ライフサイエンスコーパス: uncover

1 ng mechanisms have only recently begun to be uncovered.

2 ation, but the mechanisms are only now being uncovered.

3 tals of entry into the CNS was only recently uncovered.

4 hanisms of radiochemoresistance remain to be uncovered.

5 featuring functions of Eg and omegamax were uncovered.

6 ubstrate network has not been systematically uncovered.

7 Applied to HeLa cells, RBDmap uncovered 1,174 RNA-binding sites in 529 proteins, many

8 Our prior work uncovered 16S rRNA genes belonging to a novel, as-yet-un

9 ormed circRNA-Seq on B73 seedling leaves and uncovered 2804 high-confidence maize circRNAs, which sho

10 Our results uncover a biological role for TRMT1-catalyzed tRNA modif

11 live-tissue and super-resolution imaging, we uncover a centrosome-nucleated wheel-like microtubule co

12 nt stages of oligodendrocyte development and uncover a cohort of stage-specific oligodendrocyte-restr

13 These findings uncover a critical K(+)-Ca(2+)-adrenergic signaling axis

14 Our findings uncover a critical prosurvival function of a p53/PINCR/M

15 Our findings uncover a detrimental role of T-bet-dependent NKp46(+) I

16 These data uncover a direct role for RANK in lung cancer and may ex

17 Thus, we uncover a DNA under replication-53BP1 nuclear body forma

18 We uncover a dual regulatory role for chromatin during DNA

19 Together, these findings uncover a glioma-promoting role of BCL6 and provide the

20 Together, these results uncover a mechanism by which competitive recruitment of

21 Overall, our findings uncover a mechanism of SAC inactivation required for tim

22 ical genomics screen in Escherichia coli, we uncover a mode of action for DTPs-the disruption of meta

23 odia formation in neuronal growth cones, and uncover a molecular heterogeneity whereby different filo

24 hanism for TREX1-mediated L1 suppression and uncover a new function for TREX1 in protein destabilizat

25 Together, our results uncover a new inducer of mammalian heart regeneration an

26 These results uncover a new mechanism for Rac1 activation in tumors an

27 Taken together, our studies uncover a new metastasis-promoting pathway in Ewing Sarc

28 These results uncover a new molecular mechanism of tissue fibrogenesis

29 These findings uncover a new Ssp1-Kin1 signaling pathway, and define it

30 These findings uncover a novel acetylation-phosphorylation switch at Ly

31 an exciting model of tendon regeneration and uncover a novel cellular mechanism underlying regenerati

32 Our results uncover a novel mechanism by which MALAT1 regulates the

33 .1 gene transcription and, more importantly, uncover a novel mechanism of TFIID recruitment and gene

34 Together, these data uncover a novel mechanism through which endodermal-myoca

35 Mutations lacking nuclear localization uncover a novel mechanism whereby lipid phosphatase acti

36 e mutational history of individual cells, we uncover a novel mutational signature in healthy aging en

37 Our results uncover a novel PKCiota-AMOT-YAP1 signaling axis that pr

38 Finally, we uncover a novel role for Aurora-B regulated Astrin-SKAP

39 Collectively, these results uncover a novel role for mDia1 in Abeta-mediated synapto

40 Here, we uncover a novel role for the actin-regulatory protein Me

41 Our results uncover a novel role of GRP78 in reducing prion pathogen

42 These studies uncover a p53-Ptpn14-Yap pathway that is integral to p53

43 nter response to a cholesterol-rich diet and uncover a PDL1-dependent mechanism through which MZB cel

44 Here we analyze public data sets and uncover a previously unappreciated role of epigenome der

45 tructural roles for yeast CAF-1 subunits and uncover a previously unknown critical function of the mi

46 These findings uncover a previously unrecognized role for MUC1-C in dri

47 We uncover a retrograde extension mechanism for axon growth

48 We uncover a role in senescence for the potent tumor suppre

49 From the studies, we uncover a sequential, two-step mechanism of cellular rep

50 dings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-depe

51 Our results uncover a very significant role for PRMT5 in GBMNS self-

52 eurons, which are crucial for chemotaxis, we uncovered a Ca(2+) NFL leading to adaptation that would

53 ng, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but

54 oral adaptation to social defeat in mice and uncovered a critical contribution of neural projections

55 ployed a poly(A) tag sequencing protocol and uncovered a different poly(A) profile in esp5.

