ライフサイエンスコーパス: understanding of how

1 a high frequency of deletions advancing our understanding of how a RAD51 paralog is involved in main

2 Our data expand our understanding of how a single neuroendocrine cell coordi

3 60 data sets show that GRACE can improve our understanding of how a transcriptional network is re-wir

4 Despite our increased understanding of how abiotic factors influence plant phe

5 s the canonical nucleosome structure for the understanding of how accessibility to genomic DNA is reg

6 However, there is currently little understanding of how accounting for unreported catches (

7 The study improves our understanding of how adenoviruses establish infection in

8 essionals have a comprehensive knowledge and understanding of how adolescents experience living with

9 A mechanistic understanding of how adolescents optimize social predict

10 A better understanding of how aging promotes CVD is therefore urg

11 physiology and may have implications for our understanding of how altered folate availability causes

12 These findings may have implications for our understanding of how altered folate availability causes

13 However, we lack an understanding of how an interface can select some ligand

14 ch developments require detailed mechanistic understanding of how an SNP influences phenotype (and th

15 However, we lack understanding of how and to what extent climate has shap

16 this experimental therapy, we need a better understanding of how and which mtDNA is tagged for repli

17 wledge of the surface structure will aid the understanding of how and which type of interface will be

18 ponses to these materials, and improving our understanding of how and why certain particulate materia

19 l of these species requires a well-developed understanding of how animals use these new landscapes to

20 An understanding of how antibiotic resistance mutations sha

21 However, our understanding of how AP1 signaling changes may underlie

22 on modelling (SEM) to achieve a system-level understanding of how aridity, mean annual temperature an

23 fundamental unanswered questions that limit understanding of how arrestin-dependent GPCR signaling c

24 es, and osmotic stress; however, a molecular understanding of how ASK proteins are controlled remains

25 inesin conformation that revises the current understanding of how ATP binding is coupled to forward s

26 iod as one of significant progress toward an understanding of how attitudes form and change in three

27 Furthering the mechanistic and molecular understanding of how bacteria affect the nervous system

28 Surprisingly, we still lack a fundamental understanding of how bacteria build, maintain and expand

29 This study broadens the understanding of how bacteria diversify at the genomic l

30 y remains poorly characterized, impeding our understanding of how basal processes and endfeet influen

31 ural circuits are perturbed, and the limited understanding of how basic circuit functions relate to t

32 l feedback (PSF) framework has catalyzed our understanding of how belowground microbiota impact plant

33 cept to symbiotic fungi facilitated a better understanding of how biodiversity can be jointly shaped

34 's On Growth and Form, we review our current understanding of how biological forms are created and ma

35 ns between bacterial cells has broadened our understanding of how both pathogens and non-pathogens in

36 elling techniques, could greatly enhance our understanding of how cancer responds to treatment, and a

37 sed cooperative loops have also inspired our understanding of how catalytic loops appear in ecologica

38 mmunotherapeutic platform demands a thorough understanding of how cell death induced in the context o

39 This requires a deep understanding of how cell signaling pathways converge on

40 We focus on recent advances in our understanding of how cells actively sculpt tissues and h

41 he potential to pave the way toward a better understanding of how cells function at the molecular lev

42 Optogenetics promises to deepen our understanding of how cells perceive and respond to compl

43 vers of aggregation and toxicity adds to the understanding of how cellular homeostasis can be deterio

44 e single-cell level, thus providing a fuller understanding of how changes at single synapses translat

45 Collectively, this study augments our understanding of how cholesterol metabolism can modulate

46 s in different tissues and can assist in the understanding of how chromatin states affect gene regula

47 in sub-Saharan Africa (SSA) require a better understanding of how climate and other drivers influence

48 Despite detailed understanding of how climate influences N-fixation enzym

49 Our review illustrates how an understanding of how climate model outputs are derived a

50 marine ecosystems, and facilitates a greater understanding of how climate-driven changes in freshwate

51 y the groundwork for an improved mechanistic understanding of how colonization influences development

52 ly defined IAT class, and contributes to our understanding of how commensal and pathogenic E. coli co

53 Our results contribute to our understanding of how communities assembly and how specie

54 which can confound cataloging of members and understanding of how communities function.

