ライフサイエンスコーパス: unfolded

1 ause its other interacting proteins are also unfolded.

2 salt there are only two species, folded and unfolded.

3 panning residues 12 to 20 and 204 to 210 are unfolded.

4 protein that is highly soluble and natively unfolded.

5 Exogenous application of low unfolded alpha-synuclein concentrations is able to incre

6 ich translocate across the outer membrane as unfolded amyloid precursors through a secretion system.

7 outer-membrane protein channel through which unfolded amyloid substrates are translocated.

8 pe protein, whereas the N-terminal domain is unfolded and comprises an ensemble of random conformers,

9 t-guest peptide series (AAXAA) as a model of unfolded and denatured states to examine the intrinsic p

10 We show that single proteins, kept unfolded and extended by a mechanical force, undergo acc

11 aled a semi-compact intermediate between the unfolded and folded ensemble that is locally more flexib

12 h, G4-DNA-forming conditions, a plurality of unfolded and folded species were present.

13 n a background of K+) with native, partially unfolded and highly extended conformations of an adenine

14 Even in unfolded and intrinsically disordered proteins, internal

15 -known function of J-domains of transferring unfolded and misfolded proteins to Hsp70.

16 ivo depends on the architectures of both the unfolded and native conformations.

17 n vitro the Htm1-Pdi1 complex processes both unfolded and native proteins albeit with a preference fo

18 histamine, but when Spy0125 was mechanically unfolded and subjected to forces of 50-350 piconewtons,

19 hydrophobic membrane bilayers, they must be unfolded and translocated by a membrane-embedded channel

20 that the cortactin repeats are intrinsically unfolded, and the experimentally observed radius of gyra

21 lar interactions between residues within the unfolded beta-domain.

22 For the unfolded BSA/curcumin complex, it was found thatp DeltaH

23 The I2 state is more unfolded, but it retains some residual secondary structu

24 re, we investigate whether globular proteins unfolded by SDS can be refolded upon addition of C12E8 a

25 enhances the propensity of the intrinsically unfolded C-terminal domains to drive pathological aggreg

26 Instead, the stability is conferred by the unfolded central domain of CENP-C and the folded N-termi

27 motions expected for an unstructured, fully unfolded chain.

28 s to protein folding homeostasis by engaging unfolded client proteins in a process that is tightly co

29 unoglobuline preparation and three sera with unfolded CMV antigens enhanced clearly the neutralizing

30 lagen hybridizing peptide (CHP), which binds unfolded collagen by triple helix formation, to detect m

31 second longest-lived metastable state was an unfolded, compact monomer with little similarity to the

32 A protein forced to be continuously unfolded completely loses its ability to contract by fol

33 nts and the exposed aromatic surfaces in the unfolded conformer that offset the stronger solvophobic

34 ble unfolded (intermediate) --> irreversible unfolded (denatured) state, we study the thermal denatur

35 nd POFUT1 can distinguish between folded and unfolded EGF repeats raised the possibility that they pa

36 e measured via their influence on the folded-unfolded equilibrium of an N-arylimide rotor.

37 ion between BiP AMPylation and the burden of unfolded ER proteins suggests a post-translational mecha

38 cal relevance, because these proteins remain unfolded for extended periods of time during their bioge

39 denaturation above zero degrees, because the unfolded form at low temperature is more expanded than t

40 n, resulting in protein unfolding, where the unfolded form interacts with cardiolipin acyl chains wit

41 ding pathway, and we are able to assign each unfolded form observed in our gas-phase data set to the

42 periments indicate the presence of partially unfolded forms (PUFs) of UCH-L1 under native conditions.

43 y unanticipated structural role for natively unfolded GLFG repeats as Velcro to link NPC subcomplexes

44 ryl groups and the surface hydrophobicity of unfolded globular proteins were the main characteristics

45 vented conversion into protonated, partially unfolded (green) phycocyanin species.

46 with a hybrid i-motif/hairpin species and an unfolded hairpin species.

47 cally stable complex between hnRNP K and the unfolded i-motif.

