ライフサイエンスコーパス: underscore the need

1 These null findings underscore the need for a long-term approach in evaluati

2 These findings underscore the need for additional quality assurance in

3 viral escape are not inextricably linked and underscore the need for additional research into the mec

4 erapy in patients with stage III disease and underscore the need for adequate surveillance of patient

5 long-term durability of CMD2 resistance and underscore the need for alternative sources of resistanc

6 ps in data, modeling, and communication that underscore the need for an open, shared network to frame

7 e methodological limitations, these findings underscore the need for assessing whether dermatological

8 Our studies also underscore the need for bacterial cells to balance bindi

9 arding who provides specific aspects of care underscore the need for better care coordination, inform

10 obal population increases and climate change underscore the need for better comprehension of how plan

11 e more accurate ASD prevalence estimates and underscore the need for better detection, assessment, an

12 ucting salient lifetime health behaviors and underscore the need for careful interpretation.

13 he Journal, findings reported by Rhee et al. underscore the need for caution in drawing conclusions o

14 These findings underscore the need for circumspection in the computatio

15 e of bariatric surgery for treating NASH and underscore the need for clinical trials in this area.

16 quiescent, chemoresistant state and thereby underscore the need for combinatorial approaches to impr

17 Our results underscore the need for complete maps of genetic variati

18 scale differences in phenological strategies underscore the need for considering regional climate his

19 To underscore the need for continued empirical attention to

20 Temporal changes in MATS coverage underscore the need for continued monitoring of antigen

21 replication and transmission in mammals and underscore the need for continued public health surveill

22 on dispersal in insect-pollinated trees, but underscore the need for continued research on tropical s

23 ronaviruses as important human pathogens and underscore the need for continued research toward the de

24 y for transmission in a direct contact model underscore the need for continued study of H7 subtype vi

25 ltiple tiers of neuroscience information and underscore the need for cultural and infrastructure chan

26 These harsh realities underscore the need for developing improved treatment pa

27 These findings underscore the need for early clinical follow-up of surv

28 t of this disorder on the patient and family underscore the need for effective management strategies.

29 e modest efficacy, have safety concerns that underscore the need for effective peripherally acting dr

30 encouraging, the limited clinical responses underscore the need for enrichment of T cells with desir

31 levels in sub-Saharan Africa, these findings underscore the need for expanded access to second-line A

32 Our results underscore the need for extensive and multifaceted varia

33 WCNTs through selective reaction schemes and underscore the need for fluorescence spectroscopy to be

34 These results underscore the need for further characterization and ide

35 The findings underscore the need for further evaluation of air pollut

36 These data underscore the need for further investigation of ustekin

37 These observations underscore the need for further investigation to identif

38 are a particularly vulnerable population and underscore the need for further research.

39 lk and the minimal dependence on L chirality underscore the need for future exploration of the roles

40 These observations underscore the need for improved HCV surveillance and pr

41 The purpose of this article is to underscore the need for improved nutrition and physical

42 ity and specificity of individual biomarkers underscore the need for including at least one biomarker

43 These findings underscore the need for increased use of validated patie

44 The results underscore the need for integration of different aspects

45 ds predict long-term disease progression and underscore the need for interventions that protect again

46 They underscore the need for investigating cognitive processe

47 Our results underscore the need for large pooling efforts with tumor

48 ical performance of urine-based HPV sampling underscore the need for larger studies to evaluate urine

49 These findings underscore the need for mental health services for many

50 alance and therapy-skewing genetic variance, underscore the need for more comprehensive, disease-tail

51 The results underscore the need for more detailed assessment of bior

52 ses and continued outbreaks in avian species underscore the need for more effective measures for the

53 of the apparent rise in sepsis incidence and underscore the need for more reliable surveillance metho

54 nd suggest impaired cerebellar function, but underscore the need for more research to clarify the sou

55 terature on pulmonary biomarkers in COPD and underscore the need for more systematic studies in the f

56 Results underscore the need for much wider adoption of field-sca

57 tions of this short-term, noninvasive method underscore the need for new research that uses alternati

58 sociated with available treatments for NSCLC underscore the need for novel agents with improved effic

59 nmental pressures and shifting supply chains underscore the need for novel chemical activities, while

60 These findings underscore the need for novel therapies and suggest that

61 Our findings underscore the need for ongoing research in this area bu

62 strategy to augment protective antibody but underscore the need for optimal engagement of CD8 T cell

