ライフサイエンスコーパス: unloading

1 e pulses, a phenomenon we refer to as 'batch unloading'.

2 f mass flow and diffusion (convective phloem unloading).

3 functional cardiac recovery after mechanical unloading.

4 e of ongoing atrophic remodeling during LVAD unloading.

5 ing regression of cardiac hypertrophy during unloading.

6 ikely due, at least in part, to baroreceptor unloading.

7 ion of cardiac hypertrophy during mechanical unloading.

8 and NIOV+Air, signifying respiratory muscle unloading.

9 sting no direct involvement in cargo loading/unloading.

10 no atrophic remodeling after prolonged LVAD unloading.

11 anical load but hypertrophy can regress upon unloading.

12 unofluorescent imaging during RBC O2 loading/unloading.

13 C-like complex (Elg1-RLC) functions in PCNA unloading.

14 ading, freezing, and thawing, and during CPA unloading.

15 much of the large deformation is removed on unloading.

16 y of Scx-mutant callus was not due to muscle unloading.

17 R plays a dynamic role during ligand loading/unloading.

18 trol subjects and increased after mechanical unloading.

19 emic hemodynamics resulting in biventricular unloading.

20 led; 54 underwent 8.0 +/- 1.2 months of LVAD unloading.

21 esponsible for the bone loss associated with unloading.

22 hereas NIPBL facilitates cohesin loading and unloading.

23 anical stress during hemodynamic loading and unloading.

24 n hearts and is reduced following mechanical unloading.

25 that tdy1 plants are not defective in phloem unloading.

26 ession levels of RANK and c-fms in bone upon unloading.

27 and functional recovery during chronic LVAD unloading.

28 tion should probably start within 2 weeks of unloading.

29 hat this effect was reverted upon mechanical unloading.

30 raction (50 to 100%) of plastic strain after unloading.

31 tant role in facilitating ligand loading and unloading.

32 ociated with greater left ventricular volume unloading.

33 as urinary deoxypyridinoline excretion upon unloading.

34 the increase in MBF, indicating enhanced O2 unloading.

35 ess chondrocyte responses to, and following, unloading.

36 ythrocyte S-nitrosothiol content, EM, and O2 unloading.

37 soleus muscles due to 1-14 days of hind limb unloading.

38 y remodeling of the myocardium due to volume unloading.

39 s that occur to the myocardium due to volume unloading.

40 to 25 cm H2O in terms of respiratory muscle unloading.

41 in each - without any mechanical loading and unloading.

42 ative role for these Suc transporters in Suc unloading.

43 ing aging, estrogen deficiency, and skeletal unloading.

44 s >1 microm did not improve after mechanical unloading.

45 ifested through reversible detwinning during unloading.

46 ficance during cardiac pressure overload and unloading.

47 rostin and RANKL/OPG ratio in the setting of unloading.

48 ption, or stop bone loss induced by skeletal unloading.

49 l strength, and material strength induced by unloading.

50 ts exposed to longer durations of mechanical unloading.

51 dominated by wells with high frequencies of unloadings.

52 of the emissions from all wells with liquid unloadings.

53 mes decreased as early as 30 days after LVAD unloading (113 vs. 77 ml/m(2), p < 0.01, and 92 vs. 60 m

54 ass decreased as early as 30 days after LVAD unloading (114 vs. 95 g/m(2), p < 0.05) and continued to

55 that the central estimate of emissions from unloadings (270 Gg/yr, 95% confidence range of 190-400 G

56 After 6 months of LVAD unloading, 34% of patients had a relative LV ejection fr

57 midday episodic emissions from manual liquid unloadings (a routine operation in this basin and elsewh

58 The rapid loading and unloading abilities demonstrated by these selective micr

59 Proposed mechanisms include skeletal unloading, abnormalities in calciotropic hormones, and c

60 n stress that include water mass loading and unloading above the aquifer surface.

61 These studies suggest that the unloading activity of RFC maximizes the utilization of P

62 ts aspects of its function distinct from its unloading activity.

63 ication factories, probably through its PCNA-unloading activity.

64 This "unloading" activity can be enhanced by mismatches betwee

65 We examined the effect of human ventricular unloading after implantation of left ventricular assist

66 Mechanical unloading after left ventricular assist device implantat

67 by providing significant volume and pressure unloading, allow a reversal of stress-related compensato

68 iated with recovery from those of mechanical unloading alone and identify potential predictors and no

69 reviewed, both those demonstrated with LVAD unloading alone in patients bridged to transplantation a

70 Both mechanical overload and unloading alter t-tubule structure, but the mechanisms m

71 n, was stable for several hours after phloem unloading and could be used to study phloem transport in

72 provements accompanied by respiratory muscle unloading and dyspnea reductions in patients with severe

73 indicates that assumptions regarding liquids unloading and estimated ultimate recovery (EUR) of wells

74 P-SR GTPase complex is required to drive the unloading and initiate translocation of cargo proteins.

75 nses to selective carotid baroreceptor (CBR) unloading and loading in 14 young (22 +/- 1 years) and o

76 ement was achieved by 6 months of mechanical unloading and persisted over the 1-year follow up.

