ライフサイエンスコーパス: unexpected

1 acterial regulation of eukaryotic mating was unexpected.

2 other than CMM in NTN1 mutation carriers was unexpected.

3 TRF2 interacts with TIN2 with an unexpected 2:1 stoichiometry in the context of shelterin

4 Surprisingly, unexpected absorption features, which are associated wit

5 movement rate but not to the intentional, or unexpected, adjustment of lick position or to sensory fe

6 l tolerated, without any clear signal of any unexpected adverse effects.

7 Because lawsuits may be triggered by an unexpected adverse outcome superimposed on a strained pa

8 d consistent with the underlying disease; no unexpected adverse reactions were reported.

9 To understand the unexpected affinity for the CB1 receptor, we devised a 3

10 Cocrystal structures revealed 3 binds to an unexpected allosteric site between the C-terminal and th

11 OnGuard2 also predicted with VPD unexpected alterations in K(+) channel activities and ch

12 ows an integrative perceptual effect and was unexpected, although it is consistent with work on motio

13 The unexpected anaerobic bioavailability of negatively charg

14 These data demonstrate unexpected and compensatory changes involving the TM in

15 Our work reveals an unexpected and conserved role for DELLA genes in control

16 energy surface of aryl nitrenes has revealed unexpected and fascinating reactions.

17 mixed histiocytosis [MH]), we identified an unexpected and heretofore undescribed frequent occurrenc

18 ophila FXS model, we discovered a completely unexpected and highly robust neuronal dye iontophoresis

19 Some of these results were unexpected and may appear counterintuitive to some obser

20 We report evidence for an unexpected and obligatory step early in the initiation i

21 This identified unexpected and pervasive translational regulation of mos

22 However, in 2012 unexpected and rapid mesospheric cooling was observed.

23 Aboveground emissions of H2 were an unexpected and substantial component of the ecosystem H2

24 rythrocytic parasite development revealed an unexpected and substantial slowing of parasite maturatio

25 Unexpected and unusual reactivity of 2-methylimidazolium

26 The discovery of the unexpected anomeric memory effect is further supported b

27 The unexpected architecture for the SDA complex provides a f

28 ne desulfurases, the SDA structure adopts an unexpected architecture in which a pair of ISD11 subunit

29 Previously, we have shown how unexpected arousal modulates metacognition.

30 ver time following HSCT, and they suggest an unexpected association of picobirnaviruses with early po

31 gions unique to the mammalian IP5 2-K, as an unexpected basic patch on the protein surface.

32 This was unexpected because UL21 has been shown to be required fo

33 or some parameter values, the model predicts unexpected behavior including polymorphic equilibria and

34 of stomatal movements, uncovering previously unexpected behaviors of stomata.

35 Our results demonstrate that this new and unexpected behaviour can be ascribed to an interplay bet

36 ks of interacting dynamical systems can have unexpected behaviours when the signal between the vertic

37 An unexpected binding mode for oxaloacetate was observed in

38 d mass range and sensitivity readily exposes unexpected binding of the ribosome-associated protein SR

39 w that protein folding can have profound and unexpected biological effects on such diverse processes

40 Here we show that unexpected blinking during graphene oxide-to-reduced gra

41 of elemental sulfur in THF affords 4(*) via unexpected C-H bond activation, which represents the fir

42 Among well-conserved miRNAs, we observed unexpected cases of clade-specific variation in 5' end p

43 al that senescence-associated stemness is an unexpected, cell-autonomous feature that exerts its detr

44 Here we find an unexpected cellular and molecular mechanism behind such

45 find that acute stress leads to dynamic and unexpected changes in eIF4F-mRNA interactions that are s

46 n of the fluorescence fluctuations exhibited unexpected changes with protein concentration.

47 an underexplored ring system and showed some unexpected chemistry.

