ライフサイエンスコーパス: unload

1 e pulses, a phenomenon we refer to as 'batch unloading'.

2 I+unload group (49% versus 28%, MI versus MI+unload).

3 work, 2823 versus 655 mm Hg.mL, MI versus MI+unload).

4 f mass flow and diffusion (convective phloem unloading).

5 slide away, PCNA re-engages with RFC and is unloaded.

6 Contralateral control joints were left unloaded.

7 ifested through reversible detwinning during unloading.

8 ficance during cardiac pressure overload and unloading.

9 rostin and RANKL/OPG ratio in the setting of unloading.

10 ption, or stop bone loss induced by skeletal unloading.

11 l strength, and material strength induced by unloading.

12 ts exposed to longer durations of mechanical unloading.

13 functional cardiac recovery after mechanical unloading.

14 e of ongoing atrophic remodeling during LVAD unloading.

15 ing regression of cardiac hypertrophy during unloading.

16 ikely due, at least in part, to baroreceptor unloading.

17 sting no direct involvement in cargo loading/unloading.

18 ion of cardiac hypertrophy during mechanical unloading.

19 y of Scx-mutant callus was not due to muscle unloading.

20 and NIOV+Air, signifying respiratory muscle unloading.

21 no atrophic remodeling after prolonged LVAD unloading.

22 anical load but hypertrophy can regress upon unloading.

23 led; 54 underwent 8.0 +/- 1.2 months of LVAD unloading.

24 unofluorescent imaging during RBC O2 loading/unloading.

25 C-like complex (Elg1-RLC) functions in PCNA unloading.

26 ading, freezing, and thawing, and during CPA unloading.

27 much of the large deformation is removed on unloading.

28 R plays a dynamic role during ligand loading/unloading.

29 trol subjects and increased after mechanical unloading.

30 emic hemodynamics resulting in biventricular unloading.

31 esponsible for the bone loss associated with unloading.

32 hereas NIPBL facilitates cohesin loading and unloading.

33 anical stress during hemodynamic loading and unloading.

34 and functional recovery during chronic LVAD unloading.

35 y remodeling of the myocardium due to volume unloading.

36 s that occur to the myocardium due to volume unloading.

37 to 25 cm H2O in terms of respiratory muscle unloading.

38 in each - without any mechanical loading and unloading.

39 ative role for these Suc transporters in Suc unloading.

40 s >1 microm did not improve after mechanical unloading.

41 ing aging, estrogen deficiency, and skeletal unloading.

42 mes decreased as early as 30 days after LVAD unloading (113 vs. 77 ml/m(2), p < 0.01, and 92 vs. 60 m

43 ass decreased as early as 30 days after LVAD unloading (114 vs. 95 g/m(2), p < 0.05) and continued to

44 After 6 months of LVAD unloading, 34% of patients had a relative LV ejection fr

45 The rapid loading and unloading abilities demonstrated by these selective micr

46 Proposed mechanisms include skeletal unloading, abnormalities in calciotropic hormones, and c

47 n stress that include water mass loading and unloading above the aquifer surface.

48 These studies suggest that the unloading activity of RFC maximizes the utilization of P

49 ts aspects of its function distinct from its unloading activity.

50 ication factories, probably through its PCNA-unloading activity.

51 This "unloading" activity can be enhanced by mismatches betwee

52 We examined the effect of human ventricular unloading after implantation of left ventricular assist

53 Mechanical unloading after left ventricular assist device implantat

54 by providing significant volume and pressure unloading, allow a reversal of stress-related compensato

55 reviewed, both those demonstrated with LVAD unloading alone in patients bridged to transplantation a

56 Both mechanical overload and unloading alter t-tubule structure, but the mechanisms m

57 Comparisons between unloaded and loaded live cells demonstrate both spatial

58 n, was stable for several hours after phloem unloading and could be used to study phloem transport in

59 provements accompanied by respiratory muscle unloading and dyspnea reductions in patients with severe

60 indicates that assumptions regarding liquids unloading and estimated ultimate recovery (EUR) of wells

61 ement was achieved by 6 months of mechanical unloading and persisted over the 1-year follow up.

