ライフサイエンスコーパス: uncoupling protein 1

1 wn adipose tissue respiration independent of uncoupling protein 1.

2 tissue-derived AAMs expressed high levels of uncoupling protein 1.

3 of heat through the actions of mitochondrial uncoupling protein 1.

4 genes characteristic of brown fat, including uncoupling protein 1.

5 ch encodes the key thermogenic mitochondrial uncoupling protein-1.

6 restriction caused by ectopic expression of uncoupling protein-1.

7 om these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissip

8 MTII treatment also stimulated uncoupling protein 1 activity in the brown adipose tissu

9 Uncoupling protein-1 acts in brown adipose tissue (BAT)

10 ivated receptor gamma coactivator 1alpha and uncoupling protein 1 and 3, and these changes can be rev

11 temperature as a result of higher levels of uncoupling protein 1 and a low abundance of the proinfla

12 validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the a

13 press markers of brown and beige fat such as uncoupling protein 1 and transmembrane protein 26.

14 vated receptor-gamma-coactivator-1alpha, and uncoupling protein-1 and -2 were increased in WAT.

15 apular brown fat but increased expression of uncoupling protein-1 and -2.

16 n uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismuta

17 ed high body temperature via upregulation of uncoupling protein-1 and mitochondrial oxygen consumptio

18 Conversely, the expression of uncoupling protein-1 and of the same mitochondrial genes

19 enic fat cell that express the mitochondrial uncoupling protein-1 and thus represent a powerful targe

20 low in adipocytes, are up-regulated, as are uncoupling proteins 1 and 2.

21 ets, including PPARgamma coactivator 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase

22 ubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regul

23 ein alpha (C/EBPalpha), fatty acid synthase, uncoupling protein-1, and glucose transporter 4.

24 Uncoupling protein 1(+) beige adipocytes are dynamically

25 neither presence nor thermogenic function of uncoupling protein 1(+) beige adipocytes contributed to

26 h number of mitochondria and the presence of uncoupling protein 1, brown fat adipocytes can be termed

27 dipose tissue (WAT) were stained for CB1 and uncoupling protein-1 by immunofluorescent staining.

28 Based on cell-specific markers and on uncoupling protein-1 (characteristic of both BAT and bei

29 Moreover, the abundance of uncoupling protein 1 competent brite cells in white adip

30 This increased uncoupling protein-1 content in brown adipose tissue, bu

31 uced a smaller increase in BAT blood flow in uncoupling protein 1-deficient mice than in wild-type mi

32 increase BAT blood flow, CU was performed in uncoupling protein 1-deficient mice with impaired BAT ac

33 ipose tissue (BAT)-deficient obese UCP1-DTA (uncoupling protein 1-diphtheria toxin A) mice.

34 loss was significantly associated with less uncoupling protein 1 expression (P = 0.006, R(2) = 0.09)

35 Cytochrome c oxidase activity, uncoupling protein 1 expression and maximal norepinephri

36 rd white adipocytes while directly elevating uncoupling protein 1 expression and pre-adipocyte differ

37 Pep19 induced uncoupling protein 1 expression in both white adipose ti

38 evation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose

39 Uncoupling protein 1 expression induced by Pep19 in 3T3-

40 ific defect in proton leak due to attenuated uncoupling protein 1 expression.

41 acids, glycolysis, fatty acid synthesis, and uncoupling protein 1 expression.

42 Energy expenditure and uncoupling protein-1 expression in BAT were slightly but

43 si stimulated significantly higher levels of uncoupling protein-1 expression in BAT, and completely r

44 PYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue

45 /-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the br

46 The localization of uncoupling protein-1, glucose transporter-1, and norepin

47 lt, lipolysis, as well as the mRNA levels of uncoupling protein 1, guanosine monophosphate reductase,

48 POMC gene delivery enhanced uncoupling protein 1 in brown adipose tissue (BAT) by mo

49 We found that CB1 was colocalized with uncoupling protein-1 in BAT, but neither protein was fou

50 nterscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positiv

51 teraction between free fatty acids and UCP1 (uncoupling protein-1) leading to de-energization of mito

52 However, uncoupling protein-1 levels were not increased in silden

53 ic markers PPARgamma coactivator 1 alpha and uncoupling protein 1, mirrored the differentiation patte

54 Moreover, CNTF(Ax15) increased uncoupling protein 1 mRNA expression in BAT and energy e

55 Uncoupling protein-1 mRNA in brown adipose tissue was re

56 Uncoupling protein-1 mRNA levels in brown adipose tissue

57 ose tissue but expresses neither brown (e.g. uncoupling protein 1) nor white adipocyte markers.

58 c acid) porphyrin], overexpression of either uncoupling protein 1 or manganese superoxide dismutase,

59 membrane potential, or by overexpression of uncoupling protein 1 or superoxide dismutase.

60 ase 1), catalase, glutathione S-transferase, uncoupling protein-1, or transcription factor liver X re

61 d body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white

62 short versions of the adipocyte protein 2 or uncoupling protein-1 promoters or micro-RNA target seque

63 t is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration

64 ined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of t

65 BAT uncoupling protein 1 (UCP-1) content was significantly d

66 esis requires upregulation of Pgc-1alpha and uncoupling protein 1 (Ucp-1) in brown adipose tissue.