63 pitate the discontinuation of treatments and underscore the need for patient education and counseling

64 The results of the study underscore the need for prevention and cessation of smok

65 uine encephalitis virus and West Nile virus, underscore the need for research aimed at characterizing

66 These observations underscore the need for rigorous evaluation of thermodyn

67 These results underscore the need for routine screening and treatment

68 e any significant exposure to HPV occurs and underscore the need for screening programs that cover al

69 These findings underscore the need for sequencing complete crop chlorop

70 These findings underscore the need for standardizing QFT-GIT preanalyti

71 These data underscore the need for studies of controlled reoxygenat

72 These data underscore the need for studying endogenous gamma-secret

73 These data underscore the need for sustained efforts in increasing

74 ustry relationships are highly prevalent and underscore the need for their active disclosure and mana

75 tests, and ethical concerns about animal use underscore the need for trustworthy in vitro assays.

76 Nonetheless, the results underscore the need for urgent actions being undertaken

77 These results underscore the need for validating gene targets in every

78 ancies between calculations and measurements underscore the need for validation and refinement of exi

79 Recent data have underscored the need for a structured management algorit

80 of a devastating disease such as cancer has underscored the need for developing comprehensive panels

81 The recent explosion of genomic data has underscored the need for interpretable and comprehensive

82 erm treatment efficacy and side-effects have underscored the need for large numbers of patients, much

83 Participants underscored the need for optimal patient care in Europe,

84 The process of classifying these variants underscores the need for a more comprehensive and divers

85 This particular nature of the disease underscores the need for a more comprehensive evaluation

86 for which survivors seek follow-up care and underscores the need for a multidisciplinary approach to

87 onship of physical well-being to suicidality underscores the need for a multidisciplinary approach to

88 This outbreak underscores the need for a national surveillance system

89 highly pathogenic infection in avian species underscores the need for a preventive vaccine that can b

90 erent in diversifying the research workforce underscores the need for a rigorous scientific approach,

91 This lack of consensus underscores the need for a systematic assessment of vary

92 circa 1950 in southern and midwestern states underscores the need for additional interventions to pro

93 arriers to receipt of biologic therapies and underscores the need for additional studies to further d

94 ia, but the emergence of imatinib resistance underscores the need for additional therapies.

95 V-associated neurocognitive disorders (HAND) underscores the need for adjunctive therapy that targets

96 obal eradication is achieved, and it further underscores the need for all countries to maintain high

97 eins in the intact blood plasma/serum, which underscores the need for alternative approaches.

98 eletions, irrespective of imatinib exposure, underscores the need for alternative therapies.

99 rate of approval of novel anti-cancer agents underscores the need for better preclinical models of th

100 This study underscores the need for caution in targeting carcinoma-

101 ds are at increased risk for overdose, which underscores the need for close supervision of these pati

102 usage, and side-effects in spondyloarthritis underscores the need for combining data from well charac

103 relatively high rate of incident OAG and OHT underscores the need for community screening programs in

104 NSCLC among different ethnic groups and that underscores the need for consideration of these differen

105 pecies, reassort, and generate novel strains underscores the need for continued risk assessment in ma

106 H7N2 virus in the northeastern United States underscores the need for continuous surveillance of emer

107 This study underscores the need for development of additional corre

108 iple sclerosis patients surveys progress and underscores the need for further work to evaluate the ef

109 implications on risk screening programs and underscores the need for high-resolution genotyping of m

110 l mutations for diverse diseases, this study underscores the need for in vivo functional evaluation o

111 tion and social and occupational functioning underscores the need for investigations of amygdala modu

112 ity in early access to liver transplantation underscores the need for local and national policy initi

113 Our study underscores the need for long-term clinical trials in ad

114 rucial in the management of HBV carriers and underscores the need for long-term monitoring.

115 changing ice climate on the health of beluga underscores the need for long-term studies.

116 interferon and ribavirin combination therapy underscores the need for more effective and safer new tr

117 This work underscores the need for more pathologically representat

118 l nodes of the addiction neurocircuitry, and underscores the need for more research into how these co

119 icity of the NF-kappaB signaling pathway and underscores the need for more selective strategies to th

120 ing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with no

121 nceptions about diagnosis and treatment, and underscores the need for new diagnostic approaches.

122 matopoietic stem cell transplantation, which underscores the need for new treatment regimens.

