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1 and rigid substituents in 5'-position appear unfavorable.
2 ch should make hole trapping by Ag(+) highly unfavorable.
3 g-like parameters for these ligands remained unfavorable.
4 the ground up, even where other factors are unfavorable.
5 whereas t(4;14), t(14;16), and t(14;20) are unfavorable.
6 increase in curvature are thermodynamically unfavorable.
7 , while amide sp(2)O-sp(3)C interactions are unfavorable.
8 state where electron transfer is kinetically unfavorable.
9 Cu potential to enable the thermodynamically unfavorable 1e(-) reduction of O2, and the resulting Cu(
10 rences for individual pairs of favorable and unfavorable aaRS-amino acid complexes, but were unable t
11 rimentally verified favorable complexes from unfavorable aaRS-Tyr complexes; (2) MD-MM/PBSA provided
12 erved in the simulations, largely due to its unfavorable access to residue D154, which provides impor
14 additional environmental factors related to unfavorable alterations in the microbiota have been prop
15 and strong anti-tumor responses, in vivo in unfavorable AML subtypes and BRCA wild-type breast cance
17 n to crystalline aggregates is enthalpically unfavorable and entropically favorable, qualitatively si
18 nders the formation of iodine vacancy states unfavorable and is responsible for the reduction in cond
20 wt %/83 mol % H2 O, this segregation becomes unfavorable, and the DES structure is disrupted; instead
21 his step is expected to be thermodynamically unfavorable, and therefore, it is unclear how AIP-produc
22 2O(0)-Arg(+) interactions with hydronium but unfavorable Asp(-)-X(-)/X(+)-Arg(+) interactions with an
23 water to generate methanol and H2 is highly unfavorable at any temperature (DeltaG of reaction appro
24 en eliminated, the gap between favorable and unfavorable attachment and did so by two mechanisms: (1)
27 yield at -78 degrees C the thermodynamically unfavorable axial O-acylation product; acyl migration is
29 hile amide sp(2)O-alkylurea interactions are unfavorable, becoming more unfavorable with increasing a
31 molecularly engineered astrocytes to turn an unfavorable brain environment into a favorable one for e
32 e and insulin resistance are associated with unfavorable cardiac structure and function, particularly
33 ention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR
34 ns of plasma choline were associated with an unfavorable cardiometabolic risk-factor profile [lower h
37 ersons with adenoma were more likely to have unfavorable cholesterol profiles at the time of colonosc
39 ervention, particularly in patients who have unfavorable clinical features in whom procedures may be
40 ses, and suggest that these effects underlie unfavorable clinical outcome experienced by SLAMF1(lo) p
41 vels, pointing to a more general reaction to unfavorable conditions and a diversion away from prolife
42 length and reduced attraction and (2) under unfavorable conditions attachment increased via reduced
43 The climate dipoles juxtapose favorable and unfavorable conditions for seed production and wintering
45 ncreases intracellular glucose levels during unfavorable conditions, including growth factor deficien
49 he nuclei be monomeric; that is, an initial, unfavorable conformational change is rate limiting for t
50 brain insulin resistance in obesity may have unfavorable consequences for whole-body glucose homeosta
51 e fusion/autophagosome maturation could have unfavorable consequences, which might require careful op
52 dynamic analysis revealed both favorable and unfavorable contributions from the IDRs surrounding the
53 a step forward in identifying predictors of unfavorable course in pCIS and POMS and supports a prote
58 tion is associated with worse health status, unfavorable discharge outcome and shorter survival of br
60 ven by intraocular pressure (IOP) as well as unfavorable drug disposition exerted by drug transporter
61 discovering and developing new antibiotics, unfavorable economics, and a hostile regulatory environm
