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1 demographic, harnessing mobile technology to unleash a cadre of youth community climate health worker
3 ronal amyloid beta build-up is sufficient to unleash a global and beta-site amyloid precursor protein
7 sive pathways or directly activating DCs can unleash a T-cell response, and although clinical efficac
9 state the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote
12 idence that suppression of X-Y crossing-over unleashed a second dynamic: selfish X-Y arms races that
13 22, the Hunga Tonga-Hunga Ha'apai volcano(1) unleashed a violent underwater eruption, blanketing the
14 flammatory response to AKI, danger signaling unleashes a cascade of precisely timed, interdependent,
15 rverse response in which a compromised organ unleashes a coordinated series of reactions that exacerb
16 y, BTZ-mediated interference of proteostasis unleashes a p53-dependent cell cycle-associated death me
17 king p53 expression in the breast epithelium unleashes a torrent of DNA damage responses (DDRs) at th
18 pressing activation-induced deaminase, which unleashes a tsunami of mutations in the immunoglobulin l
19 potentially other metabolic enzymes, thereby unleashing a cascade of metabolic perturbations that are
20 ses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precance
21 are considered by some to be responsible for unleashing a flood of direct-to-consumer advertising.
23 use model of skin irAEs and reveal that ICIs unleash aberrant immune responses against skin commensal
24 o evidence suggests that reactive astrocytes unleash Abeta effects in pathological tau phosphorylatio
25 lic adenosine monophosphate binding not only unleashes active PKAc but also leads to the targeting of
26 ity in the protease and has the potential to unleash activity in the zymogen to produce autoactivatio
29 r deficiency during prenatal development may unleash an anomalous form of NMDA receptor-independent L
30 deletion impaired pancreatic commitment and unleashed an unexpected degree of cellular plasticity to
31 t mitigation by industrialized countries has unleashed an unfair burden on developing countries, so d
32 terns (DAMPs) released by injured host cells unleashes an inflammatory cascade that amplifies tissue
33 n but not EGFR or c-Src overexpression alone unleashes an oncogenic signaling program that leads to h
34 f the 3' end of the Thg1 substrate tRNA(His) unleashes an unexpected reverse polymerase activity of w
35 e pyroptosis by cleaving GSDMA after Gln246, unleashing an active N-terminal fragment that triggers p
36 this constraint, allowing TM association and unleashing an intrinsic propensity of the intracellular
37 y of effector T cells can be therapeutically unleashed, and is now being exploited for the treatment
38 n-specific IFNGamma-producing Th1 cells were unleashed, and the incidence of diabetes increased to th
39 n complex 1 (mTORC1) signal transduction was unleashed, and this coincided with liver dysfunction ref
41 -PD-L1, and others in early development, can unleash anti-tumor immunity and mediate durable cancer r
42 could thwart their pro-cancer activities and unleash anti-tumor immunity, but efforts to accomplish t
43 uccessful targeting of immune checkpoints to unleash anti-tumor T cell responses, resulting in durabl
46 cumulation of extracellular adenosine to (a) unleash antitumor immune cells from inhibition by intrac
48 Tregs impaired organ allograft tolerance and unleashed antitumor immunity via epigenetic activation o
53 tical role for miR-155 in Th17 cells as they unleash autoimmune inflammation and finds that this occu
54 distinct tolerance pathways can synergize to unleash autoimmunity and have implications for the genet
55 to resemble that of the sinoatrial node and unleashed automaticity originating at the site of inject
57 l efficacy across various types of cancer by unleashing both T and natural killer (NK) cell-mediated
58 ndria, where the therapeutic powers could be unleashed, both photodynamically and photothermally.
