ライフサイエンスコーパス: undesired

1 notrophic methanogenesis, an outcome that is undesired.

2 5-membered C-ring in a model system, but an undesired 6-membered C-ring in the actual system.

3 lts from cytokine receptor pleiotropy and/or undesired activation of off-target cells.

4 cate the use of Hsp90 inhibitors in blocking undesired activation of TGFbeta signaling in diseases.

5 he role of negative selection in eliminating undesired activities and achieving high specificity rema

6 ly, both CD4-17b CARs were devoid of a major undesired activity observed with the CD4 CAR, namely, re

7 e full advantage of carbon by mitigating the undesired activity.

8 Undesired adsorption of DNA to the surrounding non-targe

9 surface-based biosensors, the nonspecific or undesired adsorption of the probe is an important charac

10 spectrometry, by eliminating surfaces where undesired adsorption/desorption processes can occur.

11 the dimerization tendency, which could cause undesired aggregation of target proteins; and (iv) the s

12 ions and within certain distances that allow undesired amplification.

13 ing and restoring homeostasis, can result in undesired and occasionally lethal physiological response

14 ctor to another, assuming that the former is undesired and the latter is desired.

15 erone has several desired effects as well as undesired and unknown effects.

16 ini interaction is a biomarker assay for the undesired androgenic responses in vivo.

17 of the CNS to contribute to the desired and undesired anesthesia end points.

18 e needed for antigen-specific suppression of undesired antibody responses, particularly to T cell-dep

19 ange) that occurs under quench conditions is undesired as it leads to loss of information.

20 iazines tested altered cell morphology, this undesired aspect was further investigated by exploring p

21 The induction of undesired autoimmune responses should be considered when

22 ups during the second cyclization favored an undesired azabicyclo[3.2.1]octane ring system, an outcom

23 for the ligation reactions, suppressing the undesired azide reduction that was competing.

24 TiO2 (a-TiO2) on W:BiVO4/F:SnO2 blocks this undesired back reduction and dramatically improves the p

25 LDI with HDX has been challenging because of undesired back-exchange reactions during analysis.

26 ation (HePI-MS) source avoids, or minimizes, undesired back-exchange reactions usually encountered du

27 generally applicable to reduce or eliminate undesired background expression of transgenes.

28 rally results in significant accumulation of undesired background mutations.

29 process but also slows down the rate of the undesired background reaction.

30 elimination step relative to the rate of the undesired beta-hydride elimination.

31 carbene (NHC) ligand is effective to inhibit undesired beta-hydrogen elimination.

32 ized to favor the tricyclic product over the undesired bicyclic product resulting from diene metathes

33 hampered by severe side effects due to their undesired binding to healthy cells.

34 a disinfectant/cleaner generator that limits undesired biofilm formation and as a washing agent in wa

35 he K-index increase and the formation of the undesired biogenic amines.

36 Drugs typically exert their desired and undesired biological effects by virtue of binding intera

37 indings will be useful either for preventing undesired bubble formation or, on the contrary, for "wri

38 selectivity but also avoids formation of the undesired but thermodynamically favored epimer.

39 were modulated to minimize the formation of undesired by-products.

40 l features, affecting the production of this undesired byproduct, as well as weak interactions respon

41 ic processes that minimize the production of undesired byproducts and operate with high energy effici

42 or MEQ and specificity with respect to other undesired bZIP-type interactions was used to generate a

43 Embedding in resin causes undesired C impurities.

44 ganic molecule can lead to the activation of undesired C-H bonds by a non-selective catalyst.

45 Ultimately, undesired C-N cyclization thwarted the final projected C

46 To avoid undesired cell death, this apoptotic pathway is tightly

47 s limitations by avoiding contributions from undesired cell types.

48 et-specific, and general method for removing undesired cells before transplantation.

49 ly)ethylene glycol diacrylate to encapsulate undesired cells in a hydrogel, allowing for retrieval of

50 In catalytic copolymerization, undesired chain transfer after incorporation of a polar

51 3(CF3)2 to the propagating catalyst prevents undesired chain-termination and -transfer processes.

52 tuning of the degradation profile results in undesired changes in other properties.

53 eptavidin, for ultra-stable labeling without undesired clustering.

54 of the transporter led to severe toxicity or undesired CNS pharmacodynamic effects.

55 of protein variants inside cells, minimizing undesired coevolution and propagation of nonfunctional l

56 clease targets on homologous chromosomes, an undesired collateral effect that has not been described

57 Both syntheses involved formation of undesired compounds E-4a-h that formed simultaneously wi

58 ing and yet continue to engage in, even when undesired consequences emerge.

59 may have counterintuitive, albeit temporary, undesired consequences.

60 This labeling scheme largely eliminates undesired contributions to (13)C relaxation and greatly

61 particularly impactful, due to limiting the undesired coordination of 1-azadiene to the Lewis acid a

62 primers to amplify desired targets and avoid undesired cross reactions can be a combinatorial challen

63 produce a desired phenotypic outcome without undesired cross talk between c-di-GMP-dependent systems.

64 -care (POC) biosensor devices are limited by undesired cross-detection of other non-analyte proteins

65 ll activity but carries the risk of creating undesired cross-reactivity leading to potential serious

66 o a few of the congeners with high degree of undesired cross-reactivity.

67 tween some systems raises the possibility of undesired cross-talk between a histidine kinase and a no

68 erize two separate molecular systems without undesired crosstalk.

69 mediate specific interactions while avoiding undesired crosstalk.

70 crystals, excluding the possible presence of undesired CuO or Cu phases.

71 MeCN/water can improve yields and reduce the undesired dealkylation side reaction.

72 for this reaction due to the possibility of undesired decarboxylative pathways and the susceptibilit

73 Undesired decomposition of H(2)O(2) is not a limiting fa

74 agnitude, but this gain is accompanied by an undesired decrease in selectivity.

75 macromolecules of this type-either to avoid undesired degradation, or to ensure rupture at predeterm

76 ver, the mechanism and factors affecting the undesired dehalogenation side reaction were revealed.

77 Under these conditions, formation of undesired dense polymer layers attached to the capillary

78 ts when they pass the grating walls, and the undesired dephasing may prevent interferometry with mass

79 desired detection by intended receivers and undesired detection from eavesdropping predators, prey,

80 The undesired diastereomer could be recycled to the desired

81 ting in high levels of substrate-controlled (undesired) diastereoselectivity.

82 ure, thereby minimizing the production of an undesired dichlorinated byproduct.

83 the overuse of these antibiotics to prevent undesired disease in the endemic area.

84 disorders, and graft rejection by depleting undesired disease-causing T cells while keeping the over

85 if desired but may also present a problem if undesired dissociation occurs in the course of an experi

86 optimizing the preparation processes wherein undesired doping is minimized could prompt the use of or

87 toxicity presumably due to the generation of undesired double-stranded breaks at off-target sites.

88 Thereby new insights into undesired drug effects are gained.

89 drugs and drug leads to it, possibly causing undesired drug-drug interactions.

90 This undesired effect even becomes non-measurable if the hydr

91 esistance and point toward an unintended and undesired effect of chemotherapy.

92 of TPB extract/kg of TTB did not exhibit any undesired effect on lactic bacteria which are necessary

93 of anesthetic agents to maximize the desired/undesired effect ratio.

94 The mechanism for the latter undesired effect remains unclear.

95 To prevent this undesired effect, inhibitors that selectively favor or d

96 ievement of these goals comes with potential undesired effects and risks including acne, alopecia, re

97 are micropollutants, compounds that produce undesired effects at low concentrations-as with the enzy

98 Drugs exert desired and undesired effects based on their binding interactions wi

99 ernative approach would be to screen against undesired effects early in the process, but the number o

100 s with potent antidiabetic effects but fewer undesired effects is an active field of research.

101 gh anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) a

102 t efficacy after systemic administration and undesired effects preclude their use in routine pain the

103 tivity of a dual AI/SERM could attenuate the undesired effects stemming from global estrogen depletio

104 y common to attenuate basicity to circumvent undesired effects such as lack of biological selectivity

105 programming with the potential for extensive undesired effects.

106 ting protocols may potentially mitigate such undesired effects.

107 ntial for metabolic disease but also exhibit undesired effects.

108 Undesired electrode-electrolyte interactions prevent the

109 We have exploited a typically undesired elementary step in cross-coupling reactions, b

110 ro group on the piperidinone ring, while the undesired enamine intermediate is consumed to <0.5% by u

111 x because of side effects resulting from the undesired enantiomer (distomer) and/or its metabolites,

112 f FR115427 and provides a way to recycle the undesired enantiomer in the synthesis of solifenacin.

113 to the pore rim prevents the passage of the undesired enantiomer while letting its mirror image thro

114 Unrestrained recombination causes undesired endpoints (translocation, deletion, inversion)

115 plet RP without significant competition from undesired energy transfer processes.

116 the key role of the electrolyte in limiting undesired energy-transfer reactions is highlighted by th

117 membranes can enhance the power density, but undesired entropy production due to uncontrolled mixing

118 as dimethylaminopyridine (DMAP), may induce undesired epimerization of the alpha-carbon atom in poly

119 icably, the product of this reaction was the undesired equatorial alcohol 34.

120 lear RNase III endonuclease Rnt1p to prevent undesired expression of non-functional a1 proteins.

121 sitivity and dyslipidemia but do not enhance undesired fat storage.

122 imilar to the original clone, but lacked the undesired Fc-effects, and inflammation was attenuated fu

123 Undesired Fc-mediated functions, such as platelet activa

124 With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited

125 a natural nucleotide, and can be hindered by undesired fluorescence characteristics such as self-quen

126 ng evaluation from peers previously rated as undesired for an interaction.

127 tofluorescent and 1.5% contained reactive or undesired functional groups.

128 crops, produce, and building materials from undesired fungal or bacterial growth.

129 at the DNA level to reduce the prevalence of undesired genes, minimize off-target effects and enable

130 etectable cytotoxicity and minimal levels of undesired genetic mutations in the treated yeast strains

131 We evaluated if there were undesired genomic effects of the PB transposon system to

132 owever, there has been limited evaluation of undesired genomic effects when using transposons for hum

133 tic modification of human cells with limited undesired genomic effects.

134 logy mediated by these MHC molecules without undesired global immunosuppression.

135 tionally instructed (1) desired goals or (2) undesired goals for upcoming finger reaches.

136 'Marine biofouling', the undesired growth of marine organisms such as microorgani

137 substantially devalued life in six of seven undesired health states but they were surprisingly toler

138 presence of grain boundaries in graphene is undesired, here we show that they have an ideal structur

139 vide a mechanism to prevent the formation of undesired heterodimers among the SLAM family homophilic

140 the absence of bases, consequently averting undesired homo-couplings.

141 problematic lithium-halogen exchange and/or undesired homocoupling that has kept organolithium cross

142 o engineer the nuclease interface to prevent undesired homodimerization.

143 rimentally, and could be a strategy to avoid undesired hydrolysis of the donor substrate.

144 We find that the undesired hydroxylation byproducts, typically obtained i

145 ne (I2 ) as I3 (-) , this approach precludes undesired I2 -mediated decomposition which can otherwise

146 n of the lymphatic endothelium in preventing undesired immune reactions in inflammatory conditions.

147 cell therapies to a selective suppression of undesired immune reactions, only the transfer of Ag-spec

148 an lead to adverse patient reactions such as undesired immune responses.

149 lexes effectively dampen immune responses to undesired immunodominant bridging sheet determinants.

150 study reactions and to track the presence of undesired impurities.

151 ions are limited due to the low selectivity, undesired inactivation of beneficial bacteria and damage

152 tives correlate with the minimization of the undesired induction period and offer insights for the de

153 cific dysfunctional aggregation and preclude undesired interactions between close paralogs therefore

154 nes are central in preventing aggregation or undesired interactions of flagellar proteins, including

155 step may be used to partially compensate for undesired interference.

156 he rate of propagation (kp) but also prevent undesired intra- and intermolecular chain-transfer proce

157 In this case, however, an undesired intramolecular rearrangement pathway to the co

158 e trapping is only slightly favored over the undesired isomerization pathway.

159 z transfer during the process prevents later undesired isomerizations in the adducts and keeps all he

160 The non-specific binding of undesired ligands to a target is the primary factor limi

161 enantioselectivity, as it likely discourages undesired ligation of benzoxazole substrates or intermed

162 ed circular form often are contaminated with undesired linear DNA fragments arising from shearing/deg

163 tion at nicks or gaps enables the removal of undesired linear DNA when nicked circular DNA has been e

164 on may be a viable strategy to attenuate the undesired liver uptake and pro-inflammatory responses to

165 ffect of inhibiting bacterial growth and the undesired, long-term effect of promoting the evolution o

166 or wear and tear, risking the exposure of an undesired material property.

167 ene expression in hybrid offspring following undesired mating events.

168 tightly regulated to prevent dehydration and undesired metabolic changes.

169 t channeling of intermediates and to prevent undesired metabolic cross-talk while maintaining metabol

170 hermore introduce a new constraint to filter undesired model behaviors induced by positive feedback l

171 quots of nanoRx formulations for desired and undesired molecular interactions.

172 surface area and readily adsorbs (sometimes undesired) molecular species.

173 t zero velocity correctly, which would avoid undesired motion in a prosthetic application.

174 nzero velocity prediction, which would cause undesired motion when applied to a prosthetic arm.

175 ing daily activities can potentially promote undesired movements of the endovascular sealing structur

176 ts M1 corticospinal activity associated with undesired movements when action plans change.

177 mtZFN, which limits off-target catalysis and undesired mtDNA copy number depletion.

178 rity <20 nucleotides in length, can decrease undesired mutagenesis at some off-target sites by 5,000-

179 he use of (Z)-nitroalkene substrates so that undesired nitroalkene isomerization is minimized and ena

180 This new approach reduced the undesired nonspecific adsorption of proteins and peptide

181 Potential undesired off-target effects should be considered with c

182 Potential for undesired off-target effects should be considered with t

183 f antibacterial agents targeting TMK without undesired off-target effects.

184 atches to the DNA target and thereby promote undesired off-target mutagenesis.

185 emical properties governing CNS exposure and undesired off-target pharmacology such as hERG interacti

186 cture and target concentration, and a set of undesired "off-target" complexes, each with vanishing ta

187 e of the constituent proteins to the risk of undesired oligomerization by reducing the concentration

188 the systemic circulation, where it may reach undesired organs.

189 ical thought processes that resulted in this undesired outcome and the transformation in our understa

190 ccount also documents how we adapted to this undesired outcome through an evaluation of several disti

191 ially pathological and could lead to various undesired outcomes such as DNA translocations, cellular

192 nhibition resulted in inflammation and other undesired outcomes.

193 terruptions in care that are associated with undesired outcomes.

194 y and can cause suboptimal graft function or undesired outcomes.

195 he entropic costs of assembly and precluding undesired oxidative degradation pathways.

196 role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation-beta-elimi

197 However, these additives may cause undesired parasitic reactions, such as the dissolution o

198 Furthermore, they show that this undesired pathway can be circumvented by changing from a

199 thout cellular membrane, gene regulation, or undesired pathway can circumvent some of the obstacles t

200 nergy between substrate and water suppresses undesired pathways but also that water promotes the desi

201 e new strategies that markedly suppress such undesired pathways to result in diverse aromatic compoun

202 ination, and dimer formation are competitive undesired pathways.

203 esis-stimulating agents (ESAs) may result in undesired patterns of hemoglobin variability.

204 ally amphiphilic structures that may lead to undesired peptide interactions with blood proteins and s

205 cal evidence of suppressing the formation of undesired peroxide intermediate through plasmonic effect

206 ependent nature to suppress the formation of undesired peroxide intermediate.

207 r and subjective choices, and often involves undesired perturbation to the animals and their environm

208 multitude of quantitative data with minimal undesired perturbations.

209 absence of pH-dependent .OH scavengers) such undesired phenomena can be almost completely eliminated.

210 by misexpression of the introduced gene and undesired phenotypes in transgenic lines.

211 Current methods to assess undesired photo-induced cell changes rely on qualitative

212 nt, we decrease the susceptibility of FMN to undesired photoinitiated electron-transfer reactions tha

213 to microarraying, it avoids the drawbacks of undesired physical contact with the sample; difficulty i

214 d pores at the discontinuity which result in undesired physical exclusion of large-species and (2) an

215 roxyacetophenones with minimal production of undesired polymeric degradates that are often observed u

216 Second, undesired polymerization and coke formation prevail, lea

217 minates the side isobutene isomerization and undesired polymerization/coke reactions, resulting in th

218 ected morphology by structurally eliminating undesired polymorphs.

219 yst poisoning or C-H functionalization at an undesired position, limits the application of C-H activa

220 t-related morbidity, and utilities for seven undesired post-treatment health states to estimate the q

221 s the stability of the particle and prevents undesired premature drug release until the shedding of t

222 ellent ratio of the desired secondary to the undesired primary coupling product make this method a po

223 y from stannylmethyl allyl ethers as a major undesired product in some Wittig-Still rearrangements ar

224 As a consequence, the pathway to the undesired product is strongly hindered, whereas that for

225 During chemical RNA synthesis, many undesired products may be formed.

226 d-enantiomer (racemization), degradation to undesired products or tautomerization to other isomers.

227 nditions can lead to the presence of several undesired products, including truncations, degradation p

228 polycrystalline thin films, which have some undesired properties such as large defective grain bound

229 cy of IgG and Fc fusion proteins could cause undesired properties.

230 To protect against undesired protein aggregation, living cells maintain a p

231 Further, undesired protein-protein interactions can occur in a de

232 nd indirectly neurogenesis by overcoming the undesired psychoactive effects of neuronal CB(1) cannabi

233 epimerization of the P-chiral center of the undesired (R,R)-diastereomeric phosphine oxide 19 throug

234 Pitting corrosion, known as an undesired reaction destroying Al and is enhanced by anio

235 re given, as well as the characterization of undesired reaction pathways available to the Nazarov cyc

236 As a result, the undesired reactions of bio-ethanol dehydration and aceto

237 pha to the phosphorus atom in order to avoid undesired reactions was demonstrated.

238 s in a planar form tend to produce a strong, undesired reflection of sunlight, high-index nanostructu

239 ne intermediate is responsible for producing undesired regioisomers.

240 mely, increased potency and avoidance of the undesired rendering of the genetically modified CD8 T ce

241 the absorbers do not necessarily constitute undesired resistive heating problem for photovoltaics.

242 n those absorbers can enable the exchange of undesired resistive losses with the useful optical absor

243 specific nucleotidases protect cells against undesired salvage of m(7)GMP and its incorporation into

244 When amide hydrolysis is an undesired secondary reaction, as can be the case in the

245 troleum-based fuels and biofuels, can create undesired secondary water-quality effects.

246 xcesses of one component to compete with the undesired self-aldehyde condensation reactions, we have

247 e, we considered both affinity for BZLF1 and undesired self-association, which can weaken the effecti

248 reversibility, thus allowing the excision of undesired sequences.

249 defects into the host lattice, resulting in undesired shielding of the intrinsic role of dimensional

250 often require gel electrophoresis to remove undesired side and/or degradation products.

251 esponses to pathogens, but may also have the undesired side effect of clonal expansion of T effector

252 ary for electroluminescence, or have been an undesired side effect, leading to high power requirement

253 beta-cell SSC that have to be considered as undesired side effects because the influence of these co

254 e plants, its ectopic expression can lead to undesired side effects depending on the context of the s

255 espond to other treatment modalities or have undesired side effects from topical steroids.

256 e been used in therapy despite a plethora of undesired side effects mainly attributed to the bacteria

257 itical tools for glycobiology, help to avoid undesired side effects of antivirals, and may reveal new

258 xone methiodide may be useful to prevent the undesired side effects of morphine.

259 to improve treatment effects and prevent the undesired side effects on normal cells.

260 such as acute myeloid leukemia and to avoid undesired side effects when used in standard treatments.

261 ors, acts covalently, and is associated with undesired side effects.

262 improved to increase efficacy and/or reduce undesired side effects.

263 isted technique proved to be faster, avoided undesired side products and gave better conversion, when

264 ansport to the catalyst, we demonstrate that undesired side products such as H2O2 and O2(-) arise fro

265 competitive adsorption, ethanol prevents the undesired side reaction of beta-citronellene isomerizati

266 e of carboxyl oxygens at low pH is a common, undesired side reaction.

267 rd large biomolecules, which will help avoid undesired side reactions of drugs and expand the reperto

268 new catalysts have been designed to suppress undesired side reactions often encountered when these am

269 Undesired side reactions, such as deamidation or peptide

270 y(1-vinyl-2-pyrrolidinone) added to suppress undesired side reactions.

271 in some cases the applied conditions lead to undesired side reactions.

272 ency caused by mass transfer limitations and undesired side reactions.

273 ials are needed, reducing the probability of undesired side-reactions.

274 Since the undesired signals for the interfering compounds are supp

275 selectivity, inasmuch as the nucleobase (an undesired site of reaction) is usually more nucleophilic

276 th its principal advantage and the source of undesired sneak-paths of current.

277 e cells but spontaneous dye loss resulted in undesired staining of cells.

278 l ester 17 provided spiro-lactone 18 with an undesired stereochemistry.

279 chosen to account for how they are 'used' by undesired structures and not just by the desired structu

280 The different undesired structures present in these maps were identifi

281 Here, we find that such undesired structures rapidly degrade yield with increasi

282 lexity reads; filtration of reads containing undesired subsequences (such as parts of adapters and PC

283 conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproduc

284 limited by imperfect selectivity (binding of undesired targets) and incomplete affinity (binding is r

285 N14003 (T140) that bind to CXCR4, but not to undesired targets.

286 torization, where current approaches have an undesired tendency to identify only a small number of th

287 ell carcinoma environment without unleashing undesired Th2 cytokines or IL10.

288 to cool the existing 2D crystals to prevent undesired thermal degradation and uncontrolled homogeneo

289 meliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario.

290 nately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes.

291 In addition, HS20 had no detectable undesired toxicity in mice.

292 s, the glycosylation reaction is hampered by undesired transfer of the anomeric sulfide group from th

293 mple cover measurements can be used to avert undesired transitions and initiate restoration.

294 unexpected paradigm in which a DUB prevents undesired ubiquitination to sharpen substrate specificit

295 Undesired upregulation of alanine aminotransferese (ALT)

296 Our results support a general principle of 'undesired usage'-concentrations of components should be

297 Undesired vibrational excitation is avoided because of v

298 ion is increasing, especially for those with undesired visual acuity in the absence of photic symptom

299 the dissatisfaction patients, 42% (5/11) had undesired visual acuity without symptoms of glare/optica

300 termine the actual contamination level of an undesired wild-type enzyme.