62 that the incorporation of FH had a slightly unfavorable effect on bread sensory properties but ensur
64 and lymphoid hyperplasia; indicating lagged unfavorable effects of early postnatal SHS exposure in l
65 ped a strategy to separate the favorable and unfavorable effects of LXR by exploiting the specificity
67 anion redox is also associated with several unfavorable electrochemical properties, such as open-cir
68 nd FA promotes the electron transfer against unfavorable energetics (DeltaGET up to 0.63 eV) and init
69 r both favorable (energy barrier absent) and unfavorable (energy barrier present) conditions in an im
70 D219/E220 deletion mutant, we measured more unfavorable entropic and a more favorable enthalpic cont
72 -497 to the hydroxyl group of 5, whereas the unfavorable entropy might be due to desolvation effects
75 (WD) enables plants to maintain growth under unfavorable environmental conditions, although the mecha
78 proteins to solidify their defenses against unfavorable environments and maintain their optical prop
79 eltaGsc(o) of side chains that are buried in unfavorable environments by dictating the mechanisms by
81 ccuracy in terms of clustering favorable and unfavorable enzyme-substrate complexes, but also require
82 >-9% were associated with increased risk of unfavorable events as follows: for the primary end point
83 eroning mature factors through energetically unfavorable events, thereby maintaining the cellular poo
84 e designed a rigidified ligand, which showed unfavorable experimental binding affinity due to weakene
86 e individuals does not exhibit metabolically unfavorable features; this group is referred to as metab
87 study the impact of wettability on viscously unfavorable fluid-fluid displacement in disordered media
89 om the surface of the complex that is highly unfavorable for a subset of NOD mouse CD4 cells, thereby
95 rsus nonexposed group, with a clear gradient unfavorable for physicians over technicians and nurses a
99 Projected climatic changes appear especially unfavorable for species in the subalpine zone, where maj
100 due to atmospheric and oceanic environments unfavorable for typhoon intensification in SCS, which th
106 ns were associated with an increased risk of unfavorable Glasgow Outcome Scale (risk ratio, 2.46; 95%
107 ratio, 1.78; 95% CI, 1.01-3.15; I = 43%) and unfavorable Glasgow Outcome Scale (risk ratio, 2.49; 95%
110 TV and TLG enabled restratification of early unfavorable HL patients as having low- and high-risk dis
116 the clinical imaging factors associated with unfavorable imaging profile evolution for thrombectomy i
120 fabrication process is still complicated and unfavorable in term of the large scale and long-time dur
121 ydrate and sugar intakes are associated with unfavorable infancy BMI peak characteristics and higher
123 sed transition state distortion energies and unfavorable interaction energies, arising from addition
125 osmolyte (because of the dominant effect of unfavorable interactions of KGlu with anionic and amide
126 proteins (because of the dominant effect of unfavorable interactions of KGlu with hydrocarbon groups
127 Network (NCCN) low, favorable-intermediate, unfavorable-intermediate, and high-risk were 7.3%, 9.2%,
131 pants with a favorable in comparison with an unfavorable lifestyle (bottom versus top tertile lifesty
132 tially lower risk of coronary events than an unfavorable lifestyle (defined as no or only one healthy
133 wer relative risk of coronary events than an unfavorable lifestyle (hazard ratio, 0.54; 95% CI, 0.47
135 Similarly, favorable in comparison with unfavorable lifestyle showed 30%, 31%, and 33% lower ris
136 cidence of coronary events from 10.7% for an unfavorable lifestyle to 5.1% for a favorable lifestyle
139 in which localized frustration, quantifying unfavorable local interactions, is employed as a metric
141 new, refractory, or otherwise energetically unfavorable materials to form under softer conditions.
142 minerals at high loadings (mg/mL) suggesting unfavorable membrane self-assembly in such situations.
143 prevalence of organ damage, a more frequent unfavorable metabolic profile and a higher risk of new o
145 y reaction in the absence of template highly unfavorable (most commonly by using a low concentration
146 gradients to catalyze the thermodynamically unfavorable movement of synaptic serotonin into the pres
147 identified a cohort (n = 232; 20.2%) with an unfavorable multiorgan phenotype across all 3 anatomic a
148 asymptomatic community cohort, identifies an unfavorable multiorgan phenotype associated with adverse
155 50 [0.34-0.74; p < 0.001]) and lower odds of unfavorable neurologic outcome (odds ratio(adjusted) = 0
156 lesion depth demonstrated increasing risk of unfavorable neurologic outcome as more caudal structures
158 esterly wind burst events that turned around unfavorable ocean thermocline conditions in tropical wes
159 ioavailable and brain-penetrant, suffer from unfavorable off-target binding to other CNS receptors, a
160 that a layer composed of icosahedral B12 is unfavorable on Cu and Ni but unexpectedly becomes a poss
161 in patients with early-stage favorable than unfavorable or advanced stage at first diagnosis (15-yea
162 l barrier by "trapping" the antibiotic in an unfavorable orientation in the constriction zone that su
163 tems: the alpha-systems suffer less from the unfavorable orientation of bond dipoles in the equatoria
164 , decreased FOXP1 expression correlated with unfavorable OS (HR = 1.82, 95%CI: 1.18-2.83, p = 0.007).
165 nterval [CI], 1.78-5.52) and greater odds of unfavorable outcome (adjusted odds ratio [aOR], 1.44; 95
166 5; 95% CI, 4.60-10.19) and increased odds of unfavorable outcome (aOR, 2.01; 95% CI, 1.81-2.23).
168 ntrate, P = .53), or on the occurrence of an unfavorable outcome (modified Rankin Scale score, 3-6) (
169 nctional outcome, factors associated with an unfavorable outcome (modified Rankin Scale score, 3-6),
170 nths, and 65% (28 of 43) of survivors had an unfavorable outcome (modified Rankin Scale score, 3-6).
171 ere additionally classified as survival with unfavorable outcome (mRS score of 4-5), ROSC without sur
172 ower limit of reactivity was associated with unfavorable outcome (odds ratio %cerebral perfusion pres
173 -expression MIF alleles were associated with unfavorable outcome (P= 0.005 and 0.003) and death (P= 0
174 ately predicted which patients would have an unfavorable outcome 6 or 12 months after treatment.
175 ere developed to search for risk factors for unfavorable outcome and compare progression-free surviva
176 ysoPCaC18:0 and SM C16:1 are associated with unfavorable outcome in community-acquired pneumonia, int
179 ncy is the most important risk factor for an unfavorable outcome of pregnancy in women with asthma.
180 hematoma growth of greater than 33%, and an unfavorable outcome was defined as a 90-day modified Ran
183 tween SN and ECN compared with patients with unfavorable outcome, an effect that was maintained after
184 t-associated ICH has a high mortality and an unfavorable outcome, and hematoma expansion is frequent.
196 X1, or TP53 is independently associated with unfavorable outcomes and shorter survival after allogene
197 inement to enhance efficiency while limiting unfavorable outcomes that can be exceedingly costly for
198 g treatment groups in total mortality rates, unfavorable outcomes, hematoma expansion, neurologic det
203 % of the analyzed glioblastomas and predicts unfavorable patient prognosis suggesting that haploinsuf
204 nd was positively associated with OWO and an unfavorable pattern of metabolic biomarkers, although th
206 t the Last Interglacial Maximum (LIG) was an unfavorable period for the mole shrews because of a high
207 n the cohort period presented higher risk of unfavorable periodontal outcomes (rate ratio [RR]: 1.45
211 reatment of psoriasis have failed because of unfavorable physicochemical properties and inappropriate
212 bility of ribosomal proteins by neutralizing unfavorable positive charges and thus facilitate their t
216 293 is associated with an increased risk and unfavorable postoperative prognosis of RCC, possibly by
219 lin risk factor (age > 10 years or < 1 year, unfavorable primary site of disease, >/= three metastati
220 Secondary active transporters couple the unfavorable process of solute transport against its conc
222 er odds of hypertension and diabetes) and an unfavorable profile (higher LDL cholesterol and triglyce
223 years, older donors were less likely to have unfavorable profiles; these differences were significant
224 h deletions of CDKN2A (p16) and TP53 show an unfavorable prognosis and are candidates for alternative
225 be balanced against tumor control, given the unfavorable prognosis associated with disease progressio
227 eness in clinicians and caregivers about the unfavorable prognosis in the most deprived patients.
229 4;14), t(14;16), and del(17p13) conferred an unfavorable prognosis, although statistical significance
230 e (CC vs TT + CT) independently predicted an unfavorable prognosis, with a hazard ratio of 2.531 (95%
233 d histologic parameter is an independent and unfavorable prognostic marker that could be established
234 chondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in g
235 remains unclear, this finding could carry an unfavorable prognostic significance, prompting close mon
238 ression was significantly correlated with an unfavorable relapse-free survival (RFS) in breast cancer
240 unitinib or sorafenib vs placebo in resected unfavorable renal cell carcinoma [RCC]), the largest adj
241 tophan substitutions lower the energetically unfavorable residual hydrophobic mismatch between TM4 an
243 trategies for the prevention or treatment of unfavorable responses associated with different disease
246 , or low medication efficacy led to the most unfavorable results (treating all hypertension, about In
247 e-median mitotic counts were associated with unfavorable RFS in the 1-year group but not in the 3-yea
249 early stage I/II favorable risk, early stage unfavorable risk, advanced stage [AS] III/IV) and progre
250 ad cytogenetic abnormalities associated with unfavorable risk, TP53 mutations, or both had favorable
253 age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identifie
254 ave consistently shown that patients with an unfavorable-risk cytogenetic profile and TP53 mutations
255 nse rates were higher among patients with an unfavorable-risk cytogenetic profile than among patients
256 y stage classical Hodgkin lymphoma (HL) with unfavorable-risk features were treated with 4 cycles of
257 artile range] age, 72.43 [68.75-75.53]) with unfavorable-risk prostate cancer and minimal or no comor
258 this randomized clinical trial, 206 men with unfavorable-risk prostate cancer who were seen at a Harv
263 Large-scale combinatorial mutagenesis of unfavorable sequence contexts revealed a consistent patt
264 f B:22R to E in the peptide changes a highly unfavorable side chain for the p9 pocket to an optimal o
266 ize of the largest CRLM, the number of CRLM, unfavorable site of EHD, and progression of CRLM on neoa
267 ize of the largest CRLM, the number of CRLM, unfavorable site of EHD, and progression of CRLM on neoa
270 le-stranded DNA viruses is the energetically unfavorable state of the tightly confined DNA chain with
272 that the enantioselectivity originates from unfavorable steric interactions between the substrate an
273 entropy of the unfolded state, can introduce unfavorable steric interactions in the folded state, sin
275 that MIF knockout exacerbated aging-induced unfavorable structural and functional changes in the hea
276 sented significant prognostic factors for an unfavorable survival, independently of IGHV mutation sta
278 y previous experimental scales was positive (unfavorable), the average assigned by TopGraph in a nonr
279 2+)-selective ionophore is thermodynamically unfavorable, thereby requiring a Li(+)-selective ionopho
282 the rock-salt structure, a structure that is unfavorable to resist shear strain, and they exhibit rel
284 scriptional activities, suggesting that such unfavorable topography may present a stress to attached
288 tate more readily than the ssTnC paralog, an unfavorable transition that would decrease the ITC-deriv
289 cellular and intracellular "gates" and by an unfavorable transmembrane helix configuration when both
291 r strategies might be used to ameliorate the unfavorable treatment response described in psychiatric
293 compared with unprimed Tregs when used at an unfavorable Treg:Tcon ratio, demonstrating enhanced in v
296 P < 0.001; 4+ LRTs: HR 2.5, P < 0.001), and unfavorable waitlist alphafetoprotein trend significantl
297 mational entropy can range from favorable to unfavorable, which demonstrates the potential of this th
298 p(2)C-amide sp(2)N interactions in water are unfavorable while sp(2)C-sp(3)C interactions are favorab
299 h anionic (carboxylate) and amide oxygen are unfavorable, while KGlu interactions with cationic and a
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