi

165 The uncoupling protein 2, UCP2, is a member of a family of i

166 tty-acid-induced activation of mitochondrial uncoupling protein 2.

167 by scavenging of the ROS or by inhibition of uncoupling protein 2.

168 ssigned to chromosome 12) in the area of the uncoupling protein 2/3 gene cluster.

169 Cardiac transcripts of genes encoding uncoupling proteins 2 and 3 are up-regulated in parallel

170 nction of the cardiac enriched mitochondrial uncoupling proteins 2 and 3 during delayed ischemic prec

171 a(2+) fluxes, have been described: the novel uncoupling proteins 2 and 3, the leucine zipper-EF-hand

172 bility to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth

173 Quantitative RT-PCR indicated that mRNA for uncoupling protein-2 (UCP-2) was increased in the cPLA(2

174 nscription factor-3 (Atf3) and mitochondrial uncoupling protein-2 (Ucp2) are highly induced in Tsc2-d

175 We show that genetic manipulation of uncoupling protein-2 (UCP2) directly affects substantia

176 our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with B

177 Mitochondrial uncoupling protein-2 (UCP2) is highly expressed in steat

178 Here, we demonstrated that the mitochondrial uncoupling protein-2 (UCP2) regulates NLRP3-mediated cas

179 Lipid-laden hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier tha

180 to preventing insulin release, ROS activates uncoupling protein-2 (UCP2), a mitochondrial inner membr

181 ive response in cancer cells to be linked to uncoupling protein-2 (UCP2), a mitochondrial suppressor

182 amined how liver regeneration is affected by uncoupling protein-2 (UCP2), an inner mitochondrial memb

183 The endocrine regulation of uncoupling protein-2 (UCP2), an inner mitochondrial prot

184 developmental and nutritional programming of uncoupling protein-2 (UCP2), glucocorticoid receptor (GR

185 ation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G pr

186 In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than

187 Uncoupling protein-2 depletion alone significantly atten

188 ed uncoupling protein depletion and isolated uncoupling protein-2 depletion augments ROS production i

189 iac derived myoblasts is abolished following uncoupling protein-2 depletion by RNA-interference.

190 ypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophag

191 Previous work in our lab has shown that uncoupling protein-2 is a major mediator of I/R in steat

192 is hypothesis, we see a dramatic increase in uncoupling protein-2 levels in the combination treated a

193 r-activated receptor-gamma, adiponectin, and uncoupling protein-2 mRNA levels in adipose, indicating

194 ism for modified bioenergetics that involves uncoupling protein-2 that is up-regulated in aged cells

195 nd -4, catalase, superoxide dismutase-2, and uncoupling protein-2.

196 ase in the expression of the transcripts for uncoupling proteins-2 and -3 also accompanied this incre

197 They also exhibit decreased uncoupling protein 3 (UCP3) and mitochondrial uncoupling

198 ve stress, and despite a twofold increase in uncoupling protein 3 (UCP3) content, ATP-to-O ratios and

199 Uncoupling protein 3 (UCP3) expression increases dramati

200 Uncoupling protein 3 (UCP3) has been postulated to dissi

201 ers have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery

202 These studies investigate the role of uncoupling protein 3 (UCP3) in cardiac energy metabolism

203 Uncoupling protein 3 (UCP3) is highly selectively expres

204 Uncoupling protein 3 (UCP3) is the skeletal muscle enric

205 ion, fatty acid oxidation, and mitochondrial uncoupling protein 3 (UCP3) levels, while increasing gly

206 with a 38-58% decrease in the mitochondrial uncoupling protein 3 (UCP3) levels.

207 tivator of fatty acid oxidizing enzymes, and uncoupling protein 3 (UCP3), a thermogenic mitochondrial

208 lex IV subunit 1 (COX1) was tightly bound to uncoupling protein 3 (UCP3), but this complex was disrup

209 eases free radicals through up-regulation of uncoupling protein 3 (UCP3).