77 ning future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to re

78 again soon, but stress changes from sediment unloading and previous earthquakes may eventually be suf

79 injuries, ischemia-reperfusion, and hindlimb unloading and reloading.

80 Despite effective hemodynamic unloading and remodeling, there were no differences afte

81 o be efficiently coupled to their subsequent unloading and translocation, thus providing spatial coor

82 Additional measurements of unloadings and workovers are needed to produce national

83 ensin-aldosterone system inhibiting, cardiac unloading, and blood pressure lowering properties when c

84 spect to characteristics of left ventricular unloading, and exercise performance remains largely unst

85 augmentation) produces vasodilation, cardiac unloading, and improved cardiac performance.

86 pact myocardial properties during mechanical unloading, and it could foster new lines of investigatio

87 lomerular filtration rate enhancing, cardiac unloading, and renin inhibiting.

88 also improved as early as 30 days after LVAD unloading, and this improvement persisted over time.

89 sites, 27 well completion flowbacks, 9 well unloadings, and 4 workovers).

90 PS) was collected from the loading (source), unloading (apical sink region) and shoot-root junction r

91 Three twin thicknesses after unloading are 3.2, 3.5, and 16 nm, which is consistent w

92 iac myocyte physiology because of myocardial unloading are contributors to ventricular arrhythmias in

93 ptional level, and muscle changes induced by unloading are counteracted by passive mechanical loading

94 inding, complex assembly with SRP, and cargo unloading are inextricably linked to each other via conf

95 Microgravity and unloading are known to cause osteoclast-mediated bone re

96 g the response of the skeleton to mechanical unloading are not completely understood.

97 ur results identify BRCA1-dependent helicase unloading as a critical, early event in ICL repair.

98 otype that was observed resulted from phloem unloading, as opposed to inherent properties of GLK prot

99 machinery, RNA function requires subsequent unloading at least into adjacent companion cells.

100 the transport of Stx, with cargo loading and unloading being regulated by protein kinases.

101 tics of left ventricular pressure and volume unloading between these pump designs and mode of operati

102 f the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing

103 nd at different time points after mechanical unloading by a left ventricular assist device (LVAD) by

104 ssion in human failing hearts resolved after unloading by a left ventricular assist device.

105 o maintain a high turgor to drive symplasmic unloading by bulk flow.

106 The study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial at

107 Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has

108 te is achieved upon drought by reduced xylem unloading by PtaSULTR3;3a and PtaSULTR1;1, and by enhanc

109 Hind limb unloading by tail suspension reduced bone mass in wild-t

110 Despite robust cardiac unloading, capillary density and fibrosis are unchanged

111 NPC, a process that is probably required for unloading cargo sRNA into surrounding cells.

112 eplication, but both clefts are required for unloading clamp from DNA after replication is completed.

113 Liquid unloadings clear wells of accumulated liquids to increas

114 LHCP's transmembrane domains in a productive unloading complex at the membrane.

115 Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insi

116 ngth and failure mechanism during a "loading-unloading cycle" depended on the loading rate, contact t

117 ss matrix subjected to a compressive loading-unloading cycle.

118 statistically similar throughout the loading-unloading cycle.

119 rom 1.64 to 2.29 GPa during multiple loading-unloading cycles.

120 d of MSNA, and was increased by baroreceptor unloading, decreased by baroreceptor stimulation and abo

121 PCNA unloading depends on the Elg1-containing alternative RFC

122 ndicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the

123 ic shortening, lithospheric delamination and unloading due to deglaciation and erosion.

124 locomotor blood flow with respiratory muscle unloading during activity.

125 A key aspect of tail unloading during terrestrial substorms is the accelerati

126 grain boundaries have a surprising "loading-unloading" effect.

127 m toxin (BTX) was used to investigate muscle unloading effects on callus shape.

128 f uncertainty in current estimates of liquid unloading emissions.