56 In conclusion, our work has uncovered a DsbA-like mycoredoxin that promotes mycobact

57 Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connec

58 In this study, we uncovered a means of vaccinia virus adaptation involving

59 eptors in vivoSIGNIFICANCE STATEMENT We have uncovered a mechanism underlying olfactory receptor sens

60 Results also uncovered a misdiagnosed epidemic that implicated benefi

61 We also uncovered a new type of oscillation during recovery from

62 spermidine-depleted B. subtilis speD mutant uncovered a nitrogen-, methionine-, and S-adenosylmethio

63 Together, our results uncovered a novel cellular protein that can interact dir

64 In summary, our work has uncovered a novel component and suppressor of Ca(2+)-dep

65 Further, our computational analysis uncovered a novel homo-trimeric DNA motif that mediates

66 In summary, we have uncovered a novel human mitochondrial KMT that introduce

67 Taken together, we have uncovered a novel mechanism for Smo activation by sumoyl

68 Thus, our work uncovered a novel mechanistic link of a SZ risk gene to

69 We uncovered a novel site (Y382-384) within the P2X7 recept

70 h an unbiased, genome-wide approach, we have uncovered a previously unrecognized interplay between Gl

71 Our data uncovered a role for RNH1 in global DNA replication in t

72 s involved in glycolysis/gluconeogenesis and uncovered a role for this factor in regulating anaerobic

73 Population genetic approaches have uncovered a strong association between kidney diseases a

74 phical information system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains

75 Recent evidence from one strain has uncovered a unique cell surface 'amylosome' complex that

76 , searching for co-occurring aggregates, and uncovering a group of coalescing RBPs through screens en

77 2+) sensor that binds to and modulates ACA8, uncovering a possible involvement of the CML protein fam

78 modulating heterosexual transmission of HIV, uncovering a potential strategy for protecting women fro

79 eveals ancient connections to signaling, and uncovers a ciliary protein that underlies development an

80 Our study thus uncovers a critical function of CaCC-mediated cytoplasmi

81 Overall, our work uncovers a DRG neuron-microglia interaction that respond

82 Our study uncovers a function of SRC in cell-cell communication, s

83 Our study uncovers a noncanonical thermogenic mechanism through wh

84 Our study uncovers a novel mechanism of somatic cell differentiati

85 Our study uncovers a novel molecular mechanism for regulating PD-L

86 Thus, our study uncovers a novel regulatory mechanism for the developmen

87 lished TI-seq/rRibo-seq data sets, Ribo-TISH uncovers a novel signature of elevated mitochondrial tra

88 Moreover, Coop-seq uncovers a nucleotide switch within the POU half-site wh

89 interactome of arenavirus nucleoproteins and uncovers a potent antiviral host protein that is neutral

90 Our first study of maize circRNAs uncovers a potential new way for transposons to modulate

91 This work uncovers a rare example of an ancient system of complex

92 Thus, this work uncovers a strategy in which AvrPtoB targets NPR1 and re

93 Thus, our study in live animals uncovers a VB2-sensing/response pathway that regulates f

94 Our findings uncover an additional layer of complexity, implicating l

95 Collectively, our findings uncover an essential role for PRDM15 as a chromatin fact

96 Together, these findings uncover an FcRn-dependent endosomal cellular-sorting pat

97 In conclusion, our results uncover an important aspect of the cross-talk between TG

98 Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PC

99 which NTS(HSD2) neurons drive appetite, and uncover an interaction between the NTS(HSD2) circuit and

100 rafast time-resolved optical reflectivity to uncover an intimate connection between its insulating ga

101 Consistent with our model, we uncover an inverse correlation between ribosome density

102 Our results uncover an lncRNA-mediated mechanism for HIF-1 activatio

103 These results uncover an oncogenomics paradox, whereby mutations mappi

104 ly identified dorsal horn and RVM neurons to uncover an RVM-spinal cord-primary afferent circuit cont

105 Here we uncover an unanticipated link between ADARs (ADAR1 and A

106 re-microtubule attachment dynamics, and they uncover an unexpected role for Aurora A in late mitosis.

107 Together, these findings not only uncover an unexpectedly important role of cells of origi

108 ively regulates adipokine secretion and have uncovered an evolutionarily conserved molecular link bet

109 Early applications of information theory uncovered an inconsistency.

110 Furthermore, we uncovered an integrated mechanism that acts at the trans

111 Taken together, our results have uncovered an lncRNA-based mechanism that modulates TGF-b

112 lying this model to the sperm methylomes, we uncovered an overall evolutionary expansion of the hypom

113 he known structures of a protein, our method uncovers an ensemble of structures that fully accounts f

114 Here we uncover and mechanistically characterize the NLR Nlrp9b

115 es that HIM provides nanometer resolution to uncover and rediscover critical ultrastructural characte

116 Together, these findings uncover AP-2 and clathrin as players in Slack channel re

117 Thus, miR-28 replacement is uncovered as a novel therapeutic strategy for DLBCL and

118 mapping, array CGH, and exome sequencing, we uncovered bi-allelic loss-of-function CDK10 mutations se

119 matography and mass spectrometry, we further uncovered binding of the RNA-binding protein HuR to the

120 ional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity.

121 icated rheumatological conditions, which are uncovered by comprehensive workup.

122 Competing phases can be uncovered by external perturbations such as pressure or

123 Notably, we uncovered cell state plasticity and adhesion dynamics re

124 isease (HD) has promoted numerous efforts to uncover cellular pathways that lower levels of mutant hu

125 enetic screen in near-haploid human cells to uncover cellular processes that regulate HIF1alpha.

126 Additional work to uncover -cis and -trans regulators of EIF2B5 splicing id

127 metabolic regulation in the endothelium and uncovered core metabolic pathways and mechanisms of regu

128 informatics and density-functional theory to uncover design guidelines for predicting noncentrosymmet

129 We uncovered differences in inhibitory receptor expression

130 This study uncovered differences in the fatty acid selectivity prof

131 ibility measurements in the Kondo regime, we uncover directly the charge dynamics of this peculiar me

132 e embryonic stem (mES) cell differentiation, uncovering discrete transitions across nine cell states.

133 that this iPSC-based approach can be used to uncover disease-stage-specific responses to drugs.

134 Mechanistic studies uncovered distinct catalytic activities and reaction int

135 motifs of differentially dysregulated genes uncovered distinct MEF2A co-regulators for the atrial an

136 hat is agnostic to preexisting knowledge has uncovered dozens of loci that influence glycemic dysregu

137 ve computational drug- discovery strategy to uncover drugs that are routinely used for other indicati

138 here the application of these approaches has uncovered effects of gene-environment interactions relev

139 hin a multi-component mixture can be used to uncover emergent properties arising from polypharmacolog

140 We uncover epigenomic signatures of domestication traits du

141 This screen uncovered essential residues within Synaptotagmin that s

142 Recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across

143 This approach uncovered evidence that TBK1 supports AKT/mTORC1 pathway

144 This fine-grain mapping uncovered extensive allelic interactions within enhancer

145 Contrast-enhanced imaging uncovered extrinsic compression of hepatic and portal ve

146 These findings uncover facets of CAR immunobiology and underscore the p

147 The GWAS uncovered five and 32 significant SNPs for SET, and 22 a

148 Genomic analyses uncovered four distinct genes that allow for pathway var

149 dicate that chromosomal contacts' maps could uncover functionally and clinically related genes.