62 ning future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to re

63 again soon, but stress changes from sediment unloading and previous earthquakes may eventually be suf

64 injuries, ischemia-reperfusion, and hindlimb unloading and reloading.

65 Despite effective hemodynamic unloading and remodeling, there were no differences afte

66 o be efficiently coupled to their subsequent unloading and translocation, thus providing spatial coor

67 he tracer solution still needs to be loaded, unloaded, and purged from the cell culture during the me

68 also improved as early as 30 days after LVAD unloading, and this improvement persisted over time.

69 PS) was collected from the loading (source), unloading (apical sink region) and shoot-root junction r

70 Three twin thicknesses after unloading are 3.2, 3.5, and 16 nm, which is consistent w

71 iac myocyte physiology because of myocardial unloading are contributors to ventricular arrhythmias in

72 ptional level, and muscle changes induced by unloading are counteracted by passive mechanical loading

73 inding, complex assembly with SRP, and cargo unloading are inextricably linked to each other via conf

74 Microgravity and unloading are known to cause osteoclast-mediated bone re

75 g the response of the skeleton to mechanical unloading are not completely understood.

76 ur results identify BRCA1-dependent helicase unloading as a critical, early event in ICL repair.

77 at entered the translocation stream and were unloaded at the root tip.

78 machinery, RNA function requires subsequent unloading at least into adjacent companion cells.

79 less (-2%) than that of tumors treated with unloaded beads (+42%) and oral sunitinib (6 mg every day

80 tinib), seven received 0.05 mL of 70-150-mum unloaded beads, and seven received oral sunitinib (6 mg

81 the transport of Stx, with cargo loading and unloading being regulated by protein kinases.

82 f the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing

83 ch applied force accelerates dissociation of unloaded bonds and kinetically strengthens strained bond

84 Muscle contraction reduced resorption of unloaded bone independently of the CNS, through mechanic

85 was performed at P7 for WT, cKO, and muscle-unloaded (botulinum toxin A treated) attachments for qua

86 trophic myocardium in heart failure patients unloaded by continuous-flow LVADs has not been studied.

87 nd at different time points after mechanical unloading by a left ventricular assist device (LVAD) by

88 ssion in human failing hearts resolved after unloading by a left ventricular assist device.

89 o maintain a high turgor to drive symplasmic unloading by bulk flow.

90 The study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial at

91 Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has

92 te is achieved upon drought by reduced xylem unloading by PtaSULTR3;3a and PtaSULTR1;1, and by enhanc

93 ese methods enabled the preparation of fully unloaded CalE8, providing a "clean slate" for reconstitu

94 Despite robust cardiac unloading, capillary density and fibrosis are unchanged

95 +) transients was significantly increased in unloaded cardiomyocytes (UN 227.4+/-24.9 ms(2), n=42 vs.

96 ngs of the t tubules and the cell surface in unloaded cardiomyocytes.

97 ows the SRP-FtsY complex to more efficiently unload cargo proteins.

98 NPC, a process that is probably required for unloading cargo sRNA into surrounding cells.

99 LHCP's transmembrane domains in a productive unloading complex at the membrane.

100 nity, while selecting against binding to an "unloaded" complex.

101 he centre of the sarcomere, producing, under unloaded conditions, a filament sliding of approximately

102 l cycle exercise tests, in randomized order: unloaded control and added DS of 0.6 L.

103 expression in mechanically loaded wounds vs. unloaded control wounds in an established murine hypertr

104 unctional maturation in comparison to static unloaded controls as evidenced by increased proliferatio

105 All conditions were compared to unloaded controls.

106 of friction values compared to baseline and unloaded controls.

107 Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insi

108 ss matrix subjected to a compressive loading-unloading cycle.