210 Conversely, restoration of uncoupling protein 3 expression attenuated reactive oxyg

211 ture associated with increased expression of uncoupling protein 3 in brown and white adipose tissues

212 ith WT mice, along with a marked increase in uncoupling protein 3 mRNA expression in skeletal muscle,

213 Despite the reduced P/O, uncoupling protein 3 protein levels were not different i

214 Uncoupling protein 3 was markedly downregulated in Gq or

215 me proliferator-activated receptor alpha and uncoupling protein 3, increases in mitochondrial protein

216 switches mitochondrial Ca(2+) uptake from an uncoupling protein 3- and mitochondrial calcium uniporte

217 itochondrial calcium uniporter-mediated, but uncoupling protein 3-independent pathway.

218 mics signature in mice overexpressing muscle uncoupling protein 3.

219 ls, as well as a reduction in the content of uncoupling protein 3.

220 d cell death were abrogated by knock down of uncoupling protein 3.

221 ity was increased by 25% in O vs YA muscles, uncoupling protein-3 (UCP-3) protein level was upregulat

222 ous system, increasing fatty acid oxidation, uncoupling protein-3 (UCP3) expression, and thus, energy

223 e showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of proton

224 f pyruvate dehydrogenase kinase-4 (PDK4) and uncoupling protein-3 (UCP3), genes that are known to be

225 ttenuates anoxia-reoxygenation tolerance but uncoupling protein-3 depletion does not reduce anoxia to

226 rotein-2 appears to play a greater role than uncoupling protein-3 in modulating ischemia/anoxia toler

227 RNAi of uncoupling protein-3 partially attenuates the capacity t

228 ranscription factor 1, citrate synthase, and uncoupling protein-3, although KPF itself is not a direc

229 y mouse neurons and test the hypothesis that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are sp

230 with the observed 1.5-fold increase in brain uncoupling proteins 4 and 5.

231 mitochondrial factors revealed that loss of uncoupling protein 5 (UCP5) modifies the energy balance

232 0 nM), which has been reported to facilitate uncoupling protein activity, also antagonized this actio

233 ein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to conf

234 ion, lipolysis, and thermogenesis, including uncoupling proteins and peroxisome proliferator-activate

235 ation and refolding of bacterially expressed uncoupling proteins and reexamined the transport propert

236 structures of mitochondrial transporters and uncoupling proteins are 3-fold pseudosymmetrical, but th

237 In conclusion, mitochondrial uncoupling proteins are necessary components of ischemia

238 Mitochondrial carriers, including uncoupling proteins, are unstable in detergents, which h

239 tion in this setting as a membrane potential uncoupling protein, but instead acted to control routing

240 endent of adenine nucleotide translocase and uncoupling proteins, decreased mitochondrial membrane po

241 anti-oxidant administration ameliorates the uncoupling protein-depleted anoxia-susceptible phenotype

242 In parallel combined uncoupling protein depletion and isolated uncoupling pro

243 e density was increased in insulin-resistant uncoupling protein-diphtheria toxin A (UCP-DTA) transgen

244 Mitochondrial uncoupling proteins dissociate ATP synthesis from oxygen

245 reactive oxygen species as proposed for the uncoupling protein family members (UCP).

246 Because uncoupling protein function is regulated by free fatty a

247 ose tissue, in particular, the mitochondrial uncoupling protein gene (Ucp1).

248 erformance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoup

249 f the matrix and are therefore not caused by uncoupling protein or by the opening of a nonspecific ch

250 wn adipocytes enhances the expression of the uncoupling protein PGC-1alpha, UCP1, and a series of mit

251 the transcriptional and protein abundance of uncoupling proteins that mediates thermogenesis, and it

252 ansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitocho

253 associated with a cell-specific increase in uncoupling protein (UCP) 2 and 4 expression.

254 The mitochondrial carrier uncoupling protein (UCP) 2 belongs to the family of the

255 tential and the increase in this leak due to uncoupling protein (UCP) activation by ROS.

