ライフサイエンスコーパス: universally conserved

1 in the peptidyl-transferase center, which is universally conserved.

2 iest steps of this process do not seem to be universally conserved.

3 e mode of ubiquitin recognition might not be universally conserved.

4 op in ribosomal 30 S subunits that is almost universally conserved.

5 the first six of the seven nucleotides being universally conserved.

6 nto hairpin-like structures, have emerged as universally conserved.

7 Receptors assemble into a universally conserved 12-nm hexagonal lattice linked by

8 codon helix in the decoding center using the universally conserved 16S ribosomal RNA bases G530, A149

9 cs, and leads to a model for the role of the universally conserved 16S RNA residues A1492 and A1493 i

10 The universally conserved 16S rRNA base A1493 and the kink i

11 tions in the decoding center by mutating the universally conserved 16S rRNA bases G530, A1492, and A1

12 In particular, universally conserved 23S ribosomal RNA bases U2492, C25

13 Valine tRNA having the universally conserved 3'-terminal adenosine replaced by

14 A single universally conserved A (number 2451) within the central

15 cross-linking to 23 S rRNA was mapped to the universally conserved A-2602.

16 talling, is in the immediate vicinity of the universally conserved A2062 of 23S rRNA.

17 All three base changes at the universally conserved A2451 conferred a dominant lethal

18 The universally conserved A272 is essential for the formatio

19 ivating protein that catalytically removes a universally conserved adenine from the alpha-sarcin/rici

20 me inactivating proteins (RIPs) depurinate a universally conserved adenine in the alpha-sarcin/ricin

21 e structural and biochemical features of the universally conserved adenine residue A2451 in 23S ribos

22 Both mutations affect universally conserved amino acids in domains of actin th

23 Most of these adenosine positions are universally conserved among all bacterial RNase P RNAs;

24 coli enzyme (Glu1153 in hamster CAD) and is universally conserved among CPSases.

25 nactivating factors and/or pathways that are universally conserved among eukaryotic organisms.

26 ologs characterized in this study are almost universally conserved among filamentous cyanobacteria, w

27 single-amino-acid substitutions to residues universally conserved among NNS RNA virus L proteins, we

28 Here we address whether this pathway is universally conserved among primate lentiviruses and can

29 However, the mechanism is not universally conserved among the gamma subdivision member

30 Amino acid residues Thr45, which is universally conserved among the small RNA phages, and Th

31 rally characterized in tRNAs, only a few are universally conserved, among them threonylcarbamoyl aden

32 dine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate

33 bunit and changes in the conformation of the universally conserved and essential bases A1492, A1493,

34 on particle (SRP) and its receptor compose a universally conserved and essential cellular machinery t

35 e signal recognition particle (SRP) RNA is a universally conserved and essential component of the SRP

36 CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme.

37 re briefly discussed in the context of these universally conserved and essential metabolic subsystems

38 cating that this recognition strategy is not universally conserved and may be relatively recent.

39 improving activity lay in the mutation of a universally conserved and mechanistically important resi

40 s posttranscriptional modification is almost universally conserved and occurs in the T arm of most tR

41 ons are composed of a catalytic core that is universally conserved and peripheral elements that are c

42 DNA-intercalating proline residue is almost universally conserved, and it is preceded by arginine an

43 dopt different conformations to reposition a universally conserved Asp (D) residue involved in cataly

44 In addition, mutation of the universally conserved aspartic acid abolished tRNA(Leu)

45 highly conserved threonine discriminator and universally conserved aspartic acid that were mutational

46 DnaK/Hsp70 proteins are universally conserved ATP-dependent molecular chaperones

47 om the consensus at positions other than the universally conserved AUG have little effect on RegA bin

48 dorsum scrapings were amplified by PCR with universally conserved bacterial primers and cloned into

49 The NusA protein is a universally conserved bacterial transcription elongation

50 Elongation factor P (EF-P) is a universally conserved bacterial translation factor.

51 These data illustrate the importance of two universally conserved base pairs in the RNA that form el

52 sible for the 2'-O-ribose methylation of the universally conserved base U2552 in the A-loop of the 23

