ライフサイエンスコーパス: unliganded

1 mplex with lipid A disaccharide backbone and unliganded.

2 equilibrium constants, we estimate that the unliganded AChR gating constant is E(0) approximately 6.

3 n AChRs is approximately 1.15 x 10(-7); (ii) unliganded AChRs open for approximately 80 micros, once

4 ystal structure of a synaptic tetramer of an unliganded activated mutant (M114V) of the G-segment inv

5 tations in the cytosolic loops that increase unliganded activity.

6 tors to promote the ubiquitination of mature unliganded AhR complexes.

7 rikingly different conformations of LIMBS in unliganded alphaIIbbeta3 versus alphaVbeta3, the result

8 refolding and its crystal structures in the unliganded and 3-isobutyl-1-methylxanthine (IBMX) bound

9 Crystal structures of the protein in unliganded and AMP-bound forms, determined at resolution

10 s CD4-bound state, compare this structure to unliganded and antibody-bound forms to identify structur

11 1 ortholog from the giant Mimivirus (MvNei1) unliganded and bound to DNA containing tetrahydrofuran (

12 ions (CDRs) of the TCR seen in comparison of unliganded and bound X-ray structures, NMR characterizat

13 igate full-length, glycosylated HIV gp120 in unliganded and CD4-bound forms by using small-angle X-ra

14 conformational stability for HIV-1 gp120 in unliganded and CD4-bound states.

15 models for the native HIV-1 gp120 trimer in unliganded and CD4-bound states.

16 onding loop in MvNei1 is ordered in both the unliganded and furan-bound structures, unlike other Fpg/

17 namics, respectively, demonstrates that both unliganded and glucose-bound enzymes sample multiple con

18 Models of E. coli ACPS in unliganded and holo-ACPP-bound forms solved by X-ray cry

19 utative binding region of SrpA (SrpABR) both unliganded and in complex with a synthetic disaccharide

20 These studies show that unliganded and inverse-agonist-bound beta2AR exists pred

21 results uncover a paradoxical action of the unliganded and ligand-activated PPARgamma in regulating

22 ase from Streptococcus pneumoniae (SpNic) in unliganded and ligand-bound forms.

23 ible for differential regulation of genes by unliganded and liganded ERbeta.

24 genes, we identified genes regulated by the unliganded and liganded forms of ERalpha and ERbeta in U

25 Our findings indicate that the unliganded and liganded forms of ERbeta regulate three c

26 ences of specific mutations on gating in the unliganded and liganded states.

27 Comparison of unliganded and liganded structures illustrates ligand-in

28 The comparison of unliganded and liganded structures reveals a quaternary

29 Both the unliganded and the AMP-bound ADPGK structures are in the

30 Crystal structures of gp120 in unliganded and various ligand-bound states, meanwhile, r

31 nogen o-gp140DeltaV2TV1, in both its native (unliganded) and CD4-induced (liganded) states by cryoele

32 AR adopted a conformation that resembled the unliganded AR (apo-AR), precluding nuclear localization

33 nt exposed out orientation typically seen in unliganded aromatic hydroxylases.

34 rminal effector-binding domain of CggR, both unliganded as well as in complex with the four ligands a

35 tes relate substrate transit directly to the unliganded asymmetric "carrier" (Ci) distribution.

36 structure of a MAM mutant K201A in apo form (unliganded) at 2.8-A resolutions.

37 ation promotes beta-arrestin2 recruitment to unliganded AT1 angiotensin receptor (AT1R).

38 in ANS emission observed in the presence of unliganded ATH reflects the interaction of these hydroph

39 ts a compact or "closed" domain arrangement, unliganded avian SC is flexible and exists in both close

40 al comparison of DMATase in the complex with unliganded bacterial DMATase provides a molecular basis

41 egulatory sites; ii) a simulated ensemble of unliganded Bcl2 structures reveals extensions of a known

42 a component of secretory antibodies, or when unliganded, binds and excludes bacteria.

43 stal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E).

