ライフサイエンスコーパス: unmasking

1 nts that reverse DNA methylation (epigenetic unmasking).

2 er is altered or removed in a process called unmasking.

3 y midbrain play an important role in spatial unmasking.

4 ctional coding, thereby compromising spatial unmasking.

5 identified the mechanism that regulates its unmasking.

6 roposed for this heterodimerization-mediated unmasking.

7 olyadenylation factor CPEB, failed to induce unmasking.

8 asmic polyadenylation was necessary for mRNA unmasking.

9 gulation of gene expression after epigenetic unmasking.

10 position 19 --> 20, and the alpha,beta-enone unmasking 20 --> 1.

11 mes the requirement for the CTD, possibly by unmasking a cryptic initiation site.

12 f the Notch negative regulatory region (NRR) unmasking a key proteolytic site (S2) and facilitating d

13 But recent evidence is unmasking a more substantial and long-lasting benefit of

14 elevated cardiac l-arginine concentrations, unmasking a novel mechanism of action by which nitrate e

15 ory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in

16 ting from hypotension and reflex tachycardia unmasking a reduced endocardial MBF reserve is the prima

17 ting from hypotension and reflex tachycardia unmasking a reduced endocardial myocardial blood flow (M

18 hanges in holoenzyme conformation needed for unmasking a single-strand DNA-binding activity used for

19 +) ATPase (omeprazole and SCH28080), thereby unmasking a stable, low-level leak of H(+) ions from the

20 nitiated through cleavage of the N-terminus, unmasking a tethered ligand that can then interact with

21 because auditory spatial acuity and binaural unmasking (a measure of the spatial contribution to the

22 By unmasking abnormalities in flow reserve within the infar

23 species exhibited similar amounts of spatial unmasking across the three masker types.

24 However, though there was a degree of unmasking among the patients in the active treatment gro

25 ns/deletions may cause a conformation shift, unmasking an additional CRM1-dependent nuclear export se

26 each altered the intestinal motor response, unmasking an initial inhibitory component.

27 chain inserts between conserved IR domains, unmasking an invariant receptor-binding surface that spa

28 radation by liver endothelial cells, thereby unmasking an unanticipated link between angiogenesis and

29 in the presence of a tumor Ag-targeting mAb, unmasking an underappreciated tumoricidal capacity of TA

30 on in vivo may prevent HIV-1 replication by 'unmasking' an innate anti-viral phenotype.

31 w for the quantification of activity-induced unmasking and availability for active translation.

32 We report a case of leprosy unmasking and downgrading reaction after stem cell trans

33 etermine the relative rate constants for the unmasking and hydroxylation reactions, and a qualitative

34 Using a combination of pharmacologic unmasking and microarray techniques, we identified 59 ca

35 This inflammation induced unmasking and strengthening of monosynaptic Adelta drive

36 d genes in human cancers using pharmacologic unmasking and subsequent microarray analysis.

37 e differences may be linked to the timing of unmasking and translation for that mRNA during developme

38 es, biases in the pre-vaccine carriage data (unmasking), and biases in the disease surveillance syste

39 We applied a pharmacologic unmasking approach to detect hypermethylated genes whose

40 ions utilized herein for orthogonal cysteine unmasking are not restricted to ADCs and can be broadly

41 By unmasking bacterial surface structures and enhancing the

42 added during the course of the study, before unmasking based on new clinical and biological findings

43 sent study suggest inducement of beta-glucan unmasking by echinocandins and enhancement of PMN activi

44 ative stress is likely to be responsible for unmasking Ca(2+) sparks in skinned preparations.

45 k and whether this misbalance contributes to unmasking Ca(2+) sparks.

46 triflate displacement, followed by aldehyde unmasking [CaCO3, Hg(ClO4)2, H2O].

47 Sodium channel blockers are effective in unmasking carriers of the disease.

48 Caspofungin-induced unmasking caused approximately fourfold to sevenfold inc

49 e and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells.

50 e probability of channel opening rather than unmasking channels.

51 hose developed CMV-IRR after ART initiation (unmasking CMV-IRR) and 20 experienced paradoxical clinic

52 ose the case definitions for paradoxical and unmasking CMV-IRR.

53 el to explain how cyclin B1 mRNA masking and unmasking could be regulated by the CPE is presented.

54 expansion of epithelial progenitor cells by unmasking cryptic EGF-like ectodomains that activate the

55 proteolysis, either by expressing adapters, unmasking cryptic recognition determinants, or regulatin

56 ogate Sia recognition by CD22) also had this unmasking effect, indicating that the effects of desialy

57 the shortened outer segments may lead to an unmasking effect.