129 vels, we subjected osteocytes to an in vitro unloading environment achieved by the NASA rotating wall

130 Cells deficient in PCNA unloading exhibit increased chromosome breaks.

131 fines their boundaries, and that the cohesin unloading factor WAPL and its PDS5 binding partners cont

132 LVAD-associated unloading for 6 months resulted in a substantial improve

133 (cross-sectional area) decreased after LVAD unloading from 1,238 +/- 81 mum(2) to 1,011 +/- 68 mum(2

134 We conclude that apoplasmic Suc unloading from de-energized protophloem sieve elements i

135 y, beta(+)/beta(C) was severely impaired for unloading from DNA using either DnaX or the delta subuni

136 r mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g.

137 upward flexure of the lithosphere caused by unloading from river incision between 16,000 and 10,000

138 arrested trafficking (gat), affected in GFP unloading from the phloem into the meristem.

139 The SWEET transporter may facilitate Suc unloading from the phloem to the apoplast where cell wal

140 the Elg1 complex and down-regulate its PCNA-unloading function to promote the G1/S transition.

141 ulated transcript set overlapped with muscle unloading gene expression profiles (>/=1.5-fold change;

142 stasis and body mass in response to hindlimb unloading (HU), a model for evaluating effects of weight

143 layers on mica displayed significant loading-unloading hysteresis, and the adhesive strength and fail

144 usly hypertensive rat model) or the profound unloading in a chronically unloaded heart result in impa

145 underlying the importance of Suc apoplastic unloading in Arabidopsis roots and a putative role for t

146 Runx2 and Osterix in bone were suppressed by unloading in both wild-type mice and Tg mice.

147 vity was partially restored after mechanical unloading in failing hearts (P<0.01) and was significant

148 h is needed to define the role of mechanical unloading in intensive care unit-associated weakness and

149 ligand (RANKL) expression is increased with unloading in mice.

150 sucrose transporters (SUTs) regulate phloem unloading in monocot stems is poorly understood and part

151 in Arabidopsis (Arabidopsis thaliana), while unloading in roots is less understood.

152 e phloem-pole pericycle in regulating phloem unloading in roots.

153 loading in the pulmonary circulation and O2 unloading in the systemic circulation.

154 chromatin with purified Elg1-RLC causes PCNA unloading in vitro.

155 evaluate its potential roles, such as phloem unloading, in nonphotosynthetic tissues.

156 in 20S proteasome activity was observed with unloading, in parallel to the decrease in autophagic mar

157 Countermeasures that lessen the effects of unloading include physical activity, nutritional supplem

158 In summary, mechanical unloading increases c-myc activity and c-myc-regulated g

159 ventricular assist device-induced mechanical unloading increases myocardial collagen and stiffness an

160 d presumed progressive arterial baroreceptor unloading) increases cross-spectral coherence between ar

161 Continuous-flow LVAD unloading induced in a subset of patients, both ischemic

162 revealed that OPN is critical for hind limb-unloading induced lymphoid organ atrophy through modulat

163 However, whether unloading-induced atrophy in experimental normal heart m

164 r signaling in osteoblastic cells suppresses unloading-induced bone loss specifically through the reg

165 /PTHrP receptor) signaling in osteoblasts in unloading-induced bone loss using transgenic mice.

166 d4 in soleus muscles completely reversed the unloading-induced decrease of Notch1 expression, indicat

167 However, in contrast to unloading-induced enhancement of bone resorption paramet

168 sion of a d.n. form of the protein decreased unloading-induced NF-kappaB activation and inhibited atr

169 c Col1a1 promoter (Col1a1-caPPR), suppressed unloading-induced reduction in bone mass in these transg

170 eling features might guide future studies of unloading-induced reverse remodeling of the failing huma

171 Prolonged mechanical unloading induces adult human cardiomyocyte proliferatio

172 hts from studies which investigated how LVAD unloading influences the structure and function of the f

173 capacity to interact with AGO2, it mediated unloading instead of loading of let-7 family miRNAs, the

174 unlike termination, repair-mediated helicase unloading involves the tumor suppressor protein BRCA1, w

175 CMG unloading involves ubiquitylation of its Mcm7 subunit an

176 SOST/sclerostin up-regulation in mechanical unloading is a cell-autonomous response or a hormonal re

177 articular chondrocytes is load-induced, and unloading is associated with rapid changes in PTHrP expr

178 tors that are enriched on chromatin when CMG unloading is blocked.

179 of an elg1Delta mutant suggests timely PCNA unloading is critical for chromosome maintenance.

180 vitro and in vivo analysis showed that PCNA unloading is delayed in the absence of nucleosome assemb

181 f CRL2(Lrr1), Mcm7 is not ubiquitylated, CMG unloading is inhibited, and a large subcomplex of the ve

182 Importantly, mechanical unloading leads to complete reversal in PI3Kgamma and be

183 hanced (ulnar loading) and reduced (hindlimb unloading) loading conditions.