123 This underscores the need for novel biomarkers and diagnostic

124 of endoscopic screening of patients with BE underscores the need for novel biomarkers, such as micro

125 Thus, this study underscores the need for novel strategies against CAUTIs

126 conjunction with difficulties in diagnosis, underscores the need for novel treatment strategies base

127 elae after resuscitation from cardiac arrest underscores the need for objective electrophysiological

128 This underscores the need for obstetricians to assess history

129 ring of fire-climate relationships by humans underscores the need for parameterizing thresholds of hu

130 tal pollutants may be reproductive toxicants underscores the need for prospective studies of couples

131 imate change-mediated vector range expansion underscores the need for research aimed at developing me

132 effect of both rare and common alleles that underscores the need for revising the traditional catego

133 The heterogeneity in practice we documented underscores the need for rigorous randomized trials to d

134 This unexpected event underscores the need for robust surveillance of enterovi

135 This work underscores the need for robust, standardized analytical

136 nge of important biomolecules, which further underscores the need for sensitive and selective analysi

137 This underscores the need for special attention to this vulne

138 during the past quarter of a century, which underscores the need for substantial improvements in sui

139 mortality associated with rotavirus disease underscores the need for targeted interventions, such as

140 ss that was observed in the treated patients underscores the need for the development of intervention

141 methods in which alpha-alkylation is favored underscores the need for the development of new processe

142 Our investigation underscores the need for the development of outbreak-rea

143 This outbreak underscores the need for thorough epidemiologic and labo

144 This observation underscores the need for thorough staging of both N1 and

145 ination of the 2009 pandemic influenza virus underscores the need for universal influenza vaccines th

146 of NoVs as a major gastrointestinal pathogen underscores the need for well tolerated and effective va

147 hi) monocytosis results in impaired healing, underscoring the need for a balanced and coordinated res

148 cally infected individuals are not curative, underscoring the need for a better understanding of the

149 stitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine.

150 nerated conflicting results and predictions, underscoring the need for a synthetic global analysis.

151 ternative lengthening of telomere mechanism, underscoring the need for adaptation to the presence of

152 he evidence that DMPA may increase HIV risk, underscoring the need for additional safe and effective

153 ssified in the LIPID MAPS database, strongly underscoring the need for automated classification.

154 nstitution have until now been unsuccessful, underscoring the need for better insight into thymic rec

155 nt compliance but lack requisite performance underscoring the need for better population screening te

156 ains the most lethal gynecologic malignancy, underscoring the need for better therapies.

157 e recovered concomitantly from 12% of cases, underscoring the need for biopsy and/or culture.

158 xposure is important even in this group, and underscoring the need for chemopreventive strategies.

159 ated with poor health and functional status, underscoring the need for close follow-up of this group

160 mes improve with the stringency of criteria, underscoring the need for comparability between study po

161 being a urate transporter, are key advances underscoring the need for continued investigation of thi

162 universally available nor always effective, underscoring the need for development of novel therapies

163 or- or recipient-derived inherited ciHHV-6A, underscoring the need for diagnostic testing for HHV-6 i

164 paths, undermining its unpredictability and underscoring the need for drift-insensitive vaccines.

165 ognosis of NMO remains poor in some patients underscoring the need for drug development and controlle

166 nsed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures.

167 CFU) and resistance to multiple antibiotics, underscoring the need for efficacious vaccines and thera

168 models, suffer from high computational cost, underscoring the need for efficient filtering approaches

169 redictions that are lower than observations, underscoring the need for further refinement of the halo

170 rtality in developing and developed nations, underscoring the need for HPV vaccination programs with

171 r(-/-) T cells induced much less severe EAU, underscoring the need for IL-21 in the development of th

172 tastasis when the burden of disease is high, underscoring the need for improved methods of detection

173 patients fail to respond to these therapies, underscoring the need for improvement with combination t

174 treatments are greatly underutilized in PAD, underscoring the need for improvements in patient identi

175 survivors increased substantially over time, underscoring the need for lifelong subspecialty follow-u

176 orphology that fall within the normal range, underscoring the need for more restrictive diagnostic cr

177 uman MT family remains poorly characterized, underscoring the need for new technologies to characteri

178 al ulcers) is reaching epidemic proportions, underscoring the need for new treatment modalities.

179 se disorders, treatment options are limited, underscoring the need for new, effective medications.

180 mal models could not be translated to humans underscoring the need for novel approaches.