58 ceptor agonist CPBG (1 microM), mimicked the unmasking effects of 5-HT (n = 10 of 19 neurones), while

59 0 nM), a calmodulin inhibitor, inhibited the unmasking effects of 5-HT (n = 5 of 5 neurones).

60 al analysis revealed that the most efficient unmasking element in the cyclin 3' UTR was the CPE.

61 evious binaural modeling work focused on the unmasking enabled by binaural cues at the periphery, and

62 SPn, and the V1(-/-) mice could be useful in unmasking epitopes other than the immunodominant PC epit

63 GP, may enhance immunogenicity, possibly by unmasking epitopes.

64 Pharmacological unmasking followed by microarray analysis is a powerful

65 get zone led to exclusion of patients before unmasking for the efficacy analysis.

66 termined to have ATM-negative tumours before unmasking for the primary analysis (48 in the olaparib p

67 additional hypotheses: (1) is the immediate "unmasking" found after median nerve transection NMDA rec

68 exclusively by the wild house mouse, thereby unmasking gene functions inaccessible in the domesticate

69 proteins, destroying their integrity, and/or unmasking hidden epitopes on host surfaces for colonizat

70 An epitope-unmasking, homogeneous time-resolved fluorescence (HTRF)

71 antiretroviral therapy (ART), perhaps due to unmasking immune reconstitution inflammatory syndrome (I

72 Furthermore, the role of unmasking immune reconstitution inflammatory syndrome (I

73 riatal control of complex movement, thereby "unmasking" impaired striatal control of complex movement

74 d the ability to use spatial information for unmasking in clinical populations.

75 almodulin and NO activation to NK-2 receptor unmasking in sensory neurones.

76 In order to localize this unmasking in the human brain, we have used positron emis

77 nstrated mild hyperautofluorescence (scleral unmasking) in hypopigmented choroid and no lipofuscin ab

78 ensitized excitatory kappa opioid receptors, unmasking inhibitory kappa opioid receptor signaling, an

79 aved from the reporter autonomously, thereby unmasking intense, red-shifted fluorescence emission.

80 and 8 participants developed paradoxical and unmasking IRIS, respectively, none while still receiving

81 creased rate during 3 months of ART suggests unmasking IRIS.

82 ever, the decline in the strength of spatial unmasking is attributable to the effects of bicuculline

83 This unmasking is due to the additional presence of a common

84 cent study has shown that, in frogs, spatial unmasking is more robust at the midbrain than at the per

85 ich is also a homotrimer, activates pyrin by unmasking its PYD, thereby allowing it to interact with

86 issociates vinculin's head-tail interaction, unmasking its talin- and actin-binding sites.

87 egulates DNA binding activity of sigma70 by "unmasking" its DNA binding domains.

88 suggest potential therapeutic strategies for unmasking latent reservoirs of HIV-1.

89 ort, 12% of patients met a uniformly applied unmasking lymphoma IRIS case definition.

90 Clinical characteristics and survival for unmasking lymphoma IRIS have not been described.

91 Unmasking lymphoma IRIS was defined as lymphoma within 6

92 lymphoma patients, 56 (12%) met criteria for unmasking lymphoma IRIS.

93 pears to be regulated by a conserved masking/unmasking mechanism.

94 as well as the potential application of this unmasking method to other RNA-binding proteins is discus

95 We recently developed a pharmacological unmasking microarray approach to screen unknown tumor su

96 of the IRIS event in HIV-infected patients, unmasking Mycobacterium avium complex infection after st

97 e Assays represent a promising technique for unmasking negative effects of toxicants.

98 emarkable work now offers the opportunity of unmasking new and unexpected gene functions that underli

99 unanswered, the prospects remain bright for unmasking new contributions by these unusual cells.

100 domain is missing in pros(I13) embryos, thus unmasking nuclear exclusion, resulting in constitutively

101 After 4 weeks of follow-up (study week 16), unmasking occurred and patients in the deferred treatmen

102 skeletal muscle; and (d) insulin causes the unmasking of a COOH-terminal antigenic epitope in skelet

103 ther amino acid permeases similarly involves unmasking of a cytosolic Art1-target region coupled to a

104 DMBT1 deletions, but at least one reflected unmasking of a germline DMBT1 deletion.

105 eonine, suggesting a mechanism involving the unmasking of a latent membrane localisation sequence in

106 hesis that regulatory potency is enhanced by unmasking of a ligand-binding site in the C-terminal CCP

107 These findings indicate that masking and unmasking of a lipid is central to the regulation of fer

108 Notch activation requires unmasking of a metalloprotease cleavage site remote from

109 multiple activation domains but also in the unmasking of a potent activation domain on E47/Pan1 that

110 Selective unmasking of a single hydroxyl group precedes solid-phas

111 ific N-terminal proteolytic cleavage and the unmasking of a tethered ligand.

