ライフサイエンスコーパス: unifying

1 Here, we propose a unifying abstract model of whisker movement control that

2 The result is a unifying account linking the large literature on view-ba

3 nd motion estimates and provides a rational, unifying account of a number of motion and position phen

4 nfirmed experimentally, supporting a simple, unifying account of how the brain performs object recogn

5 ging set of leukemias, and might represent a unifying Achilles' heel of kinase-driven cancers.

6 summary, our study provides a compelling and unifying allosteric activation mechanism in STKR1 kinase

7 The unifying anatomic theme of these anomalies is the presen

8 e-dependent feedbacks are widely viewed as a unifying and near-universal principle of regular-pattern

9 This unifying approach is illustrated by considering breast c

10 rategy for the use of genomic selection as a unifying approach to deliver innovative 'step changes' i

11 We give a unifying argument for the optimal work in the different

12 al.[5] have suggested that our model is not unifying because it inaccurately predicts perceptual per

13 tation by DCs is complex and without a clear unifying biological underpinning.

14 isease in C9orf72 carriers and may provide a unifying biomarker across diverse anatomical variants.

15 A section on bonding outlines a unifying bonding description that has been proposed as w

16 for potential population stratification and unifying both unrelated and family samples into a more p

17 This two-way communication suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP bindi

18 Our findings may thus provide a unifying cardiac pathophysiology that explains the repor

19 basis we claim to have provided a mechanism unifying categorically distinct perceptual errors.

20 Oxidative stress has been proposed to be a unifying cause for diabetic nephropathy and a target for

21 No unifying cause of catatonia or predisposing conditions w

22 results support the idea of prediction as a unifying cerebellar function in motor and nonmotor domai

23 aluable clues that led to the proposal of a "unifying" chain propagation mechanism beyond initiation,

24 universe and the amazing consequences of the unifying character of physical law.

25 ophage-colony-stimulating factor (GM-CSF), a unifying characteristic in the disease.

26 A unifying characteristic of DNA replication initiator pro

27 Unifying characteristics include unchecked abilities of

28 Using a unifying charge measure to compare energy needed for ele

29 ic manifestations forming a basis for novel, unifying classi fi cations.

30 pands the dynamic range of genetic switches, unifying classical gene regulation by DNA-binding factor

31 There seem to be no unifying clinical characteristics for this pediatric pat

32 Uncontrolled inflammation is a unifying component of many chronic inflammatory diseases

33 hin the orientation domain, and we present a unifying computational model of crowding phenomena that

34 Developing a unifying computational model, we propose that both pheno

35 emistry illustrate the power of the ASM as a unifying concept and a tool for rational design of react

36 We also introduce a new unifying concept called cellular pliancy as a possible e

37 As such, a unifying concept of hsCRP as a downstream surrogate biom

38 pite comprehensive studies addressing PAs, a unifying concept to interpret their molecular role is mi

39 These unifying concepts should eventually enable immune-based

40 Some unifying concepts such as potential energy surfaces, fre

41 ceptual framework of biological theories and unifying concepts, based on an evolutionary perspective,

42 unt of previously collected data, we propose unifying conceptual and mechanistic models of chaperone-

43 e how dynamical systems theory can provide a unifying conceptual framework for evolution of biologica

44 In this review, we propose a unifying conceptual framework for supportive care and di

45 order to illustrate their ubiquity within a unifying context of dynamic oscillations and energy diss

46 glucose production and lipogenesis under the unifying control of FoxO.

47 tionary psychology's potential to serve as a unifying core theory.

48 ward-open and inward-open conformations as a unifying critical step in LeuT-type transporters.

49 that make testable predictions and provide a unifying description of the myriad possible experimental

50 The unifying design principle for these materials is the avo

51 These findings support a unifying diagnosis of congenital hemangioma for these va

52 iples and applications of solid-state NMR by unifying dipolar and quadrupolar interactions and highli

53 amework for conceptualising, quantifying and unifying discordant patterns of species richness along g

54 er of the F-box subfamily lacking a distinct unifying domain) as a miR-21 target gene.

55 d (unlike scale-dependent feedbacks) lacks a unifying dynamical theory, fuelling scepticism about its

56 ocess is biologically heterogeneous, yet one unifying element is the critical role of the microenviro

57 sheds further light on the mechanism of this unifying enzymatic transformation.

58 in (MYOCD) and KLF4, have been identified, a unifying epigenetic mechanism that confers reversible SM

59 the neurulation defects, but also provides a unifying etiology for the broad spectrum of congenital m

60 t of small RNA-based mechanisms identifies a unifying eukaryotic theme.

