ライフサイエンスコーパス: unintended

1 and also on the actual harm caused-even when unintended.

2 actor's harm was intentional; when harm was unintended, a temporoparietal-medial-prefrontal circuit

3 that any drug with a bitter taste could have unintended actions in the body through stimulation of ex

4 he immune system are critical for preventing unintended activation of immune cells.

5 Failure to prevent this unintended activation raises the risk of developing exag

6 their targets, increasing the likelihood of unintended acute or chronic toxicity.

7 measure must have little chance of inducing unintended adverse consequences.

8 outcomes, but many expressed concerns about unintended adverse consequences.

9 r treatment period, but there were also some unintended adverse consequences.

10 se effects are often complex and can include unintended adverse effects.

11 Because antimicrobials can have unintended adverse health and environmental impacts, the

12 t as an ingredient, this is not the case for unintended allergen presence (UAP).

13 population restricts the advice on levels of unintended allergenic foods which should trigger precaut

14 is used to warn consumers of the presence of unintended allergens, but the lack of agreed allergen th

15 Such unintended alterations can confound interpretation of ex

16 aternal and child health problems, including unintended and adolescent pregnancy and family planning;

17 I also cover unintended and adverse consequences for the field, inclu

18 This research shows the potential for unintended and negative consequences of climate change m

19 taining conserved internal proteins may have unintended and negative consequences on the ability to i

20 rtunately, this success has been tempered by unintended and often devastating cardiac complications a

21 n gemcitabine resistance and point toward an unintended and undesired effect of chemotherapy.

22 Unintended anthropogenic deposition of sulfur (S) to for

23 nique hepatic immune physiology and provides unintended benefits for allografts by modulating various

24 For all other scenarios, an unintended bias is introduced with respect to the primar

25 etrospective epidemiologic studies; however, unintended biases may exist when analysis is performed b

26 nets of nucleic acid chemistry; however, the unintended binding of closely related sequences limits t

27 the potential for environmental release and unintended biological exposures.

28 of toxic catalysts, and side reactions with unintended biomolecules.

29 TS) caused by loss-of-function mutations, or unintended blockade of hERG1 channels by many drugs, can

30 n using our arms to interact with the world, unintended body motion can introduce movement error.

31 n using our arms to interact with the world, unintended body motion can introduce movement error.

32 alance control system attempting to minimise unintended body motion, while the later response arises

33 An upgrade with ozonation may lead to unintended bromate formation in bromide-containing waste

34 f autoimmune and vasculitic diseases through unintended but detrimental bystander damage resulting fr

35 The unintended but potentially profound consequences of infr

36 uggested that those compounds were formed as unintended byproducts.

37 Secondary outcomes included unintended cardiovascular interventions and right ventri

38 rovides a noninvasive method for probing the unintended cellular affects of these dyes.

39 , the interception of their vocalizations by unintended cetacean receivers may be particularly import

40 d the interception of their vocalizations by unintended cetacean receivers may trigger anti-predator

41 crease in forest cover is capable of driving unintended changes in circulation and precipitation.

42 mic-scale defects, structural distortion and unintended chemical functionalization, leading to unpred

43 were firmly established appears to have had unintended clinical consequences.

44 e minimal CRY2 homo-oligomerization to avoid unintended complications, while those utilizing CRY2-CRY

45 ng has been used to assess the potential for unintended composition changes in potato (Solanum tubero

46 However, perturbing pathways may have unintended confounding effects, which must also be addre

47 an be a primary goal (cow dung mixing) or an unintended consequence (anaerobic digesters).

48 The unintended consequence in which genetic diseases are unw

49 nt principle guiding organ donor testing, an unintended consequence may be an increase in deaths on t

50 An unintended consequence of DDR attenuation during infecti

51 An unintended consequence of global change is an increase i

52 Whether readmission reductions have had the unintended consequence of increasing mortality after hos

53 the basis of MELD score may have yielded the unintended consequence of increasing rates for living do

54 itation of calcite by degassing CO2, had the unintended consequence of providing insight into a poten

55 d coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogeni

56 and export of nitrogen from large lakes, an unintended consequence of single-element management that

57 This finding indicates an unfortunate and unintended consequence of the gendered naming of hurrica

58 This unintended consequence of the new regulations has meant

59 ductions in biennial mammography might be an unintended consequence of the updated guidelines.