60 ernate programmed cell death pathway that is unleashed by caspase-8 compromise and mediated by recept
61 he gene transcription and cell proliferation unleashed by deletion of p19Arf or p53 in primary mouse
67 gene transcription and migration phenotypes unleashed by p19Arf or p53 deletion in primary mouse emb
69 ution of avalanches in gene activity changes unleashed by transiently altering the activity of a sing
72 icular, we find that under the conditions of unleashed cation dynamics, the key factor that determine
73 tion unlocks immunotherapeutic strategies to unleash CD8(+) T cell-mediated anti-tumor immunity in HG
75 p110delta inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour re
76 Our findings prove that IFNAR1 signaling unleashes CD8(+) T cell effector capacity, which is vita
77 A methylation resulting from genetic lesions unleash cellular plasticity and favor oncogenic cellular
78 in that promotes chromosome biorientation by unleashing chromosomes from improperly oriented microtub
79 emonstrate that immune checkpoint inhibition unleashes commensal-specific inflammatory T cell respons
80 ch the small-molecule probe is engineered to unleash controlled amounts of reactive chemical signals
82 hibition of the phosphodiesterase 4B (PDE4B) unleashes cyclic-AMP (cAMP) inhibitory effects toward th
84 induced a profound remodeling of the TME and unleashed cytotoxic T cell (CTL)-mediated tumor eradicat
87 If apoptosis fails to execute, autophagy is unleashed due to lack of Beclin 1 cleavage by caspases a
89 nt-binding proteins (SREBPs) in T(reg) cells unleashes effective antitumour immune responses without
90 (1)-antitrypsin from the extracellular space unleashes elastase, triggering the disruption of B cell
91 the double-stranded RNA (dsRNA) sensor MDA5, unleashing endoplasmic reticulum (ER) stress and hinderi
92 f these RASSF1A regulatory relationships can unleash enhanced proliferative capacity is dependent upo
93 folding schemes for functional materials can unleash enormous potential in advancing a wide range of
95 s indicate that in initiated cells palytoxin unleashes ERK activity by down-regulating MKP-3, an ERK
97 extensively investigated, how necroptosis is unleashed following virus infection is understood for on
98 ubiquitination and proteasomal degradation, unleashing full Cdk2 activity which drives cell cycle pr
99 to evolve more independently of one another, unleashing genetic variance hidden in the linkage disequ
102 d J-protein co-chaperones of classes A and B unleashes highly efficient protein disaggregation activi
105 tations that restrict their effectiveness in unleashing host immune system components against tumors.
108 setting that institutions of integration can unleash human altruism and restore cooperation in the pr
111 reserve self-tolerance is being leveraged to unleash immunity against many tumors; however, widesprea
113 ng RNA (TERRA) in early S phase, but is then unleashed in late S phase when TERRA levels decline at t
114 works can the power of ILCs be controlled or unleashed in order to regulate or enhance immune respons
118 cytoplasm, where the biochemical events that unleash induction of antibiotic resistance mechanisms ta
122 ansferases KMT5B/C, and their downregulation unleashed inflammatory programs and compromised the surv
124 deficiency, and PD-1 but not PD-L2 blockade, unleashed insulin-specific T follicular helper CD4(+) T
126 the local CD4(+) T effector cell population, unleashing it to aggressively attack the islets, which w
128 crodroplets via real-time, long-term imaging unleash its great potential in accelerating cell-free sy
131 defense system, activated by invading DNA to unleash its TIR domain for NAD(P)(+) hydrolysis, was rec
134 eukocytes in turn support oxidation of HMGB1 unleashing its prothrombotic activity and promoting plat
135 mutations mimic Rab-mediated activation by "unleashing" kinase activity, and many, like the kinase i
139 ain-like energy-efficient computing that can unleash major transformations in future AI and data anal
140 ally specialized problem-solving strategies, unleashing massive increases in problem-solving power fo
141 Inactive mutation of either TSC1 or TSC2 unleashes mTOR signaling and consequently causes TSC, a
143 ert with the caspase-8-binding domain, which unleashes necroptosis independent of RHIM function.
144 T helper type 1 and natural killer cells, to unleash neurotoxicity and inflammation-induced neurodege
146 e their recognition properties as well as to unleash new opportunities in supramolecular chemistry.