55 s observation could prove significant to our understanding of how crystallisation ages are evaluated

56 ve preparedness, it is critical to have some understanding of how CSF would spread should it be intro

57 tion of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional

58 ng cellular ATP production, and advances our understanding of how defective FA signaling contributes

59 ation is well established, we have a limited understanding of how differences in diversity are relate

60 eighboring mesenchymal partners provides new understanding of how different cell types are maintained

61 refined spatial perspective provides unique understanding of how different components of landscape s

62 An understanding of how different domains of the environmen

63 ding strong support for the local and global understanding of how different dopants influence the pro

64 However, we have a poor understanding of how disease-specific methylation change

65 These findings further our understanding of how diversity loss will reduce the host

66 man CNS-derived cells and contributes to our understanding of how DMF may act clinically to ameliorat

67 roposed catalytic mechanism provide a better understanding of how DMSP is catabolized to generate the

68 iseases, such studies leave us with a lesser understanding of how DNA viruses adapt to hosts and how

69 in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type

70 s regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modula

71 Understanding of how each of these processes contributes

72 This has significant implications on our understanding of how early life events in childhood infl

73 To further improve our understanding of how ecosystems might respond to future

74 he remaining challenges to achieve a unified understanding of how effector activities work together t

75 A detailed mechanistic understanding of how environmental microbes influence th

76 ogy has the potential to greatly enhance our understanding of how environmental toxicants affect brai

77 However, a limited understanding of how epilepsy develops, particularly in

78 and presents a barrier; however, a complete understanding of how EPS structure relates to biological

79 These findings expand our understanding of how evolution driven by interactions oc

80 Their study has contributed to our understanding of how evolution modifies protein scaffold

81 computational biology have enabled a deeper understanding of how excitatory amino acid transporters

82 umulated by M. australiense and improves our understanding of how exposure duration will influence th

83 These findings help to enhance our understanding of how expression of the inflammatory modu

84 racellular transducer and contributes to our understanding of how FGF signaling plays diverse develop

85 ploited by species, thus limiting a complete understanding of how fish associate with reef structure.

86 ey Insight focuses on recent advances in our understanding of how flowers manipulate physical forces

87 vior may have important implications for our understanding of how fluid flow influences biofilm biolo

88 y knowledge gaps remain and gaining a better understanding of how freshwater pCO2 levels are regulate

89 etic questions and pave the road to a better understanding of how fundamental features of animal body

90 ummarise the current state-of-the-art in our understanding of how general features of amacrine cell i

91 y in cancer networks and will illuminate our understanding of how genes are modulated in a tissue-spe

92 Here were review our current understanding of how genes, growth, mechanics, and evolu

93 Our understanding of how genetic changes underlie the evolut

94 tudies and have the potential to advance our understanding of how genetic networks regulate sophistic

95 ntractions have been predicted; however, our understanding of how genetic variation may promote adapt

96 mes in greater depth, leading to an enhanced understanding of how genome sequence variants underlie p

97 y rewriting the genetic code will deepen our understanding of how genomes are designed and how the ca

98 This might contribute to further understanding of how genomic variations contribute to ca

99 ection of selection targets provide a better understanding of how geography and selection may have sh

100 However, there is little scientific understanding of how global patterns of future urban exp

101 tes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can b

102 Despite this, there is limited understanding of how HBV establishes chronic infections.

103 This study furthered our understanding of how HCMV evades inhibition by PKR and i

104 ng cardiac specification is critical for our understanding of how heart formation is initiated during

105 eins have yielded vital contributions to our understanding of how hematopoietic stem and progenitor c

106 nces of apoptotic cell sampling, advance our understanding of how homeostasis is maintained within th

107 skin microbiome structure contributes to our understanding of how host-associated bacteria are distri

108 These findings add to our understanding of how HPV replicates and the host cell pa

109 ce in the western Gulf of Alaska, but little understanding of how human foragers integrated into and

110 humans and toward robots, leading to greater understanding of how humans think, feel, and behave in t

111 However, our understanding of how hypoxia modulates the response of A

112 This deeper understanding of how immune cells and neurons interact t

113 These results advance the understanding of how independent but converging influenc

114 gaps that should be addressed to improve our understanding of how individual and group-level factors

115 offers a rare opportunity to seek a dynamic understanding of how individual-, group- and population-

116 review will highlight recent advances in our understanding of how inflammation resolution may become

117 There is currently little understanding of how initial community structure may dri

118 or regenenerative medicine, and enhances our understanding of how intrinsic and extrinsic signals sha

119 icant threat to global biodiversity, but our understanding of how invasive species impact native comm

120 A quantitative understanding of how ion transport is integrated and con

121 This study therefore provides a molecular understanding of how kinase-substrate recognition acts a

122 Here we review the current understanding of how lncRNAs help coordinate gene expres

123 These findings therefore inform our understanding of how local oscillatory activity may unde

124 tuberculosis enzyme, augmenting our current understanding of how M. tuberculosis meets its nutrient

125 Deeper understanding of how macroscopic structure affects visco

126 ation of vascularized 3D tissues requires an understanding of how material properties govern endothel

127 This study provides a mechanistic understanding of how MCPH1 controls neural stem cell fat

128 -kappaB is regulated and greatly expands our understanding of how MCV so effectively evades human imm

129 llular heterogeneity of the brain impedes an understanding of how MECP2 mutations contribute to RTT.