44 lex, and (d) the binding interaction between unliganded C-Mad2 and Cdc20 cannot be catalyzed by a C-M

45 a C-Mad2-Cdc20 complex >300-fold slower than unliganded C-Mad2, (b) a stable C-Mad2-Mad1 core complex

46 The crystal structures of the unliganded CAP containing a D138L mutation and the unlig

47 arison of the structures of the liganded and unliganded CAP suggests that cAMP stabilizes the active

48 However, asymmetric rates of unliganded carrier movement, kij, imply that an energy s

49 The rate constants for unliganded channel opening and closing were also estimat

50 this electrostatic interaction also promotes unliganded channel opening in the absence of ATP binding

51 pping in the liganded channel but not in the unliganded channel.

52 A comparison of the unliganded cis-CaaD crystal structure with that of an in

53 structural models that likely represent the unliganded closed-channel conformation and the fully lig

54 re in equilibrium with a minor population of unliganded, closed species.

55 The X-ray crystal structures of unliganded Co(2+)(2)-HAI determined at 2.10 A resolution

56 Comparison of structures of dimers of unliganded CodY and CodY-Ile derived from the tetramers

57 ranched-chain amino acids, we concluded that unliganded CodY cannot repress transcription in vivo and

58 ghts, we determined the crystal structure of unliganded CodY from Bacillus subtilis revealing a 10-tu

59 In the unliganded ColH structure, this globular dynamics is mod

60 e that PBPs typically adopt either an "open" unliganded configuration or a "closed" liganded one.

61 The DADH crystal structure comprises an unliganded conformation and a product-bound conformation

62 s of the so-far structurally uncharacterized unliganded conformation of HIV-1 gp120, which may prove

63 that bind conserved epitopes exposed on the unliganded conformation of the HIV-1 envelope glycoprote

64 econdary structure elements reveals that the unliganded conformations of both glycoprotein (gp)120 an

65 On average, unliganded core gp120 displayed >10,000-fold slower exch

66 tically, we determined crystal structures of unliganded core gp120 from HIV-1 clades B, C, and E.

67 re, we report the X-ray crystal structure of unliganded DCS at 2.4 A resolution and the structure of

68 autoinhibitory interdomain interactions hold unliganded dEGFR in an inactive state.

69 tically for the liganded complex compared to unliganded demethylase, which may correspond to the obse

70 ngaging the proapoptotic activity induced by unliganded dependence receptors are in late-stage precli

71 gate directly the effect of the JM domain on unliganded dimer stability of FGFR3, a receptor that is

72 ns are critical for the establishment of the unliganded dimer structure, and for the transition to th

73 point to a coordinated stabilization of the unliganded dimeric state of FGFR3 by its JM and TM domai

74 Our data reveal a correlation between unliganded dimerization and tumorigenic signaling and su

75 ers in the absence of ligand, and that these unliganded dimers are phosphorylated.

76 The data suggest that FGFR3 unliganded dimers are stabilized by receptor-receptor co

77 ny of these receptors are capable of forming unliganded dimers that are likely important intermediate

78 Although the kinetic stability of unliganded dimers was in principle sufficient for EGF-in

79 liganded during human pregnancy, it becomes unliganded during both term and preterm labour as a resu

80 presses genes that are normally repressed by unliganded EcR, thereby allowing wing patterning to prog

81 catalytic phosphorylation of tyrosine 845 on unliganded EGFR monomers is suppressed by vesicular recy

82 region studied in the context of either CD4-unliganded Env trimer or the gp41 peptide in the unbound

83 contribute to interprotomer contacts in the unliganded Env trimer, undergo rearrangement upon CD4 bi

84 on contributes to gp120 association with the unliganded Env trimer.

85 In the unliganded Env, intersubunit interactions maintain the g

86 at engage subunit interfaces upon binding to unliganded Env.

87 s where the loop is generally ordered in the unliganded enzyme or in complexes with a lesion, and dis

88 ed to the catalytic site than in the case of unliganded enzyme or the WT enzyme-Mg(2+)-3-hydroxygluta

89 In the unliganded enzyme, we observed a rather broad distributi

90 l any substantial movement compared with the unliganded enzyme.

91 atible with substrate binding as seen in the unliganded enzyme; (ii) the active "on state" seen in in

92 Oxydianions bind weakly to these unliganded enzymes and tightly to the transition state c

93 Indeed, our data reveal that activation by unliganded ERalpha and repression by estrogen-activated

94 emonstrated that in MCF7 breast cancer cells unliganded ERalpha binds to more than 4,000 chromatin si

95 re, these results suggest a pivotal role for unliganded ERalpha in controlling a fundamental caretake

96 estrogen, suggesting an unexpected role for unliganded ERalpha in E-cadherin transcription.

