ライフサイエンスコーパス: unlinked

1 m a source other than the index participant (unlinked).

2 f the seroconversion events in HPTN 052 were unlinked.

3 on that all loci in a large SNP data set are unlinked.

4 loci presumed to be selectively neutral and unlinked.

5 sequence, and the genes that encode them are unlinked.

6 uch a recombinase must be of a new family or unlinked.

7 female maps share 74 loci; 2 markers remain unlinked.

8 hereas the other members, hbpD and hbpE, are unlinked.

9 th PmSOD1 and PmSOD2 are single copy and are unlinked.

10 With uracilate, a dinuclear unlinked 1:1 adduct is formed, Mo(2)(DAniF)(3)(uracilate

11 dence, 0.5%; 95% CI, 0.4 to 0.7) and 26 were unlinked (14 in the early-ART group and 12 in the delaye

12 beta4* nAChR function after coinjection with unlinked alpha3 and beta4 subunits but increases that of

13 Unlinked alpha3, beta4, and alpha5 subunits assemble to

14 for homomeric alpha7-nAChRs constituted from unlinked alpha7 subunits.

15 After LE-PCR, unlinked amplicons are removed on streptavidin-coated ma

16 products of recombination are topologically unlinked, an essential feature of the role of FtsK in ch

17 We genotyped 24 markers along 8q24 and 80 unlinked ancestry informative markers in a hospital-base

18 lity, and genotyped six CHRM2 markers and 38 unlinked ancestry-informative markers in 239 subjects wi

19 6 markers within the ADH gene cluster and 38 unlinked ancestry-informative markers in a case-control

20 es), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers in a case-control

21 Many of the putatively selected loci were unlinked and dispersed across the genome, which was cons

22 port that the A and B mating loci are likely unlinked and follow a tetrapolar organization within the

23 tion time on the four probabilities, and the unlinked and linked cases are seen to behave similarly.

24 The FAS1 and FAS2 genes in yeast are unlinked and map on two different chromosomes.

25 significant segregation distortion, 29 were unlinked, and 59 were eliminated because they span very

26 and GA tests to the polymorphic, physically unlinked, and putatively coevolving human gamete-recogni

27 6 were examined by using 24,311 records from unlinked anonymous surveillance of injecting drug users

28 ral phyllotaxis (137.5 degrees angle) and an unlinked apical cell division pattern.

29 genes, those organized as umuDC operons and unlinked, are induced upon DNA damage in a RecA-mediated

30 andparent-grandoffspring relationships using unlinked autosomal markers among different numbers of te

31 and females; simulations using 2, 3, 4, or 5 unlinked autosomal markers with a maternally inherited c

32 At present, 11-13 unlinked autosomal microsatellite loci are typed for for

33 Data from 10 unlinked autosomal noncoding regions, resequenced in 15

34 We present an expanded data set of 50 unlinked autosomal noncoding regions, resequenced in sam

35 , SO2, and C=O, and we also studied H,H (the unlinked benzidine).

36 A novel unlinked bHLH-encoding locus is described here, ENHANCER

37 More than 21% of these genetically unlinked but strongly associated markers are not randoml

38 a variation for alpha-thalassemia and S, two unlinked, but epistatic variants.

39 d in host-associated microbes, as opposed to unlinked by mechanisms, such as lateral transfer, remain

40 RANTES variant alone or in combination with unlinked C37.

41 type I error) were examined by simulating an unlinked causal SNP and the allele count was used as a p

42 ureus are coordinately controlled by several unlinked chromosomal loci.

43 hey can independently direct the transfer of unlinked chromosomal segments containing virulence genes

44 requires specific helper phages, transfer of unlinked chromosomal segments does not, so potentially a

45 on head-to-tail target sites produces mainly unlinked circles, while that of Flp yields multiply link

46 for phylogenetics, we sequenced parts of two unlinked clathrin heavy chain genes (CLTC and CLTCL1).

47 tions were not detected in epidemiologically unlinked clones within or between hospitals.

48 Linked and unlinked CMS patients had similar demographic and clinic

49 ted HSP genes, both chromosomally linked and unlinked, coalesce into discrete intranuclear foci.

50 A are very similar to what has been found in unlinked complexes.

51 the halves of the cyclic ligand relative to unlinked complexes.