61 species (RNS), has been proposed as an early unifying event linking the bioactivation of drugs to hep

62 ument for a science of intentional change by unifying evolutionary psychology (EP) with the standard

63 cribe macrophage activation-with the goal of unifying experimental standards for diverse experimental

64 of neural information processing and offer a unifying explanation for contextual phenomena in fields

65 ne the DAT recycling mechanism and provide a unifying explanation for previous, seemingly disparate,

66 ical phenotypes and thus provides a possible unifying explanation for similar findings observed in sp

67 Their findings provide the long-awaited unifying explanation for the diverse phenotypes of the p

68 This work thus provides a unifying explanation for the evolution of specificity in

69 Thus, our findings reveal a potentially unifying explanation for the oftentimes inconsistent rel

70 bind sialic acid and C3b on cells provides a unifying explanation for their association with aHUS.

71 in updating internal models provides a novel unifying explanation for these findings.

72 We propose a unifying explanation of several characteristic features

73 ts in various PRC2 null adult tissues lack a unifying explanation.

74 circadian pathology in bipolar disorder is a unifying explicatory model for the high psychiatric and

75 tools and techniques based on Cas9, a single unifying factor capable of colocalizing RNA, DNA and pro

76 ultiple Ca(2)(+) effectors, PKG emerges as a unifying factor to control multiple cellular Ca(2)(+) si

77 This unifying feature among otherwise widely differing selfis

78 A unifying feature for the two components is Toll-like rec

79 P1 in the regulation of fibrosis, which is a unifying feature of CKD.

80 A unifying feature of many proteins associated with ALS, i

81 The most striking, unifying feature of meiotic clade AAA ATPases may be the

82 and thus can no longer be considered as the unifying feature of POLR3A disease.

83 of neurological disorders (SPG1-71) with the unifying feature of prominent lower extremity spasticity

84 A unifying feature of these tumours are mutations in ATRX.

85 disease, but it is presently not clear what unifying features, if any, these mutants share to make t

86 In addition to these unifying features, symptom profiles also differed among

87 ever, the lack of a conceptual framework for unifying findings across models, combined with host vari

88 died in the last decade, there still lacks a unifying framework able to embrace all the proposed metr

89 This "perimeter release model" provides a unifying framework accounting for developmental changes

90 eview, we synthesize these mechanisms into a unifying framework and introduce a hitherto unappreciate

91 This article describes a unifying framework encompassing Bayesian and reinforceme

92 interactions between motion and position, no unifying framework exists to account for these two key f

93 We propose a unifying framework for characterizing network proximity

94 Here we describe a unifying framework for detecting rich clubs which intuit

95 of first-generation land surface models as a unifying framework for ecophysiological understanding st

96 t the stand or landscape scale may provide a unifying framework for linking plant and microbial commu

97 an abstract conceptual level, it provides a unifying framework for perception, action, and cognition

98 sian brain hypothesis provides an attractive unifying framework for perception, cognition, and action

99 s that proceed via a radical intermediate, a unifying framework for predicting C-H activation barrier

100 of cross-repressive interactions provides a unifying framework for progenitor maintenance, the timin

101 self-regulation in young children provides a unifying framework for the study of school readiness.

102 One of the challenges to a unifying framework for the study of teaching behavior wi

103 nal connectivity streams, offers a potential unifying framework for the unexplained discrepancies in

104 a continuum of these strategies, provides a unifying framework for understanding leaf gas-exchange r

105 Our approach thus provides a unifying framework for understanding warming effects on

106 connectivity abnormalities in autism, but no unifying framework has emerged to date.

107 Our unifying framework may help to better understand control

108 be explained quantitatively within a single unifying framework of branching and annihilating random

109 A unifying framework of how these systems operate is curre

110 ractions, it has been difficult to outline a unifying framework to directly link NP properties to exp

111 pproach is broadly applicable and provides a unifying framework to explain the temporospatial pattern

112 propose that these principles may provide a unifying framework underlying diversity-generating metab

113 We present a unifying framework where these seemingly distinct result

114 multiplex Kuramoto model not only provides a unifying framework, but also has a direct connection to

115 This state diagram provides a unifying framework, compatible with prior experimental a

116 This unifying framework, which reproduces APL, normal progeni

117 k reconstruction with genetic mapping into a unifying framework.

118 s of endpoints or modes-of-action, lacking a unifying framework.

119 ndent movements and space-use lack a general unifying framework.

120 o observed brain activation phenomena into a unifying framework.

121 A unifying function associated with the default mode netwo

122 he framework destabilization hypothesis as a unifying general mechanism for both SOD aggregation and

123 h precise mathematical structure suggested a unifying generative process, as reflected in the title o

124 for the evolution of novelties is a common, unifying goal at the intersection of evolutionary and de

125 Here we show that the framework of this unifying graviproprioceptive model can be readily extend

126 Connections unifying hemispheric sensory representations of vision a

127 We further discuss the role of saliva in unifying host innate immune defenses against C. albicans

128 Our findings reveal a unifying hydrodynamic principle that is likely conserved

129 -Is) supports transient hyperactivation as a unifying hypothesis of abused drugs.

130 sue immunohistochemistry strongly supports a unifying hypothesis of induction of IFN by innate respon

131 ically rotors, is moving the field towards a unifying hypothesis that explains several otherwise cont

132 We propose a unifying hypothesis that reconciles these apparently dis

133 So far, a unifying hypothesis underpinning these pathological even

134 These data support a unifying hypothesis whereby depletion of intracellular c

135 We propose a 'unifying hypothesis' for M1 receptor signalling whereby

136 intracellular calcium dynamics, testing the 'unifying hypothesis' that rundown of inhibitory SK respo

137 professional societies to consider include: unifying implementation science activities through a sin

138 is hypothesis has the potential of providing unifying insights into multiple aspects of autism, with

139 This work yields unifying insights into the role of noise correlations.

140 tand barrier crossing events has served as a unifying intellectual theme connecting the different dis

141 cognitive linguistic (UBCL) theories offer a unifying interpretation of the different (structural vs.

142 ur results thus reveal a conserved mechanism unifying known and newly identified pause events.

143 rgery community is fragmented, does not have unifying leadership, and is missing guiding institutions

144 can ultimately be traced to an absence of a unifying life science standards framework, and (ii) make

145 e competitive network may therefore act as a unifying link between diversity and function, providing

146 holds for all of these cases by developing a unifying mathematical framework that characterizes all o

147 ct, all these approaches are variations of a unifying mathematical machinery - network propagation -

148 mote PAH susceptibility in SSc and provide a unifying mechanism across different forms of PAH.

149 These findings provide a unifying mechanism by which independent pathways affecti

150 ether, these data suggest the existence of a unifying mechanism by which TERT enhances translation in

151 A targeting by the Cmr complex and provide a unifying mechanism for all Type III systems.

152 pment, it remains unknown whether there is a unifying mechanism for development of diverse inhibitory

153 D(+) loss through PARP activation as a novel unifying mechanism for diverse effects of dioxin in vivo

154 uss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across

155 nge the concept that haploinsufficiency is a unifying mechanism for HCM caused by MYBPC3 truncating m

156 TNC upon full reduction, thereby defining a unifying mechanism for oxygen reduction and rapid IET by

157 Our data may provide a unifying mechanism for the association of PPI use with i

158 translocation into double hexamers acts as a unifying mechanism for the establishment of bidirectiona

159 ascular co-option, anti-PA serpins provide a unifying mechanism for the initiation of brain metastasi

160 ies of LaAlO3/SrTiO3 interfaces and reveal a unifying mechanism for the origins of both conductivity

161 epithelial structure, providing a plausible unifying mechanism for the premature delamination and pr

162 We demonstrate that a unifying mechanism for this variation is differences in

163 Together, our data points to a simple unifying mechanism governing the assembly of dual target

164 highlight miR-mediated MCUC dysfunction as a unifying mechanism in PAH that can be therapeutically ta

165 CCND2 mutation or PI3K-AKT activation, is a unifying mechanism in PI3K-AKT-related megalencephaly sy

166 A unifying mechanism is provided to explain the oxidation

167 This work suggests a unifying mechanism of cell uptake and propagation for ta

168 Our results provide evidence for a unifying mechanism of IRE1 activation that relies on unf

169 centrations across C, N, P and S, implying a unifying mechanism of microbial assimilating soil elemen

170 LIN28B, MYCN sponging, or genetic loss is a unifying mechanism of neuroblastoma development with bro

171 We discovered a unifying mechanism that allows GIV/Girdin, a bona fide m

172 For the first time, our studies offer a unifying mechanism that explains both renal and vascular

173 of Ca(2+) signalling in ZG cells provides a unifying mechanism that explains how transiently activat

174 The epigenome might provide the unifying mechanism that translates the influence of envi

175 Fundamentally, there is a unifying mechanism to keep the capsid protein protomer m

176 ulation of mRNA translation is emerging as a unifying mechanism underlying the pathogenesis of many n

177 his study specifically addresses a potential unifying mechanism whereby marijuana could exert rewardi

178 This analysis suggests a new framework for unifying mechanisms for generating OEE with features dis

179 to these pathologies, but there must also be unifying mechanisms underlying polyQ toxicity.

180 n nature and society, hinting at fundamental unifying mechanisms.

181 We thus provide a unifying mechanistic explanation for orientation crowdin

182 Overall, our results provide a unifying mechanistic framework that is consistent with t

183 l data can be represented by this model, and unifying mechanistic information emerges.

184 Further investigation unifying metabolic changes with functional and anatomic

185 Here we present such a unifying methodological and conceptual framework which d

186 a comparison, a major difficulty has been a unifying metric that accounts for experimental limitatio

187 Gpp and/or DksA cannot yet be explained by a unifying model and is specific to individual promoters,

188 ing three primary-sequence motifs, yielded a unifying model defining mammalian pri-miRNAs in which mo

189 Our work presents a unifying model for how PSEN or APP mutations enhance amy

190 Our work provides a unifying model for IDH-mutant gliomas and a general fram

191 We present a unifying model for isoprene emission by photosynthesizin

192 ere, integrated with previous work, led to a unifying model for telomerase subunit assembly and traff

193 Together, our data provide a unifying model for the asymmetric segregation of DNA cir

194 We describe a unifying model for the function of the RNAP TL, which re

195 We propose a unifying model in which the erythroid transcriptional pr

196 ith vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a commo

197 nfirmed experimentally, supporting a simple, unifying model of how the brain performs object recognit

198 y lead to a useful approach to formulating a unifying model of how these phospholipases behave after

199 nd basaltic lava flow fields point towards a unifying model of lava emplacement.

200 to assume memory reconsolidation provides a unifying model of psychotherapeutic change given our cur

201 Hence, we proposed a unifying model of T cell activation by HLA-I/peptide mon

202 knowledge, however, there still is no single unifying model or algorithm that can take all evolutiona

203 Here we develop a unifying model that predicts evolutionary responses to e

204 ontradictory, new results now help to draw a unifying model to explain the many functions of this pro

205 h infects vervet monkeys, our data suggest a unifying model whereby in natural hosts, in which the CC

206 seemingly defies a description with a simple unifying model.

207 ress these limitations, we introduce a novel unifying modeling framework for kinetic descriptions of

208 In summary, a unifying molecular mechanism of CO function relates it t

209 Thus, one unifying molecular mechanism underpinning response to wa

210 The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of man

211 r, our results show that in the absence of a unifying mutation by WES, clonal PCs in AL display pheno

212 y and show many gene mutations but without a unifying mutation.

213 These findings support a unifying NA-TLR-mediated mechanism of autoantibody produ

214 A similar central dogma for guiding and unifying nanoscience has been missing.

215 operiodic concept/framework for defining and unifying nanoscience.

216 We present a unifying neurocognitive framework of mechanisms underlyi

217 e a major challenge to the identification of unifying neuropathological features.

218 se results thus illustrate the potential for unifying nuclease protein delivery with AAV donor vector

219 cluding longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elu

220 reactive and proactive control into a single unifying parameter, while distinguishing action cancella

221 nt models, and strengthen the evidence for a unifying pathogenesis in CNMs via defective membrane tra

222 ns arise in human autoimmune diseases, but a unifying pathogenetic mechanism remains elusive.

223 rganic phosphate, and the findings suggest a unifying pathomechanism relating to reduced inorganic py

224 ouse models and zebrafish highlighting these unifying pathophysiological themes, here we review the c

225 c dysfunction have all been described, but a unifying pathophysiology and mechanism explaining the po

226 sly considered functionally distinct, into a unifying pathway for axonal degeneration.

227 We propose a novel, unifying peptide classification system to emphasize the

228 or the other of the empirical findings and a unifying perspective has been elusive.

229 The framework of criticality provides a unifying perspective on neuronal dynamics from in vitro

230 ces of pathological morphogenesis provides a unifying perspective that may aid in developing new ther

231 s underlying EZH2 function, and synthesize a unifying perspective that the promotion of cancer arises

232 Chronic allostatic load provides a unifying perspective with implications for etiology and

233 ical velocity-weakening friction law under a unifying phenomenological framework applicable to small

234 ical neuroenergetic conditions and provide a unifying physiological basis for these syndromes.

235 These simulations provide a unifying picture explaining existing experimental data f

236 with metal-oxide catalysts, thus providing a unifying picture for the two realms of water oxidation c

237 Our result points to a unifying picture in which these two phenomena are preced

238 arged) as the key parameter for presenting a unifying picture of the depolarization process.

239 Here we present systematic experiments and a unifying picture of these processes, based on our extens

240 Thus GIV-GEF serves as a unifying platform for integration and amplification of a

241 This exercise illustrates the unifying power of physics and the profound connections b

242 arly and late stages of disease progression, unifying previous work in the field.

243 There are, however, unifying principles and approaches that enhance the like

244 ther reactions are treated as well, and some unifying principles are outlined.

245 otides during DNA replication, provides some unifying principles as to how multidomain proteins assem

246 The unifying principles behind choices in various domains ar

247 and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely un

248 ding, infectivity, and strain dependence are unifying principles of neurodegenerative disease.

249 motifs or other sequence properties, no such unifying property of SM-responsive targets was discernib

250 g have been proposed but none has served the unifying purpose of defining a molecular target that can

251 We show that the model provides a unifying quantitatively consistent account of a variety

252 We illustrate this proposition by unifying recent findings from different research themes

253 A unifying result is that the largest 5% of leaks typicall

254 No single unifying risk factor has been identified.

255 g pathophysiology hypothesis by suggesting a unifying role of dysregulation in neuronal excitability

256 it has had limited scope in an area with few unifying rules.

257 l control of dialkyne systems and provides a unifying strategy for chemoselective CuAAC ligations in

258 ane of the parasite, represents a unique and unifying structure characteristic to all organisms belon

259 gy that has resulted in the development of a unifying synthesis of one C18 (weisaconitine D), one C19

260 re special motifs, yet generally providing a unifying systematic classification of local structure ar

261 ive their formation, possibly justifying the unifying term "droplet organelle".

262 read of signal amplification, leading to the unifying term 'amplified pain syndromes'.

263 The unifying term for the syndrome-paroxysmal sympathetic hy

264 ropose the term procoagulant platelet as the unifying terminology.

265 Unifying the fields of catalysis is the key to achieving

266 that generate variation is a common pursuit unifying the life sciences.

267 d as a freely available, open-source library unifying the mechanisms of reading and writing image dat

268 l practice is discussed, along with a theory unifying the role that biology and mechanics play in imp

269 n engagement of nascent RNA is emerging as a unifying theme among both prokaryotes and eukaryotes.

270 We postulate that a potential unifying theme among tumors with the more complex genoty

271 ium that presents dysregulation of mTOR as a unifying theme in a subset of ASDs.

272 ting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biolo

273 sociated aberrant epigenetic regulation is a unifying theme in psychiatric disorders.

274 ry and DNA repair processes, thus offering a unifying theme in understanding the function and useful

275 of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite r

276 This Review discusses unifying themes between promoters and enhancers in trans

277 Finally, we highlight unifying themes with regards to the mechanisms and conse

278 et al. make an important attempt to create a unifying theoretical framework for the neuroscientific s

279 The present work provides a robust, unifying theoretical framework for understanding the det

280 We have developed a unifying theoretical framework that allows us to model b

281 their disciplinary boundaries, for lack of a unifying theoretical framework.

282 Scaling laws underpin unifying theories of biodiversity and are among the most

283 Our results provide a unifying theory for understanding the expression mechani

284 These findings support a unifying theory in which kidney injury and inflammation

285 views of the function of PMBS, and suggest a unifying theory in which PMBS indexes the confidence in

286 on and Natural Selection the essentials of a unifying theory of adaptation that remains robust today

287 Here, we offer a unifying theory of context effects on incentive value at

288 Here, we propose a unifying theory of OFC function.

289 We also show and explain that the unifying theory of thermal convection originally develop

290 We develop a unifying theory which links the dynamics of our model to

291 ffects on action and cognition, we suggest a unifying theory.

292 ypic driver of BCR -ABL1-negative MPNs and a unifying therapeutic target.

293 By unifying these novel observations with insights from mon

294 We propose a model unifying these observations in which ManLMN is a versati

295 Here we provide a mechanistic link unifying these two features.

296 al behavior is evolutionarily viable, yet no unifying treatment exists of the psychological decision-

297 A unifying treatment is presented for the steady state qua

298 transport may represent a convergence point unifying two prominent working models for the developmen

299 neral mathematical framework that provides a unifying umbrella to relate fundamental and effective (o

300 f Pauling, Weiss, and McClure/Goddard into a unifying view of O2 bonding, tuned toward reversible oxy