130 research questions to answer to enhance our understanding of how MedSD affects CVD risk or how these

131 the notion that there are major gaps in our understanding of how microbial communities degrade ligno

132 findings have important implications in the understanding of how microRNAs influence the co-expressi

133 While many studies advanced our understanding of how microtubule-associated proteins tun

134 Our results not only help in the understanding of how mitochondria cope with replicative

135 ctin-mitochondria interaction, enhancing our understanding of how mitochondria properly localize in a

136 in chromosome segregation, we have a limited understanding of how molecular features of tubulin prote

137 A key limitation is our lack of understanding of how molecular structure impacts on the

138 se results are a first step to gain a better understanding of how mood fluctuations in real life are

139 tiviral state, as well as providing a better understanding of how multiple arms of the immune system

140 nse to climate change requires a mechanistic understanding of how multiple factors interact to limit

141 either FTD or NCL, in part because of a poor understanding of how mutations in genes such as GRN cont

142 arget tissues and cells and by an incomplete understanding of how nanoparticle structure affects biod

143 Our results allow for a quantitative understanding of how natural calcium sulfate deposits ma

144 ks in higher organisms has prevented a clear understanding of how natural environmental conditions af

145 aluable but would be facilitated by a better understanding of how natural human CMV infection is acqu

146 d four distinct products, thus advancing our understanding of how neo-functionalization events have s

147 review highlights recent developments in our understanding of how neural circuits, pubertal hormones,

148 forms a foundation for a more comprehensive understanding of how neural information is directed and

149 Here we review our increasing understanding of how neuronal activity regulates oligode

150 process are not well described, limiting our understanding of how new species are created.

151 However, there are still gaps in our understanding of how nitrate signaling affects biologica

152 de formation are well characterized, but our understanding of how non-native disulfides are reduced s

153 Our results further our understanding of how novel morphological and biochemical

154 ther histone chaperones, and it advances our understanding of how nucleosomes and their epigenetic in

155 Results extend the understanding of how organic carbon and nitrite loads mo

156 e bacteria have developed as a model for the understanding of how organization of particles can influ

157 owing maternal loss has been documented, but understanding of how orphans allocate bonding to reconst

158 is in S. pyogenes reported here enhances our understanding of how other Gram-positive bacteria produc

159 However, a clear understanding of how (p)ppGpp promotes virulence in E. f

160 sis approaches, however, are simplifying our understanding of how p53 functions as a transcription fa

161 maturation of beta-like cells.Our incomplete understanding of how pancreatic beta cells form limits t

162 model may reveal a better pathophysiological understanding of how PE transitions to CTEPH in human tr

163 An understanding of how perturbed mechanical properties imp

164 otics and immune modulators by expanding the understanding of how PG is processed by lytic enzymes.

165 The fundamental understanding of how phonons move and the physical mecha

166 represents a significant step forward in our understanding of how physicochemical theories (such as C

167 and opportunity in developing a mechanistic understanding of how plants detect and respond to drough

168 review, we present an update on the current understanding of how plants recognize and respond to non

169 This finding expands our understanding of how platelets attach to sites of vascul

170 Current understanding of how platelets localize coagulation to w

171 Moreover, they enhance our understanding of how PMEs may be regulated by pH and pro

172 this single-cell approach provides a better understanding of how prostate cancer cells respond heter

173 popular, highlighting the need for a greater understanding of how proteins behave in the absence of s

174 to biochemistry to structural biology to an understanding of how proteins evolve interaction specifi

175 atomic details of these structures helps our understanding of how proteins work together, how mutatio

176 Here we summarize recent advances in our understanding of how PTMs and regulatory enzymes control

177 ence for microrefugia is hindered by lack of understanding of how rates of warming vary across a land

178 Our model enables an analytical understanding of how Red Queen dynamics emerge in our se

179 ociated gene loci to improve our mechanistic understanding of how resistance develops.

