ライフサイエンスコーパス: unitary conductance

1 ncentrations, and the modest increase in the unitary conductance.

2 ovalent-specific cation channel with a 23 pS unitary conductance.

3 er because of a smaller open probability and unitary conductance.

4 ) to more negative potentials, and decreased unitary conductance.

5 stinguished by their fast kinetics and large unitary conductance.

6 -channel open probability but did not change unitary conductance.

7 lo-alpha channels 3.3-fold without affecting unitary conductance.

8 ) channel open probability without affecting unitary conductance.

9 e presence of ATP and cGMP without affecting unitary conductance.

10 and NR2 leads to the appearance of a smaller unitary conductance.

11 from KIR6.2 channels mainly by their smaller unitary conductance.

12 annel open probability without affecting the unitary conductance.

13 significant effect on mean open lifetime or unitary conductance.

14 the +3 channel has the highest time-averaged unitary conductance.

15 to larger conductances rather than altering unitary conductance.

16 POPG increases both the open probability and unitary conductance.

17 increased chloride permeability and reduced unitary conductance.

18 lectivity, low Cs(+) permeability, and small unitary conductance.

19 e distal half of the N-terminus controls the unitary conductance.

20 channel long-closed states without modifying unitary conductance.

21 rences in transjunctional voltage gating and unitary conductance.

22 uppress cumulative inactivation and increase unitary conductance.

23 ter single-channel gating characteristics or unitary conductance.

24 ity and relatively little, if any, effect on unitary conductance.

25 obability of Kv7.4 channels without changing unitary conductance.

26 ctivity and permeation properties, including unitary conductance.

27 onstant is similar for channels of different unitary conductances.

28 g agents, allowing identification of 4 major unitary conductances.

29 de, different ion selectivities, and diverse unitary conductances.

30 Unitary conductance (140 mM [K+]o) was also little affec

31 sitive alpha7-containing nAChRs have a small unitary conductance (18 pS), brief open time kinetics an

32 l littermate mice there were three principal unitary conductance - 22 pS, 111 pS and 178 pS.

33 Cell-attached recordings revealed three unitary conductances: 5 to 6 pS, 10 to 12 pS, and 20 to

34 ntent of the MT channel sets the gradient in unitary conductance along the cochlea.

35 nnels with a similarly broad distribution of unitary conductance amplitudes are also observed in reco

36 actin filaments caused a 2-fold decrease in unitary conductance and a 2-fold increase in open probab

37 tes, can result in a threefold difference in unitary conductance and alter the direction and amount o

38 llular N-terminus substantially increase the unitary conductance and cation selectivity of the chimer

39 TRPC1 subunits are important in determining unitary conductance and conferring channel activation by

40 Receptors lacking the N1 CTDs had larger unitary conductance and faster deactivation kinetics, re

41 PsChR exhibited approximately 3-fold higher unitary conductance and greater relative permeability fo

42 s of the protein, that when mutated, affects unitary conductance and ion selectivity, and modulates p

43 divalent cations have marked effects on the unitary conductance and kinetic behaviour of non-selecti

44 atches of rabbit portal vein myocytes with a unitary conductance and kinetic properties that are simi

45 Unitary conductance and maximum open probability were un

46 PKP2 deficient mice, but the K(ATP) channel unitary conductance and nucleotide sensitivities remaine

47 ever, cholesterol level had no effect on the unitary conductance and only little effect on the open p

48 at synapses, channels with an unusually low unitary conductance and open-channel noise.

49 e substitutions at the 5th position decrease unitary conductance and produce a non-selective channel

50 strate a site contributing to rectification, unitary conductance and proton sensitivity in these Kir

51 ate that TRP-dependent channels have a small unitary conductance and that many channels can be gated

52 + channel, albeit partially, to decrease the unitary conductance and to stabilize the open conformati

53 lar interactions in the establishment of the unitary conductance and voltage-dependent profile of Cx4

54 248 of Cx40 yielded a chimeric channel with unitary conductance and voltage-gating profile indisting

55 pore of the channel depending on the state, unitary conductances and gating properties of each hemic

56 K(+) ions over Na(+) ions, generate a large unitary conductance, and are only weakly voltage depende

57 terized by exquisite Ca(2+) selectivity, low unitary conductance, and low permeability to large catio

58 mbination of weak voltage sensitivity, small unitary conductance, and permeation by anions as large a

59 (69 amino acids long) in the control of the unitary conductance, and role of the alternative transla

60 KCNKO exhibits concentration-dependent unitary conductance, anomalous mole fraction behavior, a

61 The unitary conductance ( approximately 250 pS; 220/20 mM Cs

62 ce for cations over anions, yet have a large unitary conductance (approximately 300 pS) and a relativ

63 ectified, K+-specific current with a 10.8 pS unitary conductance at -100 mV.

