ライフサイエンスコーパス: undescribed

1 climatic drivers behind these changes remain undescribed.

2 y including 6 compounds that were previously undescribed.

3 ar and molecular characteristics are largely undescribed.

4 Most are undescribed.

5 Among these, 36 epitopes were previously undescribed.

6 ible for this muscle function impairment are undescribed.

7 re of cold-water populations remains largely undescribed.

8 new source of PCB contamination, previously undescribed.

9 principles for these findings remain largely undescribed.

10 ctures of such trinaphthylenes were hitherto undescribed.

11 n Clostridium difficile ST6 and a previously undescribed 310kb chromosomal replacement in Staphylococ

12 Previously undescribed [4.4.0] and [5.3.0] fused-ring-containing pr

13 ymphocyte physiology, unveiling a previously undescribed activity of this cytokine on the maturation

14 This identifies a previously undescribed acute radiation response in yeast meiosis, w

15 We sought to investigate the presence of undescribed allergens in ragweed pollen.

16 unique mechanism by binding to a previously undescribed allosteric site: the interface of the two cA

17 bosomal frameshifting to generate previously undescribed alternative reading frame (ARF) proteins in

18 henotypes but also for those with previously undescribed and atypical disease presentations.

19 le-strand break (DSB) initiates a previously undescribed and selective pathway of autophagy that we t

20 We report several previously undescribed and unexpected transcriptional responses wit

21 clonal plasma cells represents a previously undescribed and unique mechanism that highlights the con

22 tentional modulation, two of them previously undescribed, and implicates scaling of the responses of

23 interbacterial antagonism confers previously undescribed antibacterial capacity to eukaryotes.

24 Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further

25 Here, we localize 11 previously undescribed apical proteins in T. gondii and identify an

26 Using a previously undescribed approach involving single guide RNA, we succ

27 In addition to identifying a previously undescribed ARRP gene, our study highlights the importan

28 This study identifies a previously undescribed aspect of picornavirus replication complex s

29 action for MSL-109 and reveals a previously undescribed aspect of viral entry that may be susceptibl

30 individual, possibly indicating a previously undescribed association with UM pathogenesis.

31 ncer, and consistently identified previously undescribed associations between radiomic imaging featur

32 Our analyses identified 11 previously undescribed associations in independent loci containing

33 These results demonstrate previously undescribed astrocyte-mediated mechanisms in the pathoge

34 'super-complex' (2:2:4), using a previously undescribed binding motif in the Unc5D TSP1 domain.

35 Here, we identified a previously undescribed biosynthetic route during human platelet-neu

36 We precisely define a previously undescribed block during late terminal differentiation a

37 The potential realization of hitherto undescribed bonding outcomes makes these macrocycles pro

38 rentiation antigens; CD20 and the previously undescribed cancer target myeloperoxidase.

39 These data define a previously undescribed causative role for 3-HAA, which is a product

40 t mutation therefore represents a previously undescribed class of cancer-related GTPase activity.

41 ve identified and characterized a previously undescribed class of poorly differentiated PanNETs in th

42 We identify a previously undescribed class of S-adenosylmethionine-dependent meth

43 ers of the FA pathway represent a previously undescribed class of selective autophagy genes that func

44 A broad spectrum of previously undescribed clinical and angiographic findings were asso

45 to genes, especially for rare or previously undescribed clinical entities.

46 endent samples, we identified two previously undescribed coding variants associated with lower platel

47 tified thousands of CREs, inferred known and undescribed complexes recruited to these CREs, and deter

48 he structure shows PLB bound to a previously undescribed conformation of SERCA in which the Ca(2+) bi

49 Together, these findings identify previously undescribed conserved chemical signals and pathways in p

50 A brother and sister developed a previously undescribed constellation of autoimmune manifestations w

51 pathways in lower eukaryotes, the previously undescribed crystal structure of a metacaspase, an inact

52 nsferases, FamD1 and FamD2, and a previously undescribed cyclase, FamC1.