48 No unexpected chemotherapy toxicity was seen, and neutropen

49 Moreover, we observe an unexpected chiral induction upon mixing two independentl

50 to the importance of clinical red flags, ie, unexpected co-occurrence of clinical features that may p

51 unique morphology and is characterized by an unexpected combination of features seen in several diffe

52 Thus, the unexpected combination of social and spatial information

53 or function in a native tissue and indicates unexpected complexity in the physiology of the Malpighia

54 igations of the reaction mechanism reveal an unexpected, concerted SNAr mechanism, with the organocat

55 olutionary genomics of viruses revealed many unexpected connections but the general scenario(s) for t

56 catch this phenomenon and (ii) highlight an unexpected consequence: the self-diffusion coefficient o

57 This result was unexpected considering the low concentration of oxidized

58 ind half field, they also reveal significant unexpected constriction of the functional field.

59 nding sites set the 5'polarity and to reveal unexpected control of the DNA phosphodiester backbone by

60 This unexpected core structure is explained by a strong coupl

61 ation and is especially useful for excluding unexpected critical language areas.

62 During the synthesis, we isolated an unexpected cyclopropane that presumably stems from a car

63 ase series, corneal transplantation revealed unexpected damage to the retina and optic nerve in chemi

64 ability of premature mortality due to sudden unexpected death in epilepsy (SUDEP).

65 tive disability, and elevated risk of sudden unexpected death in epilepsy (SUDEP).

66 table seizures, and the potential for sudden unexpected death in epilepsy (SUDEP).

67 airment and are at increased risk for sudden unexpected death in epilepsy (SUDEP).

68 Sudden unexpected death in epilepsy is a very rare outcome in B

69 The unexpected decrease in organic aerosol, likely a consequ

70 hepatocytes; the elucidation of expected and unexpected degradation products was achieved in subnanom

71 s to targeted genome sequencing revealed the unexpected deletion of a significant portion of VZV ORF

72 iscrimination of MS fragments, we report the unexpected demonstration of the anomeric memory of the g

73 In 2007, the Cassini mission reported the unexpected detection of anions with mass-to-charge ratio

74 The basis for an unexpected difference in the clinical impact of some NS3

75 These observations indicate unexpected differences in changes in myolipid metabolism

76 d from the optical screening images revealed unexpected differences in growth characteristics among s

77 o its HCV host factor activity, and identify unexpected differences in miRNA requirements for host ge

78 These unexpected differences in X dosage compensation states b

79 Atypical entities with unexpected diffusion characteristics included: adenocarc

80 Furthermore, unexpected discoveries have resulted from capabilities t

81 These unexpected discoveries raise important new questions tha

82 Two unexpected discoveries resulted from this study.

83 unbiased proteomics approach has led to the unexpected discovery of novel roles for these and other

84 Here, we detail the unexpected discovery that Panx1 (pannexin 1) channels co

85 precisely regulate forces or torques during unexpected disturbances, as required during numerous tas

86 Despite a conserved core of genes, there is unexpected diversity between these STs in terms of their

87 iation among human rhinovirus types includes unexpected diversity in the genes encoding viral proteas

88 g the first eight patients, four experienced unexpected dose-limiting toxicities: grade 4 sepsis synd

89 role for gamma delta (gammadelta) T cells as unexpected drivers of tumor development and progression.

90 This unexpected effect of heat treatment correlated with regr

91 ggered a synergistic effect and exhibited an unexpected electrocatalytic activity towards GSH oxidati

92 While different varieties of unexpected events have been studied largely independentl

93 We argue that unexpected events interrupt action and impact cognition,

94 s a sentinel, monitoring the environment for unexpected events.

95 Two new Pleistocene fossils now provide unexpected evidence of a brief and relatively recent per

96 ive reactivity represents an interesting and unexpected expansion to the established family of main-g

97 The unexpected expression of the visual opsins from the phot

98 An underestimated FDR can lead to unexpected false discoveries in the follow-up validation

99 structural similarity clustering identified unexpected FDA-approved drugs that induced DNA damage, i

100 A striking and unexpected feature of this pi bond is that the bond stre

101 ends in active site reactivity and to reveal unexpected features of active site architecture.