149 ence or absence of a normal microbiota could unleash novel plant- and microbiota-based technologies t
150 lleled chemotactic ability, after which they unleash numerous attacks on pathogens through degranulat
151 m of sorafenib involving MPhi pyroptosis and unleashing of an NK-cell response that sets it apart fro
152 erative interactions at two distinct levels: unleashing of Bak from both Bcl-xL and Mcl-1 and simulta
153 Consequently, phosphatidylserine-dependent unleashing of C1 domains seen with PKCdelta was not nece
155 g the sensing event in the periplasm and the unleashing of resistance mechanisms in the cytoplasm.
156 and autophagic cell death, possibly through unleashing of the BH3-only autophagic effector Beclin 1
157 opes for the quantitation reference, and (3) unleashing of the open-source exploration of the chemica
158 n interfaces, combined with the cAMP-induced unleashing of the PKA catalytic subunit (PKA-C) from the
160 ation properties, a recognized mechanism for unleashing oncogenic properties of chimeric transcriptio
161 ing to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of t
162 with MRD may respond to therapies aiming to unleash or enhance the graft-versus-leukemia effect.
169 ngender potent effector cell activation, and unleash previously untapped immune mechanisms against ca
170 increased TGF-beta-dependent IL-6 secretion unleashed previously addicted lung tumor cells from thei
174 restores metastatic competency while further unleashing proliferation, creating a highly lethal combi
178 intense, femtosecond laser pulses by a solid unleashes relativistic electrons, thereby creating a reg
179 aptic innervation of downstream neurons, and unleash reward-seeking behaviors in a manner that is rev
180 isruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely
182 Advances in synthetic polymer chemistry have unleashed seemingly unlimited strategies for producing b
183 osteoclastic resorption, estrogen deficiency unleashes signals that can stimulate the differentiation
184 r-of-apoptosis (IAP) family member cIAP, but unleashes Smac/DIABLO (second mitochondria-derived activ
185 s the ability of Ptc to inhibit Smo, thereby unleashing Smo activity and inducing target gene express
188 ng the fact that depolymerization of F-actin unleashes SVs focused at the apex by myosin-5 to microtu
193 biofilm formation, while low c-di-GMP levels unleash T6SS and T4SS to advance plant colonization.
195 raint and provide a mechanism to explain the unleashed TGFbeta responses in metastatic cancer cells.
196 For example, negative hyperconjugation can unleash the "underutilized" stereoelectronic power of un
200 dine monophosphate to HCV replicon cells and unleash the antiviral potential of the triphosphate.
201 lopment that need to occur in order to truly unleash the capabilities of glycoscience in the systems
202 of injury in cooperating with mutant Kras to unleash the epigenetic remodelling program of early neop
204 ther than with optimality or efficiency--can unleash the full potential of agent-based policy simulat
205 posed by trogocytosis, it may be possible to unleash the full potential of CAR NK/T therapy against c
208 Important research investment is needed to unleash the full potential of ONT sequencing for tubercu
209 est future directions for research that will unleash the full potential of these fascinating nanosyst
210 s that need to be addressed in the future to unleash the full potential of this form of therapy.
211 The tools of genome research may finally unleash the genetic potential of our wild and cultivated
212 conventional current-based devices and could unleash the great potential of 2D materials for EL devic
214 mmunotherapeutic drugs with the potential to unleash the immune system, have emerged as authentic gam
215 life to the fullest but has the potential to unleash the intellectual and vocational capacities of so
216 thermotolerant metal halide perovskites will unleash the possibility of a wide variety of high-power
217 tion treatments that could be used to better unleash the potential of adoptive cell therapies by enha
218 Therefore, these features allow STICK-NPs to unleash the potential of brain tumor therapeutics to imp
220 sing vulnerabilities on the ground, they can unleash the potential of NbS to engage on a path of tran
221 properties of narrow-bandgap perovskites and unleash the potential of perovskite-perovskite tandem so
223 roRNA (miRNA or miR) conjugation strategy to unleash the potential of targeted miRNA therapeutics, an
224 arning framework that we have established to unleash the potential of the Chemical Checker extended d
225 2) is one of the most pressing challenges to unleash the potential of these materials and the growth
226 es, researchers will avoid many pitfalls and unleash the power of computational modeling on their own
228 erivatives, to transiently suppress but then unleash the power of the immune system to maximize both
229 free or suitably masked quinone diazides to unleash the power of these classic diazo compounds in th
233 uminal STIM1 multimerization is essential to unleash the STIM C-terminal binding site for Orai1 chann
235 e pathways are a therapeutic target that may unleash the T cell responses during EBOV infection.