53 able near-cognates, the repositioning of the universally conserved bases A1492 and G530 results in in

54 within domain I of 23 S, which contains many universally conserved bases and which lies close in the

55 The 3' terminus of tRNAs has the universally conserved bases C74C75A76 that interact with

56 positions 35 and 36 in the ASL interact with universally conserved bases G530 and A1493, respectively

57 t to uncouple the mRNA-tRNA complex from two universally conserved bases in the ribosomal decoding ce

58 Two universally conserved bases of 16S ribosomal RNA that in

59 Universally conserved basic residues of the sigma subuni

60 which a 5' splice site-like sequence in the universally conserved branch site-binding region of U2 i

61 f metal ion interactions, we substituted the universally conserved bulged uridine (U51) in the P4 hel

62 The universally conserved Cas1-Cas2 integrase complex cataly

63 sertion of this glutamate finger completes a universally conserved catalytic tetrad, thereby activati

64 ed 2555 loop in domain V of 23S rRNA and the universally conserved CCA end of tRNA.

65 The signal recognition particle (SRP) is a universally conserved cellular machinery responsible for

66 The translation process involves universally conserved chemistry at almost every stage of

67 d function of the proteins reveals that such universally conserved clusters correspond to either: (i)

68 The SRP RNA is a universally conserved component of SRP that mediates key

69 A universally conserved component of SRP, SRP54 or its bac

70 Cas2 is a universally conserved core CRISPR-associated protein req

71 l RNA (rRNA) is able to find the correct and universally conserved core fold.

72 ositions G18/U55 and G19/C56 (two contiguous universally conserved D/T loop base pairs) in Drosophila

73 The J-domain of CSP shares homology with the universally conserved DnaJ family, a group of proteins t

74 While mutation of the universally conserved E285 gave a minimally functional c

75 pathogen Streptocococcus mutans of the three universally conserved elements of the SRP pathway: Ffh/S

76 tRNAs through the ribosome is catalyzed by a universally conserved elongation factor (EF-G in prokary

77 is down-regulated by phosphorylation of the universally conserved elongation factor Tu (EF-Tu).

78 idine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked

79 ntaining each of the twenty amino acids is a universally conserved, essential reaction, the absence o

80 The universally conserved eukaryotic initiation factor (eIF)

81 Vps13 (vacuolar protein sorting 13), a large universally conserved eukaryotic protein, which suppress

82 the mechanism of NusG recruitment to RNAP is universally conserved even though the regulatory outcome

83 A universally conserved event in cell division is the form

84 Universally conserved factors from NusG family bind at t

85 Notably, YrdC and YgjD are members of universally conserved families that were ranked among th

86 gs to the superfamily of ABC transporters, a universally conserved family of proteins characterized b

87 at G-protein-cytoskeleton interactions are a universally conserved feature.

88 A universally conserved "fingerloop" lines the signal sequ

89 rotrimeric structure of RPA complexes may be universally conserved from lower to higher eukaryotes.

90 We propose a universally conserved function for IF2 in facilitating t

91 Surprisingly, neither the universally conserved G nor the highly conserved A are r

92 dues at all positions tested, except for the universally conserved G-residue at the guanosine-binding

93 ons appended to the core ring structure of a universally conserved G37, adjacent to the anticodon of

94 We conclude that the universally conserved GAF domain Tyr residue, with which

95 vide a method to increase immune response to universally conserved Gag epitopes, using the p24CE immu

96 n from published genomes to search for other universally conserved genes that have the same phylogene

97 ; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of pept

98 release factor, resulting in docking of the universally conserved GGQ motif in the PTC of the 50S su

99 firms that the backbone amide of Q230 of the universally conserved GGQ motif is positioned to contrib

100 the main-chain amide group of Gln 230 in the universally conserved GGQ motif of the factor is positio

101 shows that upon stop-codon recognition, the universally conserved GGQ motif packs tightly into the p

102 The MMP1680 protein encodes a universally conserved glucosamine-6-phosphate synthase.

103 role in MCM regulation; 2) interaction of a universally conserved glutamine in the N-terminal Allost

104 Movement of a universally conserved Gly at the N terminus of Switch II

105 the structure-function relationships of the universally conserved GroE chaperone machine.

