ライフサイエンスコーパス: unfolded protein response

1 induction of caspase processing but not the unfolded protein response.

2 tch to glycolysis, oxidative stress, and the unfolded protein response.

3 uiring enzyme 1alpha, a key activator of the unfolded protein response.

4 ATF6 is a key regulator of the unfolded protein response.

5 ing of reactive mitochondrial biogenesis and unfolded protein response.

6 he HC-deficient cells displaying signs of an unfolded protein response.

7 ts basal activities in tRNA ligation and the unfolded protein response.

8 of the PRKR-like ER kinase (PERK) arm of the unfolded protein response.

9 may indicate activation of the mitochondrial unfolded protein response.

10 nd non-canonical mRNA splicing in the fungal unfolded protein response.

11 and PERK, function as stress sensors in the unfolded protein response.

12 XBP1 mRNA ligation during activation of the unfolded protein response.

13 alently-modified BiP nor by the conventional unfolded protein response.

14 ngolipid synthesis, calcium homeostasis, and unfolded protein response.

15 ockdown of HYPE prevents the induction of an unfolded protein response.

16 cell death were associated with a sustained unfolded protein response.

17 ins to populate the organelle, eliciting the unfolded protein response.

18 paB signalling, antigen presentation and the unfolded protein response.

19 t hepatocytes, resulting in induction of the unfolded protein response.

20 the IRE1 branch of the endoplasmic reticulum unfolded protein response.

21 d activation of the IRE-1alpha branch of the unfolded protein response.

22 hronic endoplasmic reticulum (ER) stress and unfolded protein response.

23 ion factor 3 (ATF3) is a key mediator of the unfolded protein response, a pathway rapidly activated d

24 actor that is secreted but also mediates the unfolded protein response acting intracellularly.

25 can unfold in the ER and be degraded via the unfolded protein response, activating ER stress and redu

26 nclude that ER Ca(2+) drainage and sustained unfolded protein response activation are key for initiat

27 correction by regulating the activity of the unfolded protein response activator inositol-requiring e

28 XBP1 expression regulates the unfolded protein response, acute-phase response, and DDR

29 that ClpXP is required for the mitochondrial unfolded protein response, additional roles for ClpXP in

30 ER expansion and activation of the unfolded protein response also peaked at 2 dynes/cm(2),

31 gen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dep

32 tem resulted in chronic dysregulation of the unfolded protein response and altered amyloid precursor

33 ntaining compounds induced the mitochondrial unfolded protein response and an ER stress response.

34 Furthermore, G-CSFR d715 suppressed unfolded protein response and apoptosis induced by an SC

35 smic reticulum homeostasis by regulating the unfolded protein response and calcium response.

36 eral mechanisms, including activation of the unfolded protein response and coordinated increases in p

37 resulted in vigorous activation of both the unfolded protein response and ER stress accompanied by i

38 ces massive protein aggregation coupled with unfolded protein response and ER stress.

39 Omega-3 fatty acids increase the unfolded protein response and improve amyloid-beta phago

40 The NE mutants have been shown to activate unfolded protein response and induce premature apoptosis

41 bs target cell-surface GRP78, activating the unfolded protein response and inducing tumor cell prolif

42 olding of these proteins is monitored by the unfolded protein response and involves protein degradati

43 eticulum stress chaperone that regulates the unfolded protein response and is overexpressed in variou

44 Our data support a role of fortilin in the unfolded protein response and its potential participatio

45 naling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewe

46 itis elegans that involves the mitochondrial unfolded protein response and mitophagy pathways.