53 We demonstrate a previously undescribed deficit in c-Kit(+) type 2 innate lymphoid c

54 related species and strains from previously undescribed Deltaproteobacteria and Aminicenantes (candi

55 All seven have previously undescribed desaturase activity on very-long-chain fatty

56 mic forebrain targets, and that a previously undescribed descending GABAergic pathway emanates from t

57 We identify a previously undescribed developmental role for the brain and reveal

58 Here, we demonstrate a previously undescribed digestive strategy in the wood-eating marine

59 insects and none attempt to address unknown, undescribed diversity.

60 ure provides a variety of stable, previously undescribed DNA topologies for future use in nanotechnol

61 uncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder.

62 Our results reveal a previously undescribed double-negative feedback loop between sponge

63 Together, our results establish a previously undescribed drug/drug target combination in glaucoma, id

64 we report the identification of a previously undescribed E3 ligase function of BRMS1 on the histone a

65 hat this VHH traps the virus in a previously undescribed early intermediate state.

66 24 due to the presence of an unpredicted and undescribed effector binding site not present in the all

67 tions, which allowed the inference of as yet undescribed effector functions.

68 affinity uptake transporters; and (v) as yet undescribed energy-efficient steps in CO(2) fixation and

69 We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infect

70 about the kinetic isotope effects of as yet undescribed enzymes, thus to make predictions as to thei

71 ler groups of antibodies bound to previously undescribed epitopes in domain II of the E protein.

72 Responses against the dominant undescribed epitopes were associated with the memory T-c

73 We demonstrate that LOX is a previously undescribed EWS/FLI-repressed target that inhibits the t

74 ion of mTOR signalling (including previously undescribed EWSR1 gene fusions), and telomere maintenanc

75 000 described and possibly up to one million undescribed extant species [1, 2].

76 disordered state and the other to previously undescribed "extended" conformations, marked by the open

77 nal analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

78 the DUF579 proteins constitute a previously undescribed family of cation-dependent, polysaccharide-s

79 the developing brain and identify previously undescribed features of Akt phosphorylation and activati

80 Some patients showed previously undescribed features such as fluorescein-negative intrar

81 096 AA individuals identified two previously undescribed FI loci, chrX FAM133A (rs213676) and chr5 PE

82 rystal structure of NRD reveals a previously undescribed fold, consisting of helix-loop-helix repeats

83 idence for an alternative pathway previously undescribed for orthomyxoviruses, whereby the spread of

84 detected at a multitude of sites previously undescribed for RNase E, including ones that regulate th

85 , acts as a thiolase, an activity previously undescribed for this family of enzymes.

86 nt tissues and thereby serve as a previously undescribed form of adipokine.

87 , we identified an unexpected and heretofore undescribed frequent occurrence of myeloid neoplasms amo

88 actor to its DNA target site is a previously undescribed function for a trans-acting noncoding RNA.

89 Here we show a previously undescribed function for NQO1 in stabilizing HIF-1alpha,

90 mbers of this cluster, identify a previously undescribed function for the miR-17 seed family in contr

91 lectively, our data demonstrate a previously undescribed function of HEV ORF3 as a viroporin, which m

92 DR, including the regulation of a previously undescribed function of KAP-1 in checkpoint response.

93 WRN-DNA2-mediated resection and identify an undescribed function of WRN as a DSB repair pathway swit

94 ily of P2X receptors could have a previously undescribed functional role of trafficking partner prote

95 We elucidate previously undescribed functions for giant AnkG, including recruitm

96 Using classic (Wt1(Cre)) and previously undescribed (G2-Gata4(Cre)) transgenic mouse models for

97 lose synthase operons and several previously undescribed genes associated with cellulose production.

98 ry, our study contributes several previously undescribed genes involved in melanoma and establishes a

99 e virus represents a distinct and previously undescribed genetic lineage of Orthopoxvirus, which is m

100 aken together, our studies reveal previously undescribed glial roles in pioneer-axon guidance, sugges

101 ing the innervation, we found two previously undescribed head muscles (the processo-articularis and d

102 Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited to the site of i

103 luding catalytic degradation to a previously undescribed heme derivative.

104 Genetic analysis revealed a separate, undescribed heterozygous mutation (c.265G>A; p.A89T) in

105 exome sequencing, we identified a previously undescribed heterozygous mutation, n.37 C > T, in the se

106 f the index case, we identified a previously undescribed homozygous missense mutation within the ubiq

107 ew disease mechanism and produced previously undescribed human ZAP-70-associated autoimmune disease.

108 niqueness claim with a study of a previously undescribed human-like beckoning gesture in bonobos that

109 between CD40L and CD40, and exert a hitherto undescribed immunoregulatory action by enhancing IL-10 p

110 ed with immunotherapy to discover previously undescribed immunotherapy targets.

111 l activation of defence responses previously undescribed in eukaryotes.

112 o mirtron genes, genetic features previously undescribed in non-mammalian vertebrates.

113 , a dual neurotransmitter phenotype hitherto undescribed in the brain of any vertebrate.

114 coupled heme containing adenylate cyclase is undescribed in the literature.

115 A new, previously undescribed-in-grapes stilbene was found after UVC treat

116 Our study identifies a previously undescribed inhibitory methylation event on ERalpha.

117 elease is blocked and implicate a previously undescribed interaction between Rrp5 and the DEAD-box pr

118 MHC II molecules, illustrating a previously undescribed interaction with CD4(+) T cells and indicati

119 oupled receptor, traffics along a previously undescribed intracellular itinerary via the Golgi comple

120 This work reveals a previously undescribed invasive mechanism whereby the secretion of

121 Here we examine the previously undescribed iron(III)-coordinating and cellular iron-mob

122 The data identify a previously undescribed, isoform-specific anticoagulant function for

123 We report many previously undescribed isoforms (human brain: approximately 13,800

124 finished genome sequence for the previously undescribed isolate SGH-10-168.

125 We also experimentally identify a previously undescribed isotropic pretransition zone where bacteria

126 n the levels of active Fur adds a previously undescribed layer of regulation in maintaining cellular

127 These results demonstrate a previously undescribed lethal side effect of repetitive doses of an

128 o Irish Traveller families with a previously undescribed lethal skeletal dysplasia characterized by f

129 e prone to become bone cells is a previously undescribed ligament.

130 le amphipathic helix present in a previously undescribed location in Atg20 within the putative BAR do

131 nce in AA individuals, and sought previously undescribed loci through trans-ethnic (AA+EA) meta-analy

132 rt that exon gamma in p16 is also part of an undescribed long noncoding RNA (lncRNA) that we have ter

133 he biosphere and geosphere, and a previously undescribed macroevolutionary driver - earth system succ

134 Here we report on previously undescribed material from this ancient snake, including

135 monstrated bioengineered route to previously undescribed materials introduces in vitro enzyme selecti

136 introduce fibre recruitment as a previously undescribed mechanism by which cells probe and respond t

137 Our findings thus provide a previously undescribed mechanism for cell-type-specific transcripti

138 Sterivex cartridges and a previously undescribed mechanism for eluting biomass was used to co

139 These findings illustrate a previously undescribed mechanism for interrupting faithful mitotic

140 We also report an as-yet-undescribed mechanism for lipase transport in eukaryotic

141 Our results show a previously undescribed mechanism for modulating spatial variation i

142 ion of the upstream transcript, a previously undescribed mechanism for rapid transcript induction.

143 Thus, we propose a previously undescribed mechanism for the development of cancer cach

144 Our results identify a previously undescribed mechanism involving miR-124 and AMPARs in re

145 Overall these results reveal a hitherto undescribed mechanism linking macrophage infiltration to

146 Our findings highlight a previously undescribed mechanism of action for neuroligins and link

147 dependent manner, demonstrating a previously undescribed mechanism of action for PRL-3.

148 This previously undescribed mechanism of carbon chain-length determinati

149 Our results imply yet undescribed mechanism of how CCDs dampen the immune resp

150 This previously undescribed mechanism of immune suppression during chron

151 p of marine arthropods [3], use a previously undescribed mechanism of internal O2 transport: flows of

152 SP90beta's functions by revealing a hitherto undescribed mechanism of MMP3 regulation.

153 f the acetyltransferase GCN5 in a previously undescribed mechanism of RA signaling in the developing

154 romoter 5' to bvgAS, suggesting a previously undescribed mechanism of transcriptional interference th

155 cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression.

156 e aberrant M-GE signal operates a previously undescribed mechanism that reduces the expression of a m

157 l antibiotic employs a unique and previously undescribed mechanism to inhibit LeuRS.

158 reported (di-)polar, axial, and a previously undescribed mechanism we named unipolar.

159 -erb ligand SR6452 functions by a previously undescribed mechanism, targeting both nuclear activity a

160 virion assembly is regulated by a previously undescribed mechanism.

161 compounds with both previously reported and undescribed mechanisms of action, including a series of

162 y cells and reside in LN based on previously undescribed mechanisms of entry.

163 This previously undescribed metabolic heterogeneity of NSCLC subtypes im

164 onverts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI ki

165 d with dysfunctional P2Y12R and a previously undescribed missense mutation in the encoding gene.

166 We find a previously undescribed modification to the core AdoMet radical fold

167 omatin fiber folding changes, and previously undescribed modifications within the histone fold domain

168 rotocol, we identify and annotate previously undescribed molecular interactions between capsid subuni

169 selectivity emerge in part from a previously undescribed motion-selective retinogeniculate pathway.

170 tumor types, we identified >1,000 previously undescribed MS indels in cancer genes.

171 functional characterization of multiple, yet undescribed, MTases, but also revealed novel features of

172 e formation may proceed through a previously undescribed multimembrane intermediate composed of vesic

173 Moreover, the model predicted new previously undescribed mutations as potentially responsible of drug

174 Known and previously undescribed mutations in BTK and PLCG2, or uncommonly, o

175 Of 38 residues mutated, 11 were previously undescribed mutations that altered chi recognition.

176 apping of known mutations and two previously undescribed mutations that perturb cellulose synthesis i

177 f five fungal plant pathogens, 66 previously undescribed mycoviruses were identified.

178 e genome segments representing 66 previously undescribed mycoviruses.

179 n together, these data identify a heretofore undescribed myocardin/BMP10 signaling pathway that regul

180 These results shed light on hitherto undescribed non-proteolytic activities of Mmp14 that are

181 ly known syntenic UCEs as well as previously undescribed nonsyntenic elements.

182 neurons and its disruption causes previously undescribed novel neuropathology accompanying abnormal u

183 nformation, we have annotated 291 previously undescribed or only partially annotated transcript isofo

184 However, ProPublica's use of a previously undescribed outcome measure (composite of in-hospital mo

185 absence of centrioles activates a previously undescribed p53-dependent cell death pathway in the rapi

186 Ibov5, and found that it uses two different, undescribed packaging strategies.

187 nscriptomic evidence, including a previously undescribed paired box 8 (PAX8)-nuclear factor, erythroi

188 We discover four previously undescribed paired neurons, the primary protocerebral an

189 ectively, these results uncover a previously undescribed pathway by which CD8alpha+ DCs emerge indepe

190 These results suggest a previously undescribed pathway for HTG and illustrate the power of

191 osure cases showed a distinct and previously undescribed pattern of interface astroglial scarring at

192 Here, we present a previously undescribed PCR-based assay for RNR activity measurement

193 small interfering RNA revealed a previously undescribed peptide-selective Ag-presentation pathway by

194 tive B cells, and they identify a previously undescribed peripheral B-cell tolerance mechanism agains

195 the literature of hGLUTs, and two previously undescribed Phe amide-derived inhibitors.

196 Two previously undescribed phenomena were observed in this category: (1

197 ton structuring applications, we observed an undescribed phenomenon in photochemistry that dictates r

198 s mediated by Cdc7 kinase through previously undescribed phosphorylations on GINS that induce an asso

199 Characterization of these previously undescribed photosensors using CD spectroscopy supports

200 ed acetylome, identifying over 70 previously undescribed physical interaction partners for the comple

201 We identified Lhx2 as a previously undescribed player during cardiac and pharyngeal muscle

202 the structural assignments of the previously undescribed polyketide analogues.

203 The potential of hitherto undescribed polyketides from P. malabarica as natural an

204 ta demonstrate the existence of a previously undescribed population of Ag-specific memory Tregs that

205 distances, which points out to a previously undescribed positional artifact.

206 data identified SUMOylation as a previously undescribed post-translational modification of STAT3 and

207 ity of the evolution of TTX resistance in an undescribed predator-prey relationship between TTX-beari

208 These previously undescribed prematurely cleaved and polyadenylated pre-m

209 C6On synthons as well as several previously undescribed products.

210 ograde tracing studies revealed a previously undescribed projection of the avian dorsal pallidum.

211 Network complexity, a previously undescribed property of the rhizosphere microbiome, appe

212 de V proteins (SCVPs), encoding a previously undescribed protein family.

213 We identify three previously undescribed protein layers of the pyrenoid: a plate-like

214 teria share a gene that encodes a previously undescribed protein, named herein BefA (beta Cell Expans

215 and neurodegenerative roles for a previously undescribed protein, TMEM184b.

216 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially incre

217 ollen transcriptome identified 93 previously undescribed proteins for further study, 64 of which were

218 e to peptides from several of the previously undescribed proteins, most of which were not targeted by

219 Recent work has linked a previously undescribed protist with mass-mortality events in the Un

220 ymnesin series as well as over 20 previously undescribed prymnesin-like molecular features.

221 analysis suggests that the first step of an undescribed pterin degradation pathway is catalyzed by A

222 differentiation; and "MK-MEP," a previously undescribed, rare population of cells that are bipotent

223 cture-based mutagenesis, reveal a previously undescribed receptor-receptor interaction between the Ep

224 mide synthesis pathway, lead to a previously undescribed recessive Mendelian disorder in the progress

225 ndings demonstrate that PLK2 is a previously undescribed regulator of alpha-synuclein turnover and th

226 We conclude that dynactin plays a previously undescribed regulatory role in the spindle assembly chec

227 erence (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequen

228 Together, these data identify a previously undescribed role for ABCs as potent APCs and suggest ano

229 Here we show a previously undescribed role for GAB2 in NRAS-driven melanoma.

230 Our studies demonstrate a previously undescribed role for HoxA10 in terminating emergency gra

231 tory virus infection represents a previously undescribed role for ISG15 and demonstrates the importan

232 ollectively, our data provide evidence of an undescribed role for kisspeptin in integrating sexual an

233 These results identify a previously undescribed role for Mtb's ICLs in antioxidant defense a

234 Herein, we report a previously undescribed role for the AhR signaling pathway as an ess

235 a in frog eggs, and it suggests a previously undescribed role for the Greatwall-PP2A:B55delta interac

236 (RBCs) may play an important but previously undescribed role in cardioprotection.

237 erproducing Populus, suggesting a previously undescribed role in SA-mediated redox regulation.

238 together, our data demonstrate a previously undescribed role of claudin-7 as a colon cancer suppress

239 nd ORRM3 on RNA editing reveals a previously undescribed role of RRM-containing proteins as mitochond

240 Herein, a previously undescribed role of saNOS in S. aureus aerobic physiolog

241 identified several proteins with previously undescribed roles in heterochromatin regulation.

242 Our results highlight previously undescribed roles of HIF1alpha and interactions among ma

243 A substrates could therefore help define the undescribed roles of the 19 DEAD-box proteins that funct

244 K(+)-ATPase structures revealed a previously undescribed rotamer transition of the hydroxymethyl side

245 Our study reveals a previously undescribed route for the biogenesis of hydropolysulfide

246 ry vehicle in the brain suggested previously undescribed routes for cisplatin-based therapy.

247 oblastoma multiforme and suggests previously undescribed routes for drug and gene delivery to treat o

248 ur analyses revealed a high degree of so far undescribed sequences, suggesting a high number of unkno

249 Thus, we have characterized previously undescribed sex differences in behavioral responses to e

250 Here, we report a previously undescribed SIM setup that is fast enough to record 3D t

251 and Chip-Seq analyses identified previously undescribed Sin3a targets including genes involved in ce

252 ylation and depalmitoylation of a previously undescribed site of modification, Cys-265 within the thi

253 These results identify previously undescribed sites at which glutamatergic and GABAergic i

254 holinergic system suggest the presence of an undescribed sleep state in the hippopotamus, as well as

255 V in Africa are at high risk of a previously undescribed small airway disease, with >40% of unselecte

256 ly lacked pigment and exhibited a previously undescribed small colony variant-like phenotype.

257 lates were associated with novel, previously undescribed SNP lineages that were unique to each countr

258 fore rodent enterocytes contain a previously undescribed soluble cytosolic FOX that may function in t

259 matodes, while also implicating a previously undescribed source of chemical signaling.

260 (AhpD)/AhpC, using alpha-KG as a previously undescribed source of electrons for reductase action.

261 -binding bispecificity suggests a previously undescribed source of modularity and flexibility in gene

262 Most of the described and probably undescribed species on Earth are insects.

263 gion V sequencing and represent a previously undescribed species within the M. terrae complex.

264 nd color forms that were analyzed (including undescribed species), 336 exhibit some morphological sim

265 polymorphic color forms and an additional 33 undescribed species.

266 families (nine individuals) with previously undescribed splice site and missense mutations in CTLA4.

267 Here, we present previously undescribed stable isotope determinations of charred cer

268 These previously undescribed structures, termed endocardial flowers, have

269 ncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and arunci

270 These findings add a severe, previously undescribed syndrome featuring erythrokeratodermia and c

271 positions in two children with a previously undescribed syndrome featuring primary aldosteronism and

272 We report and model a previously undescribed systematic error causing spurious excess cor

273 groups independently identified a previously undescribed T cell cosignaling molecule; one referred to

274 t a noncanonical site, exposing a previously undescribed tethered ligand that triggers biased G-prote

275 ted MHC binding peptides from the previoulsy undescribed TG proteins were screened for T-cell reactiv

276 ; and suggest that p110delta is a previously undescribed therapeutic target for the treatment of psyc

277 N5 whose modification regulates a previously undescribed, tissue-specific mechanism of RA signaling t

278 show that these genes belong to a previously undescribed Toll subfamily and that members of this subf

279 eam of the CD28 Vav motif induced previously undescribed transcriptional regulation of B lymphocyte-i

280 o the inner chloroplast envelope membrane by undescribed translocases.

281 In addition, previously undescribed transmission clusters were discovered.

282 hain assembly complex serves as a previously undescribed tumor suppressor in the liver, restraining T

283 in the motor path ECM depend on a previously undescribed two-step mechanism involving Hedgehog/Gli an

284 We have identified a previously undescribed type of flavin enzyme that is exclusive to o

285 Here, we identify a yet undescribed UGT2B17 mRNA overexpression in poor-risk chr

286 the outbreak strains belong to a previously undescribed variant, designated NAPCR1.

287 In addition, two previously undescribed variants (at positions 2083 and 2345 of the

288 as, 37 orangutans and 2 gibbons and observed undescribed variation in great apes.

289 This discovery represents a hitherto undescribed vertebrate pathway that links luminance dete

290 This study identifies a previously undescribed viral mechanism for attenuating the host ada

291 ein expression and report several previously undescribed viral RNAs, including bicistronic transcript

292 olecular mechanisms involved in a previously undescribed virulence regulatory pathway of an important

293 ntified a 10.5-kb sequence from a previously undescribed virus of the Flaviviridae family, which we d

294 lows enrichment and sequencing of previously undescribed viruses as well as known viruses.

295 disease symptoms, contained three previously undescribed viruses belonging to the Partititiviridae (A

296 ause the patterning of the central tendon is undescribed, we analyzed the expression of genes regulat

297 ahaliotrema mizellei and Metahaliotrema sp. (undescribed) were used to develop an automated technique

298 c profiling of glioma, offering a previously undescribed window into their metabolic heterogeneity, a

299 DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations.

300 di-(3-methylbut-2-enyl)xanthone a previously undescribed xanthone and three triterpenes: ambonic acid