109 statistically similar throughout the loading-unloading cycle.

110 rom 1.64 to 2.29 GPa during multiple loading-unloading cycles.

111 t 50% of individual working capacity, during unloaded cycling at 0 W (muscle pump alone), during unlo

112 d cycling at 0 W (muscle pump alone), during unloaded cycling with isocapnic hyperpnea (muscle and ve

113 d of MSNA, and was increased by baroreceptor unloading, decreased by baroreceptor stimulation and abo

114 PCNA unloading depends on the Elg1-containing alternative RFC

115 ndicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the

116 Unloaded DRC4 diffuses before docking at its axonemal as

117 ic shortening, lithospheric delamination and unloading due to deglaciation and erosion.

118 locomotor blood flow with respiratory muscle unloading during activity.

119 their "top" face (furthest from bilayer) and unload each of them selectively upon addition of a speci

120 grain boundaries have a surprising "loading-unloading" effect.

121 m toxin (BTX) was used to investigate muscle unloading effects on callus shape.

122 f uncertainty in current estimates of liquid unloading emissions.

123 vels, we subjected osteocytes to an in vitro unloading environment achieved by the NASA rotating wall

124 Cells deficient in PCNA unloading exhibit increased chromosome breaks.

125 fines their boundaries, and that the cohesin unloading factor WAPL and its PDS5 binding partners cont

126 ce/group) within each genotype and HU groups unloaded for 2 weeks.

127 orway rats at 10 months of age were hindlimb unloaded for a period of 2 weeks.

128 LVAD-associated unloading for 6 months resulted in a substantial improve

129 (cross-sectional area) decreased after LVAD unloading from 1,238 +/- 81 mum(2) to 1,011 +/- 68 mum(2

130 We conclude that apoplasmic Suc unloading from de-energized protophloem sieve elements i

131 r mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g.

132 upward flexure of the lithosphere caused by unloading from river incision between 16,000 and 10,000

133 The SWEET transporter may facilitate Suc unloading from the phloem to the apoplast where cell wal

134 the Elg1 complex and down-regulate its PCNA-unloading function to promote the G1/S transition.

135 ulated transcript set overlapped with muscle unloading gene expression profiles (>/=1.5-fold change;

136 up, total infarct size was reduced in the MI+unload group (49% versus 28%, MI versus MI+unload).

137 t were decreased after reperfusion in the MI+unload group (mean left ventricular wall stress, 44 658

138 in the MI group but was increased in the MI+unload group.

139 We find that an unloaded hair bundle can behave very differently from on

140 ) or the profound unloading in a chronically unloaded heart result in impaired t-tubule structure, wi

141 V peptide loaded autologous target cells and unloaded HLA-B8(+) EBV LCL target cells.

142 absence of MAT reduced bone loss in hindlimb-unloaded (HU) mice.

143 usly hypertensive rat model) or the profound unloading in a chronically unloaded heart result in impa

144 underlying the importance of Suc apoplastic unloading in Arabidopsis roots and a putative role for t

145 vity was partially restored after mechanical unloading in failing hearts (P<0.01) and was significant

146 h is needed to define the role of mechanical unloading in intensive care unit-associated weakness and

147 ligand (RANKL) expression is increased with unloading in mice.

148 sucrose transporters (SUTs) regulate phloem unloading in monocot stems is poorly understood and part

149 in Arabidopsis (Arabidopsis thaliana), while unloading in roots is less understood.

150 e phloem-pole pericycle in regulating phloem unloading in roots.

151 loading in the pulmonary circulation and O2 unloading in the systemic circulation.

152 chromatin with purified Elg1-RLC causes PCNA unloading in vitro.

153 evaluate its potential roles, such as phloem unloading, in nonphotosynthetic tissues.