97 ased upon ERalpha silencing, suggesting that unliganded ERalpha participates, together with other fac

98 t virtually no gene regulation occurred with unliganded ERalpha, whereas many genes were regulated by

99 strogen-induced binding sites, we found that unliganded-ERalpha binding is specifically linked to gen

100 The observation that the unliganded ErbB2 kinase preferentially serves as the act

101 ing, imply that the tethered conformation of unliganded ErbBs evolved to prevent crosstalk among ErbB

102 ereas class III genes were regulated by both unliganded ERbeta and E(2).

103 Class I genes were regulated primarily by unliganded ERbeta.

104 Furthermore, we show that the unliganded extended monomeric core of gp120 (coree) assu

105 Trp/Arg(H100)Trp double mutant (1E9dm) as an unliganded Fab at 2.05 A resolution and in complex with

106 Although the existence of unliganded FGFR1 dimers on the surface of living cells h

107 his approach we observed homodimerization of unliganded FGFR1 that is independent of its surface dens

108 he JM domain and a TM pathogenic mutation on unliganded FGFR3 dimer stability are additive.

109 rmation being significantly populated in the unliganded FKBP51 domain is more consistent with a confo

110 xide (TMAO), an osmolyte that stabilizes the unliganded folded form of the protein, enabled us to stu

111 otein fromPseudomonas putidaCSV86 (ppGBP) in unliganded form (2.5 A) and complexed with glucose (1.25

112 g from Archaeoglobus fulgidus, AfUbiA, in an unliganded form and bound to Mg2+ and two different isop

113 the X-ray crystal structures of NolR in the unliganded form and complexed with two different 22-base

114 ructures of the catalytic domain of hPARG in unliganded form and in complex with three inhibitors: AD

115 ase in the melting temperature compared with unliganded form and ppGBP-galactose complex.

116 Klebsiella pneumoniae OHCU decarboxylase in unliganded form and with bound allantoin.

117 The unliganded form is the "on-state" active kinase that pho

118 The unliganded form of nitroxide spin-labeled HIV-1 protease

119 The crystal structure of the unliganded form of the interleukin-7 alpha receptor (IL-

120 a recently published X-ray structure of the unliganded form of the ovine BMPR-II ECD as a guide.

121 protein (Env) trimer maintain the metastable unliganded form of the viral spike.

122 e report the structure of this domain in its unliganded form, allowing definition of the structural c

123 of the catalytic core of yeast Pol alpha in unliganded form, bound to an RNA primer/DNA template and

124 In the unliganded form, the same loop points away from the acti

125 trinsically accessible to the protein in the unliganded form.

126 ith lipid A carbohydrate backbone and in the unliganded form.

127 ructural comparisons of various liganded and unliganded forms of CCR and CAD2 highlight substantial c

128 uctural comparisons of antibody-liganded and unliganded forms of CD3epsilon from a single species, wh

129 The structures of three unliganded forms of S25-26 have a labile complementary-d

130 Thus the liganded and the unliganded forms of the CSD respectively provide the str

131 (proportional, variant 1/KD(in)) and slower unliganded "free" carrier transit from inside to outside

132 The studies revealed unliganded full-length gp120 to be considerably more dyn

133 dels of predominant solution conformation of unliganded full-length Myo1c and Myo1c bound to Neph1 we

134 ti-CD4i MAbs, including MAb 21c, which bound unliganded, full-length gp120 held in a constrained conf

135 Superposition of this unliganded GAF-A with the previously reported NMR struct

136 Comparison of the unliganded GAF-B of PDE2A (215-900) with previous struct

137 y mutations of these prolines with regard to unliganded gating (DeltaG0) and the affinity change for

138 ng equilibrium constant only by changing the unliganded gating equilibrium constant (E(0)) and did no

139 For 25 different constructs, the unliganded gating equilibrium constant (E(0)) was correl

140 The unliganded gating equilibrium constant is smaller and le

141 Knowing both the di- and unliganded gating equilibrium constants (E(2) and E(0))

142 steric" cycle as follows: diliganded gating, unliganded gating, dissociation from the C(losed) confor

143 We find that the small domain of unliganded GCK is intrinsically disordered and samples a

144 proteolysis, we map the site of disorder in unliganded GCK to a 30-residue active-site loop that clo

145 changes proposed from previous structures of unliganded GlpG.

146 loop and quaternary interactions restraining unliganded gp120 from "snapping" into this conformation.

147 extraordinary reduction in entropy, neither unliganded gp120 nor free CD4 was substantially unstruct

148 contribute to the noncovalent association of unliganded gp120 with gp41.

149 ence suggests are proximal to the V3 loop in unliganded gp120, also resulted in decreased gp120-gp41

150 he sampling of the CD4-bound conformation by unliganded gp120.

151 We show that unliganded gp140 trimers adopt a quaternary arrangement

152 e beta-switch region, which is a loop in the unliganded GPIb alpha but switches to a beta-hairpin in

153 catenin binding partners, indicating that an unliganded groove is absolutely required for an orientat

154 Unliganded H2-Q10 adopted a classical MHC-I fold and pos

155 putational methods to distinguish individual unliganded HA trimers from those that have bound C179 an

156 tabilizing its open state and the opening of unliganded HCN1, which occurs as though already disinhib

157 strate here that in epidermal keratinocytes, unliganded heterodimers of vitamin D receptor (VDR)/RXR-

158 found moderate levels of PAG associated with unliganded HIV-1 and SIV virions incubated with the thre

159 Our observations revealed unliganded HIV-1 Env to be intrinsically dynamic, transi

160 How does unliganded HIV-1 maintain CD4-binding capacity and regul

161 Notably, all of these unliganded HIV-1 structures resembled the CD4-bound stat

162 e beta/alpha-barrel structures with those of unliganded HMGCL and R41M reveals substantial difference

163 Here we report the 2.6A crystal structure of unliganded human SC (hSC) and comparisons with a 1.7A st

164 FbpA, including one in which the protein was unliganded (i.e., apoFbpA) and one in which the protein

165 conformation between the IDE-ATP complex and unliganded IDE, but regions of the active site and C-ter

166 ed at the heterotetrameric interfaces in the unliganded IDH hetero-octamer are reduced in the ligand-

167 3 and TNF-alpha, particularly in response to unliganded IgE.

168 lin bound that allows direct comparison with unliganded IR and suggests a mechanism by which ligand r

169 Unliganded L5* VL domains crystallize as a similar antip

170 We show that unliganded LEP-R displays significant flexibility in a h

171 d structure, we report two structures of the unliganded light chain with and without the Zn(II) cofac

172 The two unliganded lobes present a canonical open conformation a

173 rier complex requires a higher proportion of unliganded low-affinity inside sites (proportional, vari

174 n crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orient

175 hat 1) the Fab-Fc or Fab-Fab interactions in unliganded mAbs are retained in digested products, and 2

176 ding insights into the ATPase stimulation by unliganded MalE.

177 In X-ray solution structures, the CARDs in unliganded MDA5 are flexible, and RNA binds on one side

178 mical and structural studies reveal that the unliganded, multidomain cIAP1 sequesters the RING domain

179 eased probability for phosphorylation of the unliganded mutant dimers.

180 tation alters ectodomain structure such that unliganded mutant EGFR adopts an extended, dimerization-

181 g NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3.

182 ther biochemical and spectroscopic analysis, unliganded NikA was overexpressed and purified.

183 leading to the loosening of a flap, which in unliganded NMT structures, occludes the protein substrat

184 his complex bound with GAG analogues, and of unliganded Norrin and Fz4CRD.

185 on, NTS1-7m bound to NT was more stable than unliganded NTS1-7m.

186 that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lys

187 nscriptional repression of cellular genes by unliganded nuclear receptors.

188 etrahedral oxydianions, which bind weakly to unliganded OMPDC and tightly to the enzyme-transition st

189 Here, we use PRE to study the unliganded open-closed transition of another PBP: glutam

190 rably larger than DHEA, can bind only to the unliganded (open) enzyme, whereas DHEA binds both the op

191 me), could be appropriately explained by the unliganded, open crystal structure in that it both yield

192 We estimated the unliganded opening and closing rate constants of neuromu

193 to conventional ligand-gated channels (e.g. unliganded openings and constitutive mutations).

194 d drugs, the lack of a BmrR structure in its unliganded or apo (DNA free and drug free) state hinders

195 there are several structures of Nei enzymes unliganded or bound to an abasic (apurinic or apyrimidin

196 3 or NCoR for TRE-bound TR.RXR heterodimers, unliganded or saturated with different THs.

