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1 rotein, it helps to maintain precursor cells undifferentiated.
2 ion factor, and contain MCs that are largely undifferentiated.
3 emains vigorous, pluripotent, and relatively undifferentiated.
4 ransition state (24h), compare with cells at undifferentiated (0h) and fully differentiated (48h) sta
5 nstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that resp
6 rom Nf1-mutant tumors, Rb1-mutant tumors are undifferentiated and aberrantly express homeobox gene cl
7 ms, whereas a rare subpopulation of cells is undifferentiated and associated with a neural stem cell
9 ratinocyte transcriptome, RNAs isolated from undifferentiated and differentiated cell populations of
10 tion under basal and regulated conditions in undifferentiated and differentiated cultures to show the
11 (+)/H(+) exchanger 3 activity was similar in undifferentiated and differentiated enteroids, and was a
15 ompare the labeling of sialoglycoproteins in undifferentiated and differentiated human erythroleukemi
16 y, its cellular distribution is different in undifferentiated and differentiated skeletal muscle cell
19 c subpopulation or phenotypically defined as undifferentiated and highly clonogenic ALDH(+)/CD49f(+)/
20 rs homozygous for Trp53(R172H) mutation were undifferentiated and highly metastatic, exhibited minima
23 pecies, which have, respectively, relatively undifferentiated and strongly differentiated adult caste
25 itrullinated protein Ab-positive arthralgia, undifferentiated arthritis (UA), early RA, and establish
26 lishment and maintenance of HPV infection in undifferentiated basal cells of the squamous epithelia r
27 res, and resulted in the manifestation of an undifferentiated basal/stem cell-associated phenotype in
32 ls (CSCs), a small and elusive population of undifferentiated cancer cells within tumors that drive t
34 = 1,998), small cell carcinoma (n = 1,524), undifferentiated carcinoma (n = 559), and other (n = 2,1
35 ous cystic pancreatic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant ce
36 inous cystic neoplasm with a component of an undifferentiated carcinoma with osteoclast-like giant ce
37 ical sarcomatoid profile were present in the undifferentiated carcinoma with osteoclast-like giant ce
38 he presence of pleomorphic giant cells in an undifferentiated carcinoma with osteoclast-like giant ce
39 , large interior cell patches expressing the undifferentiated cell marker LHX9, and a loss of differe
40 rphology observations supported retention of undifferentiated cell phenotype at 12 degrees C, transit
42 24 reduced both the levels of HPV genomes in undifferentiated cells and amplification upon differenti
43 is known about how chromosomes are packed in undifferentiated cells and how nuclear organization chan
44 y protein DNMT3L, which is only expressed in undifferentiated cells and recruits DNMT3A to initiate D
45 stem cells (MSCs).New vascular networks from undifferentiated cells are essential for repair/regenera
46 tured epidermal cell sheets (CES) containing undifferentiated cells are useful for treating skin burn
47 hematopoietic stem cells (HSCs) are the most undifferentiated cells at the top of the hematopoietic h
48 flow at low, nontoxic concentrations through undifferentiated cells by providing buffering storage fo
50 onsecutive generations of differentiated and undifferentiated cells during Th2 polarization in vitro.
51 t that EBV(+) cancers usually contain mostly undifferentiated cells may be due in part to these cells
53 molecular similarities between neoblasts and undifferentiated cells of other organisms raise the poss
54 ells either reacquire epigenetic features of undifferentiated cells or maintain an epigenetic signatu
55 FZD7 expression is significantly elevated in undifferentiated cells relative to differentiated cell p
58 cell niches, maintain a pool of multipotent, undifferentiated cells that divide and differentiate to
59 type specification relies on the capacity of undifferentiated cells to properly respond to specific d
61 from LL and TZ cultured in DMEM give rise to undifferentiated cells with high growth capacity, and he
62 egion devoted to a slow rate of growth among undifferentiated cells, and an anterior region in which
63 ion patterns, its promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK29
66 lity of transcriptionally inactive genes: In undifferentiated cells, PBX1 is bound to the H1-compacte
67 iomyogenesis, including the specification of undifferentiated cells, the establishment of heart patte
68 rated through the rearrangement of a pool of undifferentiated cells, there is nonetheless proliferati
70 ond class ('stable') were pre-established in undifferentiated cells, with enhancers constitutively ma
79 Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where
82 reveals that cells on the outer edge of the undifferentiated colony begin to differentiate first and
83 markers, suggesting these cells represent an undifferentiated component of the niche with vascular co
87 derm initially consists of a single layer of undifferentiated, cuboidal epithelial cells that stratif
88 ating ESCs (serum/LIF) with more homogeneous undifferentiated culture (2i/LIF), we examine the role o
90 stinal stem cells (ISCs) and their transient undifferentiated daughters, termed enteroblasts (EB).
91 development in various tissues consisting of undifferentiated dysplastic cells exhibiting global chan
93 tic studies to investigate the role of Utf1 (Undifferentiated embryonic cell transcription factor 1)
94 carbohydrate metabolism is most prominent in undifferentiated embryonic stem cells, whereas the fatty
100 pithelial cells expressed E-cadherin and the undifferentiated epithelial cell markers keratin 5 and 1
101 as (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymph
102 rstand how teeth and taste buds develop from undifferentiated epithelium or how variation in organ de
103 RNA-sequencing studies further revealed that undifferentiated ESCs hemizygous for Rps5 showed reduced
105 scrub typhus, the leading cause of treatable undifferentiated febrile illness in tropical Asia, cause
107 ls were measured in patients presenting with undifferentiated fever to hospitals in Colombo District,
108 ts in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic f
114 pothesized that excessive planar division of undifferentiated germ cells promotes their self-renewal
117 feration of malignant cells, larger pools of undifferentiated glioma cells, and an increase in macrop
121 both sexes (which represents a rare case of "undifferentiated" gonochoristic species that usually go
122 ile of glycoproteins detected varies between undifferentiated HEL cells and those differentiated to m
124 methyltransferase (DNMT)3b preferentially in undifferentiated hESCs as compared with CXCR4+ or islets
125 ch tumors were more aggressive and exhibited undifferentiated histology, increased vascularity, and h
127 osides showed strong binding reactivity with undifferentiated hPSCs and their glycoproteins, and did
128 rase ST6GAL1 was preferentially expressed in undifferentiated hPSCs compared to non-pluripotent cells
129 In addition, downregulation of ST6GAL1 in undifferentiated hPSCs led to a decrease in POU5F1 (also
130 n, we have compared the epigenetic status of undifferentiated human embryonic stem cells (hESCs), hES
134 ltrasound in the evaluation of patients with undifferentiated hypotension has been proposed in severa
135 fects, namely, germ cell loss (predominantly undifferentiated), induction of multinucleated gonocytes
137 Central to this process is the expansion of undifferentiated intermediates known as transit-amplifyi
139 To understand these lineages, we sorted undifferentiated invariant NK T progenitor cells and eac
143 ation into NSCs, the subsequent depletion of undifferentiated iPSCs from the NSCs, and concentrating
144 ne xenotransplantation model, indicated that undifferentiated iPSCs, independent of X chromosome comp
146 ent efficiency of intramyocardially-injected undifferentiated-iPSCs, day 4 mesodermal cells, and day
148 ntium T3SS induced an excessive expansion of undifferentiated Ki67-positive epithelial cells, which i
149 e-tracking strain in selected areas, such as undifferentiated left ventricular hypertrophy, cardio-on
154 osteoblasts (CFU-Os), a surrogate marker of undifferentiated mesenchymal cells able to differentiate
156 olarized epithelial organ that develops from undifferentiated mesenchyme, although the mechanisms tha
157 1alpha1-Cre and Osteocalcin-Cre to transform undifferentiated mesenchyme, preosteoblasts and mature o
159 y, we now observed that macrophages, but not undifferentiated monocytes, support this interaction.
163 RP directly binds to H19 in the cytoplasm of undifferentiated multipotent mesenchymal C2C12 cells, an
165 treatment, PRDM16 induces Ucp1 expression in undifferentiated murine embryonic fibroblasts, that this
167 MR expression is cell autonomous in both undifferentiated myoblasts and differentiated myotubes f
169 eam effector of PAX3-FOXO1 that maintains an undifferentiated myogenic phenotype that is characterist
173 High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma c
174 eport that IL-33 expression is induced in an undifferentiated, non-dividing esophageal epithelial cel
175 MBD1 deficiency leads to the accumulation of undifferentiated NSCs and impaired transition into the n
176 inal pigment epithelium, choroidal thinning, undifferentiated nuclear layers of the retina, and a per
177 as softened and was enhanced when the 'soft' undifferentiated nucleus was stiffened through pharmacol
179 on indications for scleral lens therapy were undifferentiated ocular surface disease, exposure kerato
180 sions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs)
182 hNSCs, but not in UC-MSCs and ADSCs, either undifferentiated or differentiated, though IFNgamma rece
183 that are otherwise not easily accessible to undifferentiated organisms, though expression of these n
184 id not distinguish large differences between undifferentiated OSKM and OSKMV iPSCs; however, some dif
185 percalcemic type (SCCOHT) is the most common undifferentiated ovarian malignancy in women under 40 ye
188 ority of Notch2-deficient tumors revealed an undifferentiated phenotype as determined by their morpho
189 at 12 degrees C showed similar viability and undifferentiated phenotype as the non-stored control sug
190 activation signature in a context of gaining undifferentiated phenotype in a p53-null sarcoma system
195 d increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiate
196 showed encouraging activity in patients with undifferentiated pleomorphic sarcoma or dedifferentiated
197 e, including four (40%) of ten patients with undifferentiated pleomorphic sarcoma, two (20%) of ten p
199 human genome is compatible not only with the undifferentiated pluripotent state, but also with differ
200 IEN, and PUNISHER, specifically expressed in undifferentiated pluripotent stem cells, cardiovascular
202 ant COL4A3 chains (G1334E mutation) in human undifferentiated podocytes and tested their effects in v
203 regulated in mature adipocytes compared with undifferentiated preadipocytes in both human and mouse s
204 plexity and integration emerge from uniform, undifferentiated precursor tissues remains limited.
205 time points, PLP-EGFP was expressed in Sox2+ undifferentiated precursors in the spinal cord ventricul
208 cyte genes and represses hepatocyte genes in undifferentiated progenitor cells in vitro and in embryo
209 at reflects the H3K4me3 modifications in the undifferentiated progenitor cells of the baboon SVZ.
210 le for Siah2 in the early events that signal undifferentiated progenitor cells to become mature adipo
211 omatin activation mark H3K4me3 is present in undifferentiated progenitor cells within the SVZ of adul
212 OUP-TFII protein expression level is high in undifferentiated progenitors and gradually declines duri
213 3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available
214 ied neurons survive as well in vivo as their undifferentiated progenitors, and undergo less prolifera
217 neage, with Lin28b being highly expressed in undifferentiated prosensory cells and let-7 miRNAs being
219 ese safety studies show the lack of residual undifferentiated PSC, negligible tumorigenic potential b
220 miR-193a-mediated maintenance of PECs in an undifferentiated reactive state might be a prerequisite
221 ently reduced vigilance measured in terms of undifferentiated reactivity to salient cues (indexed by
226 hown to be oncogenic in chondroblastomas and undifferentiated sarcomas by inhibiting H3K36 methyltran
227 t for PRC2-regulated genes and similarity to undifferentiated sarcomas harbouring BCOR-CCNB3 fusions.
229 veloping SCs displayed hyperproliferation of undifferentiated SCs incompatible with normal myelinatio
231 and overall titers similar to those seen in undifferentiated SH-SY5Y cells and the related SK-N-SH c
232 tive" (DVR highest in surrounding NAWM), or "undifferentiated" (similar DVR across lesion, perilesion
233 scle but very low in the fetal tissue and in undifferentiated skeletal muscle cells and myoblasts.
234 tal cells, less differentiated embryonal and undifferentiated small cells (SCU) progressively lose EG
235 Stimulated by retinoic acid gene 8 (Stra8), undifferentiated spermatogonia accumulated in unusually
237 omerase knockout strains causes depletion of undifferentiated spermatogonia and eventual loss of all
238 Transcriptomic comparisons of Tert(High) undifferentiated spermatogonia and Tert(Low) differentia
239 ia and eventual loss of all germ cells after undifferentiated spermatogonia drop below a critical thr
240 Fancb mutation resulted in the reduction of undifferentiated spermatogonia in spermatogenesis, sugge
241 ling resulted from an arrest of entry of the undifferentiated spermatogonia into S phase; and (3) ret
242 ial stem cells (SSCs) are a subpopulation of undifferentiated spermatogonia located in a niche at the
243 TB) disruption even though the population of undifferentiated spermatogonia remains similar to normal
244 h telomerase levels as a basis for purifying undifferentiated spermatogonia using fluorescence-activa
245 file of PLZF and SALL4 regulatory targets in undifferentiated spermatogonia, including SSCs, which wi
246 high telomerase expression is a hallmark of undifferentiated spermatogonia, the mitotic population w
252 duction of GDNF by PM cells is essential for undifferentiated spermatogonial cell development in vivo
253 plays a key role in maintaining VSMCs in an undifferentiated stage in order to promote their prolife
255 highly expressed in hESCs to maintain their undifferentiated state and prevent default neural fate.
256 oxi3 maintains dental epithelial cells in an undifferentiated state and thereby regulates multiple st
257 in satellite cells and acts to maintain the undifferentiated state by stimulating Pax7 expression an
258 -steroidogenic progenitor cells retain their undifferentiated state during fetal stage and become adu
260 intaining dividing cells in a proliferative, undifferentiated state for a longer period of time.
261 e generated prenatally and then remain in an undifferentiated state for long periods, being detectabl
263 at Tcf3 is a mediator of self-renewal and an undifferentiated state in stem and progenitor cells in s
264 at maintained proliferative potential and an undifferentiated state in stroma coculture and engrafted
265 c program in myoblasts and by maintaining an undifferentiated state in their sister cells through Not
266 essary for maintenance of the proliferative, undifferentiated state in vitro Characterizing successfu
269 t the lack of polarity establishment and the undifferentiated state of geranylgeranyltransferase type
270 al pathways by which these cells maintain an undifferentiated state while preserving their capacity t
271 moval of culture conditions that maintain an undifferentiated state, mouse embryonic stem cells (ESCs
272 canonical WNT and maintains the cells in an undifferentiated state, whereas cytosolic WISP2 regulate
278 is involved in maintaining stem cells in an undifferentiated state; however, it is often unclear whi
280 uncover a role for Prmt5 in maintaining the undifferentiated status of female germline stem cells.
281 o-1 has been found to be associated with the undifferentiated status of mouse and human embryonic ste
282 old higher yield of cardiomyocytes from each undifferentiated stem cell as compared with 3D-standard
284 al and basal myoepithelial cells, as well as undifferentiated stem cells and more restricted progenit
285 eads to highly aggressive tumours containing undifferentiated stem cells and their differentiated der
287 KIT, between differentiated tumor cells and undifferentiated stem-like tumor cells, helps maintain t
288 intenance of cycling cell lineages relies on undifferentiated subpopulations consisting of stem and p
289 boon SVZ, we developed a technique to purify undifferentiated SVZ cells while preserving the endogeno
290 nfections with other pathogens that cause an undifferentiated systemic febrile illness, including inf
291 orls of three separate perianth organs each (undifferentiated tepals), more than two whorls of three
295 esence or absence of oncogenic RAS, and form undifferentiated tumors when transplanted into the mouse
296 eoplasia) or the PDAC stage led to invasive, undifferentiated tumors with enhanced hypoxia, epithelia
299 a-catenin exhibited a perinuclear pattern in undifferentiated wild-type cells, it predominantly local
300 , synaptic and subthreshold activity remains undifferentiated within the local field potential (LFP).
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