67 In uncoupling protein 1 (UCP-1) knockout mice, the middle a

68 In the present study, we have measured uncoupling protein 1 (UCP-1) mRNA, a specific marker for

69 wn AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-l

70 Brown adipose tissue uncoupling protein-1 (UCP-1) mRNA levels (collected Day

71 n were prevented by overexpression of either uncoupling protein-1 (UCP-1) or manganese superoxide dis

72 mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dis

73 ), leptin, C/EBPalpha, and PPARgamma but not uncoupling protein-1 (UCP-1), the CD45 hematopoietic lin

74 orrelates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncou

75 uch as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long

76 expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription

77 dipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energ

78 (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in BA

79 m promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-

80 tasis, lipoprotein lipase, the mitochondrial uncoupling protein 1 (UCP1) and sterol regulatory elemen

81 Both uncoupling protein 1 (UCP1) and UCP3 are important for m

82 h was accompanied by increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose ti

83 Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is prec

84 Uncoupling protein 1 (UCP1) catalyzes fatty acid-activat

85 is occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration.

86 Uncoupling protein 1 (UCP1) dissipates energy and genera

87 Uncoupling protein 1 (UCP1) diverts energy from ATP synt

88 s previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3

89 eling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and

90 A 90% reduction in uncoupling protein 1 (UCP1) expression in interscapular

91 ses the endogenous PGC-1alpha protein level, uncoupling protein 1 (UCP1) expression, and oxygen consu

92 nduces mitochondrial dysfunction and reduces uncoupling protein 1 (UCP1) expression.

93 ed to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interactio

94 ent in liver did not alter the expression of uncoupling protein 1 (Ucp1) gene, which regulates thermo

95 lic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.

96 ses expression of the brown adipocyte marker uncoupling protein 1 (UCP1) in both adipose tissue depot

97 t production and decreased the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

98 VMH BDNF thermogenic effects are mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

99 bese Mc4r-null females were unable to induce uncoupling protein 1 (UCP1) in brown adipose tissue in r

100 is is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocyte

101 n through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals.

102 LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes,

103 Uncoupling protein 1 (UCP1) is highly expressed in brown

104 Uncoupling protein 1 (UCP1) is nearly absent in brown ad

105 Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshiver

106 Uncoupling protein 1 (UCP1) is the established mediator

107 nts of heat through activation of the unique uncoupling protein 1 (UCP1) located within the inner mit

108 Uncoupling protein 1 (UCP1) mediates nonshivering thermo

109 Uncoupling protein 1 (UCP1) plays a central role in nons

110 dependent transcription of the mitochondrial uncoupling protein 1 (UCP1) promoter by beta(3)AR requir

111 We combined an uncoupling protein 1 (UCP1) reporter system and expressi

112 tem regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adren

113 This was associated with recruitment of uncoupling protein 1 (UCP1)(+) beige adipocytes in WAT,

114 al analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brow

115 n browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermoge

116 Uncoupling protein 1 (UCP1), a mitochondrial H(+) transp

117 he expression of PGC1alpha, PDK4, PPARalpha, uncoupling protein 1 (UCP1), and neuron-derived orphan r

118 thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue ha

119 t of glucose homeostasis were independent of uncoupling protein 1 (UCP1), but required expression of

120 protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food

121 ssue (BAT), characterized by the presence of uncoupling protein 1 (UCP1), has been described as metab

122 uce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with

123 high glucose after overexpression of either uncoupling protein 1 (UCP1), superoxide dismutase 2 (SOD

124 The level of uncoupling protein 1 (UCP1), the key thermogenic protein

125 Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (UCP1)-based) and skeletal muscle (

126 attributed to its role in fuel oxidation and uncoupling protein 1 (UCP1)-mediated thermogenesis.

127 ession localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Ald

128 sion analyses and found that a population of uncoupling protein 1 (UCP1)-positive human adipocytes po

129 haracterized by the appearance of pockets of uncoupling protein 1 (UCP1)-positive, multilocular adipo

130 thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1).

131 on the principal effector of thermogenesis: uncoupling protein 1 (UCP1).

132 of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1).

133 ough thermogenic respiration, which requires uncoupling protein 1 (UCP1).

134 omys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1).

135 both electron transport chain components and uncoupling protein 1 (UCP1).

136 fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1).

137 r thermogenic energy expenditure mediated by uncoupling protein 1 (UCP1).

138 ng thermogenesis involved the stimulation of uncoupling protein 1 (UCP1; P<0.01), peroxisome prolifer

139 issipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates

140 etrakis (4-benzoic acid) porphyrin (MnTBAP), uncoupling protein-1 (UCP1) HVJ-liposomes, or manganese

141 ous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tis

142 ice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in the artery wall.

143 Uncoupling protein-1 (UCP1) is a brown fat-specific mito

144 Uncoupling protein-1 (UCP1) is abundantly expressed in t

145 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in w

146 Uncoupling protein-1 (UCP1) mRNA in brown adipose tissue

147 BAT activation, namely increased lipolysis, uncoupling protein-1 (UCP1) mRNA, and glucose uptake, ar

148 known, as they lack brown adipose tissue and uncoupling protein-1 (UCP1), which mediate adaptive non-

149 eta3 agonists in nonprimate species leads to uncoupling protein 1 up-regulation and weight loss, the

150 lood vessels after exposure to cold, whereas uncoupling protein-1 was expressed in the cytoplasm unde

151 Expression levels of the tissue-specific uncoupling protein-1 were 180 times higher in BAT than i

152 ramembraneous segments and the mitochondrial uncoupling protein 1, which is a transmembrane protein e

153 o up-regulate and activate the mitochondrial uncoupling protein 1, which mediates a proton conductanc

154 ction and brown adipose tissue expression of uncoupling protein-1, which is regulated by sympathetic