197 ween the BeF(3)(-)-activated complex and the unliganded (or apo) complex determined previously reveal

198 t be coupled to intracellular asymmetry with unliganded partners favoring the activator kinase positi

199 They also suggest possible actions of the unliganded (passive) gating ring or added short tails on

200 nt from those of any known structures of the unliganded PDE5 and its complexes with the inhibitors.

201 Comparison with the unliganded PfAldo structure shows that the two arginines

202 Crystal structures of unliganded PGT121, 10-1074, and their likely germ-line p

203 ned from small angle x-ray scattering of the unliganded PimA and the PimA.GDP complexed forms clearly

204 We propose that unliganded PLC-beta exists in equilibrium between a clos

205 imine (lambda(max) 416 nm; A), two different unliganded PLP states of the enzyme (lambda(max) at 409

206 omains relative to their orientations in the unliganded polymerase structure.

207 nd negated RANTES induction, suggesting that unliganded PPARgamma is obligatory for NF-kappaB signali

208 In summary, unliganded PR-B enhanced proliferative responses to estr

209 enome-wide microarray analyses revealed that unliganded PR-B induced robust expression of a subset of

210 In contrast, unliganded PRA paradoxically activates Cx43 transcriptio

211 Moreover, unliganded PRB but not PRA enhanced FAK Tyr397 phosphory

212 Surprisingly, unliganded PRB but not PRA strongly enhanced cell migrat

213 ibrium molecular dynamics trajectory for the unliganded PreTS.

214 s, Mg(2+) replaced three Ca(2+) sites in the unliganded Protein C or APC.

215 most bound-like conformation in ensembles of unliganded protein structures and providing input for fr

216 ntegral component of secretory Abs, or as an unliganded protein that can mediate interactions with ba

217 t to be detectable from the structure of the unliganded protein, even when substantial conformational

218 ocking the set of NAMFIS conformers into the unliganded proteins with GLIDE followed by MM-GBSA scori

219 conformational free energy landscape of the unliganded proteins.

220 ity signatures of the TCRs, the structure of unliganded QL9-L(d) was solved and compared to structure

221 Hence, gene repression mediated by the unliganded RARgamma2-co-repressor complex constitutes a

222 Comparison of Ca(2+)-bound and unliganded RCK domains suggests a physical mechanism for

223 ilon-methionine and obtained HSQC spectra of unliganded receptor as well as receptor bound to an inve

224 We report here an unliganded receptor structure in the common gamma-chain

225 epends on both the intrinsic tendency of the unliganded receptor to open and the amount of agonist bi

226 four different conformational states for the unliganded receptor.

227 showed a ratio that was identical to that of unliganded receptors, agonist-bound D2 receptor-ligand c

228 imes for binding and the spatial gradient of unliganded receptors.

229 Pro236 in a position similar to that in the unliganded reverse transcriptase structure, and the dist

230 We propose that the maintenance of unliganded RNF146 in an inactive state may serve to main

231 ing pocket, which was previously observed in unliganded RT, is dramatically suppressed by efavirenz.

232 Co-adaptation involves trafficking of unliganded sensors between the surface membrane and recy

233 The Glu-202 side chain of unliganded SP-A extends out into the solvent and away fr

234 Comparison of these complexes with the unliganded SP-A neck and carbohydrate recognition domain

235 The apo-cluster encompasses unliganded species and complexes with nonpeptidic ligand

236 A comparison of all 28 subunits of the unliganded species with the peptidic liganded forms demo

237 nooxygenase, stachydrine demethylase, in the unliganded state (at 1.6 A resolution) and in the produc

238 arently affect the relative stability of the unliganded state and CD4-induced conformations.

239 Env proteins are kinetically trapped in the unliganded state and require the drug to negotiate CD4-i

240 ontribute to gp120-trimer association in the unliganded state and to CD4 binding.

241 diverse conformations that make up the gp120 unliganded state are reasonably ordered.

242 g cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic int

243 ontribute to gp120-trimer association in the unliganded state but also help secure CD4 binding.