150 Network alignments have been used to uncover functionally conserved network parts and to tran

151 Here, the authors uncover functions, in response to DNA damage, for the br

152 We aimed to uncover genes influencing skin colour in African-admixed

153 Thus, we uncovered genes that modify the interpretation of morpho

154 Our work has uncovered genetic contributions to skin aging and confir

155 These results uncovered genotype-by-environment interactions that supp

156 Tuba-seq uncovers genotype-dependent distributions of tumor sizes

157 Previous studies have uncovered heightened prostatic susceptibility to hormone

158 We uncover here the function of a gene that supports this t

159 that the paradigm of metabolic bioactivation uncovered here should be considered for the evaluation a

160 The properties of UL8 uncovered here suggest that UL8 may be involved in the g

161 Such complex network analysis allows to uncover hidden plants relationships related to their evo

162 tivity controlled by educating receptors and uncover how cytokine stimulation overcomes NK cell educa

163 e discuss recent findings that have begun to uncover how different parts of the secretory pathway dir

164 ailed balance broken) statistical system and uncover how switching policy affects oscillatory trends

165 viral proteins improves, we will undoubtedly uncover how the multifunctional nature of these HIV-1 re

166 ecamtiv mecarbil also provides insights into uncovering how force is generated by molecular motors.Om

167 e two disciplines, highlighting the recently uncovered importance of protein-protein interactions, es

168 in-based epigenetic inheritance has now been uncovered in all domains of life.

169 hite flowers in I. loxense differs from that uncovered in previous studies, pointing to multiple mech

170 sfully exploit a modulation doping scheme to uncover, in conjunction with a scanning tunnelling micro

171 engagement of Bcl-2 protein inhibitors, and uncover inhibitor-dependent competitive PPIs.

172 erating high quality EWS-RNA interactome, we uncovered its specific and prevalent interaction with a

173 ied mutations onto the SHMT structural model uncovered key residues for structural stability, ligand

174 Our study uncovers key roles for TNF and, to a lesser extent, IL-1

175 These findings, thus, uncover limitations of structural analysis of drug bindi

176 s in several brain cortices has consistently uncovered low-dimensional manifolds that capture a signi

177 Our analysis uncovers major differences in ribonucleotide repair betw

178 er algorithms have successfully been used to uncover many novel bacterial ncRNA classes in recent yea

179 This newly uncovered mechanism for Ca(2+) mobilization by beta2AR h

180 GTP hydrolysis controls septin assembly, and uncover mechanisms by which cells construct defined sept

181 Personalized studies to uncover mechanisms leading to disease recurrence within

182 detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.

183 Uncovering mechanisms that control immune responses in t

184 Herein, we review recent efforts to uncover microbiome-derived natural products, describe th

185 We further uncover more gp93 biology by identifying CNPYb as a coch

186 early resolving phylogenic relationships, we uncovered mutated LCP1 and WNK1 as novel CLL drivers, su

187 nt and relapse isolates of M. intracellulare uncovered mutations in a previously uncharacterized locu

188 The uncovered neural circuits and their molecular and cellul

189 Overall, our analyses uncover new complexities in the control of CPK28 and pro

190 pathogenesis represents a useful strategy to uncover new drug targets.

191 These findings uncover new mechanisms by which AMPK could potentially m

192 our understanding of the disease and help to uncover new relations between cancer driving genes and p

193 In addition, we uncover new targets of investigation in both sexes, whic

194 parative analyses of extant species that are uncovering new evidence for evolutionary changes in the

195 Using the chick embryo, we uncover novel genes in the gene regulatory network under

196 Our study aims to uncover novel insights into channel gating through in-de

197 trates how the study of diverse bacteria may uncover novel mechanisms involved in regulating bacteria

198 Our data uncover novel mechanisms linking MITF-dependent inhibiti

199 Whole-genome RNA sequencing uncovers novel miR-141-regulated molecular targets in PC

200 Collectively, our data uncover Nudt21 as a novel post-transcriptional regulator

201 ing cell line responses to 265 compounds, we uncovered numerous TFs whose activity interacts with ant

202 enealogical processes with recombination can uncover past population history in unprecedented detail.