64 The unexpectedly high unitary conductance at low salt concentrations can be ex

65 alysis was applied to estimate AMPA-receptor unitary conductance before and after LTD induction in a

66 The K(ATP) channel unitary conductance, block by MgATP and activation by Mg

67 This manipulation did not modify unitary conductance, but decreased the frequency of tran

68 nce of K(+) channel populations with similar unitary conductances, but distinct channel kinetics and

69 eceptor/Cl- channels including open time and unitary conductance changed independently of the presenc

70 G-evoked channel activity, with no change in unitary conductance, channel mean open times or burst du

71 The unitary conductances, channel kinetics, and other charac

72 displaying voltage dependence, kinetics, and unitary conductance characteristic of native T-type Ca2+

73 x37 yielded a chimera channel with increased unitary conductance close to that of Cx37.

74 cell-attached patch clamp showed comparable unitary conductance, current-voltage data, and open prob

75 -15 pS (n = 15 cell pairs); despite this low unitary conductance, Cx36 channels were permeable to the

76 Unitary conductance decreased thus: Ba2+ > Ca2+ (14.5 pS

77 The pores showed an up to 70% reduction in unitary conductance, depending on the length of the inse

78 annels formed in the A7r5 cells display many unitary conductances distinct from homomeric/homotypic C

79 Thus, changes in unitary conductance do not contribute to current upregul

80 average the values fell within the range of unitary conductances estimated previously for synaptic A

81 lthough RyR1 channels exhibited the expected unitary conductance for Cs(+) in bilayer lipid membranes

82 currents in cell-attached patches yielded a unitary conductance for Kir7.1 of approximately 2 pS.

83 l-attached apical membrane patches yielded a unitary conductance for RPE Kir of approximately 2 pS.

84 issociation constant (Ki) for amiloride, and unitary conductances for delta alpha beta gamma-ENaC dif

85 idney (HEK) cells (150 mM external KCl), the unitary conductances form a broad distribution, ranging

86 the density of functional channels and their unitary conductance (from 20 to 11 pS).

87 Cx50D3E gap junction channels showed reduced unitary conductance (gamma(j)) of the main open state, r

88 P(o) x number channels; N) and decreased the unitary conductance (gamma) of BK channels.

89 However, the unitary conductance (gamma) of neuronal somatodendritic

90 was to chart the concentration-dependence of unitary conductance (gamma) to physiological Ca concentr

91 Although the unitary conductance (gamma) was much greater with barium

92 Transfectants revealed maximum unitary conductances (gamma(j)) of 135 pS for Cx26 and 5

93 lpha3beta4)2alpha3-nAChR function [decreased unitary conductance (>/=50%), altered burst proportions

94 The unitary conductances in patches with a single active cha

95 Cation channels with unitary conductance, ion selectivity and Ca2+-dependence

96 BK channels are large unitary conductance K(+) channels cooperatively activate

97 nnels that differ from the homomers in their unitary conductance, kinetic behavior, subcellular local

98 ely 52 pS) and large ( approximately 220 pS) unitary conductance levels.

99 The average maximum unitary conductances measured in KCl were 175 pS (30 mM)

100 Neither the unitary conductance nor the characteristics of the volta

101 atches evoked single channel currents with a unitary conductance of 1.9 pS.

102 ajority of spontaneous cation channels had a unitary conductance of 13 pS and Vr was shifted to +4 mV

103 lysis of sheep Kir2.3 channels showed a mean unitary conductance of 13.1+/-0.1 pS in 15 cells, which

104 ents revealed single-channel activity with a unitary conductance of 137 pS.

105 y activated by Gbetagamma subunits and has a unitary conductance of 16 pS.

106 ening of apamin-sensitive K+ channels with a unitary conductance of 17.0+/-0.2 pS.

107 d folds, LukF and LukS produce a pore with a unitary conductance of 2.5 nS [1 M KCl and 5 mM HEPES (p

108 non-selective cation channel currents with a unitary conductance of 2.6 pS which were not inhibited b

109 Single-channel currents had a unitary conductance of 210 pS, typical of Cx50.

110 was -1.81 +/- 0.2 pA, which corresponds to a unitary conductance of 22 pS.

111 patches spontaneous channel currents with a unitary conductance of 23 pS were observed.

112 jority of spontaneous channel currents had a unitary conductance of 23 pS, reversal potential (Vr) of

113 sensitive single-channel K(+) current with a unitary conductance of 246-pS in freshly isolated corona

114 ed patches, we detected single channels with unitary conductance of 3.2 pS, reversal potential of +72

115 The E158N Kir4.1 mutant had a unitary conductance of 35 pS and a midpoint pH for chann

116 97 elicited single-channel activities with a unitary conductance of 40 pS.

117 tuted taste epithelial membranes: one with a unitary conductance of 40-60 pS, and the other with a co

118 ative potentials and (iii) had an underlying unitary conductance of 43 pS rather than the 12 pS seen

119 a tolbutamide-sensitive channel exhibiting a unitary conductance of 44.1 pS.

120 road anion selectivity and the channel has a unitary conductance of 5-7 picosiemens.

121 a7 antisense treatment is characterized by a unitary conductance of 50 pS and prolonged opening durat

122 luctuations in planar lipid bilayers, with a unitary conductance of 57 pS in 1 M KCl and numerous lar

123 single-channel level, the T6'S mutant has a unitary conductance of 61.7 +/- 5.8 pS, similar to that

124 Single Ca(2+)-activated Cl() channels with a unitary conductance of 7.8 pS were resolved in excised p

125 ll membranes to form channels that exhibit a unitary conductance of 70-100 picosiemens under physiolo

126 mbrane, ATP- and PKA-dependent gating, and a unitary conductance of 8 picosiemens (pS).

127 minor component was attributable to reduced unitary conductance of 8-12 %.

128 mM KCl, the skeletal muscle NMCC exhibits a unitary conductance of ?160 pS and high, voltage-indepen

129 out patches and these channel currents had a unitary conductance of about 2 pS.

130 atches evoked single-channel activity with a unitary conductance of about 23 pS and with similar kine

131 Slack channels rectify outwardly with a unitary conductance of about 25-65 pS and are inhibited

132 In 110 mM Ba(2+), unitary conductance of alpha(1S) is approximately half t

133 ly rectifying K+ (GIRK)1 and GIRK4, and have unitary conductance of approximately 35 pS with symmetri

134 tive to levcromakalim and glibenclamide with unitary conductance of approximately 35pS.

135 re in planar lipid bilayers, with a measured unitary conductance of approximately 4.8 nanosiemens, wh

136 constituted into planar lipid bilayers had a unitary conductance of approximately 50 pS, were highly

137 d(3+) -sensitive Ca(2+) influx channels with unitary conductance of approximately 56 pS.

138 a voltage-dependent K(+) channel that has a unitary conductance of approximately 60 pS.

139 The V140T mutation in Kir1.1 led to a unitary conductance of approximately 70 pS, and the G210

140 d a significant decrease in the synaptic and unitary conductance of CA1 pyramidal neuron GABA(A) rece

141 argazin, we found that the rectification and unitary conductance of channels underlying excitatory po

142 e (V(j)) gating sensitivity, and reduced the unitary conductance of Cx45.6-43N gap junctional channel

143 ting sensitivity, open-closed stability, and unitary conductance of Cx50 gap junction channels.

144 that although cholesterol did not affect the unitary conductance of GIRK2, it significantly enhanced

145 n other experiments, high Mg(2+) reduced the unitary conductance of hCx37 homotypic gap junction chan

146 ver, noise analysis showed that the apparent unitary conductance of kainate-type channels is signific

147 Since the unitary conductance of KCNQ3 is five- to 10-fold greater

148 The unitary conductance of KirNB was 23 pS (155 mM [K(+)](o)

149 Unitary conductance of mCx30.2 hemichannels was approxim

150 mice harboring an Lhfpl5 null mutation, the unitary conductance of outer hair cell mechanotransducer

151 n the synaptic cleft may change the apparent unitary conductance of postsynaptic AMPA receptors.

152 Single gBK channels have a unitary conductance of similar250 pS, and the currents s

153 In 1.5 mM [Ca(2+)](o) the unitary conductance of SOCs was significantly greater in

154 The unitary conductance of the channel underlying I(A) was u

155 ing a subsequent attenuation of the apparent unitary conductance of the channel.