102 Local perturbations have therefore revealed unexpected features of polarity establishment.

103 Genetic blockade of autophagy revealed an unexpected feedback loop whereby knocking down the autop

104 Our results show an unexpected FIN219 conformation and demonstrate various d

105 Interpretation: Our unexpected finding of increased telomere attrition durin

106 In the present report, we make the unexpected finding that blood glucose levels change sign

107 this review we summarize and integrate these unexpected findings and discuss the mechanistic implicat

108 Unexpected findings are also being made; for example, th

109 Unexpected findings from the immune system of sea urchin

110 Unexpected findings include the following: 1) basal body

111 Here we show the unexpected findings of an investigation into the correla

112 These unexpected findings suggest that impairing microglial TR

113 This led to the unexpected findings that the AU dinucleotide dictates th

114 MMB treatment ameliorated anemia, which was unexpected for a JAK1/2 inhibitor, because erythropoieti

115 ferences in selective connectivity that seem unexpected for closely related species.

116 tions within the polymer chains leads to the unexpected formation of porous carbon nanoribbons.

117 m and progenitor cell depletion, a phenotype unexpected from the previously reported single knockout

118 These studies identify a novel and unexpected function for GPR120 and suggest that antagoni

119 Comt2, the murine ortholog of LRTOMT, has an unexpected function in the regulation of mechanotransduc

120 This unexpected function of ANGPTL4 invites re-interpretation

121 Our results highlight an unexpected function of HDAC6-CTTN axis as a positive reg

122 Here, we reveal an unexpected function of LPA that transfigures CD11b(+) mu

123 Here we describe an unexpected fundamental role for ACKR1 in hematopoiesis a

124 lly important for basic science as they make unexpected, fundamental discoveries.

125 Unexpected germline variants involved PALB2 and CHEK2.

126 Overall, our work unveiled unexpected glucose carbon flows of TRCs in melanoma that

127 l to the identification of both targeted and unexpected glycoforms.

128 There were 3 cases of unexpected hepatitis C virus transmission, all from an a

129 Here, using single-cell RNA-seq, we unearth unexpected heterogeneity among SCs and TACs of hair foll

130 The unexpected identification of dihydromyricetin in leaf ex

131 The diagnoses were unexpected in 8 of 23 (35%), and clinical management was

132 Second, an unexpected in vivo abundance of stable cleaved proteins

133 These unexpected in vivo data are most consistent with a model

134 ulated in CCR7-deficient mice, displaying an unexpected increase in the systemic IgA responses.

135 Septic fabpi-TAg mice had an unexpected increase in villus proliferation compared wit

136 ation die-offs and crashes (86%) rather than unexpected increases, and ignoring heavy-tailed process

137 endations known to reduce the risk of sudden unexpected infant death has contributed to a slowing in

138 omerase fit and function together as well as unexpected insight into telomerase interaction at telome

139 the same, and how such sameness can provide unexpected insights into apparently unrelated phenomena.

140 d by previous biochemical analyses, but adds unexpected insights.

141 We report unexpected inter-nanorod lithium-ion transport, where th

142 A genetic screen revealed an unexpected interaction of MYO2 and genes required for mi

143 highly diastereoselective manner through an unexpected intramolecular nucleophilic attack.

144 While this is unexpected, it supports the praxis of the current model.

145 We found an unexpected large proportion of NATs with protein coding

146 In addition, MPNs show unexpected layers of genetic complexity, with multiple a

147 ctivators and inhibitors and demonstrates an unexpected level of autoregulatory scaffolding in mammal

148 eceptor transport dynamics and points toward unexpected ligand specificity in the mechanisms of chemo

149 Our results highlight an unexpected ligand-independent induction mechanism and su

150 In this issue, Rhys et al. report an unexpected link between clustering capacity and cortical

151 Our study makes an unexpected link between the mRNA capping machinery and t

152 that theta burst neural activity produced an unexpected long-lasting reduction in astrocyte free Ca(2

153 alysis of beneficial mutations pointed to an unexpected, long-range allosteric pathway towards the ac