48 on trustworthiness perception from faces has unfolded in a way that is strikingly reminiscent of Juss

49 repetitive region of SasG are intrinsically unfolded in isolation, but these E domains fold in the c

50 at readily assemble in vitro but shown to be unfolded in vivo.

51 ng of S. aureus or E. coli antigens, whereas unfolded influenza H1N1 or respiratory syncitial virus a

52 cheme right arrow over left arrow reversible unfolded (intermediate) --> irreversible unfolded (denat

53 nding questions the very existence of partly unfolded intermediates in the SOD1 aggregation process a

54 y for immunoglobulin light-chains populating unfolded intermediates that result in amyloid formation,

55 charge states in mass spectra and generating unfolded ion structures, yet key details of its mechanis

56 These results indicate that these highly unfolded ions can be considered quasi-one-dimensional, a

57 s, we observed that CaM preferentially binds unfolded K-Ras4B hypervariable regions (HVRs) and not al

58 e trigger loop (TL), which cycles between an unfolded loop and an alpha-helical hairpin [trigger heli

59 Unfolded maps of histologically determined boundaries we

60 A pathway from the natively unfolded microtubule-associated protein Tau to a highly

61 veal a sharp transition from folded dimer to unfolded monomer between pH3 and pH 2, and suggest the e

62 gregation is enhanced by the presence of the unfolded N-terminal region of the sequence and by destab

63 ntageous for entropically favored binding of unfolded OMPs to chaperones and, by facilitating conform

64 nditions, as a result of the accumulation of unfolded or misfolded proteins in the ER.

65 Parallel factor analysis (PARAFAC) and unfolded-partial least squares coupled to residual bilin

66 lated by the program Flexible-Meccano for an unfolded peptide of this length.

67 lysis, which allows nonspecific digestion of unfolded peptides by trypsin.

68 p tyrosines that contact an 80-angstrom-long unfolded polypeptide along the axial channel.

69 ng mechanisms as well as the interactions of unfolded polypeptide chains with other cell components.

70 eassemble in a cooperative manner from their unfolded polypeptide subunits, without biological chaper

71 plasmic transport is an assembly of natively unfolded polypeptides, which contain phenylalanine-glyci

72 ficiencies in chaperone holdase activity for unfolded polypeptides.

73 anges in the elasticity and refolding of the unfolded polyprotein in the presence of SDS.

74 oplasmic reticulum (ER) stress, triggered by unfolded protein accumulation in the ER, contributes to

75 mechanism of IRE1 activation that relies on unfolded protein binding-induced oligomerization.

76 rmine size and charge state scaling laws for unfolded protein ions formed by supercharging while elim

77 simulations, and theory to the same system: unfolded protein L.

78 y caused by the aggregation of the initially unfolded protein molecules.

79 ich leads to activation of the mitochondrial unfolded protein response (mitoUPR).

80 tochondrial transcript factor A) or adaptive unfolded protein response (reduced concentration of heat

81 these pathways, including the mitochondrial unfolded protein response (UPR(MT)) and mitophagy, are a

82 The mitochondrial unfolded protein response (UPR(mt)) has been associated

83 , which regulates mitochondrial dynamics and unfolded protein response (UPR(mt)) in the host.

84 sfunction is by activating the mitochondrial unfolded protein response (UPR(mt)), a transcriptional r

85 global induction of a mitochondrial-specific unfolded protein response (UPR(mt)), affecting whole-ani

86 the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein response (UPR(mt)).

87 etrograde pathways such as the mitochondrial unfolded protein response (UPR(mt)).

88 stress-response mechanism, the mitochondrial unfolded protein response (UPR(MT)).

89 The unfolded protein response (UPR) adjusts the cell's prote

90 mediated activation of all three branches of unfolded protein response (UPR) and apoptotic genes.

91 network of key cellular processes including unfolded protein response (UPR) and autophagy in respons

92 induction of the IRE1alpha/XBP1 axis of the unfolded protein response (UPR) and culminating in termi

93 ), which is associated with induction of the unfolded protein response (UPR) and disruption of autoph

94 f procollagen I ER export could activate the unfolded protein response (UPR) and drive HSC apoptosis.