244 ane envelope glycoprotein that stabilize the unliganded state by modulating the transitions from the

245 v to change conformation from the metastable unliganded state in response to the binding of ligands (

246 the overall shape of ct-AChBP in the apo or unliganded state is similar to that of homologues with k

247 ciency virus (SIV) must be maintained in the unliganded state of the envelope glycoprotein trimer.

248 1 has the ability to pass through its GDP or unliganded state prior to being GTP-loaded.

249 d roughly 20-fold more rapid exchange in the unliganded state than regions of low diversity (outer do

250 gp120 and regulates Env transitions from the unliganded state to downstream conformations.IMPORTANCE

251 state by modulating the transitions from the unliganded state to the CD4-bound state.

252 v conformational changes from the metastable unliganded state to the fusion-active state.

253 in decreased gp120-gp41 association (in the unliganded state) and decreased chemokine receptor bindi

254 rimeric Env displayed on native HIV-1 in the unliganded state, in complex with the broadly neutralizi

255 istic insights into the metastability of the unliganded state, receptor-induced conformational change

256 tes HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates,

257 ylated HIV-1 Env trimer in its uncleaved and unliganded state.

258 ut maintain the extended conformation in the unliganded state.

259 presents the first structure of HDAC8 in the unliganded state.

260 --> close" conformational equilibrium in the unliganded state.

261 the efficiency with which Env moved from the unliganded state.

262 th the cytoplasm and nucleus that stabilizes unliganded steroid receptors, controls the catalytic act

263 One loop is flexible in the unliganded structure but observed in the presence of sul

264 chanism of control involving deformations in unliganded structure from a functionally critical state

265 on where a region that was disordered in the unliganded structure is now observed in the active site

266 Here we report the first, to our knowledge, unliganded structure of EBOV GP, and high-resolution com

267 In addition to an unliganded structure solved using selenomethionyl single

268 of a GAF domain for which both liganded and unliganded structures are known.

269 or the ligand-bound sugar SBPs, but very few unliganded structures are reported.

270 ximab; however, unlike Cetuximab, one of the unliganded structures in S25-26 shows significant order

271 Applications to unliganded structures of 15 PPI target proteins show tha

272 lex at a resolution of 2.1 A, as well as the unliganded structures of D8 and LA5-Fab at resolutions o

273 ) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto).

274 by difficulties in the production of stable, unliganded target proteins.

275 tal structure of the catalytic domain of the unliganded TbrPDEB1 and its use for the in silico screen

276 The unliganded TbrPDEB1 X-ray structure was subjected to a s

277 stid PDECs and the crystal structures of the unliganded TcrPDEC1 catalytic domain and its complex wit

278 The unliganded tetrameric Hb S has axial and lateral contact

279 When unliganded, the CSD inhibits hyperpolarization-dependent

280 It is well documented that unliganded thyroid hormone receptor (TR) functions as a

281 g a simple two-state transition from an open-unliganded to closed-liganded state during the transport

282 The transition from the unliganded to the CD4-bound state is regulated by two po

283 nce and presence of hormone, suggesting that unliganded TR engagement with repressive complexes on ch

284 In this model, the unliganded TR forms stable, chromatin-bound complexes wi

285 ction in vivo and mediates repression by the unliganded TR in hypothyroidism.

286 er examine NCoR1's role in repression by the unliganded TR, we deleted NCoR1 in the livers of euthyro

287 aling that can be worsened by an increase in unliganded TRalpha.

288 bility of developing selective modulators of unliganded transcription factors to dial out adverse eff

289 outward movement of negative charges in the unliganded transporter.

290 that beta-catenin physically associated with unliganded TRbeta or TRbetaPV.

291 ion of the stability of the V3 pocket in the unliganded trimer or disruption of favorable V3/pocket i

292 o quaternary interactions that stabilize the unliganded trimer.

293 when CD4-liganded gp120 was compared to CD4-unliganded trimeric envelope structures.

294 angement similar to that displayed by native unliganded trimers on the surface of intact HIV-1 virion

295 erative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the pr

296 from VDR-null mice, revealing a role for the unliganded VDR in canonical Wnt signaling.

297 apidly on CD4-liganded virions and slowly on unliganded virions, although both reached similar levels

298 er for the ligand-bound mutants than for the unliganded wild-type channel.

299 Structural comparison with unliganded, wild type RGS2 and of other RGS domain/Galph

300 nded CAP containing a D138L mutation and the unliganded WT CAP were determined at 2.3 and 3.6 A resol