1 ed down assembly of AGO2-let-7b-mRNA complex
unexpectedly.
2 Unexpectedly,
15 of 25 patients without diplopia (60%) h
3 Unexpectedly,
a large proportion of GWAS single nucleoti
4 increased myoblast differentiation in vitro
Unexpectedly,
a marked decrease in muscle mass (10%) was
5 Unexpectedly,
AAV-CRRY-treated STGD1 mice also showed re
6 Unexpectedly,
ablation of CR3 in human amyloid precursor
7 id not affect ILC1 differentiation, NK cells
unexpectedly acquired an ILC1-like gene signature and we
8 ng CD4 T cells, but not in macrophages, and,
unexpectedly,
acted in the absence of SAMHD1 degradation
9 Unexpectedly,
actin and the actin regulators drebrin and
10 Unexpectedly,
activated STAT5 overrode Hippo-mediated in
11 Unexpectedly,
active SMAD2/3 also markedly enhances thre
12 a novel non-channel function for TRPM8 that
unexpectedly acts as a Rap1 GTPase inhibitor, thereby in
13 minates Ca(2+)-activated Cl(-) currents, but
unexpectedly also abrogates CFTR-mediated Cl(-) secretio
14 Unexpectedly,
also the organic cations Tetraethylammoniu
15 CD4 T cell memory subsets in healthy mice is
unexpectedly and strikingly reliant on this replenishmen
16 Unexpectedly,
and differently from VAV1, tyrosine phosph
17 hemical calculations, and their compositions
unexpectedly appear to be tensioned differently compared
18 although required for thyroid specification,
unexpectedly appears to be dispensable for lung specific
19 invariant Cys residues from one monomer and,
unexpectedly,
Asp8 from the other.
20 Unexpectedly,
atherogenesis was not changed in mice with
21 NaHS
unexpectedly augmented the expression of inducible NOS (
22 sphorylation sites, and we demonstrate that,
unexpectedly,
autophosphorylated CPK28 had enhanced kina
23 Unexpectedly,
because the disruption of other complement
24 ide evidence that lymphangiogenesis plays an
unexpectedly beneficial role in the regulation of cornea
25 Unexpectedly,
beta-catenin and Smad1 binding were associ
26 Unexpectedly,
blocking CenpH did not affect spindle orga
27 use measurement-based modeling to show that,
unexpectedly,
both RIS and RBS can lead to enhanced O3 f
28 rmined a crystal structure of human FZD7 CRD
unexpectedly bound to a 24-carbon fatty acid.
29 Unexpectedly,
Ca(2+) stimulation also generated large (>
30 Unexpectedly,
cactus loss-of-function alleles decrease D
31 Unexpectedly,
channels formed without KCNE1 carry at mos
32 Unexpectedly,
cIH improved whole-body glucose tolerance
33 that the amphioxus incipient neural tube is
unexpectedly complex, consisting of several AP and DV mo
34 Quite
unexpectedly,
cyanobacteria and Escherichia coli appear
35 Unexpectedly,
decreased BACH2 levels in dispersed MCL ce
36 Unexpectedly,
defective lysosomal degradation of bacteri
37 Unexpectedly,
DeltaXX showed no deficit in replication i
38 Our results
unexpectedly demonstrate that public, as well as private
39 ient in the receptor for IL-33 (Il1rl1(-/-))
unexpectedly demonstrated enhanced lung clearance of A.
40 trated that the magnitude of CoRA/FI synergy
unexpectedly depends on FI-binding affinity and the stoi
41 Unexpectedly,
depletion of KDM3A was capable of reactiva
42 We present an unusual case of a patient who
unexpectedly developed a range of anti-HLA antibodies fo
43 Even computational biologists find it
unexpectedly difficult to reproduce results from others
44 o another enzyme (prolyl oligopeptidase), we
unexpectedly discovered non-Michaelis-Menten kinetics in
45 sing a novel real-time translocase assay, we
unexpectedly discovered that Mfd translocates autonomous
46 blasts readily induces local retraction and,
unexpectedly,
distal protrusions to steer cells away.