256 tty acids are known to enhance mitochondrial uncoupling protein (UCP) activity.

257 regulated gene ucp-4, the sole mitochondrial uncoupling protein (UCP) in nematodes.

258 pathetic stimulation, activate mitochondrial uncoupling protein (UCP)-1 and oxidize fatty acids to ge

259 expression of the brown fat signature genes uncoupling protein (UCP)-1 and peroxisome proliferator-a

260 the C/EBPbeta(-/-) mice as was the level of uncoupling protein (UCP)-1 and UCP-3 in the muscle.

261 on of caloric excess through the activity of uncoupling protein (UCP)-1.

262 in resistance, fatty acid beta-oxidation and uncoupling protein (UCP)-2 expression decreased after tr

263 rylation and the expression of mitochondrial uncoupling protein (UCP)-2.

264 Indeed, BAT dissipates energy as heat via uncoupling protein (UCP)1.

265 Uncoupling protein (UCP)2 is a mitochondrial inner membr

266 Pase-2a activity, expression of mitochondria uncoupling proteins (UCP) and glucose transporters (GLUT

267 ntrations were raised, cardiac mitochondrial uncoupling proteins (UCP) increased (isoform UCP2, p<0.0

268 e transport properties and regulation of the uncoupling proteins (UCP).

269 affect protein levels of brain mitochondrial uncoupling proteins (UCP-2, 4, and 5).

270 gene clusters involved in lipid metabolism (uncoupling protein [UCP]1, UCP3, PPAR gamma coactivator

271 lity of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for sta

272 the well-known betaAR-dependent increase of uncoupling protein UCP1 expression and expansion of beig

273 own fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia a

274 ailability of mice lacking the mitochondrial uncoupling protein UCP1, has provided an opportunity to

275 ediated by beige adipocytes that express the uncoupling protein UCP1.

276 thermogenesis via enhanced expression of the uncoupling protein UCP1.

277 a the unique expression of the mitochondrial uncoupling protein UCP1.

278 gy in the form of heat via the mitochondrial uncoupling protein UCP1.

279 ogenic pathways encoded by the mitochondrial uncoupling protein (Ucp1) and mitochondrial glycerol-3-p

280 By stimulating proton leak, mitochondrial uncoupling proteins (UCP1-3) increase mitochondrial resp

281 r strategy to a structure of isoform 2 of an uncoupling protein (UCP2) binding an inhibitor recently

282 because of high levels of the mitochondrial uncoupling protein (UCP2).

283 The novel uncoupling proteins (UCP2-5) are implicated in the mitoc

284 21+/-1 vs. 18+/-1%; P<0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondr

285 scle mitochondria, associated with increased uncoupling protein (UCP3) levels.

286 disease, downregulated the expression of two uncoupling proteins (UCP4 (SLC25A27) and UCP5 (SLC25A14)

287 A novel uncoupling protein, UCP5, has recently been characterize

288 Uncoupling proteins (UCPs) are a family of proteins loca

289 Mitochondrial uncoupling proteins (UCPs) are involved in body weight r

290 Uncoupling proteins (UCPs) are located in the mitochondr

291 Uncoupling proteins (UCPs) occur in the inner mitochondr

292 Uncoupling proteins (UCPs) oppose this phenotype by indu

293 Uncoupling proteins (UCPs) regulate energy expenditure i

294 D but also demonstrates a potent ability for uncoupling proteins (UCPs) to prevent this process.

295 s superoxide generation through induction of uncoupling proteins (UCPs), and transgenic overexpressio

296 he aim of this study was to evaluate whether uncoupling proteins (UCPs), located in the inner membran

297 uggesting that these changes are mediated by uncoupling proteins (UCPs).

298 2(+/-)) mice leads to increased expresson of uncoupling proteins (UCPs).

299 by increased expression of the mitochondrial uncoupling protein uncoupling protein 2 (UCP2) in Foxa1-

300 nd that NBI-12i normalizes the expression of uncoupling protein, which is normally upregulated in ure