180 However, a precarious understanding of how resistance emerges and a lack of tr

181 of new and existing agents by advancing our understanding of how resistance evolves.

182 In order to gain a better understanding of how resistance to DNA methylation from

183 The emerging understanding of how SCI cell biology differs across les

184 However, there still is not a clear understanding of how SecDF functions, its exact role in

185 ave played a major role in enhancing current understanding of how selection and demography can impact

186 behavior and pathology, but we lack a basic understanding of how sex differences in the human cerebe

187 ractions with heme and NCoR1 and advance our understanding of how signaling through HRMs affects the

188 tic classifications will help to further our understanding of how single amacrine cell circuits act t

189 f other class I fusion proteins enhances our understanding of how small molecules can function as fus

190 onary theoretical models that can deepen our understanding of how socioeconomic inequalities can beco

191 lts lay the foundation for a more predictive understanding of how soil microbial communities respond

192 A better mechanistic understanding of how solid tumours are rejected may aid

193 results have important implications for our understanding of how spatial restriction is imposed on t

194 ploration of this technology may improve our understanding of how specific stromal composition could

195 These findings contribute to our understanding of how SPM synthesis is regulated during t

196 e acute setting, there is a lack of cohesive understanding of how staff experience and perceive the c

197 Together, these models provide a biophysical understanding of how stem cell scaling is maintained dur

198 Central to protein biology is the understanding of how structural elements give rise to ob

199 To obtain a more detailed understanding of how structure influences the function a

200 er, and are modulated by drug therapies, our understanding of how such changes shape the properties o

201 A detailed understanding of how such interfaces can be used to tail

202 esynaptic function for LRP4, enabling deeper understanding of how synapse organization is coordinated

203 This necessitates further understanding of how T follicular helper cells are regul

204 These findings not only transform our understanding of how T3 orchestrates adult brain lineage

205 The current understanding of how temperature affects mosquito and pa

206 Our understanding of how temporal variations of atmospheric

207 vents occur in the context of chromatin, our understanding of how TF-nucleosome interplay affects gen

208 ight recent advances that have increased our understanding of how the amount of tonic signal impacts

209 ecies.SIGNIFICANCE STATEMENT A comprehensive understanding of how the anatomical architecture of the

210 Here we provide a new understanding of how the auditory system extracts behavi

211 reinstatement of alcohol seeking, expand our understanding of how the BLA-->NAc pathway regulates alc

212 An improved understanding of how the brain allocates mental resource

213 ed view of motor cortex may lead to a better understanding of how the brain controls movement.

214 necessary first step toward a circuit-level understanding of how the brain generates behavior.

215 nues to have great promise in furthering our understanding of how the brain works.

216 Two recent papers advance our understanding of how the cancer genome evolves as the pr

217 Our understanding of how the course of opportunistic bacteri

218 isotope heterogeneity in plants and for our understanding of how the delta(18) O signal is incorpora

219 of key factors that govern metabolism and an understanding of how the differential capacity to metabo

220 individual isoforms, necessitating a deeper understanding of how the distinct transcriptional progra

221 However, we still lack a clear understanding of how the endogenous activity of these ce

222 Our understanding of how the endoplasmic reticulum (ER)-asso

223 Here, we highlight recent advances in our understanding of how the genome folds inside the 3D nucl

224 This limitation especially hinders our understanding of how the gut microbiota interact with th

225 A better understanding of how the host inflammatory/immune respon

226 These results advance our understanding of how the immune system limits NiV dissem

227 the first time a quantitative basis for our understanding of how the large population of definitive

228 agate actions in the cell, but an integrated understanding of how the lipid bilayer exerts its effect

229 gest volcanic systems, resulting in a better understanding of how the melt structure controls volcani

230 nition on perception would revolutionize our understanding of how the mind is organized; but without

231 However, a mechanistic understanding of how the mitochondrial Ca(2+) signaling

232 A better understanding of how the mobilization process is regulat

233 ffects on sleep/wake behavior, improving our understanding of how the PPT nucleus regulates cortical

234 ral research in monkeys has offered a better understanding of how the primate brain processes this ty

235 The research completes our understanding of how the repertoire of tetrapyrrole-base

236 These findings contribute to our understanding of how the SC processes visual inputs, a c

237 However, a quantitative and mechanistic understanding of how the signal is processed by the reci

238 Our work advances understanding of how the TRF2(TRFH) domain orchestrates

239 x-trait association studies, and an in-depth understanding of how their genetic variation has been sh