47 onment, as most infants who die suddenly and
unexpectedly do so in unsafe sleep environments.
48 strate that the far-infrared conductivity is
unexpectedly dominated by the surface states as a result
49 d glucose levels with GCGR-blocking antibody
unexpectedly doubled beta-cell mass relative to that obs
50 Unexpectedly,
DPY-21 also associates with autosomes of g
51 More broadly, our results demonstrate the
unexpectedly dynamic nature of coregulator interactions
52 Unexpectedly,
each anti-SEE mediated SEE-induced basophi
53 Unexpectedly,
elderly donors (>90 yrs) harbor fewer muta
54 ET imaging typical for svPPA, FTP signal was
unexpectedly elevated with a spatial pattern localised t
55 However, vDeltaK1L infection
unexpectedly elicited dramatically reduced infiltration
56 l with a separate hydrophobic extension that
unexpectedly engages the cap in multiple conformations (
57 correlates with transcription, whereas it is
unexpectedly enriched at transcriptionally inactive peri
58 Unexpectedly,
exacerbated caspase activation and apoptos
59 Unexpectedly,
experiments in bacterial and human cells r
60 of the UNC5 receptor family for neurons, is
unexpectedly expressed in endothelial cells specifically
61 Unexpectedly,
expression of mature HMR failed to rescue
62 rP(C) conversion, the resulting horse prions
unexpectedly failed to cause disease upon further passag
63 vivo neural recordings and optogenetics, we
unexpectedly find that both suppressing and over-activat
64 Through genetic screens, we
unexpectedly find that mutant HRAS, which is rarely foun
65 Unexpectedly,
following withdrawal of teriparatide thera
66 We
unexpectedly found that Co neurons contribute to striata
67 In 2010, our group
unexpectedly found that N-[(1r,4r)-4-[2-(7-cyano-1,2,3,4
68 In this study, however, we
unexpectedly found that two types of CpG-based tumor pep
69 to a low incidence of retinal toxicity, was
unexpectedly found to exert marked protective effects ag
70 ptors, manifesting type 1 immunity, and most
unexpectedly,
generating myofibroblasts and associated w
71 Unexpectedly,
germline-reverted CA45, while exhibiting n
72 odo-bis-silylene (2) (in a 2:1 ratio) in THF
unexpectedly gives both the first five-membered, sulfur-
73 Unexpectedly,
GS967 significantly improved survival of S
74 Unexpectedly,
HDAC6 inhibition-induced tubulin hyperacet
75 Unexpectedly,
helix VIII was found in a non-canonical po
76 However,
unexpectedly high (236)U/(238)U ratios as well as high (
77 An
unexpectedly high amount of methylglyoxal was found in m
78 The 3DE demonstrates an
unexpectedly high catalytic activity towards the HER (-0
79 We found an
unexpectedly high degree of neuronal diversity in the LT
80 The
unexpectedly high flux of cosmic-ray positrons detected
81 The observation of
unexpectedly high levels of (17)O in the bulk zeolitic l
82 med root metabolomic profiling and uncovered
unexpectedly high levels of the sesquiterpene volatile b
83 ty of RDT for malaria diagnosis, owing to an
unexpectedly high proportion of low-density infection am
84 as a Supportive Treatment (FEAST) trial, an
unexpectedly high proportion of participants from easter
85 tissue-specific, with leg muscle showing an
unexpectedly high rate of XCI escapers.
86 similar gross brain morphology, we found an
unexpectedly high variation in the expression patterns o
87 Length of stay was
unexpectedly higher in the care bundle group.