203 nome level of a clonally aged population and uncovered phenotypic variations that subject the cells t

204 Our data uncover possibilities for the arrangement of Wnt-FZD CRD

205 ategies to prevent TDP-43 aggregation and to uncover previously unexplored roles of TDP-43 in cell me

206 We uncovered previously unreported phenotypic heterogeneity

207 iates sensory molecules with cell types, and uncovers principles of gut homeostasis and response to p

208 vity optomechanics provide a new platform to uncover quintessential architectures of chaos generation

209 Our findings uncover rapid piRNA evolution reflecting contemporary TE

210 We reasoned that we could uncover regulatory pathways with new roles in hepatocyte

211 biological processes that can be analysed to uncover relationships between GR and its interactants.

212 Our efforts uncover replication-dependent and -independent ICL repai

213 Finally, we uncover reQTL effects in multiple GWAS loci and show a s

214 Moreover, the chemical complexity we uncovered resulted in the development of an improved met

215 We also uncover selective correlations between changes in signal

216 PTBS with uncovered SEMS is an effective and safe method for palli

217 cyte and nonmyocyte transcriptional programs uncovered several injury-responsive genes across regener

218 Our findings uncovered several levels of coordination of transcriptio

219 g of the genetics of primary brain tumors by uncovering several novel driver genetic alterations.

220 totypical 2D system, a GaAs quantum well, we uncover signatures of many-body effects involving electr

221 Further, single-unit recording in the MeA uncovered significant changes in the sensory representat

222 edge of yeast transcriptional regulation, we uncovered significant regulatory variation in individual

223 that using population-level smoking metrics uncovers significant relationships between maternal smok

224 To uncover specific sequence requirements within regulatory

225 on and increase throughput, and additionally uncover static and dynamic heterogeneity usually masked

226 OM goes beyond basic network inference (i.e. uncovering static interaction networks): it builds dynam

227 Consequently, we uncover statistical results in origami, finding the entr

228 In patients presenting very late ST, uncovered stent struts were a common dominant finding in

229 ofactor assimilation and serve as models for uncovering strategies deployed for allosteric signal tra

230 Recent work that has uncovered structural features and new mechanisms for spe

231 rding to time intervals from index stenting: uncovered struts and underexpansion in acute/subacute ST

232 acute/subacute ST and neoatherosclerosis and uncovered struts in late/very late ST.

233 At 21 days, uncovered struts were still present in the BVS group (3.

234 functional regulation of ISWI by the NTR and uncover surprising parallels with Chd1.

235 ialized bioinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNA

236 We further uncover that several P2X receptors, including those able

237 We next uncovered that HDAC2 is a direct target of cAMP response

238 In the present study, we uncovered that IF1 is upregulated in mouse hearts with p

239 stem and subcellular nanobody expression, we uncovered that maintenance of Mira asymmetric localizati

240 Recently, it was uncovered that MTs nucleate from preexisting MTs within

241 e array with several glycan-binding proteins uncovered that not only terminal glycoepitopes but also

242 Surprisingly, our side-by-side comparison uncovered that the African ZIKV isolate (MR-766) is more

243 Electrophysiology and EM studies uncovered that the number of multigranular compound even

244 ecent findings established a new paradigm by uncovering that their association with magnesium transpo

245 ity, combined with simple causal models, can uncover the circuit structure of sensorimotor transforma

246 We uncover the complex multistage process of capsid assembl

247 These results uncover the critical role of oxytocin signaling in a mol

248 In an attempt to uncover the determinants of immunodominance among severa

249 tein-interaction, and functional studies, we uncover the early events of C. elegans brain assembly.