237 which can be achieved by silencing SOCS1 to unleash the unbridled signaling of IL-12 and the downstr
239 in regulatory and systems genomics can help unleash the value of whole-genome sequencing for persona
240 easure both its genes and gene products, has unleashed the concept of tailoring therapy to the indivi
241 led lipogenesis from nitrogen starvation and unleashed the lipogenic potential of Y. lipolytica Taken
242 Loss of a peptide in a critical location unleashed the protein from autoinhibition (as evidenced
243 ibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant t
244 to its cytoplasmic side, where its activity unleashes the expression of a set of genes, including th
245 cular complex called the inflammasome, which unleashes the proteolytic activity of a cysteine proteas
246 ind the transient ablation of Foxp3(+) Tregs unleashes the robust expansion and activation of peptide
247 itosis and proliferation and its suppression unleashes the tumor suppressive effects of senescence.
248 riptional activity, increased MYC expression unleashes the WNT oncogenic transcriptional program, pro
249 1 profoundly enhances anticancer immunity by unleashing the activity of CD8(+) T cells and NK cells.
250 B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C).
252 This work provides a promising platform for unleashing the complete potential of ideal bandgap PVSCs
254 iminate targeted therapy resistance, thereby unleashing the full potential of targeted therapies to t
255 e the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotag
256 iggering large structural rearrangements and unleashing the fusogenic potential of gp41 to induce mem
259 tion has emerged as a powerful mechanism for unleashing the oncogenic properties of chimeric transcri
260 and biological barriers is crucial for fully unleashing the potential of immunotherapeutic approaches
262 nd field-deployable detection of heparin and unleashing the potential use of heparin in future anti-C
263 standing the etiology of early-life disease, unleashing the power of administrative data will greatly
264 ar qubits is a fundamental milestone towards unleashing the power of molecular magnetism in the secon
265 d on flexibly defined structural similarity, unleashing the power of the ever greater number of solve
268 apeutic strategies that may be used to fully unleash their cytotoxic capacity for the treatment of ca
269 Similarly, many promising materials could unleash their full potential if they were available in a
270 ed products' diverse modes of action, we can unleash their full therapeutic potential and pave the wa
272 olecular profiling of these structures could unleash their potential as circulating biomarkers as wel
276 s, which cleave viral surface glycoproteins, unleashing them to refold in ways that catalyze virus-ce
277 inal four-helix bundle (4HB) domain and that unleashing this domain results in formation of a high-mo
279 In humans and mice, SP140 loss resulted in unleashed TOP activity, de-repression of developmentally
281 s have identified effective interventions to unleash tumor-specific T-cell activity in patients who n
283 breast cancer model, only the triple therapy unleashes tumor growth control and significantly reduces
288 Mutational inactivation of Dna2 nuclease unleashes unexpectedly vigorous DNA unwinding activity,
289 abilities within the current infrastructure, unleashes unparalleled ecological monitoring potential a
291 em redesign, artificial intelligence (AI) is unleashing unprecedented possibilities-could it be the k
293 , all four oxidizing equivalents of O(2) are unleashed upon 2OG, fragmenting it to ethylene (from C3
294 f the tissue-protective PD1/PD-L1 checkpoint unleashes vasculitic immunity and regulates the pathogen
296 terferes with dephosphorylation of QseB thus unleashing what appears to be an uncontrolled positive f
297 ation of unphosphorylated complexes that are unleashed when Sic1p is degraded to promote S phase.
300 pathogen-associated molecular pattern (PAMP) unleashing ZBP1/RIPK3/MLKL-dependent necroptosis unless