52 Using toxins with naturally unlinked components as a starting point is advantageous

53 ffects of multiple biallelic loci (linked or unlinked) contributing genotypic variability to one or m

54 s pneumonia [PCP], 6 colonized patients), 22 unlinked control patients (18 patients with PCP, 4 colon

55 a fide Cu(I)-inducible CsoR of a genetically unlinked copA-copZ copper resistance operon in S. aureus

56 d end-frayed structures that form readily in unlinked (dA)n.(dT)n sequences, allowing the excited-sta

57 robe APTIMA Combo 2 tests was assessed using unlinked/deidentified surplus clinical specimens previou

58 on enhancement studies demonstrated that the unlinked DENV protease exists predominantly in a closed

59 A model of unlinked diallelic loci affecting the risk of a complex

60 a neutral quantitative trait determined by n unlinked diallelic loci with additive gene action.

61 Several pairs of unlinked distorted loci showed significant deviations fr

62 that differ distinctly in their topology: an unlinked DNA circle, a linked DNA circle within a pseudo

63 Unlinked DNA in 43 BC(5)F(2) individuals was found prima

64 repairs of each of these sites with multiple unlinked DNA templates.

65 ive to the reference), 26% are insertions of unlinked DNA, 9% are tandem duplications, and 6% are inv

66 ation of genes, of single domains, or of two unlinked domains.

67 guides methylation of itself as well as two unlinked duplicated PAI genes, PAI2 and PAI3.

68 Mutation of cya-8 is suppressed when a long unlinked duplication is present.

69 ce of Unstable factor for orange1 (Ufo1), an unlinked epigenetic modifier of p1, restored the cob glu

70 This procedure can identify unlinked epistatic BTL, demonstrated by our simulations

71 yIm-6, and with 10-fold higher affinity than unlinked f-ImPyIm.

72 genetic evidence suggests that other S-locus unlinked factors are also required for GSI.

73 ons (T494M) is seen repeatedly in apparently unlinked families raising the possibility of a mutation

74 ignificantly lower compared to 51 cases from unlinked families, among individuals either 50 to 70 or

75 e a conceptual bridge between the previously unlinked fields of phylogenetics and mathematical spatia

76 erized as a transcriptional repressor of the unlinked fliC gene when FljB is expressed.

77 the FliC mRNA leader block expression of the unlinked fljB gene.

78 uals who were HIV seroconcordant but virally unlinked from their spouses were then tested by this met

79 option with adoption of controlled charging, unlinked fuel economy regulations, and renewable electri

80 to medium composition and to mutations at an unlinked gene called car.

81 In this study, we provide evidence that an unlinked gene carried within the Salmonella pathogenicit

82 ber of the pca regulon, which includes three unlinked gene clusters that encode five enzymes required

83 lution of these two functionally related but unlinked gene clusters.

84 allel functional differentiation at multiple unlinked gene duplicates: two alpha-globin paralogs on c

85 f the steps apparently being catalysed by an unlinked gene encoding a 6-methylsalicylate synthase.

86 e syp-encoded response regulator SypG and an unlinked gene encoding the sensor kinase RscS in control

87 This striking example of a balanced unlinked gene network polymorphism introduces a remarkab

88 a naturally occurring dominant allele of an unlinked gene, CIF2(D).

89 ed that a protein encoded by a chromosomally unlinked gene, espA, is also secreted by strains that co

90 this pathogen, and find that the products of unlinked genes associate to form multisubunit transporte

91 Two unlinked genes FER1 and FER2 encoding ferritin subunits

92 We found that although unlinked genes partition populations by geographic regio

93 ome Helitron subfamilies, with as many as 10 unlinked genes providing DNA inserts within a single ele

94 in many ways depending on allelic variants, unlinked genes, epigenetic factors, and environmental ex

95 to and within H. melpomene using a series of unlinked genes, genes linked to color pattern loci, and

96 To infer a species phylogeny from unlinked genes, phylogenetic inference methods must conf

97 nes have much higher coexpression rates than unlinked genes, supporting a role for chromatin modellin

98 mbers of trans-regulated genes (regulated by unlinked genetic loci) that link to a single locus or eQ

99 window on the interactions between multiple unlinked genetic loci.

100 We targeted three unlinked genetic loci: the mitochondrial control region,

101 d evolution based on the cotransformation of unlinked genetic markers in naturally competent microorg

102 can be controlled by genotyping a few dozen unlinked genetic markers.

103 utant lesions rather than contributions from unlinked genetic or environmental modifiers.

104 ation tree inference are mainly designed for unlinked genetic variants (e.g. single nucleotide polymo

105 We apply pong to 225 705 unlinked genome-wide single-nucleotide variants from 242

106 nome scan for linkage disequilibrium between unlinked genomic regions in naturally occurring hybrid p

107 rt and medium range (up to 100 kb) LD in six unlinked genomic regions in the partially selfing domest

108 em, we could demonstrate high frequencies of unlinked germinal transposition of dSpm in rice.

109 , nearly complete mitochondrial genomes, 430 unlinked high-quality SNPs shared across all Pocillopora

110 their own DNA, the GTAs exclusively transfer unlinked host DNA, and the SaPIs combine the capabilitie

111 that occurred through physically separated, unlinked hr elements.

112 The arrays are nonhomologous, physically unlinked in mammals, and encode functionally interdepend

113 frequently coincided with an insertion at an unlinked, independently targeted site, suggesting enrich

114 ccur at the boundary, whereas if the two are unlinked initially, then the singularity will occur in t

115 etic strategies to enrich for both local and unlinked insertions were used to distribute Ds insertion

116 Their relationship to each other and various unlinked interacting genes has been enigmatic.

117 ked genetically while others are genetically unlinked is consistent with multiple modes of origin.

118 These genes were found to be present at unlinked locations scattered throughout the genome, an a

119 measure of gene-gene interaction between two unlinked loci (or genes).

120 We show that multiple, unlinked loci act largely additively to determine positi

121 mutation rate, both in a model of completely unlinked loci and in a model of completely linked loci,

122 Two unlinked loci appear to control behavioural development

123 Second, the coalescent processes at unlinked loci are correlated with the genealogy at the s

124 ptions such as infinite population size with unlinked loci at linkage equilibrium (LD) under mutation

125 rts in the USA, computes the MP for multiple unlinked loci by assuming statistical independence, mult

126 quences of this for patterns of variation at unlinked loci for two kinds of demographic events: the o

127 Forward simulations of unlinked loci have shown that the decline in heterozygos

128 tching can drive allelic association between unlinked loci in a contemporary human population, and th

129 utilize the presence of correlation between unlinked loci in a disease-enriched sample as evidence o

130 lele model (GAM) involves a finite number of unlinked loci in an infinitely large population, with a

131 oken into 48 pieces and distributed over two unlinked loci in Stylonychia.

132 Selection on unlinked loci in the genetic background may greatly incr

133 locally adaptive configuration of physically unlinked loci in Western Europe.

134 d molecular levels how mating-type and other unlinked loci interact to enable microbial pathogenesis.

135 he mud1 and mud2 mutations correspond to two unlinked loci mapping on different chromosomes.

136 iation expected for gene trees from multiple unlinked loci sampled from a single species history afte

137 ging because it involves multiple linked and unlinked loci that exert their influence in an epistatic

138 onstraints of gene-gene independence between unlinked loci to increase power.

139 measure of gene-gene interaction between two unlinked loci were also investigated.

140 ture population pedigrees in such a way that unlinked loci will show deviations from the standard pre

141 gies indicate frequent recombination between unlinked loci, but there is no evidence of recombination

142 fluences the trait, including epistasis with unlinked loci, correlated environmental effects within f

143 in evolutionary biology: mutations occur at unlinked loci, have equivalent effects, and combine mult

144 s that assume gene-gene independence between unlinked loci, not in the entire population, but only co

145 nd phenotype, including interactions between unlinked loci, the prevailing strategies for analysis of

146 t sunn and sickle correspond to separate and unlinked loci, whereas the sunn/skl double mutant exhibi

147 Using sequences at four unlinked loci, which were determined from multiple speci

148 eraction among the products of at least four unlinked loci, with one entire chromosome being inherite

149 allelic association, even between physically unlinked loci.

150 e statistical non-independence of alleles at unlinked loci.