47 tein aggregation activates the mitochondrial unfolded protein response and PINK1-Parkin-mediated mito

48 ich regulates the endoplasmic reticulum (ER) unfolded protein response and promotes cell survival upo

49 on and survival in NOD mice by enhancing the unfolded protein response and suggest that blockade of P

50 utrient deficit acted in turn to trigger the unfolded protein response and the amino acid response, l

51 Whereas activation of some components of the unfolded protein response and the pro-apoptotic mediator

52 The CCPG1 gene is inducible by the unfolded protein response and thus directly links ER str

53 vates both the IRE1 and PERK branches of the unfolded protein response and ultimately leads to IRE1-d

54 5A leads to endoplasmic reticulum stress, an unfolded protein response and up-regulation of chaperone

55 p53 levels, reduced apoptosis, an attenuated unfolded protein response, and accordingly are resistant

56 NA repair, mTORC1 signaling, features of the unfolded protein response, and altered cholesterol homeo

57 endoplasmic reticulum stress, activated the unfolded protein response, and caused cell death by apop

58 O2-treated E. coli induces the mitochondrial unfolded protein response, and inhibition of a gut pepti

59 ix protein and a member of the mitochondrial unfolded protein response, and its ability to suppress m

60 S1P) is implicated in lipid homeostasis, the unfolded protein response, and lysosome biogenesis.

61 a potent inducer of cellular stress and the unfolded protein response, and ORMDL3 was found to play

62 Targeting the unfolded protein response, and particularly PERK-branch

63 stream pathways, including autophagy and the unfolded protein response, are coregulated with neurotox

64 cluding autoimmunity, firmly positioning the unfolded protein response as a major therapeutic target

65 GRP78 is widely used as a marker of the unfolded protein response, associated with sustained ER

66 This was followed by activation of the unfolded protein response at 8 weeks and overt beta cell

67 athogens target innate immune signaling, the unfolded protein response, autophagy, and cellular metab

68 e findings suggest likely differences in the unfolded protein response between murine and human photo

69 ically, combination regimens that impair the unfolded protein responses block the emergence of aggres

70 Although the ER stress agents activated the unfolded protein response, both ATF4 and CHOP activation

71 sttranscriptionally and independently of the unfolded protein response by adjusting the endogenous le

72 ase (PERK, encoded by EIF2AK3) branch of the unfolded protein response directly contributes to diseas

73 yeast that chronic VPA treatment induces the unfolded protein response due to increasing ceramide lev

74 pression of ER chaperones, and activated the unfolded protein response element (UPRE), suggesting tha

75 expression and aggregation and activation of unfolded protein response/endoplasmic reticulum (ER) str

76 ith NE mislocalization and activation of the unfolded protein response/ER stress (UPR/ER stress).

77 Surprisingly, canonical mitochondrial unfolded protein response genes mediated by ATF5 are not

78 asic leucine zipper 60), two RSRE containing unfolded protein-response genes, bridges MEcPP-mediated

79 During the unfolded protein response, GRP78-an endoplasmic reticulu

80 ed stress response (ISR), a component of the unfolded protein response, has long been known to regula

81 Small molecules that modulate the unfolded protein response have the potential to treat a

82 asmic reticulum stress and activation of the unfolded protein response help to determine cell fate an

83 R luminal protein aggregation and consequent unfolded protein response hyperactivation and tissue inj

84 that controls variation in the mitochondrial unfolded protein response in both mouse and Caenorhabdit

85 xygen species and abnormal activation of the unfolded protein response in cells targeted by autoimmun

86 damage sensor HSF1, FA did not activate the unfolded protein response in either the endoplasmic reti

87 tion of endoplasmic reticulum stress and the unfolded protein response in intestinal epithelial cells

88 er that is characterized by a failure of the unfolded protein response in islet beta cells with subse

89 The increased unfolded protein response in rock1 plants and suppressio

90 modulation of GRP78, master regulator of the unfolded protein response in the endoplasmic reticulum,

91 sruption in Ca(2+) homeostasis and defective unfolded protein responses in aging axons.

92 al participation in human diseases caused by unfolded protein response.IRE1alpha is an ER stress sens

93 The unfolded protein response is a three-pronged signaling a

94 We confirmed that the unfolded protein response is activated by this lipid str

95 The unfolded protein response is an endoplasmic reticulum st

96 Thus, our data suggest that the Unfolded Protein Response is coupled with the co-transla

97 Activation of the unfolded protein response is emerging as a common theme

98 dence for association between asthma and the unfolded protein response is emerging.