240 across different temperatures would advance understanding of how thermally activated processes contr

241 ated to PAH pathogenesis but without a clear understanding of how these abnormalities are initiated,

242 an be immunomodulatory, but there is limited understanding of how these contribute to inter-individua

243 A better understanding of how these enzymes interact with their s

244 , and our study provides further mechanistic understanding of how these enzymes maintain genome integ

245 ul algal blooms (CHABs), yet we have limited understanding of how these events affect freshwater bact

246 yed in physical therapy that can improve our understanding of how these factors change under patholog

247 ith, and provide validation for, the current understanding of how these factors influence ENM transpo

248 r interpretations of forest dynamics and our understanding of how these forests are responding to glo

249 During this time, our understanding of how these kinases regulate DNA repair a

250 We still lack an understanding of how these microbial communities are str

251 e of forest regeneration, yet we have a poor understanding of how these N fixers influence the trees

252 Recent studies in mice have advanced our understanding of how these neurons are specified, migrat

253 lar electron transfer proteins are known, an understanding of how these proteins bind to their metal

254 However, we currently lack a generalizable understanding of how these soil communities will change

255 Our understanding of how these spatial regulators are deploy

256 ts with malignant gliomas; however, a better understanding of how these tumors escape immune surveill

257 in that drive viral assembly, we further our understanding of how these viruses assemble and egress f

258 Our limited understanding of how these viruses interact with their h

259 American population, we still have a limited understanding of how they affect pregnancy and fetal dev

260 normal laboratory growth conditions, and our understanding of how they are silenced is in its infancy

261 s that have been overlooked due to a lack of understanding of how they function.

262 n diverse actin-based processes [1], but our understanding of how they mechanistically contribute to

263 tity of these genetic factors, improving our understanding of how they shape retinal function.

264 To gain understanding of how this binding process is modulated,

265 ists in plankton communities, we have little understanding of how this biodiversity influences the bi

266 recent advances that have contributed to our understanding of how this complex molecule is transporte

267 effective prevention strategies requires an understanding of how this condition develops and progres

268 e key to DNA virus adaptation, improving our understanding of how this group of pathogens evolves.

269 and suggest the next steps towards a better understanding of how this important group of disease vec

270 An increased understanding of how this is achieved is critical for id

271 We do not yet have a clear understanding of how this metabolic activity changes dur

272 protein acetylation dynamics is critical for understanding of how this modification influences protei

273 Although the current understanding of how this overlooked element improves pl

274 ing tissue homeostasis, yet there is limited understanding of how this process is regulated.

275 An understanding of how threonine phosphorylation regulates

276 Our findings lead to a better understanding of how TLR-ligand based adjuvants can alte

277 he nanoscale is a rich and dynamic area, our understanding of how to control and harness it and dial-

278 (RFS) strategy is still low due to a limited understanding of how to determine the best mutation cand

279 To develop an understanding of how to interpret these signals and the

280 esistance that would be helpful for a better understanding of how to manage antibiotic-resistant bact

281 the data are that individuals vary in their understanding of how to maximize income, with misunderst

282 These findings advance our theoretical understanding of how to predict and enhance the wisdom o

283 re finding success; however, there is little understanding of how to translate monomer sequence to ph

284 A better understanding of how to uncouple anti-tumor activity fro

285 As a first step toward a molecular understanding of how Toc159 mediates preprotein import,

286 A complete understanding of how topographical properties affect cel

287 al components may be able to inform a deeper understanding of how traits evolve.

288 Nevertheless, we have a very incomplete understanding of how tropical arthropod communities are

289 However, our understanding of how tropical cyclones currently affect

290 h levels of species diversity hamper current understanding of how tropical forests may respond to env

291 D chromosome structure and function, but our understanding of how various factors contribute to the s

292 demiology, and genetics have led to a deeper understanding of how vascular disease affects cognition.

293 However, we presently lack a systematic understanding of how vegetation responds to asymmetric s

294 irus responses and enhancing our fundamental understanding of how viral manipulation of direct presen

295 terest and may well fundamentally change our understanding of how viral replication is regulated.

296 rporation.IMPORTANCE Our findings expand our understanding of how viruses utilize capping, suggesting

297 of additional experimentation to enrich our understanding of how vision works on a broad scale.

298 These results provide new understanding of how widely used immunosuppressive drugs

299 This more detailed understanding of how xylem and leaf hydraulic traits var

300 Our study provides an understanding of how ZIKV initiates transmission in new