151 inkage disequilibrium, even among physically unlinked loci.

152 the power to detect interaction between two unlinked loci.

153 to detect gene-gene interaction between two unlinked loci.

154 and made it applicable to data from multiple unlinked loci.

155 em inverted repeat plus two singlet genes at unlinked loci.

156 linkages and a number of interactions among unlinked loci.

157 aneously obtain parasites genotypes at three unlinked loci.

158 locus subject to viability selection and an unlinked locus that causes sex-specific modification of

159 A partial explanation is provided by an unlinked locus, identified by QTL analysis, that display

160 ividuals to assess levels of variation at an unlinked locus.

161 Multiplex analysis of these four unlinked makers was able to distinguish all three common

162 Both linked and unlinked marker pairs are incorporated in the model.

163 named linkage group) or associated with five unlinked markers (Omm1159, Omm1367/i, Omy325UoG, OmyRGT5

164 of the mates cannot be controlled, but where unlinked markers have been collected for a set of female

165 gregated in a manner similar to that for two unlinked markers in one round of retroviral replication.

166 or resistance (QTL markers) as well as other unlinked markers increased significantly in the first ge

167 ause the predicted recombination rate of two unlinked markers is 50%, we conclude that markers 1 kb a

168 equency changes in the QTL markers and other unlinked markers suggest that the reduced fitness in the

169 The QTL are spread across many unlinked markers, yet QTL placed with linked markers are

170 ion studies due to allelic association among unlinked markers.

171 art of 5A, relative to the LD observed among unlinked markers.

172 he merits of several methods for using null (unlinked) markers to protect against false positives due

173 In tetrapolar species, two unlinked mating-type loci exist (A and B), whereas in bi

174 ination between epidemiologically linked and unlinked MeV variants identified in Sweden during 2013-2

175 f parameters (the current version applies to unlinked microsatellite data).

176 the intervening domain II and compared to 11 unlinked microsatellite loci.

177 suggesting that pure-species genotypes carry unlinked modifier alleles that increase sexual dimorphis

178 -locus cysteine-rich (SCR) genes, as well as unlinked modifier loci required for SI.

179 Unlinked modifiers that alter the segregation ratio are

180 which suggests that interaction with either unlinked modifying genes and/or the normal NF1 allele ma

181 e linked system were similar to those of the unlinked modules, suggesting that it may be feasible to

182 rning the newly replicated chromosomes to an unlinked monomeric state is essential to cell survival.

183 out of adaptation, relative to the number of unlinked mutations, suggesting that divergence hitchhiki

184 Linked and unlinked National Cardiovascular Data Registry patients

185 time-dependent probability of fixation of an unlinked neutral locus.

186 values, and differ in allele frequency at an unlinked neutral marker locus.

187 to loci for Plasmodium resistance and other unlinked neutral markers were determined over 12 generat

188 Forward-time simulations for unlinked, neutral, autosomal, common loci were performed

189 However, phylogenetic analyses of 20 unlinked nuclear genes reveal a genome-wide signal that

190 nfer resistance to erythromycin define three unlinked nuclear loci in C. reinhardtii.

191 In addition, a new unlinked nuclear mutation was discovered in mcd1-2, whic

192 ion when data are available from a number of unlinked nucleotide sites.

193 opes for CD4 and CD8 T-cell recognition are "unlinked" on different cells (recipient and donor antige

194 The unlinked operons that comprise the Escherichia coli CytR

195 bstrate is supercoiled, these circles can be unlinked or form multiply linked catenanes.

196 duction, for populations under selection for unlinked or linked loci and for the specific application

197 AL2 gene and decreased the expression of the unlinked OsPAL6 gene.

198 Ne) from linkage disequilibrium (LD) between unlinked pairs of genetic markers has become an importan

199 aled that the standard vp8 stock contains an unlinked, partially dominant suppressor of the vp8 mutat

200 tients, and 13 (17%) of 75 epidemiologically unlinked patients (three-way comparison exact p<0.0001).

201 as accompanied by a dramatic accumulation of unlinked pentapeptide stems with no change in the tetrap

202 analysis contain two hmw loci in conserved, unlinked physical locations on the chromosome.

203 imprinted locus acting epistatically on two unlinked polymorphic loci, Nstr1 and Nstr2.