99 reticulum stress, suggesting that an altered unfolded protein response is unlikely to account for the

100 tein, a transcription factor involved in the unfolded protein response, is only translated when it is

101 biogenesis, triggering of the mitochondrial unfolded protein response, loss of mitochondrial membran

102 odium parasites have a fundamentally reduced unfolded protein response machinery for reacting to ER s

103 responses, primarily the intersection of the unfolded protein response, mitochondrial dysfunction, au

104 ich leads to activation of the mitochondrial unfolded protein response (mitoUPR).

105 /-) macrophages attenuates the mitochondrial unfolded-protein response (mtUPR) as measured by express

106 tment-specific stress responses, such as the unfolded protein response of the endoplasmic reticulum (

107 its protein translation without inducing the unfolded-protein response or affecting mRNA stability.

108 hat enforced FAM46C expression activated the unfolded protein response pathway and induced mitochondr

109 We utilized the terminal unfolded protein response pathway to systematically defi

110 ripts associated with the interferon and the unfolded protein response pathways was altered following

111 ic reticulum stress response and upregulated unfolded protein response pathways, which have been show

112 through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in contr

113 The unfolded protein response proteins GRP78, ATF6 and XBP1s

114 one, and endoplasmic reticulum/mitochondrial unfolded protein response proteins.

115 ADI-PEG20 inhibited mTORC1 and activated the unfolded protein response providing a mechanism for inhi

116 oplasmic reticulum stress and the associated unfolded protein response, rather than the endocrine, ad

117 tochondrial transcript factor A) or adaptive unfolded protein response (reduced concentration of heat

118 The unfolded protein response regulator binding immunoglobul

119 dy movement, activation of the mitochondrial unfolded protein response reporter, CO2 production, mito

120 activating SKN-1/Nrf2 and the mitochondrial unfolded-protein response, respectively.

121 several stress-response pathways such as the unfolded protein response, ROS detoxification, DNA repai

122 eostasis regulators (ligands), including the unfolded protein response sensor ATF6 and the ER degrada

123 (HSPA6, HSPA1A, DNAJB4, HMOX1), (iii) early unfolded protein response signaling (phospho-PERK, phosp

124 lication by limiting the damaging effects of unfolded protein response signaling in addition to enhan

125 ivation of reactive oxygen species-dependent unfolded protein response signaling is the underlying mo

126 zed acinar cells by suppressing the adaptive unfolded protein response signaling pathway.

127 en at a very low dose, lewisite up-regulates unfolded protein response signaling, inflammatory respon

128 requiring enzyme (IRE)-1 and inhibits their unfolded protein response signaling.

129 null mutants in GRX6 display a more intense unfolded protein response than wild-type cells upon trea

130 nstrated that mitochondria possess their own unfolded protein response that is activated in response

131 uce the activation of 1 of the 3 branches of unfolded protein responses, the inositol-requiring enzym

132 stress - and the activation of the adaptive unfolded protein response to restore homeostasis.

133 We investigated the role of the core unfolded protein response transcription factor X-box bin

134 e, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring

135 n (SIRT)1- and SIRT3-dependent mitochondrial unfolded protein response, triggering an adaptive mitoho

136 1 maintains ER homeostasis by initiating the unfolded protein response (UPR(ER)).

137 these pathways, including the mitochondrial unfolded protein response (UPR(MT)) and mitophagy, are a

138 The mitochondrial unfolded protein response (UPR(mt)) has been associated

139 , which regulates mitochondrial dynamics and unfolded protein response (UPR(mt)) in the host.

140 iptional response known as the mitochondrial unfolded protein response (UPR(mt)) to promote cell surv

141 Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling

142 sfunction is by activating the mitochondrial unfolded protein response (UPR(mt)), a transcriptional r

143 global induction of a mitochondrial-specific unfolded protein response (UPR(mt)), affecting whole-ani

144 riptional program known as the mitochondrial unfolded protein response (UPR(mt)), which includes gene

145 ied a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated b

146 stress-response mechanism, the mitochondrial unfolded protein response (UPR(MT)).

147 the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein response (UPR(mt)).

148 etrograde pathways such as the mitochondrial unfolded protein response (UPR(mt)).