181 g to development-distinct effects on growth, underscoring the need for novel risk assessment strategi

182 tastatic disease despite standard treatment, underscoring the need for novel therapeutic targets and

183 ost candidate off-target sites will be rare, underscoring the need for prescreening of patients throu

184 uthern and eastern Africa and Latin America, underscoring the need for routine national HIV drug-resi

185 ergencies increased after bariatric surgery, underscoring the need for screening for suicide risk dur

186 ls often fail to reproduce human phenotypes, underscoring the need for the generation and study of al

187 atic dental injuries are often irreversible, underscoring the need for therapies that protect dental

188 and their quality of life on a daily basis, underscoring the need for these parameters to ideally be

189 ivo analysis showed no effect on metastasis, underscoring the need for thorough preclinical investiga

190 sease progression among HIV-positive people, underscoring the need for transitional treatment and hea

191 ifferent backgrounds are joining this field, underscoring the need for unity regarding the use of ter

192 This underscores the need of understanding these effects in t

193 romise in vitro and in vivo, these outbreaks underscore the need to accelerate drug discovery.

194 tor-based regimens in sub-Saharan Africa and underscore the need to accelerate the study and approval

195 These findings underscore the need to account for individual glacier ge

196 ronaviruses can be enhanced by Abs, and they underscore the need to address the evolving diversity of

197 lnerability of black Americans, our findings underscore the need to address the potential impact of m

198 These patterns underscore the need to adopt a sociocentric perspective

199 These studies underscore the need to apply multiple biophysical and bi

200 From a clinical perspective, these results underscore the need to assess cognitive and motor functi

201 These findings underscore the need to assess exposure to NIS inhibitors

202 These findings underscore the need to assess the selectivity of small-m

203 Cost containment pressures underscore the need to better understand how nursing res

204 le and rapid growth in shale gas development underscore the need to better understand its environment

205 el swine-origin 2009 A(H1N1) influenza virus underscore the need to better understand the pathogenesi

206 These results underscore the need to consider antibiotic concentration

207 Our findings underscore the need to consider the microbiome when eval

208 Finally, we discuss future directions that underscore the need to consider victimization a social s

209 the return of results to all individuals and underscore the need to develop innovative approaches and

210 clinical translation of EZH2 inhibitors and underscore the need to develop novel EZH2 inhibitors to

211 The findings underscore the need to develop sustainable synthesis rou

212 The findings presented here underscore the need to evaluate a nonlive RSV vaccine ca

213 These findings underscore the need to evaluate neural actions of proges

214 The promising preliminary findings underscore the need to evaluate therapy directed against

215 These results underscore the need to expand exploration beyond the fro

216 Results underscore the need to explicitly integrate microbes int

217 nts of mTORC pathways in fibrotic states and underscore the need to further delineate mTORC2 signalin

218 These studies underscore the need to further elucidate the mechanisms

219 These data underscore the need to further investigate the processes

220 n dynamics and ecological interactions, that underscore the need to further understand how trait-medi

221 These findings underscore the need to genotypically stratify melanoma p

222 ies in sustaining O. formigenes colonization underscore the need to identify the derived factors indu

223 g principles of precision medicine in stroke underscore the need to identify, value, organise and ana

224 Low rates of maternal mental health care underscore the need to improve recognition and delivery

225 These findings underscore the need to improve treatment of patients wit

226 Therefore, we underscore the need to incorporate behavioral ecology in

227 Thus, these data underscore the need to incorporate population history wh

228 These results underscore the need to increase efforts to identify HIV-

229 These findings underscore the need to increase sampling and reporting e

230 with cascading impacts on marine ecosystems, underscore the need to link macroecology with evolutiona

231 The present results underscore the need to measure absorption cross sections

232 These findings underscore the need to move beyond richness as a surroga

233 These results underscore the need to obtain multiple, geographically d

234 bsyndromal mood symptoms in all four classes underscore the need to optimize treatment.

235 nd its association with subsequent mortality underscore the need to promote awareness of this complic

236 Our analyses underscore the need to quantify the transmissibility of

237 rmacological response and therapy compliance underscore the need to recognize the independent and syn

238 vated incidence of diarrheagenic E. coli and underscore the need to redouble efforts to prevent the t

239 Importantly, our results underscore the need to sample across taxonomic groups to

240 Survey results underscore the need to standardize practices.

241 These data underscore the need to strengthen programmes and target

242 The results underscore the need to tailor interventions individually

243 are growth-inhibited by antiprogestins, and underscore the need to target PR-B and associated kinase

244 ging land uses or pesticide applications and underscore the need to test for climate impacts at both

245 relevance of gray matter atrophy in MS, and underscore the need to understand its causes.