154 re, we present evidence for DNA damage as an unexpected means to shape a protective chromatin environ

155 otein over its associated motor and offer an unexpected mechanism by which filaments of the cytoskele

156 These findings uncover an unexpected mechanism of glucose sensing in skeletal myoc

157 oligodendroglial lineage genes, and reveals unexpected mechanisms mediating tumor viability and inva

158 d molecules such as secondary bile acids and unexpected microbial molecules including Pseudomonas-ass

159 These data show an unexpected morphological disparity in dancing damselfly

160 The unexpected nature of disasters leaves little time or res

161 he return of locomotor activity following an unexpected negative stimulus, electric shock.

162 Collectively, our findings uncover an unexpected new activity of GCV and identify the STING pa

163 This study reveals an unexpected new phenotype in a physical property of centr

164 Our findings reveal an unexpected new role for NKG2D in the regulation of B1a c

165 In this study, we identify an unexpected non-cell autonomous role of epidermal polarit

166 Our study shows that PHB has an unexpected nuclear role in hESCs that is required for se

167 Here, mechanisms and implications of this unexpected, O-linked ADP-ribosylation are speculated on.

168 The unexpected observation that function can be derived from

169 Rakova et al. report the unexpected observation that long-term high salt intake d

170 An unexpected observation was that the ASGR also appears to

171 Here, we report unexpected observations on the nucleation and growth of

172 These unexpected observations raise the possibility that some

173 Among unexpected observations, we found that migraine, typical

174 as not without its twists and turns, but the unexpected often led to new revelations and insights.

175 associated pathogenic genetic variants with unexpected, often multisystem, human phenotypes.

176 This unexpected ON-OFF segregation within a small-field amacr

177 ges we identify in these specimens, the most unexpected one is the change from fully toothed jaws in

178 When presented with unexpected or counterintuitive testimony, children are p

179 everal recent papers report spectacular, and unexpected, order of magnitude improvement in creep life

180 tual framework for the complex and sometimes unexpected outcome of CLR ligation in bacterial and fung

181 veness of MC4R agonists in obesity may be an unexpected outcome of neuronal injury with disrupted cla

182 kines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.

183 Exon skipping adds to the unexpected outcomes that must be accounted for, and perh

184 tions in signals that can lead to additional unexpected outcomes.

185 ng each administration, the government faced unexpected pandemics, ranging from the HIV/AIDS pandemic

186 )2, revealed an electronic structure with an unexpected partially delocalized spin, as evidenced by e

187 Our findings reveal an unexpected pathogenic role for Ly6C(hi) iMOs in promotin

188 Our analysis suggested that this unexpected pattern might have resulted from stronger pri

189 We identify several unexpected patterns for core cell-cycle proteins in acti

190 the RNA cleavage reaction, illustrating the unexpected Pb(2+)-accelerated catalysis, intrinsic terti

191 pon reaction with Cd(2+) or Fe(2+); however, unexpected pentagonal structures were formed, that is, [

192 n frontal cortical grey matter perfusion but unexpected perfusion decreases in regions of the brain n

193 There was an unexpected persistence of immunoglobulin G almost until

194 e, our simulations predict several novel and unexpected phenomena.

195 gnals on the minimum set of driver nodes, an unexpected phenomenon arises: due to computational or ex

196 cular Cell, Benvegnu et al. (2017) report an unexpected phenomenon by which the E3 ligase mahogunin r

197 These findings reveal an unexpected plasticity that maintains coordinated planar

198 One unexpected, possibly related, serious adverse reaction t

199 No intraoperative complications or unexpected postoperative AEs were reported.

200 r PSMA-targeted RGS and also hint toward the unexpected potential of (99m)Tc-PSMA-I&S as a SPECT imag

201 Here, we revealed the unexpected predominance of a tetranuclear [Cu4(GS)6] clu

202 Explaining the unexpected presence of dune-like patterns at the surface

203 The unexpected pro-oncogenic functions of Rac GTPase-activat

204 ained by means of oxidation and a subsequent unexpected protecting-group migration.

205 hanism of IFN subversion by RV and reveal an unexpected protective effect of RV infection on endotoxi

206 a-lattice Al-OH species, and it also reveals unexpected proton exchange between extra-lattice Al-OH s

207 esponses) after unexpected reward than after unexpected punishment.

208 The unexpected reaction of one of these 1,4-oxazepanes in th

209 ese complexes provides a rationale for their unexpected reactivity.

210 dehydrogenase and a cytochrome P450-produces unexpected rearrangements in strictosidine when assayed

211 At intermediate energy, a previously unexpected rebound mechanism contributes significantly t

212 ovative technique led to the discovery of an unexpected record confinement regime with positive net h

213 We observe an unexpected regime of fast diffusion immediately after ph

214 These findings unravel an unexpected regulatory concept executed by coiled-coil MD

215 This unexpected relationship between aminoacyl-tRNA decoding

216 These findings establish an unexpected relationship between lipogenesis and protein

217 process of licensing in the lung revealed an unexpected relationship between these organs.

218 This unexpected response of human mDCs to P. falciparum exhib

219 the anterior and posterior insula, and 3) to unexpected reward omission in the caudate body.

220 ns, and anterior and posterior insula, 2) to unexpected reward receipt in the anterior and posterior

221 vioral learning (ie, faster responses) after unexpected reward than after unexpected punishment.

222 Compared to predictable rewards, unexpected rewards elicited markedly different granule c

223 Over the last five decades, new and unexpected RNA-related phenomena emerged almost yearly.

224 y decreasing transcription, demonstrating an unexpected role for 3'-UTR sequences in transcriptional

225 e pruning of GnRH dendrites, highlighting an unexpected role for a vesicular protein in the maturatio

226 ule attachment dynamics, and they uncover an unexpected role for Aurora A in late mitosis.

227 Our results reveal an unexpected role for CtsB in leukocyte extravasation and

228 EpCAM expression during EMT, demonstrate an unexpected role for EpCAM in the regulation of ERK and d

229 They also observe an unexpected role for MLL2 in MLL-rearranged leukemia cell

230 ct of chromatin decondensation and reveal an unexpected role for Myc in the establishment of nuclear

231 DNA end-joining activity, thus revealing an unexpected role for Red1 in recombination-based DNA repa

232 and murine salivary gland, we demonstrate an unexpected role for SOX2 and parasympathetic nerves in g

233 human beta-cell maturation and identifies an unexpected role for the ROCKII pathway in the developmen

234 Cytosolic) as a novel AKT substrate, with an unexpected role in actin cytoskeleton regulation via an

235 ogical insulators and that topology plays an unexpected role in Earth's climate system.

236 S2, demonstrates NLS2 plays an important and unexpected role in influenza A virus infection.

237 Here, we describe an unexpected role in non-coding RNA-directed DNA methylati

238 Here, we describe an unexpected role of ATR in mitosis.

239 Our results reveal an unexpected role of CD6 in the pathogenesis of intestinal

240 Collectively, these data highlight an unexpected role of cGAS in responding to mobile-element

241 In this study, we demonstrate an unexpected role of eosinophils during plasmatic coagulat

242 Stoichiometric experiments demonstrate an unexpected role of lithium alkoxide in the carbon-carbon

243 Our findings elucidate an unexpected role of TH1 cells in vasculature and immune r

244 ase b1-deficient mice, our results reveal an unexpected role of white adipocytes in maintaining prope

245 muscles in a developmental setting and find unexpected roles for distinct planarian muscle fibers.

246 Overall, these observations identify unexpected roles for RIPK1 and RIPK3 kinases in the prod

247 These studies identify unexpected roles for the microbiome and innate immune si

248 omerases, and several findings have revealed unexpected roles of type I DNA topoisomerases, a subclas

249 This unexpected route to stealthin C reveals a distinct appro

250 duced IOP and medication use without raising unexpected safety concerns, offering a minimally invasiv

251 No new or unexpected safety issues were reported for either treatm

252 er with computational modeling, revealed the unexpected SAR of these carbasugar SGLT2 inhibitors, and

253 This unexpected "saturation" of the catalytic activity above

254 om mice of either sex triggers extensive and unexpected Schwann cell elongation and branching to form

255 behaviour is rather different, indicating an unexpected sensitivity of the twist-bend phase to molecu

256 Unexpected sensitivity to dasatinib with half maximal in

257 iling captures disease-relevant features and unexpected sensitivity to relevant drugs, which warrants

258 Two unexpected serious adverse events occurred, both for the

259 n cause for intraneural perineuriomas and an unexpected shared pathogenesis with intracranial meningi

260 uO4 under pressure, which reveal a large and unexpected shift of p* with pressure, driven by a corres

261 Unexpected shortening (and, thus, strengthening) of the

262 Surface high mobility is unexpected since bismuth is not a topological insulator

263 aimed at facilitating balance recovery after unexpected slippages.

264 These observations uncover an unexpected social experience-dependent component to the

265 catchment likely enter rivers and provide an unexpected source to northern estuaries.

266 ation rely on Galphai subunits, revealing an unexpected specificity of selected GPCR intracellular si

267 Theoretical investigations uncovered unexpected stabilizing CH-pi interactions between the li

268 s, such as azido or cyano anions, react with unexpected stereo- or regioselectivity under standard gl

269 In addition, our analysis reveals an unexpected stiffening of the polar regions of the stomat

270 We demonstrate that this unexpected stimulation arises from Tg-induced conformati

271 ing and the origin of human ERP phenomena to unexpected stimuli.SIGNIFICANCE STATEMENT Traditional au

272 ely to report perceiving an expected than an unexpected stimulus.

273 An unexpected superconductivity enhancement is reported in

274 xpressed initial reactions, particularly to "unexpected" surgical wounds healing by secondary intenti

275 ing renewed experimental study and revealing unexpected surprises in mRNA splicing and the genetic co

276 This unexpected swing in the response prompted us to investig

277 Other, unexpected synergies appear, including with the plasma m

278 alpha-sulfenyl-beta-diketones followed by an unexpected tandem deacylation.

279 biochemical inhibition demonstrate that the unexpected target of actinonin in P. falciparum and Toxo

280 diction error of the brain, where rewards at unexpected times (10.00 h and 19.00 h) elicit higher act

281 [62%] of 265 had an adverse event), with no unexpected toxic effects.

282 No unexpected toxicities were recorded.

283 l cardiomyocytes has yielded insight into an unexpected transcriptional regulatory mechanism by which

284 These results demonstrate an unexpected transfer of PCP complexes between neighbors a

285 atient and graft survival as well as risk of unexpected transmission of HIV, HBV, and HCV were equiva

286 s examined experimentally, and a classically unexpected trend is that the selectivity increases as th

287 elavant to PARASHIFT contrast agents reveals unexpected trends in the magnetic susceptibility anisotr

288 These structures reveal an unexpected tripartite interface between synaptotagmin-1

289 cal skin carcinogenesis, which highlights an unexpected tumor-suppressive activity of MIF in murine s

290 Here, we provide genetic evidence of an unexpected tumour-promoting effect of NKG2D in a model o

291 Now in an unexpected twist, King and colleagues have expanded the

292 However, recent genetic studies have added unexpected twists to this mechanism: certain NCR peptide

293 edback, while changes in its activity signal unexpected uncertainty.

294 precedented among eukaryotes, and highlights unexpected variation in plastid genome architecture.

295 Our data reveals an unexpected variation occurs in domain mobility, prFMN bi

296 This may have facilitated unexpected variations in isolation and dispersal of homi

297 The unexpected volume change originates from the high percen

298 ct-object mergers, known sources detected in unexpected ways, and completely unknown sources.

299 These observations illustrate an unexpected yet prominent phenotype associated with the l

300 l knowledge of genomic context can result in unexpected, yet potentially informative observations.