95 Here, we show that PLIN2 modulates the unfolded protein response (UPR) and ER stress in pancrea

96 increases endoplasmic reticulum (ER) stress/unfolded protein response (UPR) and mitochondrial ROS pr

97 ydrogen peroxide, on their ability to induce unfolded protein response (UPR) and their effects on the

98 Autophagy and the unfolded protein response (UPR) both promote activation

99 n factor that is the central effector of the unfolded protein response (UPR) in budding yeast.

100 g to light the distinctive complexity of the unfolded protein response (UPR) in plants.

101 of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in regulating these two

102 ulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-fol

103 The unfolded protein response (UPR) is a cytoprotective path

104 The unfolded protein response (UPR) is a shared pathway util

105 The unfolded protein response (UPR) is activated by various

106 The unfolded protein response (UPR) is activated to cope wit

107 The unfolded protein response (UPR) is an ancient signaling

108 The unfolded protein response (UPR) is essential for physiol

109 sed chaperone gene expression, and apoptotic unfolded protein response (UPR) markers, CHOP and Caspas

110 The unfolded protein response (UPR) monitors and adjusts the

111 ith a reduction in the protein levels of the unfolded protein response (UPR) negative master regulato

112 at KDM1A inhibitors induce activation of the unfolded protein response (UPR) pathway.

113 Although the unfolded protein response (UPR) plays a major role in ce

114 ases, but very little is known about how the unfolded protein response (UPR) responds to persistent E

115 ction of pro-inflammatory cytokines, ROS and unfolded protein response (UPR) signaling activation.

116 animals use a survival pathway known as the unfolded protein response (UPR) that signals between the

117 We have investigated the unfolded protein response (UPR) to endoplasmic reticulum

118 d a set of signaling mechanisms known as the unfolded protein response (UPR) to increase the folding

119 the ER folding capacity, which activates the unfolded protein response (UPR) to restore ER homeostasi

120 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis.

121 endoplasmic reticulum (ER) and activate the Unfolded Protein Response (UPR) to trigger adaptive resp

122 gated the role and mechanism for the primary unfolded protein response (UPR) transducer inositol-requ

123 ress response factors, and components of the unfolded protein response (UPR) was observed.

124 is activates an adaptive response termed the unfolded protein response (UPR) whose function is to res

125 in the ER, which leads to activation of the unfolded protein response (UPR), a conserved pathway tha

126 Activation of the unfolded protein response (UPR), a homeostatic regulator

127 RE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanis

128 es rhodopsin misfolding and induction of the unfolded protein response (UPR), an adaptive ER stress r

129 position activates the endoplasmic reticulum unfolded protein response (UPR), and UPR signaling effec

130 ERSID without affecting the induction of the unfolded protein response (UPR), but downregulation of P

131 changes in diabetes, most significantly the unfolded protein response (UPR), p53, hypoxia-related tr

132 he perinuclear area led to activation of the unfolded protein response (UPR), suggesting that specifi

133 uding the endoplasmic reticulum (ER)-induced unfolded protein response (UPR), the ubiquitin-proteasom

134 signaling pathways, collectively termed the unfolded protein response (UPR), to maintain a productiv

135 This activates the unfolded protein response (UPR), which alters the expres

136 ER stress elicits the unfolded protein response (UPR), which enhances the oper

137 metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by

138 The unfolded protein response (UPR), which protects cells ag

139 s endoplasmic reticulum stress that leads to unfolded protein response (UPR).

140 ve phosphorylation, vesicle traffic, and the unfolded protein response (UPR).

141 of a second proteotoxic stress response, the unfolded protein response (UPR).

142 for cell adaptation and survival, named the unfolded protein response (UPR).

143 intracellular signaling pathway known as the unfolded protein response (UPR).

144 and steatosis despite the activation of the unfolded protein response (UPR).

145 iculum (ER) stress and the activation of the unfolded protein response (UPR).

146 ted caspase 12 activation during an enhanced unfolded protein response (UPR).

147 in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR).

148 athway leading to ER stress and an activated unfolded protein response (UPR).

149 lance of unfolded proteins, and a heightened unfolded protein response (UPR).