154 Countermeasures that lessen the effects of unloading include physical activity, nutritional supplem

155 Continuous-flow LVAD unloading induced in a subset of patients, both ischemic

156 However, whether unloading-induced atrophy in experimental normal heart m

157 eling features might guide future studies of unloading-induced reverse remodeling of the failing huma

158 Prolonged mechanical unloading induces adult human cardiomyocyte proliferatio

159 hts from studies which investigated how LVAD unloading influences the structure and function of the f

160 capacity to interact with AGO2, it mediated unloading instead of loading of let-7 family miRNAs, the

161 unlike termination, repair-mediated helicase unloading involves the tumor suppressor protein BRCA1, w

162 CMG unloading involves ubiquitylation of its Mcm7 subunit an

163 SOST/sclerostin up-regulation in mechanical unloading is a cell-autonomous response or a hormonal re

164 tors that are enriched on chromatin when CMG unloading is blocked.

165 of an elg1Delta mutant suggests timely PCNA unloading is critical for chromosome maintenance.

166 vitro and in vivo analysis showed that PCNA unloading is delayed in the absence of nucleosome assemb

167 f CRL2(Lrr1), Mcm7 is not ubiquitylated, CMG unloading is inhibited, and a large subcomplex of the ve

168 (Myo1b) and Myosin-Ic (Myo1c), have similar unloaded kinetics and sequences but substantially differ

169 Most wells without plunger lifts unload less than 10 times per year with emissions averag

170 to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labelin

171 In addition, there was left ventricular (LV) unloading manifested by a decrease in LV end-diastolic p

172 nts contain metal transporters that load and unload metals.

173 Unloaded mice exhibited high serum levels of the bone re

174 id bilayers can propel actin filaments in an unloaded motility assay, its ability to develop forces a

175 posed to 1-gravity environment or mechanical unloading (MU) for 24 hours, with or without periods of

176 sed production of reactive oxygen species in unloaded muscle fibers.

177 ts with gene expression microarray data from unloaded muscle to map several direct targets of Bcl-3 t

178 sin ATPase cycle limits contraction speed in unloaded muscles (V0).

179 iciency; there was a 31% and 23% increase in unloaded myocardial oxygen consumption in healthy and po

180 The increased unloaded myocardial oxygen consumption was confirmed in

181 In the mechanically supported group (MI+unload; n=4), percutaneous left atrial-to-femoral artery

182 sults demonstrate that Elg1-RLC functions in unloading of both unmodified and SUMOylated PCNA during

183 tly reduced, but not fully eliminated, while unloading of Ca2+ stores by thapsigargin treatment in th

184 ontrol the loading, active concentration and unloading of cargo on this track network, or to trigger

185 SRP*SR complex, and most significantly, the unloading of cargo onto the target membrane.

186 editor," capable of fine-tuning loading and unloading of CD1d molecules.

187 Depletion of Klf4 leads to unloading of cohesin at the Oct4 enhancer and disrupts l

188 in the intestine, unlike the diffusion based unloading of most controlled release devices for small m

189 al OB-folds allow CST to mediate loading and unloading of partner proteins to facilitate various aspe

190 actor C-like complex, Elg1/ATAD5-RLC, in the unloading of PCNA during replication in yeast and human

191 checkpoint kinases regulate strand-specific unloading of PCNA from stalled replication forks to main

192 y of the DNA replication machinery, and that unloading of Rad51 by Srs2 helicase is required for effi

193 We also report that unloading of RPA from sites of ICL induction is perturbe

194 mathematical modelling) to show that phloem unloading of solutes in Arabidopsis roots occurs through

195 mics the headward fluid shift and axial body unloading of spaceflight.

196 an important factor for the study of phloem unloading of Suc.

197 though the processes involved in loading and unloading of sugars and amino acids are well characteriz

198 and hypertrophy before and after mechanical unloading of the failing human heart.