246 However, recent findings underscore the need to unravel the intricacies involved

247 aning of protective immunity with time, have underscored the need to develop strategies to enhance th

248 and human immunodeficiency virus (HIV) have underscored the need to generate memory T cells for robu

249 These experiences underscored the need to optimize preparation for and res

250 st predation (and therefore, nest predators) underscores the need to acknowledge the potential comple

251 This observation underscores the need to address fatigue as a significant

252 The observed heterogeneity underscores the need to better understand assumptions th

253 origin (e.g., H5N1 and H7N9) in recent years underscores the need to better understand the factors dr

254 This recent outbreak underscores the need to better understand the pathogenes

255 This recent outbreak underscores the need to better understand the pathogenes

256 influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenic

257 rdised approach to assessment and management underscores the need to collect baseline data to support

258 higher radiation doses than do dental x-rays underscores the need to conduct a detailed radiation exp

259 vity that occurs in 3beta-HSD deficiency and underscores the need to consider a bile acid synthetic d

260 denoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny.

261 nstitutes a major bioterrorism threat, which underscores the need to develop antiviral drugs for rapi

262 osphorylated species in biology and medicine underscores the need to develop methods for the detectio

263 drug-resistant strains of avian H5N1 viruses underscores the need to develop not only new drugs but o

264 quency of LD caused by Lp and non-Lp species underscores the need to expand our knowledge of evolutio

265 Consideration of transgender health underscores the need to explicitly consider sex and gend

266 Our study underscores the need to further explore the putative lin

267 l disease and primary sclerosing cholangitis underscores the need to further understand the role of e

268 lity in patients with undiagnosed HAE-C1-INH underscores the need to identify these patients and diag

269 Our study further underscores the need to interpret altered TSPO binding i

270 The continued spread of the HIV epidemic underscores the need to interrupt transmission.

271 This outbreak underscores the need to maintain high vaccination covera

272 pathway for the evolution of enzymes, and it underscores the need to mind thermodynamic stability in

273 g expression data to endogenous controls and underscores the need to put gene measurement on an absol

274 er lipid physical properties in fluid phases underscores the need to study the function of peripheral

275 al Cre-driven PTHrP deletion, a finding that underscores the need to subject the mouse articular cart

276 petition throughout the disturbance gradient underscores the need to understand competitive interacti

277 tric) generation requiring water for cooling underscores the need to understand controls on this wate

278 This underscores the need to understand how otoconia are form

279 Mycobacterium tuberculosis, and this finding underscores the need to understand how UGM functions.

280 This underscores the need to use a means for assessment of OI

281 ly enhanced NO-mediated leishmanial killing, underscoring the need to accurately assess oxygenation i

282 atients with advanced age and a PS of >/= 2, underscoring the need to carefully consider the risk-to-

283 lity was missing from plot-based approaches, underscoring the need to combine plot and remote-sensing

284 ons and are an important therapeutic target, underscoring the need to define how these connections ar

285 s Co(II) and Zn(II) via distinct mechanisms, underscoring the need to demonstrate transferability whe

286 le if colorectal cancer is identified early, underscoring the need to detect the earliest stages of m

287 could expose many to unnecessary treatments, underscoring the need to enhance predictive accuracy wit

288 substantially from current recommendations, underscoring the need to establish clear purpose for rec

289 T to the Medicare population may be limited, underscoring the need to evaluate real-world effectivene

290 matopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanism

291 ovement in vision in a minority of patients, underscoring the need to identify additional therapeutic

292 e analogs, have limited therapeutic effects, underscoring the need to identify effective therapeutic

293 important for controlling inflammation, thus underscoring the need to identify mechanisms regulating

294 an impact cognitive and behavioral outcomes, underscoring the need to identify therapies that control

295 ia or advanced myelodysplasia often relapse, underscoring the need to intensify tumor immunity within

296 previously reported using in vitro studies, underscoring the need to measure such data on living cel

297 eting T-cell progenitors in T-ALL while also underscoring the need to tightly regulate Notch signalin

298 ase and death in immunocompromised patients, underscoring the need to understand how latency is contr

299 tive diseases like Parkinson's disease (PD), underscoring the need to understand shared molecular tar

300 rials of nicotinic agonists have been mixed, underscoring the need to understand the mechanisms for i