112 n some macular diseases may be attributed to unmasking of AF rather than to increased fluorophores wi

113 condary hydroxyl in the two resulting diols, unmasking of an exocyclic methylene group at C-11, and s

114 signaling mechanism involves the proteolytic unmasking of an N-terminal receptor sequence that acts a

115 The unmasking of beta(1-3)-glucan also results in increased

116 n-sensing prodrug platform for the selective unmasking of bioactive agents in hypoxic cells.

117 The unmasking of bromodomains and activator recruitment, con

118 .5(D1790G) exhibits Ca(2+) insensitivity and unmasking of CaM regulation of inactivation gating.

119 (1) resulting in increased longevity and the unmasking of cancer predisposition, frequently hepatocel

120 ccurred degradation of total chlorophyll and unmasking of carotenoids from 31st days after anthesis.

121 This unmasking of catalytic and regulatory potential of the L

122 Trypsin concentration and the unmasking of cleavage sites in proteins play important r

123 out disulfide reduction by (i) enhancing the unmasking of cleavage sites through elevated reaction te

124 nformational change in SCAP, detected by the unmasking of closely spaced trypsin cleavage sites.

125 Unmasking of collagen fibers was most predictive of abno

126 .g., some DMBT1 homozygous deletions reflect unmasking of constitutional deletion polymorphisms by 10

127 ith 10q loss, but all 10 deletions reflected unmasking of constitutional hemizygous deletions.

128 te specificities compatible with proteolytic unmasking of cryptic CendR motifs, the strategy describe

129 Here we report that unmasking of cryptotopes by unfolding whole cytomegalovi

130 This approach utilizes sequential unmasking of cysteine residues with orthogonal protectio

131 n by its myristoyl group, and Ca2+-dependent unmasking of different residues, may explain how each fa

132 staining is not caused by the retraction or unmasking of dynein upon detachment.

133 the truncated TrkB receptor did not involve unmasking of endogenous TrkC signaling.

134 Pharmacologic unmasking of epigenetic silencing in breast cancer cells

135 mechanism for such rapid changes may be the unmasking of existing divergent and convergent thalamoco

136 The kinetic unmasking of inhibited binding reflected in the increase

137 We propose that there is an unmasking of inhibitory mechanisms or a reduction in des

138 to show how the plasticity may relate to the unmasking of latent bulbospinal respiratory connections

139 the Leu3-dd phenotype) that cause permanent unmasking of Leu3p.

140 ecular association in the monomer results in unmasking of ligand binding sites and a significant conf

141 Under the drug, the strength of spatial unmasking of midbrain neurons approximated that of audit

142 egative mutant S6 is cytoplasmic, due to the unmasking of NES.

143 We report that the immediate unmasking of new receptive fields after acute nerve inju

144 gesting that the vagus nerve is required for unmasking of NK-2 responses.

145 ctral-domain OCT and may be explained by the unmasking of normal background RPE AF.

146 ing suggests that it is likely caused by the unmasking of normally suppressed spatially tuned excitat

147 ed prerestorative satiety mechanism, and the unmasking of other opioid-mediated signalling mechanisms

148 changes in the cerebral cortex, probably via unmasking of pre-existent connections.

149 wth of new connections), instead implicating unmasking of preexisting connections as the underlying n

150 an those without eosinophilia, suggesting an unmasking of preexisting eosinophilia as sepsis resolves

151 ractions are counterbalanced, leading to the unmasking of preferences for conformations that resemble

152 entiation of presynaptic function, including unmasking of previously "silent" synapses.

153 kg)-precipitated withdrawal hyperalgesia and unmasking of prominent opioid analgesia.

154 an organism to the risks associated with the unmasking of recessive mutations.

155 NO synthase inhibitor, blocked 5-HT-induced unmasking of SP responses (n = 10 of 10 neurones).

156 agonist, completely blocked the 5-HT-induced unmasking of SP responses (n = 10 of 10 neurones).

157 5-HT-induced unmasking of SP responses was dose dependent (EC50 = 14

158 5-HT-induced unmasking of SP responses was maximal within 5 min.

159 ediated elevation of [Ca2+]i is required for unmasking of SP responses.

160 the spermatids, where it is involved in the unmasking of stored SPDS mRNAs, leading to substantial s

161 lts from changes in synaptic strength and/or unmasking of subthreshold intermodal connections.

162 ryptic intragenic variation and (ii) enabled unmasking of such variation due to DNA replicative slipp

163 e of POP repair to prevent the postoperative unmasking of SUI in women who do not have SUI preoperati

164 onal evidence that such RIAM-mediated steric unmasking of talin triggers integrin activation.

165 fficking regulation that we term "controlled unmasking of targeting elements" (CUTE).

166 in mammalian cells suggests that masking and unmasking of the activation domain occur without the par

167 21st century, determined by the rate of the unmasking of the aerosol cooling effect by air pollution

168 ilization and by proteolysis correlates with unmasking of the alpha(M)beta2-binding site in the D-dom

169 The translocation also results in an unmasking of the ARF COOH terminus, suggesting that redi

170 restoration of the choroidal blood flow and unmasking of the big choroidal vessels.

171 Protection of the C37 carbonol and selective unmasking of the C44 carbonol completed our second gener

172 s in the C-terminal domain did not result in unmasking of the catalytic domain.

173 the phenols, O-sulfation, and photochemical unmasking of the cyclopropenone moiety.

174 ncluding domains 1 and 2, suggesting that an unmasking of the DNA binding surface may be a preconditi

175 Unmasking of the DO-1 epitope via dephosphorylation occu

176 removing the potential for metabolism-based unmasking of the embedded aniline.

177 aving greyish, granular, depigmented fundus, unmasking of the large choroidal vessels and optic atrop

178 part of the morphological substrate for the unmasking of the latent crossed phrenic pathway which me

179 terminus of full-length ARTEMIS resulted in unmasking of the N terminus and in increased ARTEMIS act

180 Hydrogenolytic unmasking of the nitroso acetal tosylate 17 containing t

181 -phase synthesis support following selective unmasking of the nucleophile incorporated in these phosp

182 umor suppressor genes based on pharmacologic unmasking of the promoter region and detection of re-exp

183 umor suppressor genes based on pharmacologic unmasking of the promoter region and detection of reexpr

184 membrane-associated factor that promotes the unmasking of the rab11-binding site in rab11BP.

185 Finally, the efficiency of the photochemical unmasking of the support bound alkylamine on a 1 mumole

186 The unmasking of the Tau-12 epitope in more mature 5A6-posit

187 s efficiently with minimal toxicity, because unmasking of their hydrophobic domains selectively occur

188 xes are excellent reagents for the effective unmasking of thiazolidine, enabling its complete removal

189 ormation through a phosphorylation-dependent unmasking of this region.

190 Unmasking of this site serves as a molecular switch that

191 rminal mitochondrial targeting sequence, the unmasking of which occurs in the hereditary calcium oxal

192 Conversely spontaneous "unmasking" of cell wall lipids may promote airway inflam

193 suggesting that cortical reorganization or "unmasking" of latent pathways can contribute to function

194 ynamics may be responsible for the apparent "unmasking" of the backbone resonances in the presence of

195 ially highly dynamic mechanisms such as the 'unmasking' of latent pathways.

196 restriction that is relieved as a result of unmasking or conformational change accompanying hsp90 di

197 uded from the analysis because of procedural unmasking or no autopsy data, as were 24 cases with a cl

198 of corticostriatal connections, perhaps via unmasking or sprouting of connections to adjacent cluste

199 maintenance of acute modifications, such as unmasking or strengthening of normally ineffective input

200 s that either promoted (V1V2 deletion, i.e., unmasking) or prevented (GPGR to GPGQ mutation, i.e., ep

201 hes, the delayed rectifier current ran down, unmasking other K+ channels.

202 In this study, we investigated spatial unmasking patterns of single neurons in the frog inferio

203 hermal grill illusion can be explained as an unmasking phenomenon that reveals the central inhibition

204 nduced by an extremely low dose of morphine, unmasking potent analgesia.

205 rphine or by a kappa opioid agonist, thereby unmasking potent opioid analgesia.

206 blocks opioid-induced hyperalgesic effects, unmasking potent opioid analgesia.

207 l magnetic resonance imaging with a gradual 'unmasking' procedure that slows down the process of visu

208 The finding that masking and unmasking proceed apparently normally when full-length L

209 Exercise testing is useful in unmasking QT prolongation in disorders associated with a

210 a qualitative correlation was found for the unmasking reaction and release of hydrogen peroxide from

211 proximal parts of cytoplasmic tails, thereby unmasking residues involved in binding the skelemin-like

212 presentatives that exhibit modest and strong unmasking, respectively.

213 not uninfected cells, it is likely that this unmasking results from a specific interaction of another

214 rs increased the sensitivity of most RGCs by unmasking rod signals, which were suppressed.

215 After high-temperature antigen unmasking, sections were incubated with mouse monoclonal

216 potential mechanisms for transduction of an "unmasking signal" from the inflamed airway to vagal affe

217 or a higher generation dendron 8 the rate of unmasking slightly decreased presumably due to steric cr

218 These findings invoke the notion of "unmasking" specific hypermutable sequences in particular

219 a carbonyl group without the requirement of unmasking steps as with other nucleophiles.

220 role of structural biology, particularly in unmasking structure-function relationships following gen

221 n markedly decreased the strength of spatial unmasking such that even large angular separation of sig

222 In this study, an epitope-unmasking technique was used to immunolocalize AE2 anion

223 osed by epitope retrieval and nuclear matrix unmasking techniques, endogenous SPARC was found to loca

224 use corneal stromas without the need for any unmasking techniques, indicating that this domain is exp

225 exposure, mGluR7 undergoes internalization, unmasking the ability of MF-SLIN synapses to undergo pre

226 ejecting this domain from the jaws, thereby unmasking the active site; and (3) final conversion to R

227 Unmasking the addition products gives acyl cyanide inter

228 each the quaternary structure of M-hexamers, unmasking the cryptic epitopes, whereas D-hexamers are r

229 ed natural products are thus useful tools in unmasking the cryptic functions of conventional enzymes

230 ndability and excessive energy availability, unmasking the deleterious effects of PPARgamma mutations

231 creases transcriptional activity of SAF-1 by unmasking the DNA-binding domain.

232 ceptions of service members' tobacco use and unmasking the forces perpetuating those perceptions.

233 ry through endosomes, in which activating or unmasking the fusion complex by low pH or by proteinase

234 rs of dipeptides with long-range order, thus unmasking the influence of hydrogen bonding, chirality,

235 cellular production of estrogens but also by unmasking the inhibitory effect of androgens acting via

236 n complexes are isolated from cells, thereby unmasking the intrinsic complex ultrastability.

237 fic activity of cellular ribonucleases or by unmasking the mRNA-degrading activity of cellular toxins

238 e abrogates its inhibitory activity, thereby unmasking the NES and causing the full-length NS1 protei

239 of MLH1 and PMS2 regulates nuclear import by unmasking the NLS.

240 r presence of the NMDAR blocker, APV, hereby unmasking the NMDAR component in this process.

241 - and the C-terminal domains of ICAP-1alpha, unmasking the PTB domain, thereby permitting ICAP-1alpha

242 tions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct i

243 , devitrifies sugar--releasing the cargo and unmasking the substrate surface--thus triggering substra

244 t class the hom-thrCB operon was derepressed unmasking the threonine dehydratase activity of the thre

245 alternative splicing may be a mechanism for unmasking the transforming activity of c-myb in human le

246 y epileptic cells, but was more effective at unmasking the underlying IPSP in silent period neurons.

247 muscle that can substitute for UNC-60B, thus unmasking their functional redundancy.

248 l]methanethiosulfonate, was not effective in unmasking these sites.

249 The trial was double-blinded; some unmasking took place at age 2 years for an interim analy

250 expression driven by a program of selective unmasking, translation, and degradation of maternal mRNA

251 Unmasking ultradian rhythms in gene expression.

252 driven by a reduced number of naive T cells unmasking underlying memory clonality.

253 partner was 59 per 100 person-months before unmasking versus 53 after unmasking; we recorded no imme

254 The amount of unmasking was greater when the masker was played continu

255 re-expression in cell lines after epigenetic unmasking, we identified 13 candidate tumor suppressor g

256 rson-months before unmasking versus 53 after unmasking; we recorded no immediate change (p=0.66) or c

257 Nanoscale changes to the cell wall during unmasking were explored in live cells with atomic force

258 ong-term potentiation prompts transient mRNA unmasking, which depends on factors active during synapt