199 n advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired ca

200 Mechanical unloading of the failing myocardium reverses adipose tis

201 Therefore, unloading of the heart may contribute to the beneficial

202 s of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results i

203 the sequential recruitment, remodeling, and unloading of the targeting complex at membrane transloca

204 G actively drives the efficient delivery and unloading of translating ribosomes at the target membran

205 ect of left ventricular assist device (LVAD) unloading on cardiac endothelium and microvasculature is

206 altered sympathetic activity in addition to unloading on cardiac hypertrophy and function.

207 igate the impact of gravitational mechanical unloading on ECs phenotype as determined by patterns of

208 stigations have described the impact of LVAD unloading on key structural features of cardiac remodeli

209 These new insights into the effects of LVAD unloading on microvasculature and associated key remodel

210 s study was to test the effect of mechanical unloading on mitochondrial mass, DDR, and cardiomyocyte

211 The effects of LVAD unloading on myocardial function, electrophysiologic pro

212 s-flow left ventricular assist device (LVAD) unloading on myocardial structure and systolic and diast

213 lenge to predict the impact of LV mechanical unloading on postoperative right ventricular (RV) functi

214 0.01) and ejection fraction increases during unloading (P<0.01).

215 hose that modulate nociception, stabilize or unload painful structures, influence physiological proce

216 Transiting from an apoplasmic to symplasmic unloading pathway as the stem matures, SbSUT1 and SbSUT5

217 photriesters accelerates dissociation of the unloaded phosphorus-oxygen bond orthogonal to the pullin

218 parated when they exit the phloem during the unloading process.

219 does not have an apparent function in either unloading process.

220 These results suggest that differences in unloaded processivity between diverse kinesins is primar

221 of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly

222 How IFT trains attain speeds that exceed the unloaded rate of the slower, KIF3AB motor remains unknow

223 switch from symplasmic to apoplasmic phloem unloading, reconciling previously conflicting reports, a

224 was used to apply an equibiaxial loading and unloading regimen to fibroblast-seeded tissue equivalent

225 e-state model for CMR where both loading and unloading regulate the transition of bonds among the sho

226 NF-kB binding site is involved in the muscle unloading regulation of MuRF1.

227 h can be described as time-dependent forces (unloading/reloading cycles) acting on the Earth.

228 g therapy and left ventricular assist device unloading results in significant myocardial recovery, su

229 those regions where axons can be loaded and unloaded reversibly and those where axons are injured du

230 s of the R2TP complex, which appears to load/unload RuvBL AAA(+) adenosine triphosphatase from pre-sn

231 Response time of the unloaded server is about 90 s for a 300-residue eukaryot

232 Unloading shoes were not associated with increased proba

233 ridges, a slowing of the maximum velocity of unloaded shortening and an increased curvature of the fo

234 ast muscle) and provides novel insights into unloaded shortening velocities (declining with increasin

235 Accordingly, the unloaded shortening velocity (V0 ) is already set at the

236 e observed before disuse, whereas Po/CSA and unloaded shortening velocity reached a higher level.

237 specific force (PO /CSA) and an increase in unloaded shortening velocity, which could be a result of

238 a loss of specific force and an increase in unloaded shortening velocity.

239 in the effects of Pi on isometric ATPase and unloaded shortening velocity.

240 e (isometric force/cross-sectional area) and unloaded shortening velocity; (iii) myosin/actin ratio a

241 ery low rate of ATP utilization found during unloaded shortening.

242 gy landscape, and skewing it in favor of the unloaded side, and in some situations adding loads to th

243 In addition, LVAD unloading significantly increased interstitial and total

244 The unloading slope during the unstable slip follows the sti

245 During unloading, solutes and proteins are diverted into the ph

246 Surprisingly, at stalled forks, PCNA is unloaded specifically from lagging strands.

247 and stretch are gradually increased from the unloaded state to conditions seen in vivo.

248 cVclKO versus wild-type hearts fixed in the unloaded state.

249 for FT trafficking exists in the post-phloem unloading step.

250 Mechanical unloading stimulates a complex adaptive response that re

251 Finally, unloading stimulates apoptosis of a subset of myonuclei

252 ry signals ultimately control when and where unloading takes place.