150 tute potential cross-talk between HD and the unfolded protein response (UPR).

151 on the set of genes that is activated by the unfolded protein response (UPR).

152 The mitochondrial unfolded protein response (UPRmt) is a transcriptional p

153 actor that is secreted but also mediates the unfolded protein response acting intracellularly.

154 nclude that ER Ca(2+) drainage and sustained unfolded protein response activation are key for initiat

155 ER expansion and activation of the unfolded protein response also peaked at 2 dynes/cm(2),

156 tem resulted in chronic dysregulation of the unfolded protein response and altered amyloid precursor

157 Furthermore, G-CSFR d715 suppressed unfolded protein response and apoptosis induced by an SC

158 resulted in vigorous activation of both the unfolded protein response and ER stress accompanied by i

159 ces massive protein aggregation coupled with unfolded protein response and ER stress.

160 Omega-3 fatty acids increase the unfolded protein response and improve amyloid-beta phago

161 The NE mutants have been shown to activate unfolded protein response and induce premature apoptosis

162 bs target cell-surface GRP78, activating the unfolded protein response and inducing tumor cell prolif

163 olding of these proteins is monitored by the unfolded protein response and involves protein degradati

164 eticulum stress chaperone that regulates the unfolded protein response and is overexpressed in variou

165 Our data support a role of fortilin in the unfolded protein response and its potential participatio

166 itis elegans that involves the mitochondrial unfolded protein response and mitophagy pathways.

167 tein aggregation activates the mitochondrial unfolded protein response and PINK1-Parkin-mediated mito

168 ich regulates the endoplasmic reticulum (ER) unfolded protein response and promotes cell survival upo

169 utrient deficit acted in turn to trigger the unfolded protein response and the amino acid response, l

170 Whereas activation of some components of the unfolded protein response and the pro-apoptotic mediator

171 The CCPG1 gene is inducible by the unfolded protein response and thus directly links ER str

172 vates both the IRE1 and PERK branches of the unfolded protein response and ultimately leads to IRE1-d

173 This was followed by activation of the unfolded protein response at 8 weeks and overt beta cell

174 sttranscriptionally and independently of the unfolded protein response by adjusting the endogenous le

175 yeast that chronic VPA treatment induces the unfolded protein response due to increasing ceramide lev

176 Surprisingly, canonical mitochondrial unfolded protein response genes mediated by ATF5 are not

177 R luminal protein aggregation and consequent unfolded protein response hyperactivation and tissue inj

178 modulation of GRP78, master regulator of the unfolded protein response in the endoplasmic reticulum,

179 The unfolded protein response is an endoplasmic reticulum st

180 dence for association between asthma and the unfolded protein response is emerging.

181 reticulum stress, suggesting that an altered unfolded protein response is unlikely to account for the

182 odium parasites have a fundamentally reduced unfolded protein response machinery for reacting to ER s

183 tment-specific stress responses, such as the unfolded protein response of the endoplasmic reticulum (

184 hat enforced FAM46C expression activated the unfolded protein response pathway and induced mitochondr

185 ripts associated with the interferon and the unfolded protein response pathways was altered following

186 ic reticulum stress response and upregulated unfolded protein response pathways, which have been show

187 through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in contr

188 The unfolded protein response proteins GRP78, ATF6 and XBP1s

189 lication by limiting the damaging effects of unfolded protein response signaling in addition to enhan

190 zed acinar cells by suppressing the adaptive unfolded protein response signaling pathway.

191 en at a very low dose, lewisite up-regulates unfolded protein response signaling, inflammatory respon

192 We investigated the role of the core unfolded protein response transcription factor X-box bin

193 bout their capacity to facilitate the cell's unfolded protein response via direct interactions with a

194 r relationship between the activation of the unfolded protein response was established and the onset

195 and MafA Similarly, components mediating the unfolded protein response were decreased in islets of IR

196 ion factor 3 (ATF3) is a key mediator of the unfolded protein response, a pathway rapidly activated d

197 XBP1 expression regulates the unfolded protein response, acute-phase response, and DDR

198 that ClpXP is required for the mitochondrial unfolded protein response, additional roles for ClpXP in