88 Unexpectedly,
however, the chemokine receptor CXCR3 was
89 Unexpectedly,
however, we found that manipulation did no
90 Unexpectedly,
however, we observed increased immune cell
91 a ribosome affinity purification method that
unexpectedly identifies hundreds of ribosome-associated
92 Unexpectedly,
IL-2 reduces this threshold in CD8 but not
93 Unexpectedly,
immunofluorescence microscopy localized Tb
94 However, cTBS to caudal LPFC
unexpectedly impaired processes that are presumed to inv
95 Together, these findings not only uncover an
unexpectedly important role of cells of origin transcrip
96 s fall into a limited number of classes, and
unexpectedly,
in 82% of models, the top biomarkers were
97 Unexpectedly,
in a small number of Leavenworthia alabami
98 Unexpectedly,
in mice lacking SOCS1 expression in CD11c(
99 Unexpectedly,
in the rapid cell cycles preceding the mid
100 Unexpectedly,
in vivo examination of early-stage develop
101 Unexpectedly,
in wild-type (WT) TSCs these genes are tra
102 he paternal genome was highly restricted but
unexpectedly included genes encoding putative pluripoten
103 gher in primary versus degraded forests and,
unexpectedly,
increased 4.9% per yr from 1996 to 2014, l
104 racellular clock, the cryptochrome proteins,
unexpectedly increases in the expression of hypoexcited
105 ll autonomous origin of this disease that is
unexpectedly induced via Rag1-Cre expression in CNS inte
106 verexpression of the calcium reporter GCaMP3
unexpectedly inhibited lymphatic sprouting, presumably b
107 Unexpectedly,
innate lymphoid cells were found to have a
108 eversibly acetylated in the mitochondria and
unexpectedly is a target of SIRT1 deacetylation.
109 Unexpectedly it was found that the solution is truly hom
110 control Treg and Teff cells homeostasis but,
unexpectedly,
it is dispensable to prevent development o
111 Unexpectedly,
its exposure to UV light affords, after re
112 Unexpectedly,
K9.361 injection induced mild anaphylaxis,
113 cular environmental surveys have revealed an
unexpectedly large diversity of chytrids across a wide r
114 These findings highlight the
unexpectedly large effect that neutral osmolytes may hav
115 e contraction as abundance declines may pose
unexpectedly large extinction risks to harvested species
116 This
unexpectedly large localized optical heating effect prov
117 Unexpectedly large ocean waves or 'rogues' are sometimes
118 itation with the RNA chaperone Hfq drafts an
unexpectedly large post-transcriptional regulatory netwo
119 reatment-refractory depression identified an
unexpectedly large proportion of patients with potential
120 est that certain intronic DNA sequences play
unexpectedly large roles in directing transcription init
121 We also demonstrate that Kcnq2 ablation
unexpectedly leads to a larger action potential amplitud
122 er, targeting CXCL1, CXCL6 and CXCL8 3'-UTRs
unexpectedly led to substantial mRNA decreases.
123 Unexpectedly,
LH-21 induced anxiolysis and reverted obes
124 These phenotypes were
unexpectedly linked to mutations in the gene encoding a
125 lower light responses than peripheral cones,
unexpectedly linking cone signals to perceptual sensitiv
126 Unexpectedly,
LKB1 function in Treg cells was independen
127 escued by overexpression of either ABCD4 or,
unexpectedly,
LMBD1.
128 ion to its nuclear localization, the protein
unexpectedly localizes to motor axons.
129 Bar(CRH) neurons have
unexpectedly long dendrites, which may receive synaptic
130 across patients for planning and identifying
unexpectedly long ICU length of stay and across ICUs for
131 tions for planning ICU capacity, identifying
unexpectedly long ICU length of stay, and benchmarking I
132 ive GBS analysis platforms, SNP calls showed
unexpectedly low convergence but generally high accuracy
133 diment heated up to 100 degrees C, we found
unexpectedly low DOC concentrations in the pore waters,
134 The warfarin cohort experienced an
unexpectedly low ischemic stroke rate, rendering the eff
135 us coordination of hand movement, require an
unexpectedly low number of motor neurons, with a large c
136 second but less probable mechanism for this
unexpectedly low value of beta for SAMs of S(EG)nCH3 res
137 We observed
unexpectedly low variation in splicing rates across intr
138 rges, and reduced discharge home but also an
unexpectedly lower in-hospital mortality.