250 controlled donor/acceptor bilayer system, we uncover the genuine effects of molecular orientation on

251 CyTOF may, for example, uncover the immunological heterogeneity and differentiat

252 n vivo, while ribosome profiling and RNA-seq uncover the impact of CsrA on translation, RNA abundance

253 ference of AID for structured substrates and uncover the importance of G4 recognition and oligomeriza

254 In efforts to uncover the mechanism by which SLFN5 promotes GBM tumori

255 Despite previous studies that attempted to uncover the mechanism leading to abnormal tooth developm

256 To uncover the mechanism of action of ZnO NPs on CT activit

257 To uncover the molecular basis for this heterogeneity, we p

258 are rapidly enabling researchers to finally uncover the molecular mechanisms underpinning the astoni

259 ion with membranes, it has been difficult to uncover the molecular process that underlies its antibac

260 together, these data sets will enable us to uncover the most critical genes acting in the steps of c

261 erical methods in exhaustive simulations, we uncover the ordering in the underdoped ground state.

262 the plasma membranes of living cells and to uncover the role of clustered anchoring proteins in orga

263 To uncover the role of Vps34, the sole class III phosphoino

264 k or the genes under their control, and thus uncover the specific molecular events driving disease ri

265 synthetic-lethal interactions, this approach uncovered the chromatin helicase DNA-binding factor CHD1

266 Rare genetic syndromes have uncovered the contribution of barrier disruption, mediat

267 In addition, we uncovered the distribution of Gag correlated residues in

268 fates using a reverse engineering method and uncovered the dose-dependent rewiring of gene regulatory

269 n with CRISPR/Cas9 knockin of GFP fusion, we uncovered the global targets of UNC-30 and UNC-55.

270 tion, RNAi research on new fungal models has uncovered the role of small RNAs and RNAi pathways in th

271 opportunities for clean fuel production, but uncovering the chemistry at the electrode surface remain

272 Uncovering the mechanisms that affect the binding specif

273 vancing our knowledge of shape diversity and uncovering the molecular basis for shape generation in n

274 Uncovering the molecular basis of mammalian cardiomyocyt

275 nome sequencing has often been successful in uncovering the proteins involved in regulating compound

276 Our study, therefore, uncovers the different steps of CSB-mediated chromatin r

277 The difference between G 2W/G and G W/W uncovers the finite thermal resistance induced by the gr

278 This study uncovers the opportunity to use properties of heparanase

279 Our study uncovers the structural basis for LPS recognition, delin

280 active T and B cells allows investigators to uncover their biology and develop new therapeutic strate

281 consider host and microbiota as a whole-may uncover their code, clarifying perhaps the most fundamen

282 tory granules or secretory granule membranes uncovered their association with the actomyosin componen

283 yto-destructive macrophages will potentially uncover therapeutic strategies for dysferlinopathies.

284 Uncovering these genome-scale interactions constitutes a

285 Nm-seq uncovered thousands of Nm sites in human mRNA with featu

286 r cell renal cell carcinoma (ccRCC) has been uncovered through next-generation sequencing.

287 view, we aim to highlight what the field has uncovered thus far about movement disorders through DBS.

288 Here we uncover timely new functions of the SASP in promoting a

289 PSY was uncovered to physically interact with various Clp protea

290 We thus demonstrate that our approach can uncover trans-acting transcriptional control circuits th

291 Gene set enrichment analysis uncovered transforming growth factor-beta1 signaling act

292 ed with genetic perturbations, allowed us to uncover TRUB1 and PUS7 as the two key PUSs acting on mam

293 exome sequencing is an effective platform to uncover tumour neoantigens.

294 In particular, we uncover two new states: one contains only the azimuthall

295 monstrate the utility of SMLM in efficiently uncovering ultrastructural information of archived clini

296 We also uncover underlying principles of the CRISPR-Cas adaptati

297 el Ub-based reagents is greatly assisting in uncovering unknown aspects of Ub signaling.

298 Our finding uncovers Vangl2-Dvl interaction as a key bi-functional s

299 midine pan-BET inhibitor scaffold, which was uncovered via a virtual screen followed by testing in a

300 catalyzed pathway that forms furan-2-ones is uncovered with FeCl3, ZnBr2, and BF3.Et2O as catalysts t