60 The unintended consequence of this functional program is hig

61 tionships with peers and staff largely as an unintended consequence of trying to have a life in the n

62 assumption that head movements are simply an unintended consequence of undulation, existing only beca

63 The unintended consequence resulted from macrophage-like fet

64 As an unintended consequence, this ecological strategy of the

65 world, increases in wealth have produced an unintended consequence: a rising sense of time scarcity.

66 results can be used to anticipate potential unintended consequences and develop design pathways that

67 These efforts could have unintended consequences and increase overall surgical ep

68 taldehyde, however this approach can lead to unintended consequences due to the generation of reactiv

69 rationale for targeting these cytokines, the unintended consequences for host defense and tumor surve

70 , particularly pay for performance, may have unintended consequences for safety-net institutions cari

71 that these aberrant integrations might have unintended consequences in HIV-1-infected patients who a

72 cipating failure is useful, and anticipating unintended consequences is visionary.

73 ght some of the problems, contradictions and unintended consequences of a divergence between patient

74 lenges in measuring it and by concerns about unintended consequences of aggressive hypertension treat

75 There are benefits but also unintended consequences of antimicrobial and infection p

76 or external quality reporting, including the unintended consequences of clinician veto and clinical a

77 th advance functional design and to minimize unintended consequences of CNTs.

78 gs to Medicare and highlighting the possible unintended consequences of coverage decisions.

79 negative effects of alert fatigue, potential unintended consequences of efforts to reduce alert fatig

80 Policy actions are required to counter the unintended consequences of reduced depression treatment.

81 Unintended consequences of secondary prevention include

82 ting the substantial drawbacks and potential unintended consequences of the measure that could advers

83 s a benchmark for measuring potential future unintended consequences of the metric.

84 Unintended consequences of this included loss of toleran

85 understand metabolic activity, highlight the unintended consequences of xenobiotics, and suggest that

86 Few studies measured potential unintended consequences or adverse effects.

87 PGR) should be carefully weighed in light of unintended consequences related to perturbed neurobehavi

88 fornia winegrowing regions and points to the unintended consequences that agricultural S use may have

89 ntives that reward low HAI rates can lead to unintended consequences that can compromise medical care

90 Our data illustrate the unintended consequences that can result from agricultura

91 modulation of host immunity has intended and unintended consequences, both advantageous and disadvant

92 on, including the societal benefits and also unintended consequences, including increased costs.

93 n a boon to education and research, but with unintended consequences, including the misrepresentation

94 en generic microbiome manipulations may have unintended consequences, rendering them ineffective or e

95 that the proposed policy will have negative unintended consequences, that there are legal barriers t

96 nerally not comprehensive and are subject to unintended consequences, that there is little to no conn

97 boosting rates may introduce a new regime of unintended consequences, wherein the unvaccinated bear a

98 olicy changes could trigger a broad range of unintended consequences, with profound and lasting impli

99 e yielded disappointing results and can have unintended consequences.

100 obalisation may be worthy--but may also have unintended consequences.

101 sustainable water strategies and help avoid unintended consequences.

102 ior to widespread adoption to prevent future unintended consequences.

103 d for human interventions that may come with unintended consequences.

104 s must account for such interactions or risk unintended consequences.

105 ately evaluate impacts and avoid significant unintended consequences.

106 aluate the impacts of the industry and avoid unintended consequences.

107 arefully vetted (and monitored) for possible unintended consequences.

108 owever, these programs may lead to potential unintended consequences.

109 al quality assessment efforts may have major unintended consequences.

110 ion of shifting water demands can help avoid unintended consequences.

111 cic surgeons who associate this with several unintended consequences.

112 increased in all mesocosms, indicating that unintended contamination may result from disposal in ana

113 tices must be followed to identify and track unintended contamination with the target analytes during

114 y specific between cognate partners to avoid unintended cross-talk.

115 nvolved must be regulated, however, to avoid unintended damage to chromosomes.

116 to better understand the best ways to avoid unintended damage when ablating near thermally sensitive

117 le convergence protects bystander cells from unintended death by promoting polarized secretion of sol

118 Immediately following the 2003 advisory, unintended declines in case finding and non-selective se

119 bolites by GC-MS revealed other significant (unintended) differences between SGT lines and the WT, bu

120 luding probing about partnership separation, unintended disclosure, gender-based violence, and stigma

121 resent drug-signaling pathways to understand unintended drug actions and to facilitate drug discovery

122 is approach may limit opportunities to grasp unintended drug actions, which can open up channels to r

123 lt in efficient drugs for complex disorders, unintended drug promiscuity has detrimental contribution

124 ally used to achieve solubility can have the unintended effect of causing protein denaturation.