253 ured in a series of pressure-controlled load-unload tests to 30 mm Hg and creep tests to 15 and 30 mm

254 electron microscopy (TEM) and cyclic loading-unloading tests.

255 re the cargo in the cytosol and productively unload the cargo at the membrane.

256 Here we show that BRCA1 is required to unload the CMG helicase complex from chromatin after rep

257 rather than strictly focusing on agents that unload the heart or target systemic neurohormones.

258 % of them had an intraaortic balloon pump to unload the left ventricle).

259 s and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) ver

260 Shoes with modified midsoles to unload the medial knee conferred no additional benefit o

261 eaks of melt ('melt welts'), which partially unload the rest of the slip interface.

262 egase plays a critical role in ICL repair by unloading the CMG complex from chromatin.

263 Unloading the LA and augmentation of LA function may be

264 These data support that first unloading the left ventricle despite delaying coronary r

265 a potentially favorable energetic effect of unloading the left ventricle, and thus reduction of wall

266 remove unwanted ions; (3) final washing for unloading the lithium chloride ions.

267 embrane, disrupts the endosomal vesicles and unloads the cargo at its destination site, namely the nu

268 to a DUPA-drug conjugate, PSMA internalizes, unloads the conjugate, and returns to the surface.

269 Based on evidence that Elg1 unloads the DNA replication clamp PCNA from DNA, we test

270 Subsequently, Fap7 ATPase activity unloads the uS11:eS26 subcomplex onto its rRNA binding s

271 ormalization of ventricular diameters during unloading, the pre-explant left ventricular ejection fra

272 nditions and greater energy consumption when unloaded, therefore promoting robustness.

273 rary circulatory support, but the mechanical unloading they offer also results in significant reverse

274 lunger lifts are automatically triggered and unload thousands of times per year and these wells accou

275 ly bendable under load and can recover after unloading, thus, warranting high adhesion strength, 34 N

276 ifferences in reactivity to methacholine and unloaded tissue shortening velocity (Vmax) compared with

277 th IOP at 0-40 mmHg and remained longer than unloaded tissues after being unpressurized.

278 Upon unloading to 10 GPa, -KCl3 transforms to a yet unknown s

279 propose that coupling of fork speed and PCNA unloading to nucleosome assembly provides a simple mecha

280 in twelve immediately loaded (IL) and twelve unloaded (UI) implants.

281 andard conditions, both move with comparable unloaded velocities toward either the microtubule minus

282 ents with heart failure receiving mechanical unloading via left ventricular assist devices show incre

283 ng of the longitudinal electric field of the unloaded wake up to 83 GV m(-1) to a similar degree of a

284 f cardiac function in response to mechanical unloading was assessed by echocardiography during turndo

285 Volume unloading was seen after stage II, as expected, but ejec

286 ecies to the filling grain and their spatial unloading were investigated.

287 Similar levels of unloading were observed for neurally adjusted ventilator

288 A reduction in cell size occurs after LVAD unloading, which does not necessarily correlate with imp

289 s place in loading, and detwinning occurs in unloading, which expounds the high ductility observed in

290 as local release of isometric tension/force unloading, which is directly coupled to reactive oxygen

291 Unloading, which is probably regulated, only occurs afte

292 ding and complete plastic strain recovery on unloading, while the same experiments on single-crystall

293 eft ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clini

294 was attenuated in failing hearts chronically unloaded with a left ventricular assist device.

295 an occur that can be marked after myocardial unloading with a left ventricular assist device (LVAD).

296 mal breathing (NB), 5 min respiratory muscle unloading with a ventilator, and 5 min of NB.

297 the impact of medical therapy or ventricular unloading with assist devices are important next steps.

298 pitulated the in vivo response to mechanical unloading with increased expression of SOST (3.4 +/- 1.9

299 modynamic data revealed significant pressure unloading with LVAD.

300 While solutes are unloaded without restriction, large proteins are release