156 ct reflected, at least in part, an increased unitary conductance of the channels underlying the EPSCs

157 The unitary conductance of the channels was sensitive to the

158 gation was found in a separate study for the unitary conductance of the channels.

159 In 3 microM and 100 microM Ca2+o the unitary conductance of the single channel currents was b

160 The unitary conductance of the two splice variants were appr

161 e (V(j)) gating sensitivity, and reduced the unitary conductance of this Cx40E9,13K gap junction chan

162 no-terminal half of M1 replaced retained the unitary conductance of wild-type Cx46.

163 into a planar lipid bilayer revealed a large unitary conductance of ~8.3 nS.

164 however, detect AMPA receptors with apparent unitary conductances of <1 pS in patches from both migra

165 to steady levels roughly proportional to the unitary conductances of 35%, 50%, and 100% that the agon

166 -AM) both evoked channel currents, which had unitary conductances of approximately 2 pS.

167 Three principal unitary conductances of around 18 pS, 118 pS and 185 pS

168 The unitary conductances of F380I, F380Y and wild-type chann

169 the model revealed the relationship between unitary conductances of hemichannels and GJ channels and

170 Unitary conductances of KCNQ2 and KCNQ3 (6.2 and 8.5 pS,

171 ls 0.5; 3), the gating polarity; and 4), the unitary conductances of the gates and their rectificatio

172 abbit sarcoplasmic reticulum with respect to unitary conductance, open dwell times, and responses to

173 ngs showed that acidification did not affect unitary conductance or block the hemichannel but rather

174 eater constitutive activity and no change in unitary conductance or rectification.

175 Indole does not noticeably change the unitary conductance or the mean open duration, however,

176 s oocytes, with no change in mean open time, unitary conductance, or reversal potential, indicating a

177 obability, with no change in mean open time, unitary conductance, or reversal potential; (2) an incre

178 channels formed by these proteins differ in unitary conductance, permeability, and regulation.

179 Cx43 (heterodomain interactions) rescued the unitary conductance profile of Cx40.

180 Unitary conductance properties of I(K1) were unaffected

181 same as those opened by ATP, with respect to unitary conductance, rectification, and permeability of

182 native cardiac IKr channels in their gating, unitary conductance, regulation by potassium, and distin

183 ty (NPo) elicited by capsaicin, although the unitary conductance remained unaltered.

184 The unitary conductance, reversal potential and mean open ti

185 InsP3- and heparin-sensitive channels with a unitary conductance similar to native InsP3Rs.

186 Using weakly coupled pairs, we observed two unitary conductance states: 85 pS (85-90% of events) and

187 Moreover, an increase in the unitary conductance, steady state probability of hemicha

188 efold to fourfold but had no effect on their unitary conductances, suggesting that the increase in ma

189 TRPM4b encodes a cation channel of 25 pS unitary conductance that is directly activated by [Ca2+]

190 First, it increased unitary conductance through individual channels.

191 e, trans-ions and state (and to have a lower unitary conductance): thus, the KCNQ1 mutations alter th

192 verse mutation in Kir1.1 (N171E) reduced the unitary conductance to 27 pS (23 pS in WT Kir4.1).

193 Both drugs diminished BK channel unitary conductance to a degree that paralleled the effe

194 lpha(1C) with P-loops from alpha(1S) reduced unitary conductance to a value intermediate between thos

195 ically, while injecting controlled trains of unitary conductance transients, to electrically mimic na

196 receptor from the motor end plate decreases unitary conductance up to 80%.

197 Two mean unitary conductance values ("lower conductance" and "mai

198 no voltage dependence to their gating, small unitary conductance values and sensitivity to the bee ve

199 res with very long loops (n = 14 and 21) had unitary conductance values close to those of W(7), sugge

200 Moreover, the pattern of unitary conductance values obtained for chimeras in whic

201 attached and inside-out patches with similar unitary conductance values.

202 in detached patches showed similar levels of unitary conductance, voltage, and Ca2+ sensitivity in K(

203 Kv3.4 channels differ from Kv3.4 channels in unitary conductance, voltage-dependent activation, recov

204 Unitary conductance was described by a Langmuir isotherm

205 Unitary conductance was not affected by PIP2.

206 was shifted to more negative values and the unitary conductance was reduced when part of the externa

207 KAK, and AKK channels, and amplitude of the unitary conductances was in all cases not different from