125 Step therapy may have the unintended effect of reducing overall antidepressant use

126 ologic response and potentially result in an unintended effect.

127 Unintended effects for patients may include decreased pa

128 in order to take into account unexpected and unintended effects of (novel) processing, and to possibl

129 patients and clinicians need to be aware of unintended effects of intervention.

130 ice setting and the costs and possibility of unintended effects of its implementation.

131 te-specific DNA methylation and minimize the unintended effects of off-target DNA methylation.

132 antibiotics and Cesarean sections, may have unintended effects on babies.

133 , and a multitude of other ailments may have unintended effects on bone cell populations.

134 s study shows that fluorescent dyes can have unintended effects on cellular metabolism and care shoul

135 Blocking all endocytic trafficking can have unintended effects on other receptors as well as give ri

136 Unintended effects on provider behavior include measurem

137 spond to economic crises have pronounced and unintended effects on public health, yet public health v

138 Unintended effects on resource utilization include effec

139 There were no reported unintended effects or adverse events in either group.

140 Results indicated that unintended effects resulted from transgene flow fell wit

141 d to food-based voucher transfers could have unintended effects, and their use needs to be carefully

142 intended increases in GHG emissions or other unintended effects.

143 portant to document the nature and extent of unintended effects.

144 greater agricultural output while minimizing unintended environmental consequences is critical in the

145 The IGSM is also used to elucidate potential unintended environmental consequences of renewable energ

146 motivated by the need to address decades of unintended environmental pollution and human health impa

147 Also, the unintended establishment of Wolbachia at the introductio

148 t metabolites in food crops could present an unintended exposure route to consumers.

149 Unintended exposure to teratogenic compounds can lead to

150 ls becomes more prevalent, the likelihood of unintended exposure to these materials also increases.

151 However, in contrast to (99m)Tc-MAA, an unintended extrahepatic deposition of this beta-emitting

152 e implement measure to attenuate the risk of unintended extubation in patients receiving neuromuscula

153 hereas the glycemic response does; and 3) an unintended focus on the GI for food selection could lead

154 that apparent toxicity results may be due to unintended free wrapping agents such as polyelectrolytes

155 However, the possibility of unintended genome editing occurring through the escape o

156 ing population and that the establishment of unintended GRNs is common to virtually every cellular en

157 presented neurally, but little asks how even unintended harms influence judgment.

158 tate often trumps the effect of emotions, as unintended harms may go unpunished, regardless of their

159 The unintended health consequences of various forms of regul

160 s combined with typical food intake may have unintended health consequences, although this would requ

161 mmunities and raises concerns about possible unintended health effects.

162 t is also a source of cardiotoxicity because unintended hERG inhibition by diverse pharmaceuticals ca

163 ystem increased by 75%, and median number of unintended hospitalization days fell by 31%.

164 that cell wall modifications can indeed have unintended impacts on plant defense, but these are not a

165 This may lead to the unintended implantation of a revision prosthesis into an

166 ements about a few nutrients, with sometimes unintended implications for science, industry, and the p

167 These findings suggest that HC use may have unintended implications for women's close relationships.

168 Less than half (45%) of pregnancies were unintended in 2011, as compared with 51% in 2008.

169 ever, selection for disfavoured CPs leads to unintended increases in CpG and UpA dinucleotide frequen

170 ns should be taken to reduce the potentially unintended increases in GHG emissions or other unintende

171 e cycle perspective and if it will result in unintended increases in impacts to air and water quality

172 esult from differences in strain background, unintended indirect effects of the gene targeting, or th

173 swapped, or contaminated or if they include unintended individuals.

174 ndicated by genome-wide profiling that shows unintended induction (by GEV) of only a few dozen genes.

175 heterogeneous nature of tumor tissue and the unintended induction of muscle contractions.

176 However, the RVPA shunt group had more unintended interventions (P=0.003) and complications (P=

177 Unintended intraoperative awareness, which occurs when g

178 he possibility to resume the clinical use of unintended Kv11.1 blockers via pharmacological combinati

179 the reaction cell assembly, greatly reducing unintended light exposure that reduces the sequence fide

180 Unintended listeners, or eavesdroppers, can intercept th

181 on to the expected cross-coupled product, an unintended major product was generated.

182 (4) Could unintended medical harm result from overzealous interven

183 through specific or non-specific binding to unintended membrane protein targets.

184 However, identification of unintended modifications, owing to the genetic modificat

185 ed pluripotent stem cell clones with minimal unintended modifications.

186 solution with an efficiency of >40%, without unintended mutagenic changes at the targeted genetic loc

187 Furthermore, unintended mutations can also result from NHEJ-mediated

188 Unintended negative consequences of advance directive le

189 nce resilience and sustainability, and avoid unintended negative consequences of policy actions.

190 These findings highlight the unintended negative consequences of supplemental folic a

191 ations has many benefits, our results reveal unintended negative consequences.

192 standards for guideline development have had unintended negative consequences.

193 grain products in the United States may have unintended negative consequences.

194 Here we report an unintended negative effect of this strategy.

195 One of the unintended nitrogen (N)-loss pathways from cropland is t

196 eterious type of DNA damage, often result in unintended nucleotide insertions/deletions (indels) via

197 use as therapeutic agents can be hampered by unintended off-target effects by either or both strands

198 of the Src family kinases, which may lead to unintended off-target effects.

199 ansgenic expression of enzymes can result in unintended off-target metabolism arising from enzyme pro

200 LNA, hepatotoxicity can occur as a result of unintended off-target RNase H1 dependent RNA degradation

201 ently imperfect, generating large amounts of unintended off-target sequence.

202 However, the siRNA guide strand may bind unintended off-target transcripts via partial sequence c

203 t sequence homology to the target site, thus unintended off-targets might additionally be cleaved.

204 Discovering the unintended 'off-targets' that predict adverse drug react

205 ic targets for drug-like molecules, or their unintended 'off-targets' that predict adverse drug react

206 Reports, without data, have warned of unintended or harmful consequences of ECG screening.

207 resulting in the evolution of products with unintended or suboptimal function.

208 dispersion and also illuminates potentially unintended or unanticipated effects of varying dendrimer

209 An unintended outcome was observed in the FFV arm: a negati

210 re of prophylactic interventions can lead to unintended outcomes where "less (intervention) is more (

211 ntation, enhanced explanation of desired and unintended outcomes, and better description and measurem

212 l, and to track their impact on intended and unintended outcomes.

213 endogenous or exogenous stimuli can lead to unintended pathology.

214 g-lasting APs and guard the membrane against unintended perturbation.

215 Congenital HERG mutations or unintended pharmaceutical block of I(Kr) can lead to lif

216 Here, we show that an unintended point mutation in the agr P2 promoter of S. a

217 uses on two aspects of polypharmacology: (1) unintended polypharmacology can lead to adverse effects;

218 However, two unintended potential harms of such approaches are medica

219 ffers an unprecedented opportunity to reduce unintended pregnancies among adolescents because it is h

220 alth care could help millions of women avoid unintended pregnancies and ensure access to safe abortio

221 ivate and inform efforts to help women avoid unintended pregnancies and to monitor progress toward th

222 Approximately half of unintended pregnancies are due to contraceptive failure,

223 contraceptive methods as a means of reducing unintended pregnancies in our region.

224 rier methods, might have led to increases in unintended pregnancies in women using modern methods.

225 ned substantially between 2008 and 2011, but unintended pregnancies remained most common among women

226 Adolescents have higher rates of unintended pregnancies than any other age group.

227 The percentage of unintended pregnancies that ended in abortion remained s

228 and girls 15 to 44 years of age, the rate of unintended pregnancies that ended in birth declined from

229 Emergency contraception can prevent unintended pregnancies, but current methods are only eff

230 included in this analysis, we identified 334 unintended pregnancies.

231 t 20 years, merely by reducing the number of unintended pregnancies.

232 ed week 48 levonorgestrel concentrations and unintended pregnancies.

233 Rates of unintended pregnancy among those who were below the fede

234 The rate of unintended pregnancy among women and girls 15 to 44 year

235 Measures to reduce the incidence of unintended pregnancy and unsafe abortion, including inve

236 t sexually transmitted infections (STIs) and unintended pregnancy are a global health priority.

237 owed between 2008 and 2011; the incidence of unintended pregnancy declined by more than 25% among gir

238 sible contraceptive (LARC) methods to reduce unintended pregnancy in the St.

239 evious period of minimal change, the rate of unintended pregnancy in the United States declined subst

240 The rate of unintended pregnancy in the United States increased slig

241 The rate of unintended pregnancy in the United States is much higher

242 ation subgroups, disparities in the rates of unintended pregnancy persisted but narrowed between 2008

243 Unintended pregnancy remains a serious public health cha

244 were less than 21 years of age had a risk of unintended pregnancy that was almost twice as high as th

245 Rates of unintended pregnancy were similarly low among participan

246 and HSV-2), and levonorgestrel (LNG; targets unintended pregnancy).

247 ucational level, and history with respect to unintended pregnancy, 21.8; 95% confidence interval, 13.

248 y transmitted infections, including HIV, and unintended pregnancy.

249 f HIV, HSV-2 and HPV acquisition, as well as unintended pregnancy.

250 ased risk of HIV-1 acquisition) and prevents unintended pregnancy.

251 e health and in particular the prevention of unintended pregnancy.

252 unicate the possibility of reaction from the unintended presence of allergens in foods.

253 y contain' labelling to address the issue of unintended presence of allergens; these therefore need t

254 The use of PAL should indicate the possible, unintended presence of an allergen in a consumed portion

255 containment strategies are needed to prevent unintended proliferation of GMOs in natural ecosystems.

256 as they indicate that such tagging can cause unintended protein destabilization and concomitant effec

257 rporate mental health elements to counteract unintended psychological effects.

258 d to variations in race and its influence on unintended race-based attitudes and decisions.

259 between free V1 and Vo functions to prevent unintended reassembly of holo V-ATPase when activity is

260 ilize novel ground states yet can also cause unintended reconstructions in devices.

261 ons of Caucasian descendants has resulted in unintended reduction of power in studying non-Caucasians

262 Unintended release during production may have caused acc

263 vely impact (micro)biological receptors upon unintended release is its unique property of mediating t

264 Unintended release of CO(2) from carbon sequestration re

265 of environmental contamination caused by the unintended release of heavy fuel oil (HFO).

266 er the potential ecological impacts of their unintended release to the environment.

267 ilability, health effects (both intended and unintended), research and development investments, quali

268 integrated approaches, mindful of potential unintended results, are needed to ensure sustained, worl

269 sclerosis, although these have come with the unintended risk of PML.

270 medications that block hERG1 channels as an unintended side effect also increase arrhythmic risk.

271 term solutions exist to resolve this serious unintended side effect of radiotherapy.

272 Transgene insertions might have unintended side effects on the transgenic host, both cro

273 e along a thin ferromagnetic film as well as unintended side effects which hinder an unambiguous dete

274 shape control of nanomaterials and reducing unintended side effects.

275 ict the activity of 656 marketed drugs on 73 unintended 'side-effect' targets.

276 ts of RMTg bicuculline infusions were due to unintended spread of drug to the nearby VTA was falsifie

277 nded pharmacologic target (type A ADR) or an unintended target (type B ADR).

278 ly reported sequence-dependent regulation of unintended targeting by siRNAs.

279 h the potential for activating or inhibiting unintended targets (repurposing or repositioning).

280 ary mitochondrial diseases and are often the unintended targets of various clinically useful antibiot

281 however, simultaneously increase affinity to unintended targets with partial sequence complementarity

282 hat can result from covalent modification of unintended targets.

283 ance of cross-reactivity against epitopes in unintended targets.

284 of the target transcripts, but not of other unintended targets.

285 RECENT FINDINGS: Unintended teen pregnancies impose potentially serious s

286 nes encoding drug targets, both intended and unintended, that comprise pharmacodynamics.

287 erre Allain and colleagues argue that, while unintended, the foreign aid provided for blood transfusi

288 Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental i

289 of leukocyte activation is critical to limit unintended tissue injury during acute inflammation.

290 tion of trocars, needles, and catheters into unintended tissues or tissue compartments results in hun

291 activation of drinking water, while limiting unintended toxic consequences.

292 However, their unintended toxicity to biological organisms and its mech

293 patotoxic LNA ASOs, while the levels of many unintended transcripts were reduced in mice treated with

294 down of human HTT and minimized silencing of unintended transcripts.

295 lix P of the fingers domain, coupled with an unintended translational termination-reinitiation (split

296 ion (IMO) regulations are concerned with the unintended transportation of pathogenic bacteria through

297 To evaluate whether this unintended use of the NAS is valid, biopsy and clinical

298 ntification of approved drugs for originally unintended uses.

299 Intervention-generated inequalities are unintended variations in outcome that result from the or

300 Unintended weight loss is a hallmark of Huntington disea