106 Here, we identify a universally conserved GTPase (HflX) as a bona fide disso

107 The universally conserved GTPase elongation factor G (EF-G)

108 One insertion caused partial loss of the universally conserved GTPase, obgE/yhbZ gene.

109 protein encoded by the gene ychF is 1 of 11 universally conserved GTPases and the only one whose fun

110 YchF is one of these eight universally conserved GTPases; however, its cellular fun

111 ted the first glycine to an aspartate in the universally conserved GXXG motif of the KH domain as an

112 Although the universally conserved heat-shock response regulated by t

113 les of specific rRNA elements, including the universally conserved helix 69 (H69) of 23S rRNA, which

114 displays a predicted structure in which the universally conserved helix 8 contains an unprecedented

115 g phosphate oxygens at nucleotide A67 in the universally conserved helix P4.

116 s integrate directly via Nup120/160 into the universally conserved heptameric Y-complex, the critical

117 ia or Sec61alphabetagamma of eukaryotes is a universally conserved heterotrimeric protein channel com

118 The universally conserved His-66 of elongation factor Tu (EF

119 Mutation of its universally conserved histidine residue, which is critic

120 The universally conserved HPD motif appears to form a His-Pr

121 e interactions are not only dependent on the universally conserved IEI motif but also on arginine 133

122 These modifications are universally conserved in all domains of life.

123 loading AT domain to an Arg residue that is universally conserved in all extender unit AT domains fa

124 n the ribosome, a large RNA-protein assembly universally conserved in all forms of life.

125 gest that alpha(L) residue Glu-310, which is universally conserved in all I domain-containing integri

126 These four residues are universally conserved in all known KSs.

127 Whereas the core subunits of RNAPs are universally conserved in all three domains of life-indic

128 One of these two base-pairs is universally conserved in all TS sequences, and is identi

129 ns found in the Bacteria and Eukarya are not universally conserved in archaea.

130 motif that is recognized by K130, a residue universally conserved in beta- and gamma-proteobacteria.

131 motif (oct), 5'-GGAAGAGC-3', which is almost universally conserved in coronaviruses and is therefore

132 and TIP49) nuclear ATP binding proteins are universally conserved in eukaryotes and essential for vi

133 In addition, the 13B5 binding site is universally conserved in HCMV, contains a previously des

134 gma implicated in promoter melting, to those universally conserved in housekeeping sigmas relaxed the

135 INDING PROTEIN-LIKE (SPL) gene family appear universally conserved in land plants, but the specific f

136 Strikingly, this G-C base pair is universally conserved in phylogenetically diverse TS-cod

137 is the only membrane ATP-dependent protease universally conserved in prokaryotes, and the only essen

138 Fourth, Arg313, although universally conserved in protein kinases, and essential

139 nition of the promoter, R91, D81 and D84 are universally conserved in sigma28 orthologues.

140 LEDGF/p75 dependence is universally conserved in the retroviral genus Lentivirus

141 yladenosine (t(6)A) is a modified nucleoside universally conserved in tRNAs in all three kingdoms of

142 Thus, although t(6)A is universally conserved in tRNAs, its role in translation

143 mbly chaperone Acl4 that initially binds the universally conserved internal loop of newly synthesized

144 The universally conserved kinase-associated endopeptidase 1

145 striking exception to this divergence is the universally conserved KsgA/Dim1p enzyme family, which mo

146 A change of a universally conserved leucine to valine in the DNA-bindi

147 which microtubule attachment, mediated by a universally conserved 'linchpin' residue in kinesin (N25

148 Pro98 lies in a universally conserved linker between the calmodulin-bind

149 In particular, thiolation of the universally conserved methyl-uridine at position 54 stab

150 The universally conserved methyltransferase KsgA modifies tw

151 d mutagenesis of active site residues in two universally conserved Mg(2+)-binding domains and the ide

152 However, the universally conserved minor capsid gene vp3 could be del

153 -protein interactions, the evolution of this universally conserved molecule remains unclear.

154 C1054, a virtually universally conserved nucleotide in the 16 S (small subu

155 ants carrying mutations at A2602 and another universally conserved nucleotide in the peptidyl transfe

156 we investigated the effect of mutations at a universally conserved nucleotide of the active site of 2

157 m were tested in the ribosome by mutation of universally conserved nucleotides at 1406 to 1408 and 14

158 ion of mutant ribosomes and analysis of four universally conserved nucleotides in the innermost layer

159 ate demonstrate that the identity of several universally conserved nucleotides is not essential for f

160 aled that the antibiotic makes contacts with universally conserved nucleotides of 16S rRNA in the E s

161 e of the large subunit of the ribosome where universally conserved nucleotides surround the CCA ends

162 NA, site-directed mutations were made at the universally conserved nucleotides U2552 and G2553 of 23S

163 Here we show that there is no universally conserved number of SNARE complexes involved

164 erial virulence factor RfaH, a member of the universally conserved NusG family.

165 ed directly from OP sediment DNA by PCR with universally conserved or Bacteria-specific rDNA primers

166 gnal recognition particle (SRP) pathway is a universally conserved pathway for targeting polypeptides

167 argeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis.

168 hiff base-forming Lys-246 and the other to a universally conserved "perturbing" Lys-194 (E. coli numb

169 g, via a conserved peptidic sequence, into a universally conserved pocket.

170 The universally conserved positions G690 and U697 are genera

171 Although universally conserved positions in the barcode allow the

172 ur Nigerian children were PCR amplified with universally conserved primers and spirochetal selective

173 were examined by PCR using 16S and 23S rRNA universally conserved primers.

174 etection, and demonstrated that there are no universally conserved priming sequences among viruses an

175 Cotranslational protein translocation is a universally conserved process for secretory and membrane

176 while the reduction division of meiosis is a universally conserved process, the pre-meiotic associati

177 BipA is a universally conserved prokaryotic GTPase that exhibits d

178 The universally conserved prophase I arrest is released by a

179 Of these, TsaC and TsaD are members of universally conserved protein families.

180 00 bacterial homologs of the RecA family - a universally conserved protein involved in DNA recombinat

181 ent chain complex to the Sec61 translocon, a universally conserved protein-conducting channel in the

182 The Sec61 or SecY channel, a universally conserved protein-conducting channel, transl

183 alization of these proteins is mediated by a universally conserved protein-targeting machinery, the s

184 ily (COG0533) has been on the top-10 list of universally conserved proteins of unknown function for o

185 rRNA which, in the mature form, fold into a universally conserved pseudoknot.

186 escent-shaped molecule with two domains, the universally conserved Psi synthase catalytic domain and

187 ies show that an archael Pus10 catalyzes the universally conserved Psi55 in tRNA.

188 gene conversion reactions in which RAD51, a universally conserved recombinase, catalyses homology-di

189 that catalytically inactivate ribosomes at a universally conserved region of the large ribosomal RNA.

190 tra-domain interactions, the location of the universally conserved regions, the regions involved in p

191 -glycosidase activity directed solely at the universally conserved residue A4324 in the sarcin/ricin

192 We further demonstrated that His384, a universally conserved residue among protein tyrosine kin

193 hypervariable region; rpoC1 (TsX) changed a universally conserved residue and corresponds to yeast r

194 n this binding interaction map well onto the universally conserved residues of sMMO enzymes from diff

195 at domain II of RRF initially interacts with universally conserved residues of the 23S rRNA helices 4

196 ound conformations of the RNA shows that two universally conserved residues of the A site of 16 S rRN

197 ative amounts of label incorporated into the universally conserved residues U2506 and U2585 depend on

198 nza virus neuraminidase (NA) is formed by 11 universally conserved residues.

199 These findings suggest that universally conserved RfaH homologs may change folds to

200 The W255C mutation of the universally conserved ribosomal protein uL3 has diverse

201 Here, we show that a corridor of 20 universally conserved ribosomal RNA bases interacts with

202 the DUF143 family have been suggested to be universally conserved ribosomal silencing factors, actin

203 he E (exit) site in a process catalyzed by a universally conserved ribosome-dependent GTPase [elongat

204 The crystal structure of the universally conserved RNA-protein core of the Escherichi

205 h folding of the central pseudoknot (CPK), a universally conserved rRNA structure of the small riboso

206 Within the act CLF, neither the universally conserved S145 residue nor Q171, which align

207 and the beta7-beta9 loop as well as with two universally conserved SAG residues (Leu(137) and Tyr(144

208 translation by site-specific cleavage of the universally conserved Sarcin-Ricin loop (SRL) in 23S rRN

209 es the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin-ricin loop (SRL) leading to

210 ormation traverse the membrane by way of the universally conserved Sec pathway, whereas the twin argi

211 nto and across hydrophobic membranes via the universally conserved Sec pore.

212 branes of specific proteins occurs through a universally conserved secretory channel.

213 ally inserted into the lipid bilayer via the universally conserved SecY complex and they access the l

214 The major mechanism for this process is the universally conserved SecY/Sec61 pathway.

215 The only universally conserved sequence among all influenza A vir

216 HSF) transiently induces the expression of a universally conserved set of proteins, the heat shock pr

217 The universally conserved signal recognition particle (SRP)

218 The universally conserved signal recognition particle (SRP)

219 The universally conserved signal recognition particle (SRP)

220 The universally conserved signal recognition particle (SRP)

221 ting of membrane proteins is mediated by the universally conserved signal recognition particle (SRP).

222 viously found that a single base change at a universally conserved site in this region of the Tetrahy

223 tations, A794G, G926A, and A1519C, mapped to universally conserved sites in the 16 S RNA gene.

224 KsgA, a universally conserved small ribosomal subunit (SSU) rRNA

225 of the SRP-substrate complex occurs via the universally conserved SRP receptor (Sralpha/beta and Fts

226 Intriguingly, the otherwise universally conserved SRP RNA is missing in a novel chlo

227 This otherwise universally conserved SRP RNA is missing in the chloropl

228 ue in that it does not contain the otherwise universally conserved SRP RNA, which accelerates the ass

229 Moreover, membrane localization of the universally conserved SRP subunit SRP54, the key binding

230 The universally conserved ssDNA overhang is sequence-specifi

231 translating ribosome encounters one of three universally conserved stop codons: UAA, UAG or UGA.

232 All organisms have stress proteins, and universally conserved stress proteins can be regarded as

233 Thus, S. pombe uses a universally conserved stress-sensing machinery in novel

234 The protein binds on top of a universally conserved structural module in P RNA and int

235 In the other (closed state), the universally conserved switch 2 glycine forms a hydrogen

236 The universally conserved switch-2 may have the same role in

237 P450cin lacks the almost universally conserved threonine residue believed to be i

238 rRNA nucleotides studied have been virtually universally conserved throughout evolution.

239 Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway

240 s recruited to the TGN by the Arf1 GTPase, a universally conserved trafficking regulator.

241 Spt5p is a universally conserved transcription factor that plays mu

242 rotein EF-P, we propose that eIF5A/EF-P is a universally conserved translation elongation factor.

243 Previous studies identified two universally conserved translation elongation factors, EF

244 eIF1 is a universally conserved translation factor that is necessa

245 Elongation factor G (EF-G) is a universally conserved translational GTPase that promotes

246 base G966 and position 36 interacts with the universally conserved tRNA base U33 during translocation

247 of N6-threonylcarbamoyladenosine (t(6)A), a universally conserved tRNA modification found on all ANN

248 A universally conserved tryptophan is ideally positioned t

249 Surprisingly, the universally conserved type I topoisomerase domain which

250 site-specific nitration of the critical and universally conserved Tyr(35).

251 We find that the universally conserved Tyr34 that has a pK above 11.5 in

252 responsible for the 2'-O methylation of the universally conserved U2552 in the A loop of 23S rRNA.

253 RPR] to investigate the functional role of a universally conserved uridine in a bulge-helix structure

254 s composed of phosphate backbone moieties, a universally conserved uridine nucleobase, and at least t

255 Ten helical regions of the RNA are universally conserved while other regions vary significa

256 The universally conserved YidC protein mediates this process