ライフサイエンスコーパス: uncoupling protein 2

1 tty-acid-induced activation of mitochondrial uncoupling protein 2.

2 by scavenging of the ROS or by inhibition of uncoupling protein 2.

3 nd -4, catalase, superoxide dismutase-2, and uncoupling protein-2.

4 ssigned to chromosome 12) in the area of the uncoupling protein 2/3 gene cluster.

5 and activators of transcription 1alpha, and uncoupling protein 2, among others.

6 is increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, th

7 Cardiac transcripts of genes encoding uncoupling proteins 2 and 3 are up-regulated in parallel

8 nction of the cardiac enriched mitochondrial uncoupling proteins 2 and 3 during delayed ischemic prec

9 a(2+) fluxes, have been described: the novel uncoupling proteins 2 and 3, the leucine zipper-EF-hand

10 ase in the expression of the transcripts for uncoupling proteins-2 and -3 also accompanied this incre

11 ruvate kinase, hormone-sensitive lipase, and uncoupling proteins-2 and -3.

12 almitoyltransferase-I, acyl-CoA oxidase, and uncoupling protein-2) and their coordinating transcripti

13 ation of neuropeptide expression, as well as uncoupling protein 2, and abnormal responses to a metabo

14 to chemotherapy, increase the expression of uncoupling protein 2, and decrease the entry of pyruvate

15 In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than

16 ochondria, ATP-hydrolyzing mitochondria, and uncoupling protein 2 are not significant contributors to

17 nzymes involved in ROS scavenging, including uncoupling protein 2, catalase, and copper zinc superoxi

18 Uncoupling protein-2 depletion alone significantly atten

19 ed uncoupling protein depletion and isolated uncoupling protein-2 depletion augments ROS production i

20 iac derived myoblasts is abolished following uncoupling protein-2 depletion by RNA-interference.

21 ypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophag

22 ransgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) h

23 agouti-related peptide, neuropeptide Y, and uncoupling protein 2 in the hypothalamus, but no increas

24 Adenosine triphosphate decreased and uncoupling protein 2 increased in fa/fa rats treated wit

25 Previous work in our lab has shown that uncoupling protein-2 is a major mediator of I/R in steat

26 is hypothesis, we see a dramatic increase in uncoupling protein-2 levels in the combination treated a

27 r-activated receptor-gamma, adiponectin, and uncoupling protein-2 mRNA levels in adipose, indicating

28 anoxia and reoxygenation tolerance following uncoupling protein 2 or 3 and combined 2 and 3 RNAi show

29 ion through the AMP-activated protein kinase-uncoupling protein 2 pathway.

30 ism for modified bioenergetics that involves uncoupling protein-2 that is up-regulated in aged cells

31 tion in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of t

32 modest increases in the expression level of uncoupling protein 2 (UCP-2) leads to a rapid and dramat

33 Uncoupling protein 2 (UCP-2) was increased as were other

34 vity (which peaks at 30 minutes post-PH) and uncoupling protein-2 (UCP-2) (which begins around 30 min

35 bility to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth

36 Quantitative RT-PCR indicated that mRNA for uncoupling protein-2 (UCP-2) was increased in the cPLA(2

37 ng enzymes of free fatty acid metabolism and uncoupling protein-2 (UCP-2).

38 trated that global deletion of mitochondrial uncoupling protein 2 (UCP2(-/-)) in mice impaired glucag

39 se core temperature and white adipose tissue uncoupling protein 2 (UCP2) expression in aP2-agouti tra

40 ciation between alleles of the mitochondrial uncoupling protein 2 (UCP2) gene and obesity because UCP

41 Additionally, intracellular glutathione and uncoupling protein 2 (UCP2) gene expressions were quanti

42 Uncoupling protein 2 (UCP2) has been shown to conduct ca

43 sion of the mitochondrial uncoupling protein uncoupling protein 2 (UCP2) in Foxa1-deficient islets, r

44 Uncoupling protein 2 (UCP2) is a mitochondrial protein t

45 Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane prot

46 Here we report that mitochondrial uncoupling protein 2 (UCP2) is expressed discretely in n

47 Uncoupling protein 2 (UCP2) is involved in various physi

48 Uncoupling protein 2 (UCP2) maps to a region on distal m

49 Here we show that voluntary exercise induces uncoupling protein 2 (UCP2) mRNA expression and mitochon

50 Uncoupling protein 2 (UCP2) plays a regulating role in h

51 Uncoupling protein 2 (UCP2) uncouples respiration from o

52 atty acids (FFAs) and elevated expression of uncoupling protein 2 (UCP2) without concomitant increase

53 of glucose sensing in POMC neurons involves uncoupling protein 2 (UCP2), a mitochondrial protein tha

54 factor, CARP, and beta-myosin heavy chain), uncoupling protein 2 (UCP2), a protein involved in the c

55 ICU1), mitochondrial Ca(2+) uniporter (MCU), uncoupling protein 2 (UCP2), and leucine zipper EF-hand-

56 Uncoupling protein 2 (UCP2), by virtue of its mitochondr

57 pendent on the mitochondrial redox state via uncoupling protein 2 (UCP2)-dependent alterations in mit

58 n evoke strong upregulation of mitochondrial uncoupling protein 2 (UCP2).

59 PPARalpha target gene encoding mitochondrial uncoupling protein 2 (UCP2).

60 ty from inflammation via upregulation of the uncoupling protein 2 (UCP2).

61 d was accompanied by increased expression of uncoupling protein 2 (UCP2).

62 elated peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).

63 al respiration in mice that are dependent on uncoupling protein 2 (UCP2).

64 nscription factor-3 (Atf3) and mitochondrial uncoupling protein-2 (Ucp2) are highly induced in Tsc2-d

65 We show that genetic manipulation of uncoupling protein-2 (UCP2) directly affects substantia

66 our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with B

67 Current evidence suggests that uncoupling protein-2 (UCP2) is a regulator of insulin se

68 Mitochondrial uncoupling protein-2 (UCP2) is highly expressed in steat

69 Uncoupling protein-2 (UCP2) is present in many tissues w

70 Uncoupling protein-2 (UCP2) mediates mitochondrial proto

71 Here, we demonstrated that the mitochondrial uncoupling protein-2 (UCP2) regulates NLRP3-mediated cas

72 Lipid-laden hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier tha

73 to preventing insulin release, ROS activates uncoupling protein-2 (UCP2), a mitochondrial inner membr

74 ive response in cancer cells to be linked to uncoupling protein-2 (UCP2), a mitochondrial suppressor

75 amined how liver regeneration is affected by uncoupling protein-2 (UCP2), an inner mitochondrial memb

76 The endocrine regulation of uncoupling protein-2 (UCP2), an inner mitochondrial prot

77 developmental and nutritional programming of uncoupling protein-2 (UCP2), glucocorticoid receptor (GR

78 ation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G pr

79 The uncoupling protein 2, UCP2, is a member of a family of i

80 zed as proapoptotic; however others, such as uncoupling protein 2, were not previously known to be ap

81 itochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio