ライフサイエンスコーパス: unesterified

1 production of 14,15-EET and by metabolism of unesterified AA, thereby preventing activation of the ne

2 These findings suggested that unesterified arachidonic acid in cells is a signal for i

3 We conclude that the cellular level of unesterified arachidonic acid is a general mechanism by

4 expression of COX-2 and FACL4 as "sinks" for unesterified arachidonic acid.

5 m ionophore also was prevented by removal of unesterified arachidonic acid.

6 Cholesterol effluxed to rHDL was initially unesterified but by 24 h this cholesterol was largely es

7 PC1 protein, which normally aids movement of unesterified cholesterol (C) from the endosomal/lysosoma

8 While unesterified cholesterol (C) is essential for remodeling

9 fatty acids (P < 0.05), and lower levels of unesterified cholesterol (P < 0.05), than nontransgenic

10 terification of phospholipid acyl chains and unesterified cholesterol (UC) by the enzyme lecithin:cho

11 Unesterified cholesterol (UC) that is taken up by the li

12 rincipally excreted from the body in bile as unesterified cholesterol (UC).

13 Unesterified cholesterol accumulates in late endosomes i

14 There is accumulation of phospholipid, unesterified cholesterol and cholesterol ester in the co

15 , characterized by lysosomal accumulation of unesterified cholesterol and delayed induction of choles

16 extensive acellular areas that were rich in unesterified cholesterol and macrophage debris, the lesi

17 s characterized by lysosomal accumulation of unesterified cholesterol and multiple neurological sympt

18 sterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal s

19 or NPC2 cause intracellular accumulation of unesterified cholesterol and other lipids leading to neu

20 he enhancement in efflux of human fibroblast unesterified cholesterol and phospholipid (PL) by lipid-

21 ated livers had augmented secretion rates of unesterified cholesterol and phospholipid.

22 racellular cholesterol metabolism and making unesterified cholesterol available for steroid hormone p

23 Loss of ACAT2 activity may result in unesterified cholesterol being absorbed via an ABCA1-med

24 of tg-MPM with cholesterol or variations in unesterified cholesterol content appear to have little e

25 Doubling the unesterified cholesterol content of the plasma membrane

26 erent imaging modalities, and confirmed that unesterified cholesterol does accumulate in their OS and

27 border, whereas in the complicated lesions, unesterified cholesterol dominated in neovessel-containi

28 is clear that enrichment of fibroblasts with unesterified cholesterol enhances efflux of cholesterol

29 (m/z 385:m/z 369) was found to differentiate unesterified cholesterol from cholesterol esters.

30 are believed to facilitate the recycling of unesterified cholesterol from late endosomes/lysosomes t

31 es a protein involved in the net movement of unesterified cholesterol from the late endosomal/lysosom

32 Unesterified cholesterol had no apparent effect on parti

33 terized by the inappropriate accumulation of unesterified cholesterol in aberrant organelles.

34 tor in NPC mice altered the concentration of unesterified cholesterol in every organ in a manner cons

35 NPC2 gene that result in an accumulation of unesterified cholesterol in late endosomes/lysosomes (LE

36 mal storage disorder causing accumulation of unesterified cholesterol in lysosomal storage organelles

37 terized by the inappropriate accumulation of unesterified cholesterol in lysosomes [1].

38 sease is associated with the accumulation of unesterified cholesterol in nearly all tissues and with

39 lycolipids like GM2 and GM3 gangliosides and unesterified cholesterol in surviving Purkinje cells, as

40 the CM pathway changed the concentration of unesterified cholesterol in that organ.

41 erol homeostasis and extensive deposition of unesterified cholesterol in the skin and brain.

42 trate that the anti-cholesterol Ab recognize unesterified cholesterol in VLDL/IDL and LDL; high-densi

43 cells maintain significantly lower membrane unesterified cholesterol levels than mature-stage spleni

44 ion of the chromosome 8 locus is specific to unesterified cholesterol levels, whereas the chromosome

45 lipid stains and filipin for esterified and unesterified cholesterol or probed with antibodies to ap

46 dy mass but contains almost a quarter of the unesterified cholesterol present in the whole individual

47 atidylcholine, phosphatidylethanolamine, and unesterified cholesterol provided evidence that anionic

48 d annealing of PL-rich HDL models containing unesterified cholesterol results in double belt structur

49 ) disease, a mutation in NPC1 protein causes unesterified cholesterol to accumulate in the lysosomal

50 r NPC2 protein function that is required for unesterified cholesterol transport from the endosomal/ly

51 h postnatal, accumulation of filipin-labeled unesterified cholesterol was clearly evident not only in

52 and, in addition 4) the level of macrophage unesterified cholesterol was not rate-limiting for this

53 Esterified and unesterified cholesterol was present in all drusen and b

54 e effector, and phosphatidylethanolamine and unesterified cholesterol were essentially neutral diluen

55 abnormal accumulation of GM2 ganglioside and unesterified cholesterol within late endosomes and lysos

56 studied on r-HDL made of palmitoyloleoyl-PC, unesterified cholesterol, cholesteryl ester, and apolipo

57 aracterized by intracellular accumulation of unesterified cholesterol, sphingolipids, and other lipid

58 ), containing predominantly phospholipid and unesterified cholesterol, was morphologically heterogene

59 advanced lesions accumulate large amounts of unesterified cholesterol, which is a potent inducer of m

60 -onset hypercholesterolemia characterized by unesterified cholesterol-rich abnormal lipoproteins (lam

61 at contained PC, apo AI, and, in some cases, unesterified cholesterol.

62 alized with lipid deposits, mainly formed by unesterified cholesterol.

63 yet there was no reciprocal accumulation of unesterified cholesterol.

64 ed solubilization of phospholipid (PL)/free (unesterified) cholesterol (FC) bilayer membranes in cell

65 ve uptake of CE and efflux of cellular free (unesterified) cholesterol (FC) from COS-7 cells expressi

66 es possess four pathways for exporting free (unesterified) cholesterol to extracellular high density

67 nt formulas derived from soy or bovine milk, unesterified choline, phosphocholine, glycerophosphochol

68 ulfotransferase (SULT1A3) when compared with unesterified CoA and short chain-length acyl-CoAs.

69 nanoparticle that acts as a transporter for unesterified DHA (LDL-DHA) and demonstrates selective cy

70 ng cholesterol oxidase to selectively render unesterified DHE nonfluorescent.

71 the [3H]8,9-EET uptake by cells remained as unesterified EET.

72 4 modulates GSIS by regulating the levels of unesterified EETs and that arachidonate controls the exp

73 ellulose formation and an increased ratio of unesterified/esterified pectin.

74 nism that appears to involve substitution of unesterified (exogenous) sterol from HDL for plasma memb

75 The heart can utilize unesterified FA bound to albumin or FA obtained from lip

76 The association of unesterified fatty acid (FA) with the scavenger receptor

77 ding protein (AFABP) is believed to transfer unesterified fatty acids (FA) to phospholipid membranes

78 lmitin (DP) and saturated or polyunsaturated unesterified fatty acids (PUFAs) on both the structure o

79 The rates by which unesterified fatty acids and cholesterol move through an

80 tty acyl coenzymes A (acyl-CoAs) rather than unesterified fatty acids as the small-molecule ligands r

81 ts showed for the first time the presence of unesterified fatty acids in the nucleus of living cells

82 necessary if the PXA1 transporter delivered unesterified fatty acids into the peroxisomal matrix.

83 provide an in vivo test of this specificity, unesterified fatty acids were generated within the cellu

84 of phospholipids into lysophospholipids and unesterified fatty acids.

85 The unesterified fluorescent VLC-PUFAs distributed either eq

86 ol-rich liposomes having >90% cholesterol in unesterified form.

87 ructure on ABCA1-mediated efflux of cellular unesterified (free) cholesterol (FC) and phospholipid (P

88 e effects of apoA-I modification on cellular unesterified (free) cholesterol (FC) efflux, three recom

89 hatidylcholine (PC), sphingomyelin (SM), and unesterified (free) cholesterol (FC) from J774 macrophag

90 entrations and proportions of esterified and unesterified HDL-C.

91 that influence a component of HDL-C-namely, unesterified HDL2a-C.

92 Nonetheless, they have not been detected unesterified in the free form, presumably because of the

93 racemic PGs, particularly PGD2, were present unesterified in urine from normal animals and humans and

94 CFA-CoA) and low affinity (Kd=58-296 nm) for unesterified long chain fatty acids (LCFAs).

95 Although unesterified long chain fatty acids interact with peroxi

96 ls progressively accumulate large amounts of unesterified or "free" cholesterol (FC), a process that

97 Unesterified, or "free," cholesterol (FC) is a potent in

98 matory mediators and macrophages with excess unesterified, or "free," cholesterol (FC).

99 clerotic lesions accumulate large amounts of unesterified, or "free," cholesterol (FC).

100 mpacts wall strength and cell adhesion since unesterified pectin regions can cross-link via Ca(2+) io

101 The distribution of unesterified pectins in cyt1 cell walls is also disrupte

102 ickness of the cell walls are irregular, and unesterified pectins show an abnormally diffuse distribu

103 Using the unesterified plant sterol, sitostanol (SIT), as a nonexc

104 olymers include spectra of HG molecules with unesterified regions that are separable from methylester

105 idea that the cellular uptake and efflux of unesterified retinol by enterocytes is mediated by lipid

106 Unesterified retinol taken up by the enterocyte is compl

107 umstances there is substantial absorption of unesterified retinol via the portal route.

108 a reconstituted HDL, made with radiolabeled unesterified SIT, UC, and cholesteryl esters (CE).

109 total cholesterol (i.e., both esterified and unesterified); spectrotype 2 comprising glucose signals

110 Unesterified sterol modulates the function of eukaryotic

111 fic protein shown for the first time to bind unesterified sterol with high affinity.

112 c and most RBC pathologies and corrected the unesterified to total cholesterol ratio (0.3) and associ

113 ered from SR-BI KO mice in that the ratio of unesterified to total plasma cholesterol was normal, fem

114 in RBC maturation and abnormally high plasma unesterified-to-total cholesterol ratio (0.8) with assoc

115 Under the conditions in which unesterified tRNA binds to both the P- and E-sites of no

116 Unesterified tRNA inhibited the disassembly of the post-

117 RRF and unesterified tRNA similarly inhibited the binding of N-a

118 ed with filipin to reveal esterified (EC) or unesterified (UC) cholesterol (n = 20, 17-92 years).

119 rs is as severely impaired as degradation of unesterified very long-chain fatty acids in X-ALD and is