204 l subjects, we also genotyped subjects at 49 unlinked polymorphisms evenly distributed throughout the

205 Genotyping at 49 unlinked polymorphisms indicated that a subset of case s

206 hat enhancer-trap lines can transactivate an unlinked pOp-green fluorescent protein (pOp-GFP) reporte

207 se Mo17-specific duplications are located in unlinked positions throughout the genome.

208 d NMR spectrum, we expressed and purified an unlinked protease complex containing a 50-residue segmen

209 This unlinked protease complex was catalytically active at ne

210 the structures and functions of two normally unlinked proteins, namely, the heme binding capability o

211 Zebrafish have two unlinked protocadherin clusters, DrPcdh1 and DrPcdh2.

212 the overall energy transfer efficiency, with unlinked QDs and Cy5 hydrazide producing nearly zero bac

213 e showed that D3Tx-AOD is controlled by five unlinked QTL (Aod1-Aod5) and H2.

214 An unlinked QTL for cannabinoid quantity may also have play

215 benefit remains in the presence of a second unlinked QTL with small effect (explaining <20% of the v

216 We identified four unlinked quantitative trait loci (QTL) that interacted a

217 A sequenced isolate genome resembled an unlinked random mixture of the allelic diversity at the

218 indeterminate spikelet1 (ids1) is an unlinked recessive mutant that has a similar phenotype t

219 on factors MED-1 and MED-2 are encoded by an unlinked, redundant pair of intronless genes.

220 A paralogue of YlfA was identified on an unlinked region of the Legionella chromosome and this pr

221 an contain several misassemblies, which join unlinked regions of the genome.

222 equired for biofilm formation induced by the unlinked regulator RscS.

223 hromosomes, sister chromatids, and linked or unlinked repeats.

224 In WT vegetative cell nuclei, genetically unlinked ribosomal DNA (rDNA) loci are uniquely clustere

225 he NBSRps4/6 region and introgression of two unlinked Rps genes into Harosoy are discussed.

226 cterial recipients acquired multiple, large, unlinked segments of donor DNA, far exceeding expectatio

227 from 12.2% to 27.7% (P < .001), and 48.4% of unlinked seropositive participants were linked to HIV ca

228 tinuous property landscape from an otherwise unlinked set of discrete molecular-property values.

229 n structure was estimated on the basis of 36 unlinked simple-sequence repeat (SSR) markers.

230 o infer population structures using multiple unlinked single nucleotide polymorphisms (SNPs).

231 sets consisting of the frequency spectrum of unlinked single-nucleotide polymorphisms (SNPs).

232 n methylation, as well as methylation of two unlinked singlet PAI genes.

233 ice were retained including transposition to unlinked sites and a preference for insertion within 2.5

234 Like MuDR, TED transposes mostly to unlinked sites and can form circular transposition produ

235 e show that Ds transposed to both linked and unlinked sites and displayed a nonuniform distribution o

236 a complete summary of sequence variation at unlinked sites and more generally, its shape reflects un

237 e, and transposed copies usually insert into unlinked sites in the genome that are preferentially in

238 e among the highest seen among several dozen unlinked sites that were studied in the same subset of p

239 uency spectra that can be applied to sets of unlinked sites.

240 domesticus, we identified several physically unlinked SNP pairs that show exceptional gametic disequi

241 Using unlinked SNPs to determine the amount of background link

242 rotein (DsRed) fluorescent markers to select unlinked stable transpositions of dSpm.

243 sequence of a serovar-matched but otherwise unlinked strain.

244 We find that: (1) fewer unlinked STRPs than SNPs are needed to detect structure

245 containing the KIR and HLA class I genes are unlinked, structurally complex, and highly polymorphic.

246 unction was much more efficient than that of unlinked subunits.

247 ling of cancer cells through targeting of an unlinked synthetic dosage lethal (SDL) partner.

248 detectable T cell responses, suggesting that unlinked T cell-B cell help might support development of

249 important for amplification of siRNAs at the unlinked target site because its presence correlates not

250 e methylation in cis but also in trans at an unlinked target site, provided this sequence is transcri

251 Significantly, inactivation of either GRASP unlinked the Golgi ribbon, and the immediate effect of G

252 d are separately controlled by multiple loci unlinked to 5-HT and BDK receptors, respectively.