149 his study, we examined the ER stress and the unfolded protein response (UPR) activation in a L5 spina

150 The unfolded protein response (UPR) adjusts the cell's prote

151 ndoplasmic reticulum (ER) elicits a cellular unfolded protein response (UPR) aimed at maintaining pro

152 f and how chronic inflammation regulates the unfolded protein response (UPR) and alters ER homeostasi

153 mediated activation of all three branches of unfolded protein response (UPR) and apoptotic genes.

154 network of key cellular processes including unfolded protein response (UPR) and autophagy in respons

155 scription factor 6A), a key regulator of the unfolded protein response (UPR) and cellular endoplasmic

156 xonal regeneration through regulation of the unfolded protein response (UPR) and cholesterol biosynth

157 induction of the IRE1alpha/XBP1 axis of the unfolded protein response (UPR) and culminating in termi

158 he endogenous mutant GBA orthologs presented Unfolded Protein Response (UPR) and developed parkinsoni

159 ), which is associated with induction of the unfolded protein response (UPR) and disruption of autoph

160 f procollagen I ER export could activate the unfolded protein response (UPR) and drive HSC apoptosis.

161 ormation of GFAP aggregates and induction of unfolded protein response (UPR) and endoplasmic reticulu

162 Here, we show that PLIN2 modulates the unfolded protein response (UPR) and ER stress in pancrea

163 ed the stimulative effect of high glucose on unfolded protein response (UPR) and ER stress, whereas t

164 increases endoplasmic reticulum (ER) stress/unfolded protein response (UPR) and mitochondrial ROS pr

165 causes rapid accumulation of markers of the unfolded protein response (UPR) and subsequently induces

166 ydrogen peroxide, on their ability to induce unfolded protein response (UPR) and their effects on the

167 Autophagy and the unfolded protein response (UPR) both promote activation

168 ith ER stress, eukaryotic cells activate the unfolded protein response (UPR) by increasing levels of

169 Activation of the unfolded protein response (UPR) can be either adaptive o

170 iculum, we investigated the role of the host unfolded protein response (UPR) during L. pneumophila in

171 and protein levels for a subset of the core unfolded protein response (UPR) genes.

172 tivation of the IRE1alpha-XBP1 branch of the unfolded protein response (UPR) has been implicated in m

173 e endoplasmic reticulum (ER) stress response/unfolded protein response (UPR) has been thought to infl

174 n factor that is the central effector of the unfolded protein response (UPR) in budding yeast.

175 on of additional ER pathways that affect the unfolded protein response (UPR) in cell-based models of

176 Antiestrogen therapy induces the unfolded protein response (UPR) in estrogen receptor-pos

177 induces endoplasmic reticulum stress and the unfolded protein response (UPR) in GCs.

178 reticulum (ER) stress and enforce a terminal unfolded protein response (UPR) in OSCC.

179 g to light the distinctive complexity of the unfolded protein response (UPR) in plants.

180 of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in regulating these two

181 The role of the unfolded protein response (UPR) in tissue homeostasis re

182 ulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-fol

183 The Unfolded Protein Response (UPR) indirectly regulates ext

184 n intracellular signaling pathway called the unfolded protein response (UPR) induces a set of transcr

185 The unfolded protein response (UPR) is a cellular adaptive m

186 The unfolded protein response (UPR) is a cytoprotective path

187 The unfolded protein response (UPR) is a shared pathway util

188 The unfolded protein response (UPR) is activated by various

189 The unfolded protein response (UPR) is activated to cope wit

190 Unfolded protein response (UPR) is an adaptive reaction

191 The unfolded protein response (UPR) is an ancient signaling

192 The unfolded protein response (UPR) is an essential cell sig

193 The unfolded protein response (UPR) is essential for physiol

194 Here we show that the physiological unfolded protein response (UPR) is induced in the highly

195 asmic reticulum kinase (PERK) pathway of the unfolded protein response (UPR) is protective against to

196 The unfolded protein response (UPR) maintains protein homeos

197 sed chaperone gene expression, and apoptotic unfolded protein response (UPR) markers, CHOP and Caspas

198 inositol-requiring kinase 1 (Ire1p)-mediated unfolded protein response (UPR) modulated Arl1p activati

199 short-term stress triggers activation of the unfolded protein response (UPR) module that either leads

200 The unfolded protein response (UPR) monitors and adjusts the

201 ith a reduction in the protein levels of the unfolded protein response (UPR) negative master regulato

202 CD40 signaling also inhibits the early unfolded protein response (UPR) of activated B cells tha

203 report that inactivation of SEC63 induces an unfolded protein response (UPR) pathway that is protecti

204 at KDM1A inhibitors induce activation of the unfolded protein response (UPR) pathway.

205 death was associated with activation of the unfolded protein response (UPR) pathway.

206 immunity by suppressing translation and the unfolded protein response (UPR) pathways at the protein

207 Although the unfolded protein response (UPR) plays a major role in ce

208 The unfolded protein response (UPR) regulates endoplasmic re

209 The unfolded protein response (UPR) remediates endoplasmic r

210 A signaling network called the unfolded protein response (UPR) resolves the protein-fol

211 ases, but very little is known about how the unfolded protein response (UPR) responds to persistent E

212 nked to an interaction between DREAM and the unfolded protein response (UPR) sensor activating transc

213 ction of pro-inflammatory cytokines, ROS and unfolded protein response (UPR) signaling activation.

214 to the cell surface and is monitored by the unfolded protein response (UPR) signaling pathway.

215 oted apoptosis in RMS cells by triggering an unfolded protein response (UPR) that induced PRKR-like e

216 investigate whether ASK1 is involved in the unfolded protein response (UPR) that leads to ER stress.

217 animals use a survival pathway known as the unfolded protein response (UPR) that signals between the

218 We have investigated the unfolded protein response (UPR) to endoplasmic reticulum

219 d a set of signaling mechanisms known as the unfolded protein response (UPR) to increase the folding

220 the ER folding capacity, which activates the unfolded protein response (UPR) to restore ER homeostasi

221 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis.

222 endoplasmic reticulum (ER) and activate the Unfolded Protein Response (UPR) to trigger adaptive resp

223 gated the role and mechanism for the primary unfolded protein response (UPR) transducer inositol-requ

224 applied Perturb-seq to dissect the mammalian unfolded protein response (UPR) using single and combina

225 ress response factors, and components of the unfolded protein response (UPR) was observed.

226 is activates an adaptive response termed the unfolded protein response (UPR) whose function is to res

227 in the ER, which leads to activation of the unfolded protein response (UPR), a conserved pathway tha

228 oplasmic reticulum (ER) stress activates the unfolded protein response (UPR), a highly conserved sign

229 Activation of the unfolded protein response (UPR), a homeostatic regulator

230 vage of underglycosylated Msb2p required the unfolded protein response (UPR), a quality control (QC)

231 s to these stimuli is the IRE1 branch of the unfolded protein response (UPR), a sensor of endoplasmic

232 RE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanis

233 es rhodopsin misfolding and induction of the unfolded protein response (UPR), an adaptive ER stress r

234 Here we targeted the unfolded protein response (UPR), an adaptive reaction ag

235 Here, we investigated how the unfolded protein response (UPR), an important cytoprotec

236 doplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibiti

237 position activates the endoplasmic reticulum unfolded protein response (UPR), and UPR signaling effec

238 ERSID without affecting the induction of the unfolded protein response (UPR), but downregulation of P

239 biomodulator, BHPI, which hyperactivates the unfolded protein response (UPR), completely blocked prol

240 translation speed triggers ER stress and the unfolded protein response (UPR), further impairing the g

241 er RNA translation to regulate the mammalian unfolded protein response (UPR), immunity, and memory fo

242 in that is involved in the regulation of the unfolded protein response (UPR), intracellular ion homeo

243 Xbp1, a key mediator of the unfolded protein response (UPR), is activated by IRE1alp

244 changes in diabetes, most significantly the unfolded protein response (UPR), p53, hypoxia-related tr

245 Following activation of the unfolded protein response (UPR), rapid translation of GA

246 ATF6alpha plays a cytoprotective role in the unfolded protein response (UPR), required for cells to s

247 he perinuclear area led to activation of the unfolded protein response (UPR), suggesting that specifi

248 uding the endoplasmic reticulum (ER)-induced unfolded protein response (UPR), the ubiquitin-proteasom

249 signaling pathways, collectively termed the unfolded protein response (UPR), to maintain a productiv

250 This activates the unfolded protein response (UPR), which alters the expres

251 Insults to ER homeostasis activate the unfolded protein response (UPR), which elevates protein

252 ER stress elicits the unfolded protein response (UPR), which enhances the oper

253 genes encoding regulators and targets of the unfolded protein response (UPR), which is a protein qual

254 metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by

255 is is mediated by the rapid induction of the unfolded protein response (UPR), which profoundly reduce

256 The unfolded protein response (UPR), which protects cells ag

257 Here, we identified the beta cell unfolded protein response (UPR), which senses insulin pr

258 nvironment through genetic activation of the Unfolded Protein Response (UPR)-associated transcription

259 Protein translation is inhibited by the unfolded protein response (UPR)-induced eIF-2alpha phosp

260 PERK mediates many of the unfolded protein response (UPR)-induced events, includin

261 and steatosis despite the activation of the unfolded protein response (UPR).

262 iculum (ER) stress and the activation of the unfolded protein response (UPR).

263 athway leading to ER stress and an activated unfolded protein response (UPR).

264 ted caspase 12 activation during an enhanced unfolded protein response (UPR).

265 in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR).

266 lance of unfolded proteins, and a heightened unfolded protein response (UPR).

267 tute potential cross-talk between HD and the unfolded protein response (UPR).

268 cumulation of misfolded protein provokes the unfolded protein response (UPR).

269 mic reticulum (ER) stress and the consequent unfolded protein response (UPR).

270 on the set of genes that is activated by the unfolded protein response (UPR).

271 tion suppressed Tu-induced ER stress and the unfolded protein response (UPR).

272 nism to restore ER proteostasis known as the unfolded protein response (UPR).

273 and activates a signaling network called the unfolded protein response (UPR).

274 ty of the ER, resulting in activation of the unfolded protein response (UPR).

275 ulum (ER) stress and therefore activates the unfolded protein response (UPR).

276 and is consequently limited by an increased unfolded protein response (UPR).

277 effect of iPLA2gamma involves the ER stress unfolded protein response (UPR).

278 ell fate and requires a properly functioning unfolded protein response (UPR).

279 asma cells to bortezomib through an elevated unfolded protein response (UPR).

280 doplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR).

281 vage of HAC1 mRNA following induction of the unfolded protein response (UPR).

282 endoplasmic reticulum and activation of the unfolded protein response (UPR).

283 of a second proteotoxic stress response, the unfolded protein response (UPR).

284 s endoplasmic reticulum stress that leads to unfolded protein response (UPR).

285 ve phosphorylation, vesicle traffic, and the unfolded protein response (UPR).

286 for cell adaptation and survival, named the unfolded protein response (UPR).

287 intracellular signaling pathway known as the unfolded protein response (UPR).

288 that lens-specific mutations that elicit an unfolded-protein response (UPR) in vivo accumulate p27(C

289 ction of CHOP, a transcription factor in the unfolded-protein response (UPR) that is activated during

290 The ability of the unfolded protein response, UPR, to regulate cell homeost

291 The mitochondrial unfolded protein response (UPRmt) is a transcriptional p

292 protein-folding stress, compartment-specific unfolded protein responses (UPRs) within the ER, mitocho

293 bout their capacity to facilitate the cell's unfolded protein response via direct interactions with a

294 r relationship between the activation of the unfolded protein response was established and the onset

295 and MafA Similarly, components mediating the unfolded protein response were decreased in islets of IR

296 subfamily B couples translation rate to the unfolded protein response, which has implications for un

297 ER stress induces the unfolded protein response, which involves activation of

298 aptation, cells engage the ER stress-induced unfolded protein response, which results in PERK/Akt act

299 islets of treated mice showed a more robust unfolded protein response, with increases in Bip and ATF

300 ed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabo