ライフサイエンスコーパス: unleash

1 ations that alter the ACD building blocks to unleash a cryptic mode of chaperone action.

2 ronal amyloid beta build-up is sufficient to unleash a global and beta-site amyloid precursor protein

3 Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revo

4 sive pathways or directly activating DCs can unleash a T-cell response, and although clinical efficac

5 nucleus, allowing differentiated gametes to unleash a totipotent program following fertilization.

6 state the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote

7 This understanding has unleashed a range of emerging therapeutic approaches for

8 flammatory response to AKI, danger signaling unleashes a cascade of precisely timed, interdependent,

9 rverse response in which a compromised organ unleashes a coordinated series of reactions that exacerb

10 king p53 expression in the breast epithelium unleashes a torrent of DNA damage responses (DDRs) at th

11 pressing activation-induced deaminase, which unleashes a tsunami of mutations in the immunoglobulin l

12 are considered by some to be responsible for unleashing a flood of direct-to-consumer advertising.

13 lic adenosine monophosphate binding not only unleashes active PKAc but also leads to the targeting of

14 ity in the protease and has the potential to unleash activity in the zymogen to produce autoactivatio

15 persistent anti-relapse effects of EE can be unleashed after drug withdrawal.

16 r deficiency during prenatal development may unleash an anomalous form of NMDA receptor-independent L

17 terns (DAMPs) released by injured host cells unleashes an inflammatory cascade that amplifies tissue

18 n but not EGFR or c-Src overexpression alone unleashes an oncogenic signaling program that leads to h

19 f the 3' end of the Thg1 substrate tRNA(His) unleashes an unexpected reverse polymerase activity of w

20 this constraint, allowing TM association and unleashing an intrinsic propensity of the intracellular

21 n-specific IFNGamma-producing Th1 cells were unleashed, and the incidence of diabetes increased to th

22 n complex 1 (mTORC1) signal transduction was unleashed, and this coincided with liver dysfunction ref

23 -PD-L1, and others in early development, can unleash anti-tumor immunity and mediate durable cancer r

24 uccessful targeting of immune checkpoints to unleash anti-tumor T cell responses, resulting in durabl

25 mune checkpoint blockade (ICB) therapies can unleash anti-tumour T-cell responses.

26 s that activate a patient's immune system to unleash antitumor immunity.

27 raction disrupts DIAP1-caspase interactions, unleashing apoptosis-inducing caspase activity.

28 tical role for miR-155 in Th17 cells as they unleash autoimmune inflammation and finds that this occu

29 distinct tolerance pathways can synergize to unleash autoimmunity and have implications for the genet

30 osis and that the rapid degradation of Mcl-1 unleashes Bak to activate apoptosis.

31 Checkpoint blockade therapies unleash breaks in the immune system and induce long-last

32 ernate programmed cell death pathway that is unleashed by caspase-8 compromise and mediated by recept

33 he gene transcription and cell proliferation unleashed by deletion of p19Arf or p53 in primary mouse

34 In primates, puberty is unleashed by increased GnRH release from the hypothalamu

35 gene transcription and migration phenotypes unleashed by p19Arf or p53 deletion in primary mouse emb

36 ution of avalanches in gene activity changes unleashed by transiently altering the activity of a sing

37 x formation of both kinases with GTP-Rac1 to unleash cAMP-PKA-boosted activation of Raf-Mek-Erk.

38 p110delta inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour re

39 Our findings prove that IFNAR1 signaling unleashes CD8(+) T cell effector capacity, which is vita

40 A methylation resulting from genetic lesions unleash cellular plasticity and favor oncogenic cellular

41 in that promotes chromosome biorientation by unleashing chromosomes from improperly oriented microtub

42 ch the small-molecule probe is engineered to unleash controlled amounts of reactive chemical signals

43 hibition of the phosphodiesterase 4B (PDE4B) unleashes cyclic-AMP (cAMP) inhibitory effects toward th

44 At sites of infection, they unleash cytotoxic molecules allowing them to kill invadi

45 tment, which suggests that PD-1 blockade may unleash diverse antitumor T cell reactivities.

46 If apoptosis fails to execute, autophagy is unleashed due to lack of Beclin 1 cleavage by caspases a

47 protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia.

48 f these RASSF1A regulatory relationships can unleash enhanced proliferative capacity is dependent upo

49 s indicate that in initiated cells palytoxin unleashes ERK activity by down-regulating MKP-3, an ERK

50 extensively investigated, how necroptosis is unleashed following virus infection is understood for on

51 ubiquitination and proteasomal degradation, unleashing full Cdk2 activity which drives cell cycle pr

52 Telomere attrition unleashes genomic instability, promoting cancer developm

53 nscription factor p63; eliminating DeltaNp63 unleashes HBC multipotency.

54 d J-protein co-chaperones of classes A and B unleashes highly efficient protein disaggregation activi

55 re, diminish HipA-HipA dimerization, thereby unleashing HipA to effect multidrug tolerance.

56 tations that restrict their effectiveness in unleashing host immune system components against tumors.

57 We demonstrate that Socs2 deficiency unleashes HSC proliferation in vitro, sustaining STAT5 p

58 Hsp40-dependent manner, which is required to unleash Hsp104 protein disaggregating activity.

59 setting that institutions of integration can unleash human altruism and restore cooperation in the pr

60 ng RNA (TERRA) in early S phase, but is then unleashed in late S phase when TERRA levels decline at t

61 works can the power of ILCs be controlled or unleashed in order to regulate or enhance immune respons

62 nds, providing evidence of a trophic cascade unleashed in the absence of top-down regulation.

63 Furthermore, NSP activities unleashed increased activity of the tissue-destructive p

64 cytoplasm, where the biochemical events that unleash induction of antibiotic resistance mechanisms ta

65 CD71(+) cell ablation unleashed innate immune response and restored resistance

66 The "tip of the whip" that is unleashed is near the S339/S340 phosphorylation site and

67 the local CD4(+) T effector cell population, unleashing it to aggressively attack the islets, which w

68 major structural rearrangements in order to unleash its catalytic activity.

69 n change the genes that it regulates and can unleash its latent transforming activities.

70 gnals from talin and actin polymerization to unleash its scaffolding activity.

71 ty of this tyrosine kinase receptor, thereby unleashing its oncogenic potential.

72 eukocytes in turn support oxidation of HMGB1 unleashing its prothrombotic activity and promoting plat

73 ally specialized problem-solving strategies, unleashing massive increases in problem-solving power fo

74 Inactive mutation of either TSC1 or TSC2 unleashes mTOR signaling and consequently causes TSC, a

75 ert with the caspase-8-binding domain, which unleashes necroptosis independent of RHIM function.

76 T helper type 1 and natural killer cells, to unleash neurotoxicity and inflammation-induced neurodege

77 the next-generation treatment protocols will unleash new challenges.

78 e their recognition properties as well as to unleash new opportunities in supramolecular chemistry.

79 Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcino

80 cleavage of SET releases the inhibition and unleashes NM23-H1.

81 lleled chemotactic ability, after which they unleash numerous attacks on pathogens through degranulat

82 erative interactions at two distinct levels: unleashing of Bak from both Bcl-xL and Mcl-1 and simulta

83 Consequently, phosphatidylserine-dependent unleashing of C1 domains seen with PKCdelta was not nece

84 Unleashing of kinetochore motility through loss of resis

85 g the sensing event in the periplasm and the unleashing of resistance mechanisms in the cytoplasm.

86 and autophagic cell death, possibly through unleashing of the BH3-only autophagic effector Beclin 1

87 opes for the quantitation reference, and (3) unleashing of the open-source exploration of the chemica

88 Unleashed on a rapidly increasing sample of the planet's

89 ation properties, a recognized mechanism for unleashing oncogenic properties of chimeric transcriptio

90 ing to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of t

91 Zfp148 deficiency reduces atherosclerosis by unleashing p53 activity.

92 also impairs regulatory T cells and thereby, unleashes preexisting nephritogenic responses.

93 increased TGF-beta-dependent IL-6 secretion unleashed previously addicted lung tumor cells from thei

94 of anti-apoptotic BCL-2 family proteins can unleash pro-death molecules in cancer cells.

95 restores metastatic competency while further unleashing proliferation, creating a highly lethal combi

96 In addition, charge removal unleashes pronounced aggregation on longer timescales.

97 Thus, unleashed PTP1B activity attributable to loss of LMO4 pa

98 intense, femtosecond laser pulses by a solid unleashes relativistic electrons, thereby creating a reg

99 isruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely

100 Advances in synthetic polymer chemistry have unleashed seemingly unlimited strategies for producing b

101 osteoclastic resorption, estrogen deficiency unleashes signals that can stimulate the differentiation

102 r-of-apoptosis (IAP) family member cIAP, but unleashes Smac/DIABLO (second mitochondria-derived activ

103 s the ability of Ptc to inhibit Smo, thereby unleashing Smo activity and inducing target gene express

104 Unleashing such potential, however, requires understandi

105 ng the fact that depolymerization of F-actin unleashes SVs focused at the apex by myosin-5 to microtu

106 raint and provide a mechanism to explain the unleashed TGFbeta responses in metastatic cancer cells.

107 heckpoint inhibitors (CPIs), antibodies that unleash the antitumor immune response.

108 dine monophosphate to HCV replicon cells and unleash the antiviral potential of the triphosphate.

109 ther than with optimality or efficiency--can unleash the full potential of agent-based policy simulat

110 To unleash the full potential of graphene in electronics an

111 The tools of genome research may finally unleash the genetic potential of our wild and cultivated

112 2) is one of the most pressing challenges to unleash the potential of these materials and the growth

113 erivatives, to transiently suppress but then unleash the power of the immune system to maximize both

114 free or suitably masked quinone diazides to unleash the power of these classic diazo compounds in th

115 ed the analysis workflows comprehensively to unleash the power within RNA-seq.

116 Stimulation via C5aR is required to unleash the proinflammatory activity of synovial mast ce

117 until a threshold is reached and the tubules unleash the strain energy.

118 e pathways are a therapeutic target that may unleash the T cell responses during EBOV infection.

119 which can be achieved by silencing SOCS1 to unleash the unbridled signaling of IL-12 and the downstr

120 rated information to end users, thus helping unleash the value of the current data resources.

121 in regulatory and systems genomics can help unleash the value of whole-genome sequencing for persona

122 easure both its genes and gene products, has unleashed the concept of tailoring therapy to the indivi

123 led lipogenesis from nitrogen starvation and unleashed the lipogenic potential of Y. lipolytica Taken

124 Loss of a peptide in a critical location unleashed the protein from autoinhibition (as evidenced

125 ibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant t

126 to its cytoplasmic side, where its activity unleashes the expression of a set of genes, including th

127 ind the transient ablation of Foxp3(+) Tregs unleashes the robust expansion and activation of peptide

128 B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C).

129 eabilize the outer membrane of mitochondria, unleashing the apoptotic cascade.

130 This work provides a promising platform for unleashing the complete potential of ideal bandgap PVSCs

131 iminate targeted therapy resistance, thereby unleashing the full potential of targeted therapies to t

132 e the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotag

133 tion has emerged as a powerful mechanism for unleashing the oncogenic properties of chimeric transcri

134 d on flexibly defined structural similarity, unleashing the power of the ever greater number of solve

135 netic networks and pathways, is important to unleashing the true power of GWA studies.

136 rther tumor promoting events are required to unleash their carcinogenic potential.

137 apeutic strategies that may be used to fully unleash their cytotoxic capacity for the treatment of ca

138 Similarly, many promising materials could unleash their full potential if they were available in a

139 lation of fusion by signaling processes that unleash their fusion capacity.

140 olecular profiling of these structures could unleash their potential as circulating biomarkers as wel

141 ini of each of the three RGL-containing GEFs unleashed their full transforming potential.

142 venting resistance will ultimately be key to unleashing their full therapeutic potential.

143 s, which cleave viral surface glycoproteins, unleashing them to refold in ways that catalyze virus-ce

144 inal four-helix bundle (4HB) domain and that unleashing this domain results in formation of a high-mo

145 s have identified effective interventions to unleash tumor-specific T-cell activity in patients who n

146 man renal cell carcinoma environment without unleashing undesired Th2 cytokines or IL10.

147 Mutational inactivation of Dna2 nuclease unleashes unexpectedly vigorous DNA unwinding activity,

148 f the tissue-protective PD1/PD-L1 checkpoint unleashes vasculitic immunity and regulates the pathogen

149 ousehold and their owner during 14 30-40 min unleashed walks.

150 terferes with dephosphorylation of QseB thus unleashing what appears to be an uncontrolled positive f

151 ation of unphosphorylated complexes that are unleashed when Sic1p is degraded to promote S phase.

152 te that Sirt1-induced deacetylation of FoxOs unleashes Wnt signaling.

153 the nitric oxide pathway promotes cancer by unleashing Wnt/beta-catenin signaling.