199 NA repair, mTORC1 signaling, features of the unfolded protein response, and altered cholesterol homeo

200 ix protein and a member of the mitochondrial unfolded protein response, and its ability to suppress m

201 a potent inducer of cellular stress and the unfolded protein response, and ORMDL3 was found to play

202 stream pathways, including autophagy and the unfolded protein response, are coregulated with neurotox

203 GRP78 is widely used as a marker of the unfolded protein response, associated with sustained ER

204 athogens target innate immune signaling, the unfolded protein response, autophagy, and cellular metab

205 During the unfolded protein response, GRP78-an endoplasmic reticulu

206 ed stress response (ISR), a component of the unfolded protein response, has long been known to regula

207 biogenesis, triggering of the mitochondrial unfolded protein response, loss of mitochondrial membran

208 n (SIRT)1- and SIRT3-dependent mitochondrial unfolded protein response, triggering an adaptive mitoho

209 The ability of the unfolded protein response, UPR, to regulate cell homeost

210 subfamily B couples translation rate to the unfolded protein response, which has implications for un

211 ER stress induces the unfolded protein response, which involves activation of

212 ed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabo

213 ins to populate the organelle, eliciting the unfolded protein response.

214 paB signalling, antigen presentation and the unfolded protein response.

215 t hepatocytes, resulting in induction of the unfolded protein response.

216 the IRE1 branch of the endoplasmic reticulum unfolded protein response.

217 d activation of the IRE-1alpha branch of the unfolded protein response.

218 hronic endoplasmic reticulum (ER) stress and unfolded protein response.

219 ATF6 is a key regulator of the unfolded protein response.

220 induction of caspase processing but not the unfolded protein response.

221 nd non-canonical mRNA splicing in the fungal unfolded protein response.

222 cell death were associated with a sustained unfolded protein response.

223 al participation in human diseases caused by unfolded protein response.IRE1alpha is an ER stress sens

224 expression and aggregation and activation of unfolded protein response/endoplasmic reticulum (ER) str

225 ically, combination regimens that impair the unfolded protein responses block the emergence of aggres

226 sruption in Ca(2+) homeostasis and defective unfolded protein responses in aging axons.

227 uce the activation of 1 of the 3 branches of unfolded protein responses, the inositol-requiring enzym

228 stress-related disorders, activation of the unfolded protein sensor protein kinase RNA-like ER kinas

229 that this drug: i) activates markers of the unfolded protein stress response such as Hac1 mRNA splic

230 stranslation was insufficient to activate an unfolded protein stress response.

231 membrane aberrancy induced by palmitate from unfolded protein stress, our analysis shows that generic

232 ibute to UPR activation, but deletion of the unfolded protein stress-sensing luminal domain of the UP

233 e amino acid substitution that results in an unfolded protein that is prone to polymerization.

234 ant question of a Gaussian chain (such as an unfolded protein) binding to a sequence of receptors wit

235 a tight helix that grips an 80 A stretch of unfolded protein.

236 /-) macrophages attenuates the mitochondrial unfolded-protein response (mtUPR) as measured by express

237 that lens-specific mutations that elicit an unfolded-protein response (UPR) in vivo accumulate p27(C

238 When unfolded proteins accumulate in the endoplasmic reticulu

239 mRNA for the transcription factor Hac1 when unfolded proteins accumulate in the endoplasmic reticulu

240 Unfolded proteins activate UPR signaling across the ER m

241 o sets of measurements for the dimensions of unfolded proteins and IDPs in the absence of chemical de

242 Structural and dynamic investigations of unfolded proteins are important for understanding protei

243 The fundamental backbone dynamics of unfolded proteins arising due to intrinsic varphi-psi di

244 Peptides and unfolded proteins bind to hIRE1alpha LD's MHC-like groov

245 tive structural and dynamical description of unfolded proteins both at the global and the local level

246 Unfolded proteins compete for BiP and restore IRE1(LD) t

247 that ClpXP is dispensable for degradation of unfolded proteins in S. aureus.

248 -induced autophagy is due to accumulation of unfolded proteins in the endoplasmic reticulum.

249 quantitative picture of internal friction in unfolded proteins that could not be attained from the in

250 Endoplasmic reticulum stress causes unfolded proteins to populate the organelle, eliciting t

251 he molecular origins of internal friction in unfolded proteins using atomistic simulations, coarse-gr

252 stress arises from accumulation of misfolded/unfolded proteins when protein load overwhelms the ER fo

253 ve enzymes, a highly attuned surveillance of unfolded proteins, and a heightened unfolded protein res

254 at are important for binding and stabilizing unfolded proteins.

255 esolution structures of their complexes with unfolded proteins.

256 We considered that the unfolded region may alleviate the steric hindrance produ

257 urther analyses revealed that the N-terminal unfolded region of cargo proteins is critical for their

258 n at the 26S proteasome requires a partially unfolded region to facilitate substrate entry into the p

259 ing adaptive molecular evolution analyze the unfolded site frequency spectrum (SFS), a vector of coun

260 Populating transient and partially unfolded species is a crucial step in the formation and

261 The partially unfolded species possess an unstructured beta-domain and

262 ods (NPLS1 and NPLS2) and an analysis of the unfolded spectra by partial least squares methods (PLS1

263 We use the unfolded spectra to estimate the frequency and strength

264 ility and its kinetic accessibility from its unfolded state (U state).

265 residue-level PP2 dihedral angle bias in the unfolded state and PP2 helical structure in the native s

266 ins cannot attain their knot randomly in the unfolded state but must pay the cost of knotting through

267 s up through these intermediate forms to the unfolded state in an energy-ordered sequence, one foldon

268 Because the unfolded state of hTRF1 is only marginally populated and

269 Our results suggest that the unfolded state of most foldable sequences is expanded; w

270 lecule spectroscopy, we have scrutinized the unfolded state of outer-membrane phospholipase A (OmpLA)

271 lidate the further compaction of the already unfolded state of phosphoglycerate kinase (PGK) with dec

272 Accurate models of the unfolded state of the partially disordered CcdA antitoxi

273 sampling and a better representation of the unfolded state of the protein.

274 ificantly larger size for the 52 knot in the unfolded state that can be further tightened with higher

275 ures spanning the spectrum from the extended unfolded state to the native fold, yielded nearly 120 mu

276 quilibrium away from the extended, partially unfolded state towards a compact, pre-organized conforma

277 emble that is locally more flexible than the unfolded state, as judged by SHAPE modification.

278 ing of pp32 is quite broad and lies near the unfolded state, with structure apparent only in the C-te

279 bserved that corresponded to a folded and an unfolded state.

280 ral ensembles representative of the observed unfolded state.

281 ements show that internal friction dominates unfolded-state dynamics at low denaturant concentration,

282 This combination enables us to probe unfolded-state dynamics on different length scales, corr

283 the case of outer-membrane proteins (OMPs), unfolded-state properties are of particular physiologica

284 modynamic equilibrium between the folded and unfolded states of a protein can pinpoint residues of cr

285 lthough helicity is largely abolished in the unfolded states of both proteins, unfolding is completel

286 Unfolded states of proteins and native states of intrins

287 thermodynamic equilibrium between native and unfolded states of proteins.

288 onverting and conformationally heterogeneous unfolded states that lack the fast chain-reconfiguration

289 We find partly unfolded states where one or more repeats are unfolded t

290 , and the free energy distribution of partly unfolded states, and to determine how those energies dep

291 of proteins marginally more stable than the unfolded states.

292 this ion atmosphere with both the folded and unfolded states.

293 ions allowed RACER to distinguish folded vs. unfolded states.

294 , all force fields predict that Abeta adopts unfolded structure dominated by turn and random coil con

295 amatically reduced to only 2% of that of the unfolded structure.

296 form a closed spiral staircase encircling an unfolded substrate, directing it toward the flat, symmet

297 and is phosphorylated on two residues at its unfolded tail domain.

298 found that stabilizing either the folded or unfolded TL conformation decreased termination rate.

299 nfolded states where one or more repeats are unfolded to be energetically accessible.

300 In describing how the renaissance has unfolded, we attempt to describe different points of vie