253 suggested because most of the families were unlinked to any one quantitative trait locus.

254 abnormal alpha-dystroglycan immunolabelling, unlinked to any reported CMD loci.

255 The remainder appear to be unlinked to brassinosteroids and related to primary and

256 s PAK-2 activation function but functionally unlinked to CD4 and MHC class I downregulation or enhanc

257 so detect other divergent regions apparently unlinked to color pattern differences.

258 e genes for recessive dRTA in eight kindreds unlinked to either known disease locus.

259 nclude most of the dark asteroids previously unlinked to families.

260 that when female recombination modifiers are unlinked to female drivers, recombination modifiers that

261 s, the hlyD and tolC genes were adjacent but unlinked to hlyB; neither locus was part of an operon co

262 ile the majority of the hair keratins remain unlinked to human phenotypes.

263 genomic sequence at 8p23 in 6 MODY families unlinked to known MODY genes that showed evidence of lin

264 es in a substantial proportion of MODY cases unlinked to known MODY genes.

265 d to the discovery of three genes heretofore unlinked to malignant breast cancer that were reproducib

266 errant protein synthesis or stability and is unlinked to PKCalpha function.

267 We determined that the psc mutation is unlinked to previously characterized maize leaf carbohyd

268 These data show that ARC, previously unlinked to pulmonary hypertension, is a critical determ

269 females have an increased etiological burden unlinked to rare deleterious variants on the X chromosom

270 ed entities with rates of formation that are unlinked to speciation rates, in which case the causes o

271 Thus, productive replication of RRV is unlinked to that of rhEBV; factors that influence activa

272 expressed GFP and in which the hpt gene was unlinked to the acceptor DNA.

273 tification may lead to association with loci unlinked to the disease locus.

274 cleotides that were either tightly linked or unlinked to the excision site.

275 The action of PP2AB'1 in response to ABA is unlinked to the generation of calcium oscillations, as t

276 he accumulation of inherited defects at loci unlinked to the met1 mutation.

277 his phenotype was caused by a genetic change unlinked to the original cheW mutation.

278 We show that several of these genes are unlinked to the putative A. lyrata SRK, Aly13.

279 ce to other P. parasitica (At) isolates, was unlinked to the RPP2 locus; this class included AtSGT1b.

280 ion of three pistil essential modifier genes unlinked to the S-locus (HT-B, 120K, and NaStEP) unveils

281 n was associated with a pollen-part mutation unlinked to the S-locus in the apricot (Prunus armeniaca

282 cade of events involving other gene products unlinked to the S-locus that are crucial to the self-inc

283 ive factor that causes SC that is physically unlinked to the S-locus.

284 MES-4 appears unlinked to transcription elongation, thus distinguishin

285 at the Vwf locus (Mvwf5), as well as 2 loci unlinked to Vwf (Mvwf6-7) using a backcross approach wit

286 stribution and exhibit a greater fraction of unlinked transpositions when compared with Ds elements.

287 rk, we present a mixture model of linked and unlinked trios and develop a statistical method to estim

288 d for some loci, the estimated proportion of unlinked trios approaches or exceeds 50%, suggesting the

289 to detect association even the proportion of unlinked trios is high (75%).

290 ss mice depends on interactions with another unlinked tumor modifying locus, Skts15, that overlaps Tg

291 ced by DNA damage, while uvrA and one of the unlinked umuC genes were somewhat derepressed in the abs

292 the nonspecific effects are a result of the unlinked, unreacted CPP.

293 ked to Ii compared with vaccination with the unlinked vaccine.

294 Furthermore, we show that an unlinked variant, AGT M235T, previously implicated in hy

295 le SNPs within a non-recombining region, not unlinked variants.

296 No epistasis was detected among vQTL, so unlinked vQTL presumably have independent effects on sur

297 and cold shock in this study were previously unlinked with temperature stress.

298 ociated with eRF1 mutants are quantitatively unlinked with translation termination defects, suggestin

299 In each case, K65R coexisted unlinked with variants carrying 2-5 thymidine analog mut

300 We found that six unlinked ysp genes responded to NaCl and required YsaE/S