184 tricular samples before and after mechanical unloading (LVAD).

185 to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labelin

186 In addition, there was left ventricular (LV) unloading manifested by a decrease in LV end-diastolic p

187 posed to 1-gravity environment or mechanical unloading (MU) for 24 hours, with or without periods of

188 sults demonstrate that Elg1-RLC functions in unloading of both unmodified and SUMOylated PCNA during

189 tly reduced, but not fully eliminated, while unloading of Ca2+ stores by thapsigargin treatment in th

190 l analysis confirms a lag in the loading and unloading of cardiac iron with respect to liver iron, an

191 egulation of motor proteins, the loading and unloading of cargo and the turnover of flagellar protein

192 ontrol the loading, active concentration and unloading of cargo on this track network, or to trigger

193 SRP*SR complex, and most significantly, the unloading of cargo onto the target membrane.

194 editor," capable of fine-tuning loading and unloading of CD1d molecules.

195 Depletion of Klf4 leads to unloading of cohesin at the Oct4 enhancer and disrupts l

196 Unloading of endoplasmic reticulum (ER) Ca(2+) stores ac

197 in the intestine, unlike the diffusion based unloading of most controlled release devices for small m

198 sma during exercise, in association with the unloading of O(2) from haemoglobin, while ATP and adenos

199 al OB-folds allow CST to mediate loading and unloading of partner proteins to facilitate various aspe

200 actor C-like complex, Elg1/ATAD5-RLC, in the unloading of PCNA during replication in yeast and human

201 checkpoint kinases regulate strand-specific unloading of PCNA from stalled replication forks to main

202 either Rad24 or Elg1, catalyzed significant unloading of PCNA.

203 y of the DNA replication machinery, and that unloading of Rad51 by Srs2 helicase is required for effi

204 iv) these species disassemble through either unloading of RFC.PCNA from DNA or dissociation of PCNA i

205 We also report that unloading of RPA from sites of ICL induction is perturbe

206 mathematical modelling) to show that phloem unloading of solutes in Arabidopsis roots occurs through

207 mics the headward fluid shift and axial body unloading of spaceflight.

208 an important factor for the study of phloem unloading of Suc.

209 though the processes involved in loading and unloading of sugars and amino acids are well characteriz

210 Mechanical unloading of the failing human heart decreases markers o

211 and hypertrophy before and after mechanical unloading of the failing human heart.

212 n advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired ca

213 Mechanical unloading of the failing myocardium reverses adipose tis

214 Therefore, unloading of the heart may contribute to the beneficial

215 s of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results i

216 Mechanical unloading of the rat heart increases both protein synthe

217 the sequential recruitment, remodeling, and unloading of the targeting complex at membrane transloca

218 G actively drives the efficient delivery and unloading of translating ribosomes at the target membran

219 ect of left ventricular assist device (LVAD) unloading on cardiac endothelium and microvasculature is

220 altered sympathetic activity in addition to unloading on cardiac hypertrophy and function.

221 igate the impact of gravitational mechanical unloading on ECs phenotype as determined by patterns of

222 stigations have described the impact of LVAD unloading on key structural features of cardiac remodeli

223 These new insights into the effects of LVAD unloading on microvasculature and associated key remodel

224 s study was to test the effect of mechanical unloading on mitochondrial mass, DDR, and cardiomyocyte

225 The effects of LVAD unloading on myocardial function, electrophysiologic pro

226 s-flow left ventricular assist device (LVAD) unloading on myocardial structure and systolic and diast

227 lenge to predict the impact of LV mechanical unloading on postoperative right ventricular (RV) functi

228 s, we investigated the effects of mechanical unloading on regulation of PI3Kgamma activity and intrac

229 0.01) and ejection fraction increases during unloading (P<0.01).

230 Transiting from an apoplasmic to symplasmic unloading pathway as the stem matures, SbSUT1 and SbSUT5

231 2.5 subassemblies are capable of opening and unloading PCNA from circular DNA.

232 During the unloading period, soleus muscle fibre cross-section decr

233 loading of PCNA were strongly inhibited, and unloading predominated.

234 parated when they exit the phloem during the unloading process.

235 does not have an apparent function in either unloading process.

236 t Tdy1 may play a role in phloem loading and unloading processes.

237 of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly

238 However, despite beneficial cardiac unloading properties, reductions in renal perfusion pres

239 ended on the loading rate, contact time, and unloading rate.