139 Unexpectedly,
lower odds of cardiovascular mortality wer
140 Unexpectedly, &
lt;25% of all ER DNA binding events were aff
141 Unexpectedly,
lytic effects required significantly highe
142 Unexpectedly,
many transcriptional effects of O-GlcNAc t
143 Unexpectedly,
MBD2 binding to methylated CpGs induces DN
144 Unexpectedly,
metabolic and physiological analyses showe
145 Unexpectedly,
mice lacking hepatic lipogenesis have a tw
146 Unexpectedly,
mice lacking platelet PITPalpha form throm
147 WASP are unable to grow, make pseudopods or,
unexpectedly,
migrate using blebs.
148 defense from innate to adaptive immunity is
unexpectedly mirrored at the cellular level by the capac
149 Unexpectedly,
morc-1 is dispensable for siRNA inheritanc
150 e that TCs will become stronger, larger, and
unexpectedly more destructive under global warming.
151 ripiprazole with more initial akathisia and,
unexpectedly,
more sedation.
152 Unexpectedly,
morphogenesis was interrupted at a stage a
153 Unexpectedly,
NMDARs have also been shown to signal meta
154 Unexpectedly,
nuclear and mitochondrial DNA analyses sug
155 y of grazoprevir, its combination with R155K
unexpectedly nullified this effect.
156 pression screen with 23 mammalian ZDHHCs, we
unexpectedly observed that more than half of the ZDHHCs
157 An imidazo[1,5-a]pyridine derivative was
unexpectedly obtained through the action of Fe(2+) on a
158 Unexpectedly,
oral and intraperitoneal glucose tolerance
159 Unexpectedly,
our data also revealed a possible motor-ne
160 Unexpectedly,
our findings thus establish miRNA regulati
161 Unexpectedly,
our studies revealed that cellular externa
162 that SK2 is nuclear in primary neurons and,
unexpectedly,
overexpressed SK2 is neurotoxic in a dose-
163 We now show that,
unexpectedly,
Par3 is essential for mammary cell surviva
164 Unexpectedly,
pathogenic ataxin-3 with a mutated Rad23-b
165 Unexpectedly,
Pca1 immunization generated cross-reactive
166 Unexpectedly,
phosphorylated IkappaB-alpha also mediated
167 Unexpectedly,
PI(4,5)P2 depletion also caused loss of pr
168 Unexpectedly,
Pml(-/-) embryos survive acute glutathione
169 Unexpectedly,
Pol II transcription of the transgene was
170 l class of potent antitubercular agents that
unexpectedly possessed notable utility against the kinet
171 Unexpectedly,
Prc1E and Kif4A were also required for rad
172 neutrophils form unstable aggregates and are
unexpectedly primed to respond robustly to inflammatory
173 limited to the brain, but we have now found
unexpectedly profound pathology in the human INCL spinal
174 Unexpectedly,
prolonged voluntary abstinence prevented t
175 Unexpectedly,
proteins involved in transcellular Ca(2+)
176 truct the eight-membered ring of the target,
unexpectedly provided a cyclopentene (67%), which arises
177 ll death pathway regulated by TAK1, which is
unexpectedly provoked by inhibition of caspase activity
178 Unexpectedly,
PTP4A2 minimally interacts with SRC and do
179 This process is
unexpectedly rapid and reversible, consistent with the f
180 In addition, blockade of trkB
unexpectedly reduced the functional benefit of STN DBS o
181 emnants of the decaying warming in late 2014
unexpectedly reignited since February 2015 and grew into
182 shows strong intratumoral heterogeneity and
unexpectedly remains regulated in colorectal cancer irre
183 Unexpectedly,
respiratory impairment by mdivi-1 occurs w
184 nents Rheb or Rptor, mTORC1 loss of function
unexpectedly resulted in a profound skin barrier defect
185 Knock-down of PI3Kgamma
unexpectedly resulted in loss of ERK activation to recep
186 rod function reveals that these individuals
unexpectedly retain substantial vision in daylight.
187 hereas human bone marrow erythroblast nuclei
unexpectedly retain their spherical morphology.