240 switch from symplasmic to apoplasmic phloem unloading, reconciling previously conflicting reports, a

241 was used to apply an equibiaxial loading and unloading regimen to fibroblast-seeded tissue equivalent

242 Bone tissues respond to mechanical loading/unloading regimens to accommodate (re)modeling requireme

243 e-state model for CMR where both loading and unloading regulate the transition of bonds among the sho

244 NF-kB binding site is involved in the muscle unloading regulation of MuRF1.

245 h can be described as time-dependent forces (unloading/reloading cycles) acting on the Earth.

246 The LVAD unloading resulted in increased microvascular density ac

247 g therapy and left ventricular assist device unloading results in significant myocardial recovery, su

248 direct real-time evidence of water molecules unloading reversibly from these channels, thereby acting

249 Hind limb unloading, sciatic nerve denervation, starvation, and di

250 Unloading shoes were not associated with increased proba

251 Mechanical unloading significantly decreased mRNA transcript levels

252 In addition, LVAD unloading significantly increased interstitial and total

253 The unloading slope during the unstable slip follows the sti

254 During unloading, solutes and proteins are diverted into the ph

255 for FT trafficking exists in the post-phloem unloading step.

256 Mechanical unloading stimulates a complex adaptive response that re

257 Finally, unloading stimulates apoptosis of a subset of myonuclei

258 Col1a1-caPPR transgenic (Tg) mice, hind limb unloading suppressed bone formation parameters in vivo a

259 cells', thereby establishing a supply-based unloading system for the regulation of K+ distribution.

260 ry signals ultimately control when and where unloading takes place.

261 electron microscopy (TEM) and cyclic loading-unloading tests.

262 pletions and conventional natural gas liquid unloadings that need to be further addressed.

263 egase plays a critical role in ICL repair by unloading the CMG complex from chromatin.

264 tin-null mice were characterized followed by unloading the incisors.

265 Unloading the LA and augmentation of LA function may be

266 These data support that first unloading the left ventricle despite delaying coronary r

267 a potentially favorable energetic effect of unloading the left ventricle, and thus reduction of wall

268 remove unwanted ions; (3) final washing for unloading the lithium chloride ions.

269 ormalization of ventricular diameters during unloading, the pre-explant left ventricular ejection fra

270 Upon unloading, these internal residual stresses cause strain

271 rary circulatory support, but the mechanical unloading they offer also results in significant reverse

272 ur by design (condensate flashing and liquid unloadings), they occur more than an order of magnitude

273 ssue by altering erythrocyte rheology and O2 unloading through an increase in bioactive nitric oxide

274 ly bendable under load and can recover after unloading, thus, warranting high adhesion strength, 34 N

275 Upon unloading to 10 GPa, -KCl3 transforms to a yet unknown s

276 propose that coupling of fork speed and PCNA unloading to nucleosome assembly provides a simple mecha

277 Prolonged mechanical unloading (UN) of the heart is associated with detriment

278 Combination therapy consisting of mechanical unloading using a left ventricular assist device (LVAD)

279 ents with heart failure receiving mechanical unloading via left ventricular assist devices show incre

280 f cardiac function in response to mechanical unloading was assessed by echocardiography during turndo

281 Volume unloading was seen after stage II, as expected, but ejec

282 etween lengthening (loading) and shortening (unloading) was also recorded.

283 ecies to the filling grain and their spatial unloading were investigated.

284 Similar levels of unloading were observed for neurally adjusted ventilator

285 Methane emissions from liquid unloadings were measured at 107 wells in natural gas pro

286 A reduction in cell size occurs after LVAD unloading, which does not necessarily correlate with imp

287 s place in loading, and detwinning occurs in unloading, which expounds the high ductility observed in

288 as local release of isometric tension/force unloading, which is directly coupled to reactive oxygen

289 Unloading, which is probably regulated, only occurs afte

290 ding and complete plastic strain recovery on unloading, while the same experiments on single-crystall

291 eft ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clini

292 Mechanical unloading with a left ventricular assist device (LVAD) d

293 an occur that can be marked after myocardial unloading with a left ventricular assist device (LVAD).

294 mal breathing (NB), 5 min respiratory muscle unloading with a ventilator, and 5 min of NB.

295 the impact of medical therapy or ventricular unloading with assist devices are important next steps.

296 2+) channel-mediated Ca(2+) entry after S/ER unloading with cyclopiazonic acid (in Ca(2+)-free medium

297 pitulated the in vivo response to mechanical unloading with increased expression of SOST (3.4 +/- 1.9

298 modynamic data revealed significant pressure unloading with LVAD.

299 We examined the effect of mechanical unloading with ventricular assist device (VAD) therapy o

300 Hindlimb unloading yielded a significant increase in Sost express