188 The structure
unexpectedly revealed a novel open conformation of the P
189 ls, resulting in enhanced MMP-9 release, and
unexpectedly revealed genetic polymorphisms in MMP-9 tha
190 itution of the SMURF2.RNF11 complex in vitro
unexpectedly revealed robust SMURF2 E3 ligase activity,
191 These experiments
unexpectedly revealed that, whereas Cin8 ATPase kinetics
192 Not
unexpectedly,
saliva samples have high levels of exogeno
193 the bacterial pathogen Staphylococcus aureus
unexpectedly secretes and repurposes the lipoylated E2 s
194 cNGc and UDP-GalNGc and the latter allows an
unexpectedly selective incorporation of N-glycolyl group
195 Unexpectedly,
Sema3a- and Nrp2-mediated control of islet
196 Unexpectedly,
significant portions of pancreas-resident
197 Unexpectedly,
silencing of the heterochromatic HML and H
198 measured angleZrPH =66.7 degrees ] which is
unexpectedly similar to that found in cryogenic, spectro
199 Unexpectedly,
SJB7, a close analog of SPA70, is an hPXR
200 Our results show
unexpectedly slow incubation (2.8 and 5.8 mo) like those
201 Unexpectedly,
solving the crystal structure of Tda2 reve
202 Unexpectedly,
splicing of Col1a1 (seal) mRNA followed th
203 Unexpectedly,
ST2 deletion led to an overall increase in
204 etrically conjugate with oligothienyls in an
unexpectedly stable form, and produce a "metal-free" A-D
205 placenta as well as other tissues and rather
unexpectedly,
stem cells as well as reprogrammed induced
206 anomolar binding affinity to m4-1BBL with an
unexpectedly strong avidity effect.
207 Computer-tutored birds exhibited
unexpectedly strong heritability for song tempo and comp
208 We observed an
unexpectedly strong inverse correlation between Env-spec
209 50,000 Drosophilid fly wings to demonstrate
unexpectedly strong positive relationships between varia
210 This
unexpectedly strong spin-coupling effect is further conf
211 ver the existence of natural populations and
unexpectedly suitable agro-climatic conditions initiated
212 Unexpectedly,
Syn-2 knockout mice exhibited paradoxical
213 Unexpectedly,
T-bet-tg mice died 2 to 3 weeks after infe
214 Unexpectedly,
T124N/T174I IN substitutions inhibited pro
215 led a serine/threonine phosphatase fold that
unexpectedly targets tyrosine-phosphorylated peptides.
216 Unexpectedly,
tau mRNA and protein levels did not differ
217 eceptors containing Y190T mutations revealed
unexpectedly that both alpha9 and alpha10 subunits equal
218 in precursors of brown adipocytes, we found
unexpectedly that GR is dispensable for brown adipose ti
219 The structures show
unexpectedly that indirect sequence recognition dictates
220 In this study, we have found
unexpectedly that peptide linkers tethering WW domains i
221 Here, we demonstrate
unexpectedly that primary dermal fibroblasts from pre-sy
222 This study reveals,
unexpectedly,
that complement-related from one cell regu
223 Here we demonstrate,
unexpectedly,
that peroxisome proliferator-activated rec
224 Unexpectedly,
the clones were also highly resistant to t
225 Unexpectedly,
the degree of inhibition of both parameter
226 Unexpectedly,
the development of tellurite resistance is
227 Unexpectedly,
the enzymatic activity of the variants did
228 Unexpectedly,
the extracellular mouth of the ion pore re
229 Unexpectedly,
the fine structure of the fatty acids was
230 Unexpectedly,
the growth inhibitory effect of F. oxyspor
231 Unexpectedly,
the lack of IL-1 signaling increased the m
232 Unexpectedly,
the late ERK activation negatively correla
233 Unexpectedly,
the latter reveals an intertwined two-doma
234 Interleukin (IL)-4 and,
unexpectedly,
the mast cell marker CPA3 predicted UCP1 g
235 Unexpectedly,
the mutation that increases novobiocin res
236 Unexpectedly,
the periplasmic adaptor protein CusB is a
237 Unexpectedly,
the pre-organized Si-B separation in 1 ena
238 sites of the PH domain, the Arf GTPase and,
unexpectedly,
the Sec7 domain.
239 Unexpectedly,
the solution structure of the most potent
240 Unexpectedly,
the subsequent establishment of chromatin
241 Unexpectedly,
the switch I mutations had only modest eff
242 Unexpectedly,
the sympathoactivation at HA that was evid
243 Unexpectedly,
the transcription factor is an ortholog of
244 Unexpectedly,
there was little evidence of microbial tra
245 Unexpectedly,
there was no correlation between monthly c
246 Unexpectedly,
these neurons receive convergent input fro
247 Unexpectedly,
these seeds accumulated significantly high
248 Unexpectedly,
this complementarity extends to these prot
249 tional salience of old and new stimuli, but,
unexpectedly,
this effect was not reflected in the subst
250 Unexpectedly,
this occurs in the absence of overt inflam
251 Unexpectedly,
this weakened dimerization elicits more su
252 Unexpectedly,
transcriptome profiling showed that EZH2 p
253 Unexpectedly,
transient clinical improvement with fever
254 Unexpectedly,
TRX1 inhibition also elevates androgen rec
255 Unexpectedly,
unbiased whole-transcriptome analyses of a
256 ur studies of HMO-microbial interactions, we
unexpectedly uncovered a novel HMO property to directly
257 Unexpectedly,
upon desensitization the tagged D2 recepto
258 Unexpectedly,
viral oncogene knockdown had no effect on
259 Unexpectedly,
VTA dopamine neuron activity in high alcoh
260 erplay between the different excited states;
unexpectedly,
water favors population of the dark states
261 Unexpectedly,
we also detected autophagy deficiency.
262 Unexpectedly,
we also found that mutant SERPINB7 mRNAs h
263 Unexpectedly,
we also observed enhanced autocrine produc
264 Unexpectedly,
we discover high levels of somatic hypermu
265 Unexpectedly,
we discovered that pasteurization of A. mu
266 Unexpectedly,
we do not observe a correlation between th
267 Unexpectedly,
we find that a catalytically inactive muta
268 Unexpectedly,
we find that excitotoxicity provokes an ea
269 Unexpectedly,
we find that the formation of Ub chains by
270 Unexpectedly,
we find using time-lapse fluorescence imag
271 Unexpectedly,
we found a coat protein dimer sequestered
272 Unexpectedly,
we found that Bax deletion in developing a
273 Unexpectedly,
we found that circulating HSV-2 strains ca
274 Unexpectedly,
we found that phosphorylation of the ABD a
275 Unexpectedly,
we found that polymerized and non-assemble
276 Unexpectedly,
we found that reducing miR-210 significant
277 Unexpectedly,
we found that repeats occurred independent
278 Unexpectedly,
we found that RVM GABAergic neurons facili
279 Unexpectedly,
we found that the relA knockout strains de
280 Unexpectedly,
we found that this pore opens independent
281 Unexpectedly,
we found that vRNA-vRNA association in cyt
282 Unexpectedly,
we found that wild-type p53 exerts a domin
283 Unexpectedly,
we found two mutually exclusive altered su
284 Unexpectedly,
we identified PABPN1-dependent ALYREF bind
285 Unexpectedly,
we identified the presence of different sp
286 Very
unexpectedly,
we identify a new response pathway to OXPH
287 Unexpectedly,
we identify a subset of genes that adopted
288 Unexpectedly,
we observe a sharp decrease in CTCF occupa
289 Unexpectedly,
we observe that >40% of all miRNAs tested
290 Unexpectedly,
we observed only mild up-regulation of ISG
291 Unexpectedly,
we observed that imaA mutants bound higher
292 Unexpectedly,
we show that a full reduction in eIF3j aff
293 Unexpectedly,
we show that the nucleosome acidic patch i
294 Unexpectedly,
we show that the piRNA pathway components
295 ot been reported previously in L. major, but
unexpectedly,
we were unable to generate fkp40(-)/afkp80
296 rapy against a particular condition may have
unexpectedly weak effects on mortality, as treated patie
297 Unexpectedly,
while multiple satiety-related visceral si
298 Unexpectedly,
while promoter-proximal BRD4 occupancy cor
299 However,
unexpectedly,
without translation reprogramming an ATF4-
300 Unexpectedly,
ZIKV exhibits a broad tropism and persiste